W A Hsueh

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Peroxisome proliferator-activated receptor gamma: implications for cardiovascular disease
    Willa A Hsueh
    Division of Endocrinology, Diabetes, and Hypertension, David Geffen School of Medicine, University of California, Los Angeles Warren Hall, Suite 24 130, 900 Veteran Avenue, Los Angeles, CA 90095, USA
    Hypertension 43:297-305. 2004
  2. ncbi request reprint PPARgamma and atherosclerosis: effects on cell growth and movement
    W A Hsueh
    Division of Endocrinology, Diabetes and Hypertension, UCLA, Department of Medicine, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 21:1891-5. 2001
  3. ncbi request reprint Treatment of type 2 diabetic nephropathy by blockade of the renin-angiotensin system: a comparison of angiotensin-converting-enzyme inhibitors and angiotensin receptor antagonists
    Willa A Hsueh
    Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, University of California Los Angeles, Warren Hall, 900 Veteran Avenue, Suite 24 130, Los Angeles, CA 90024, USA
    Curr Opin Pharmacol 2:182-8. 2002
  4. ncbi request reprint Peroxisome proliferator-activated receptor-gamma in the renal mesangium
    Willa A Hsueh
    UCLA School of Medicine, Los Angeles, California 90095, USA
    Curr Opin Nephrol Hypertens 11:191-5. 2002
  5. ncbi request reprint Introduction: New insight into understanding the relation of type 2 diabetes mellitus, insulin resistance, and cardiovascular disease
    Willa A Hsueh
    Division of Endocrinology, Diabetes, and Hypertension, University of California Los Angeles School of Medicine, Los Angeles, California 90095 7073, USA
    Am J Cardiol 92:1J-2J. 2003
  6. ncbi request reprint The central role of fat and effect of peroxisome proliferator-activated receptor-gamma on progression of insulin resistance and cardiovascular disease
    Willa A Hsueh
    Division of Endocrinology, Diabetes, and Hypertension, University of California Los Angeles School of Medicine, Los Angeles, California 90095 7073, USA
    Am J Cardiol 92:3J-9J. 2003
  7. ncbi request reprint Role of endothelial dysfunction in insulin resistance
    Willa A Hsueh
    Division of Endocrinology, Diabetes, and Hypertension, University of California Los Angeles School of Medicine, Los Angeles, California 90095 7073, USA
    Am J Cardiol 92:10J-17J. 2003
  8. pmc Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice
    Dennis Bruemmer
    Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, Warren Hall, Suite 24 130, 900 Veteran Avenue, Los Angeles, California 90095, USA
    J Clin Invest 112:1318-31. 2003
  9. ncbi request reprint Insulin resistance and the endothelium
    Willa A Hsueh
    Division of Endocrinology, Diabetes, and Hypertension, University of California, Los Angeles, USA
    Am J Med 117:109-17. 2004
  10. ncbi request reprint Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice
    A R Collins
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    Arterioscler Thromb Vasc Biol 21:365-71. 2001

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Peroxisome proliferator-activated receptor gamma: implications for cardiovascular disease
    Willa A Hsueh
    Division of Endocrinology, Diabetes, and Hypertension, David Geffen School of Medicine, University of California, Los Angeles Warren Hall, Suite 24 130, 900 Veteran Avenue, Los Angeles, CA 90095, USA
    Hypertension 43:297-305. 2004
    ..In this review, we summarize the important role of PPARgamma as a molecular target for thiazolidinediones and its implications for the control of vascular inflammation and proliferation for the cardiovascular system...
  2. ncbi request reprint PPARgamma and atherosclerosis: effects on cell growth and movement
    W A Hsueh
    Division of Endocrinology, Diabetes and Hypertension, UCLA, Department of Medicine, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 21:1891-5. 2001
    ..Thus, TZD activation of PPARgamma may protect against atherosclerosis both by normalizing proatherogenic metabolic abnormalities of the insulin resistance/diabetes milieu and through an inhibition of vascular cell growth and movement...
