Walter M Holleran

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Matrix metalloproteinase inhibitors reduce phorbol ester-induced cutaneous inflammation and hyperplasia
    W M Holleran
    Department of Dermatology, School of Medicine, University of California San Francisco
    Arch Dermatol Res 289:138-44. 1997
  2. pmc Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death
    Vidyullatha Vasireddy
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA
    Hum Mol Genet 16:471-82. 2007
  3. ncbi request reprint Epidermal sphingolipids: metabolism, function, and roles in skin disorders
    Walter M Holleran
    Department of Dermatology, School of Medicine, University of California San Francisco, 94121, USA
    FEBS Lett 580:5456-66. 2006
  4. ncbi request reprint Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis
    Evi Houben
    Department of Toxicology, Dermato Cosmetology, and Pharmacognosy, Vrije Universiteit Brussels, Belgium
    J Lipid Res 47:1063-70. 2006
  5. ncbi request reprint Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing
    Mao Qiang Man
    Department of Dermatology, University of California and VA Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 126:386-92. 2006
  6. pmc Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism
    Peter M Elias
    Dermatology Services, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    J Lipid Res 49:697-714. 2008
  7. ncbi request reprint Epidermal-specific defect of GPI anchor in Pig-a null mice results in Harlequin ichthyosis-like features
    Mariko Hara-Chikuma
    Basic Research Laboratory, Kanebo Ltd, 5 chome Kotobuki cho, Odawara shi, Kanagawa ken 250 0002, Japan
    J Invest Dermatol 123:464-9. 2004
  8. ncbi request reprint Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function
    Martin J Behne
    Department of Dermatology, University of California San Francisco, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 120:998-1006. 2003
  9. ncbi request reprint De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes
    Yoshikazu Uchida
    Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, School of Medicine, University of California, San Francisco, USA
    J Invest Dermatol 120:662-9. 2003
  10. ncbi request reprint The potential of metabolic interventions to enhance transdermal drug delivery
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, Department of Dermatology and Medicine, University of California San Francisco, California 94121, USA
    J Investig Dermatol Symp Proc 7:79-85. 2002

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Matrix metalloproteinase inhibitors reduce phorbol ester-induced cutaneous inflammation and hyperplasia
    W M Holleran
    Department of Dermatology, School of Medicine, University of California San Francisco
    Arch Dermatol Res 289:138-44. 1997
    ..Moreover, the delivery of this class of inhibitors across intact stratum corneum implies that MMP inhibition could provide an approach to the topical treatment of inflammatory dermatoses...
  2. pmc Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death
    Vidyullatha Vasireddy
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA
    Hum Mol Genet 16:471-82. 2007
    ..These findings demonstrate that ELOVL4 is required for generating VLFA critical for epidermal barrier function, and that the lack of epidermal omega-O-acylceramides is incompatible with survival in a desiccating environment...
  3. ncbi request reprint Epidermal sphingolipids: metabolism, function, and roles in skin disorders
    Walter M Holleran
    Department of Dermatology, School of Medicine, University of California San Francisco, 94121, USA
    FEBS Lett 580:5456-66. 2006
    ..Enzymatic processes in the hydrolysis of glucosylceramide and sphingomyelin, and the roles of sphingolipids in skin diseases, are the focus of this review...
  4. ncbi request reprint Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis
    Evi Houben
    Department of Toxicology, Dermato Cosmetology, and Pharmacognosy, Vrije Universiteit Brussels, Belgium
    J Lipid Res 47:1063-70. 2006
    ....
  5. ncbi request reprint Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing
    Mao Qiang Man
    Department of Dermatology, University of California and VA Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 126:386-92. 2006
    ..Since the liposensors are activated by endogenous lipid metabolites, they may serve as unique regulators of barrier homeostasis...
  6. pmc Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism
    Peter M Elias
    Dermatology Services, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    J Lipid Res 49:697-714. 2008
    ..The barrier abnormality provokes the clinical phenotype in these disorders not only by stimulating epidermal proliferation, but also by inducing inflammation...
  7. ncbi request reprint Epidermal-specific defect of GPI anchor in Pig-a null mice results in Harlequin ichthyosis-like features
    Mariko Hara-Chikuma
    Basic Research Laboratory, Kanebo Ltd, 5 chome Kotobuki cho, Odawara shi, Kanagawa ken 250 0002, Japan
    J Invest Dermatol 123:464-9. 2004
    ....
