Walter M Holleran
Affiliation: University of California
- Matrix metalloproteinase inhibitors reduce phorbol ester-induced cutaneous inflammation and hyperplasiaW M Holleran
Department of Dermatology, School of Medicine, University of California San Francisco
Arch Dermatol Res 289:138-44. 1997..Moreover, the delivery of this class of inhibitors across intact stratum corneum implies that MMP inhibition could provide an approach to the topical treatment of inflammatory dermatoses...
- Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal deathVidyullatha Vasireddy
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA
Hum Mol Genet 16:471-82. 2007..These findings demonstrate that ELOVL4 is required for generating VLFA critical for epidermal barrier function, and that the lack of epidermal omega-O-acylceramides is incompatible with survival in a desiccating environment...
- Epidermal sphingolipids: metabolism, function, and roles in skin disordersWalter M Holleran
Department of Dermatology, School of Medicine, University of California San Francisco, 94121, USA
FEBS Lett 580:5456-66. 2006..Enzymatic processes in the hydrolysis of glucosylceramide and sphingomyelin, and the roles of sphingolipids in skin diseases, are the focus of this review...
- Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermisEvi Houben
Department of Toxicology, Dermato Cosmetology, and Pharmacognosy, Vrije Universiteit Brussels, Belgium
J Lipid Res 47:1063-70. 2006....
- Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processingMao Qiang Man
Department of Dermatology, University of California and VA Medical Center, San Francisco, California 94121, USA
J Invest Dermatol 126:386-92. 2006..Since the liposensors are activated by endogenous lipid metabolites, they may serve as unique regulators of barrier homeostasis...
- Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolismPeter M Elias
Dermatology Services, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
J Lipid Res 49:697-714. 2008..The barrier abnormality provokes the clinical phenotype in these disorders not only by stimulating epidermal proliferation, but also by inducing inflammation...
- Epidermal-specific defect of GPI anchor in Pig-a null mice results in Harlequin ichthyosis-like featuresMariko Hara-Chikuma
Basic Research Laboratory, Kanebo Ltd, 5 chome Kotobuki cho, Odawara shi, Kanagawa ken 250 0002, Japan
J Invest Dermatol 123:464-9. 2004....
- Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier functionMartin J Behne
Department of Dermatology, University of California San Francisco, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Invest Dermatol 120:998-1006. 2003..Thus, full barrier competence appears to require the extension of acidification in microdomains from the SC/SG interface outward toward the skin surface in the immediate postnatal period...
- De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytesYoshikazu Uchida
Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, School of Medicine, University of California, San Francisco, USA
J Invest Dermatol 120:662-9. 2003..Thus, increased de novo ceramide synthesis signals ultraviolet B-induced apoptosis, by a pathway independent of, but in concert with, caspase-3 activation...
- The potential of metabolic interventions to enhance transdermal drug deliveryPeter M Elias
Dermatology Service, Veterans Affairs Medical Center, Department of Dermatology and Medicine, University of California San Francisco, California 94121, USA
J Investig Dermatol Symp Proc 7:79-85. 2002..Yet, while these new approaches hold great promise, if equally effective in human skin, they pose new questions about the risks of a highly permeabilized stratum corneum...
- Omega-O-acylceramide, a lipid essential for mammalian survivalYoshikazu Uchida
Department of Dermatology, School of Medicine, University of California San Francisco, Veterans Affairs on Medical Center, San Francisco, CA 94121, United States
J Dermatol Sci 51:77-87. 2008..These results indicate not only that acylCer are critical lipid components for mammalian survival, but also that keratinocytes deploy a complex metabolic pathway leading to the formation of these unique Cer...
- NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imagingMartin J Behne
Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, California 94121, USA
J Biol Chem 277:47399-406. 2002....
- On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramidesYoshikazu Uchida
Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA, USA
J Dermatol Sci 51:37-43. 2008..However, since the metabolic fates of each pseudo-Cer remain unknown, their widespread deployment in topical agents has raised concern about potential toxicities...
- Basis for the permeability barrier abnormality in lamellar ichthyosisPeter M Elias
Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
Exp Dermatol 11:248-56. 2002....
- Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiationYoshikazu Uchida
Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA
J Biol Chem 282:13211-9. 2007..Thus, late differentiation-linked increases in FA2H expression are essential for epidermal permeability barrier homeostasis...
- A role for ceramide in driving cancer cell resistance to doxorubicinYong Yu Liu
Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, 700 University Ave, Monroe, LA 71209, USA
FASEB J 22:2541-51. 2008..These data indicate that ceramide-governed GCS gene expression drives cellular resistance to doxorubicin...
- A homolog of Drosophila grainy head is essential for epidermal integrity in miceStephen B Ting
Rotary Bone Marrow Research Laboratories, c o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050
Science 308:411-3. 2005..These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution...
- Ceramide reduction and transcriptional up-regulation of glucosylceramide synthase through doxorubicin-activated Sp1 in drug-resistant HL-60/ADR cellsYoshikazu Uchida
Department of Hematology and Oncology, Clinical Sciences for Pathological Organs, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Cancer Res 64:6271-9. 2004..Together, the results suggest that transcriptional up-regulation of GCS through DOX-induced activation of Sp1 is one potential mechanism to regulate ceramide increase and apoptosis in HL-60/ADR cells...
- Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesisKhemissa Bejaoui
Day Neuromuscular Research Laboratory, Charlestown, Massachusetts, USA
J Clin Invest 110:1301-8. 2002..These results indicate that the HSN1-associated mutations in LCB1 confer dominant negative effects on the SPT enzyme...
- Glucosylceramide synthesis and synthase expression protect against ceramide-induced stressYoshikazu Uchida
Dermatology Service, Department of Veterans Affairs Medical Center, San Francisco, CA, USA
J Lipid Res 43:1293-302. 2002..Thus, SMase-induced stress initiates a response in keratinocytes that includes upregulation of GlcCer synthesis which may protect against the deleterious effects of excess Cer...
- Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiationAlexandra Charruyer
Department of Dermatology, School of Medicine, University of California, Northern California Institute for Research and Education, and Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Biol Chem 283:16682-92. 2008....