  3. ncbi request reprint Treatment of type 2 diabetic nephropathy by blockade of the renin-angiotensin system: a comparison of angiotensin-converting-enzyme inhibitors and angiotensin receptor antagonists
    Willa A Hsueh
    Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, University of California Los Angeles, Warren Hall, 900 Veteran Avenue, Suite 24 130, Los Angeles, CA 90024, USA
    Curr Opin Pharmacol 2:182-8. 2002
    ..These are significant benefits beyond those associated with conventional therapy and blood pressure control...
  4. ncbi request reprint Peroxisome proliferator-activated receptor-gamma in the renal mesangium
    Willa A Hsueh
    UCLA School of Medicine, Los Angeles, California 90095, USA
    Curr Opin Nephrol Hypertens 11:191-5. 2002
    ..Thus PPARs appear to have enormous implications for the management of cardiovascular disease...
  5. ncbi request reprint Introduction: New insight into understanding the relation of type 2 diabetes mellitus, insulin resistance, and cardiovascular disease
    Willa A Hsueh
    Division of Endocrinology, Diabetes, and Hypertension, University of California Los Angeles School of Medicine, Los Angeles, California 90095 7073, USA
    Am J Cardiol 92:1J-2J. 2003
  6. ncbi request reprint The central role of fat and effect of peroxisome proliferator-activated receptor-gamma on progression of insulin resistance and cardiovascular disease
    Willa A Hsueh
    Division of Endocrinology, Diabetes, and Hypertension, University of California Los Angeles School of Medicine, Los Angeles, California 90095 7073, USA
    Am J Cardiol 92:3J-9J. 2003
    ..Although more research is needed, data suggest that PPAR-gamma ligands may prevent the progression of insulin resistance to diabetes and endothelial dysfunction to atherosclerosis...
  7. ncbi request reprint Role of endothelial dysfunction in insulin resistance
    Willa A Hsueh
    Division of Endocrinology, Diabetes, and Hypertension, University of California Los Angeles School of Medicine, Los Angeles, California 90095 7073, USA
    Am J Cardiol 92:10J-17J. 2003
    ..These agents have recently been shown to improve endothelial function in the early stages of insulin resistance. Results from ongoing trials with thiazolidinediones will reveal whether they will also reduce cardiovascular end points...
  8. pmc Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice
    Dennis Bruemmer
    Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, Warren Hall, Suite 24 130, 900 Veteran Avenue, Los Angeles, California 90095, USA
    J Clin Invest 112:1318-31. 2003
    ..These data suggest an important role for leukocyte-derived OPN in mediating Ang II-accelerated atherosclerosis and aneurysm formation...
  9. ncbi request reprint Insulin resistance and the endothelium
    Willa A Hsueh
    Division of Endocrinology, Diabetes, and Hypertension, University of California, Los Angeles, USA
    Am J Med 117:109-17. 2004
    ..This article reviews the relation between endothelial dysfunction and cardiovascular disease, assesses the endothelium in the spectrum of insulin resistance, and examines the effect of the thiazolidinediones on endothelial function...
  10. ncbi request reprint Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice
    A R Collins
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    Arterioscler Thromb Vasc Biol 21:365-71. 2001
    ..These observations suggest that the inhibition of early atherosclerotic lesion formation by troglitazone may result, at least in part, from direct effects of PPARgamma activation in the artery wall...
  11. pmc Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance
    M O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, 8700 Beverly Blvd, Room B 131, Los Angeles, CA 90048, USA
    Diabetologia 56:1282-90. 2013
    ..Insulin clearance is a highly heritable trait, for which few quantitative trait loci have been discovered. We sought to determine whether validated type 2 diabetes and/or glycaemic trait loci are associated with insulin clearance...
  12. ncbi request reprint Response of experimental retinal neovascularization to thiazolidinediones
    T Murata
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Arch Ophthalmol 119:709-17. 2001
    ..CLINICAL RELEVANCE: The TZDs are widely prescribed and should be evaluated for their potential to inhibit the progression of diabetic retinopathy...