  8. ncbi request reprint Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function
    Martin J Behne
    Department of Dermatology, University of California San Francisco, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 120:998-1006. 2003
    ..Thus, full barrier competence appears to require the extension of acidification in microdomains from the SC/SG interface outward toward the skin surface in the immediate postnatal period...
  9. ncbi request reprint De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes
    Yoshikazu Uchida
    Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, School of Medicine, University of California, San Francisco, USA
    J Invest Dermatol 120:662-9. 2003
    ..Thus, increased de novo ceramide synthesis signals ultraviolet B-induced apoptosis, by a pathway independent of, but in concert with, caspase-3 activation...
  10. ncbi request reprint The potential of metabolic interventions to enhance transdermal drug delivery
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, Department of Dermatology and Medicine, University of California San Francisco, California 94121, USA
    J Investig Dermatol Symp Proc 7:79-85. 2002
    ..Yet, while these new approaches hold great promise, if equally effective in human skin, they pose new questions about the risks of a highly permeabilized stratum corneum...
  11. doi request reprint Omega-O-acylceramide, a lipid essential for mammalian survival
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California San Francisco, Veterans Affairs on Medical Center, San Francisco, CA 94121, United States
    J Dermatol Sci 51:77-87. 2008
    ..These results indicate not only that acylCer are critical lipid components for mammalian survival, but also that keratinocytes deploy a complex metabolic pathway leading to the formation of these unique Cer...
  12. ncbi request reprint NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging
    Martin J Behne
    Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Biol Chem 277:47399-406. 2002
    ....
  13. pmc On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA, USA
    J Dermatol Sci 51:37-43. 2008
    ..However, since the metabolic fates of each pseudo-Cer remain unknown, their widespread deployment in topical agents has raised concern about potential toxicities...
  14. ncbi request reprint Basis for the permeability barrier abnormality in lamellar ichthyosis
    Peter M Elias
    Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Exp Dermatol 11:248-56. 2002
    ....
  15. ncbi request reprint Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA
    J Biol Chem 282:13211-9. 2007
    ..Thus, late differentiation-linked increases in FA2H expression are essential for epidermal permeability barrier homeostasis...
  16. doi request reprint A role for ceramide in driving cancer cell resistance to doxorubicin
    Yong Yu Liu
    Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, 700 University Ave, Monroe, LA 71209, USA
    FASEB J 22:2541-51. 2008
    ..These data indicate that ceramide-governed GCS gene expression drives cellular resistance to doxorubicin...
  17. ncbi request reprint A homolog of Drosophila grainy head is essential for epidermal integrity in mice
    Stephen B Ting
    Rotary Bone Marrow Research Laboratories, c o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050
    Science 308:411-3. 2005
    ..These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution...
  18. ncbi request reprint Ceramide reduction and transcriptional up-regulation of glucosylceramide synthase through doxorubicin-activated Sp1 in drug-resistant HL-60/ADR cells
    Yoshikazu Uchida
    Department of Hematology and Oncology, Clinical Sciences for Pathological Organs, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Cancer Res 64:6271-9. 2004
    ..Together, the results suggest that transcriptional up-regulation of GCS through DOX-induced activation of Sp1 is one potential mechanism to regulate ceramide increase and apoptosis in HL-60/ADR cells...
  19. pmc Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis
    Khemissa Bejaoui
    Day Neuromuscular Research Laboratory, Charlestown, Massachusetts, USA
    J Clin Invest 110:1301-8. 2002
    ..These results indicate that the HSN1-associated mutations in LCB1 confer dominant negative effects on the SPT enzyme...
  20. ncbi request reprint Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress
    Yoshikazu Uchida
    Dermatology Service, Department of Veterans Affairs Medical Center, San Francisco, CA, USA
    J Lipid Res 43:1293-302. 2002
    ..Thus, SMase-induced stress initiates a response in keratinocytes that includes upregulation of GlcCer synthesis which may protect against the deleterious effects of excess Cer...
  21. pmc Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation
    Alexandra Charruyer
    Department of Dermatology, School of Medicine, University of California, Northern California Institute for Research and Education, and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 283:16682-92. 2008
    ....