  13. ncbi request reprint Expression and function of peroxisome proliferator-activated receptor-gamma in mesangial cells
    S B Nicholas
    Department of Medicine, Division of Nephrology, Division of Endocrinology, Diabetes, and Hypertension, UCLA School of Medicine, Los Angeles, California, USA
    Hypertension 37:722-7. 2001
    ..Excess glomerular PAI-1 allows the accumulation of extracellular matrix, leading to glomerulosclerosis. These results have therapeutic implications for diabetic nephropathy as well as for proliferative mesangial diseases of the kidney...
  14. ncbi request reprint Troglitazone inhibits growth of MCF-7 breast carcinoma cells by targeting G1 cell cycle regulators
    F Yin
    Division of Endocrinology, Diabetes and Hypertension, UCLA School of Medicine, Los Angeles, California 90095, USA
    Biochem Biophys Res Commun 286:916-22. 2001
    ..Targeting of G1 regulatory proteins, particularly cyclin D1, and the resulting induction of G1 arrest by TRO may provide a novel antiproliferative therapy for human breast cancer...
  15. ncbi request reprint Doxazosin inhibits retinoblastoma protein phosphorylation and G(1)-->S transition in human coronary smooth muscle cells
    U Kintscher
    Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, School of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 20:1216-24. 2000
    ..This G(1)-->S blockade likely results from an inhibition of mitogen-induced Rb hyperphosphorylation through prevention of p27 downregulation...
  16. ncbi request reprint Angiotensin II induces migration and Pyk2/paxillin phosphorylation of human monocytes
    U Kintscher
    University of California Los Angeles School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes, and Hypertension, Los Angeles, California, USA
    Hypertension 37:587-93. 2001
    ..Furthermore, the promigratory actions of Ang II in human monocytes are associated with the phosphorylation of 2 cytoskeleton-associated proteins, Pyk2 and paxillin...
  17. ncbi request reprint Troglitazone inhibits angiotensin II-induced DNA synthesis and migration in vascular smooth muscle cells
    K Graf
    University of Southern California, School of Medicine, Department of Medicine, Los Angeles 90033, USA
    FEBS Lett 400:119-21. 1997
    ..The present study demonstrates that troglitazone inhibits AII-induced DNA synthesis, migration and MAP kinase activation in VSMCs which are important molecular events for the development of neointimal hyperplasia and atherosclerosis...
  18. ncbi request reprint Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells
    S Wakino
    Division of Endocrinology, Diabetes, and Hypertension, School of Medicine, 142-8555 UCLA, 900 Veteran Ave, Los Angeles, CA 90095, USA
    J Biol Chem 276:47650-7. 2001
    ..PPARgamma ligands regulate p21(Cip1) at a post-translational level by blocking PKCdelta signaling and accelerating p21(Cip1) turnover...
  19. ncbi request reprint Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and G1--> S transition in vascular smooth muscle cells
    S Wakino
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, and the Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 275:22435-41. 2000
    ..These data demonstrate that PPARgamma ligands are antiproliferative drugs that act by modulating cyclin-dependent kinase inhibitors; they may provide a new therapeutic approach for proliferative vascular diseases...
  20. ncbi request reprint Retinoids inhibit proliferation of human coronary smooth muscle cells by modulating cell cycle regulators
    S Wakino
    Division of Endocrinology, Diabetes, and Hypertension, School of Medicine, University of California, Los Angeles 90095, USA
    Arterioscler Thromb Vasc Biol 21:746-51. 2001
    ..These data demonstrate that retinoids have antiproliferative activity by modulating G(1) --> S cell cycle regulators in human CASMCs through inhibition of Rb phosphorylation and elevation of p27(Kip1) levels...
  21. ncbi request reprint Coincident linkage of fasting plasma insulin and blood pressure to chromosome 7q in hypertensive hispanic families
    L S Cheng
    Division of Medical Genetics, Steven Spielberg Pediatric Research Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Circulation 104:1255-60. 2001
    ..In the present study, we provide further support for the hypothesis of a genetic basis for the BP-IR relationship from a genetic linkage study...
  22. pmc Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis
    X Guo
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Diabetologia 55:2183-92. 2012
    ..We have previously documented a high heritability of insulin clearance in a Hispanic cohort. Here, our goal was to confirm the high heritability in a second cohort and search for genetic loci contributing to insulin clearance...
  23. ncbi request reprint Control of vascular cell proliferation and migration by PPAR-gamma: a new approach to the macrovascular complications of diabetes
    W A Hsueh
    Department of Medicine, University of California School of Medicine, Los Angeles 90095-7073, USA
    Diabetes Care 24:392-7. 2001
    ..Activation of PPAR-gamma, newly defined in vascular cells, may be a useful approach to protect the vasculature in diabetes...
  24. ncbi request reprint Doxazosin inhibits monocyte chemotactic protein 1-directed migration of human monocytes
    U Kintscher
    University of California, Los Angeles, School of Medicine, Division of Endocrinology, Diabetes and Hypertension, 90095, USA
    J Cardiovasc Pharmacol 37:532-9. 2001
    ..4+/-6.6%. Dox 10 microM. The present study demonstrates a potential novel antiatherosclerotic action of Dox by blocking MCP-1-directed monocyte migration, which might be partly mediated by inhibition of MMP-9 activity...
  25. ncbi request reprint Mitogen-activated protein kinase activation is involved in platelet-derived growth factor-directed migration by vascular smooth muscle cells
    K Graf
    University of Southern California, Los Angeles, USA
    Hypertension 29:334-9. 1997
    ..These experiments provide the first evidence that activation of MAPK is a critical event in PDGF-mediated signal transduction regulating VSMC migration...
  26. ncbi request reprint Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction
    S M Jackson
    Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles 90095 1679, USA
    Arterioscler Thromb Vasc Biol 19:2094-104. 1999
    ..These results suggest that certain PPAR activators may help limit chronic inflammation mediated by VCAM-1 and monocytes without affecting acute inflammation mediated by E-selectin and neutrophil binding...
  27. ncbi request reprint Angiotensin II and alpha(v)beta(3) integrin expression in rat neonatal cardiac fibroblasts
    K Graf
    Division of Endocrinology, Diabetes and Hypertension, University of California Los Angeles, School of Medicine, Los Angeles, CA, USA
    Hypertension 35:978-84. 2000
    ..The present findings support the current concept that integrins participate in the control of fibroblast behavior during cardiac remodeling mechanisms...
  28. doi request reprint Critical role for osteopontin in diabetic nephropathy
    Susanne B Nicholas
    Division of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Kidney Int 77:588-600. 2010
    ....
  29. pmc PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis
    Yasunori Takata
    Division of Endocrinology, Diabetes, and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7073, USA
    Proc Natl Acad Sci U S A 105:4277-82. 2008
    ..These studies uncover crucial proinflammatory mechanisms of AngII and highlight actions of PPARdelta activation to inhibit AngII signaling, which is atheroprotective...
  30. pmc Synthetic LXR ligand inhibits the development of atherosclerosis in mice
    Sean B Joseph
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095 1662, USA
    Proc Natl Acad Sci U S A 99:7604-9. 2002
    ..These observations provide direct evidence for an atheroprotective effect of LXR agonists and support their further evaluation as potential modulators of human cardiovascular disease...
  31. ncbi request reprint Coronary circulatory dysfunction in insulin resistance, impaired glucose tolerance, and type 2 diabetes mellitus
    John O Prior
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 6948, USA
    Circulation 111:2291-8. 2005
    ....
  32. ncbi request reprint Troglitazone inhibits angiotensin II-induced extracellular signal-regulated kinase 1/2 nuclear translocation and activation in vascular smooth muscle cells
    S Goetze
    University of California, Los Angeles, School of Medicine, Division of Endocrinology, Diabetes and Hypertension, 90095, USA
    FEBS Lett 452:277-82. 1999
    ....
  33. ncbi request reprint Peroxisome proliferator-activated receptor gamma agonists: their role as vasoprotective agents in diabetes
    Florian Blaschke
    Department of Endocrinology, Diabetes and Metabolism, Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Endocrinol Metab Clin North Am 35:561-74, ix. 2006
    ..The combination of increased insulin sensitivity, improved lipid profile, and reduced inflammation may explain the cardiovascular benefits of this class of drugs..
  34. ncbi request reprint The 3' untranslated region of the lipoprotein lipase gene: haplotype structure and association with post-heparin plasma lipase activity
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Becker B 128, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 90:4816-23. 2005
    ..Haplotypes comprising six single nucleotide polymorphisms (SNPs) (intron 7 to intron 9) of the lipoprotein lipase (LPL) gene appear to influence risk for atherosclerosis and insulin resistance in Mexican-Americans...
  35. ncbi request reprint Osteopontin modulates angiotensin II-induced fibrosis in the intact murine heart
    Alan R Collins
    Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine, University of California at Los Angeles, 90095, USA
    J Am Coll Cardiol 43:1698-705. 2004
    ..Osteopontin (OPN) is upregulated in left ventricular hypertrophy and is stimulated by angiotensin II (AngII). Our objective was to determine whether mice deficient in OPN would be protected from AngII-induced cardiac fibrosis...
  36. ncbi request reprint Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries
    Florian Blaschke
    Division of Endocrinology, Diabetes, and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, USA
    Circ Res 95:e110-23. 2004
    ..The full text of this article is available online at http://circres.ahajournals.org...
  37. pmc Economic benefits of intensive insulin therapy in critically Ill patients: the targeted insulin therapy to improve hospital outcomes (TRIUMPH) project
    Archana R Sadhu
    Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Diabetes Care 31:1556-61. 2008
    ..The purpose of this study was to analyze the economic outcomes of a clinical program implemented to achieve strict glycemic control with intensive insulin therapy in patients admitted to the intensive care unit (ICU)...
  38. ncbi request reprint Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells
    Fen Yin
    Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, California, CA 90095, USA
    Oncogene 23:4614-23. 2004
    ..Our finding of GADD45 induction by TRO may provide a new insight concerning the mechanisms for TRO's antiproliferative and pro-apoptotic effects in breast cancer cells...
  39. ncbi request reprint Lipoprotein lipase is a gene for insulin resistance in Mexican Americans
    Mark O Goodarzi
    Division of Medical Genetics, Department of Pediatrics, Steven Spielberg Pediatric Research Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Diabetes 53:214-20. 2004
    ..3 mg/min). This haplotype-based genetic analysis provides compelling evidence that variation in the LPL gene plays a role in determining insulin resistance in this ethnic group with a high prevalence of the insulin resistance syndrome...
  40. pmc Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis
    Evren Caglayan
    Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Diabetes 57:2470-9. 2008
    ..We thus investigated the hypothesis that PPARgamma ligands could attenuate cardiac fibrosis...
  41. ncbi request reprint Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy
    Susanne B Nicholas
    Division of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Kidney Int 67:1297-307. 2005
    ..PAI-1 may promote ECM buildup by preventing plasmin and matrix metalloproteinase (MMP) activation. However, the importance and mechanism of PAI-1 action in the pathogenesis of diabetic nephropathy is unknown...
  42. ncbi request reprint Effect of plasminogen activator inhibitor-1 in diabetes mellitus and cardiovascular disease
    Christopher J Lyon
    Division of Endocrinology, Diabetes and Hypertension, University of California at Los Angeles, Los Angeles, California 90095, USA
    Am J Med 115:62S-68S. 2003
    ..This article reviews the regulation of PAI-1, its activity in various disease states, and available treatment options...
  43. ncbi request reprint The predictive role of blood glucose for mortality in subjects with cardiovascular disease
    Sidney C Port
    Department of Mathematics, University of California Los Angeles, Los Angeles, CA 90095 1555, USA
    Am J Epidemiol 163:342-51. 2006
    ..009). These findings suggest that although 5.55 mmol/liter (normal) may be a useful mortality risk division (albeit with different implications for the two sexes), 6.99 mmol/liter (diabetic) is not, especially for men...
  44. ncbi request reprint Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes
    Florian Blaschke
    Division of Endocrinology, Diabetes, and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 26:28-40. 2006
    ..In this review, we summarize the critical role of PPARs in regulating inflammation, lipoprotein metabolism, and glucose homeostasis and their potential implications for the treatment of obesity, diabetes, and atherosclerosis...
  45. ncbi request reprint Evidence for joint genetic control of insulin sensitivity and systolic blood pressure in hispanic families with a hypertensive proband
    A H Xiang
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Circulation 103:78-83. 2001
    ..3% of variation in their correlation. CONCLUSIONS: Clustering of hypertension and insulin resistance in Hispanic Americans is accounted for in part by heritable factors both associated with and independent of BMI...
  46. ncbi request reprint Angiotensin II has multiple profibrotic effects in human cardiac fibroblasts
    H Kawano
    Department of Medicine, Division of Endocrinology, Diabetes, and Hypertension, University of California at Los Angeles School of Medicine, CA 90024, USA
    Circulation 101:1130-7. 2000
    ..Angiotensin II (Ang II) is implicated in cardiac remodeling and is increasingly recognized for its profibrotic activity...
  47. pmc Improvement in coronary vascular dysfunction produced with euglycaemic control in patients with type 2 diabetes
    T H Schindler
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095 1735, USA
    Heart 93:345-9. 2007
    ..To determine the effect of plasma glucose lowering on coronary circulatory function in type 2 diabetes mellitus...
  48. ncbi request reprint Vascular protective effects by activation of nuclear receptor PPARgamma
    Shu Wakino
    Division of Endocrinology, Diabetes and Hypertension, School of Medicine, University of California, Los Angeles, Warren Hall, Second Floor, Suite 24 130, 900 Veteran Avenue, Box 957073, Los Angeles, CA 90095, USA
    J Diabetes Complications 16:46-9. 2002
    ..Pharmacologic activation of PPARgamma in vascular cells may provide a novel therapeutic approach to retard diabetes-associated vascular disease...
  49. ncbi request reprint Transcriptional repression of ATP-binding cassette transporter A1 gene in macrophages: a novel atherosclerotic effect of angiotensin II
    Yasunori Takata
    Division of Endocrinology, Diabetes, and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Circ Res 97:e88-96. 2005
    ..This new evidence suggests that Ang II, a well-known proinflammatory and pro-oxidative factor, alters macrophage cholesterol homeostasis by repressing ABCA1 to promote foam cell formation and atherosclerosis...
  50. ncbi request reprint SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse
    Mark O Goodarzi
    Cedars Sinai Medical Center, Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Blvd, Becker B 131, Los Angeles, CA 90048, USA
    Diabetes 56:1922-9. 2007
    ..Thus, we sought to determine whether variation in the human SORCS1 gene was associated with diabetes-related traits...
  51. ncbi request reprint PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4
    Ulrich Kintscher
    Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, University of California, Los Angeles, School of Medicine, Los Angeles, Calif 90095, USA
    Circ Res 91:e35-44. 2002
    ..The full text of this article is available at http://www.circresaha.org...
  52. ncbi request reprint Coronary vasomotor abnormalities in insulin-resistant individuals
    Manuel J Quiñones
    Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
    Ann Intern Med 140:700-8. 2004
    ..It is unclear when vascular abnormalities begin in this spectrum of metabolic effects...
  53. ncbi request reprint Association of the diabetes gene calpain-10 with subclinical atherosclerosis: the Mexican-American Coronary Artery Disease Study
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Diabetes 54:1228-32. 2005
    ..The fact that the diabetes gene CAPN10 also influences the risk for atherosclerosis shows that inherited factors may underlie the frequent co-occurrence of these two conditions...
  54. ncbi request reprint A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor
    Florian Blaschke
    Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Circ Res 99:e88-99. 2006
    ..Our observations identify a novel mechanism of inflammatory gene regulation by LXR ligands. Thus, inhibition of CRP expression by LXR agonists may provide a promising approach to impact initiation and progression of atherosclerosis...
  55. ncbi request reprint Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans
    Mark O Goodarzi
    Division of Medical Genetics, Department of Medicine, Cedars Sinai Medical Center and UCLA, Los Angeles, California, USA
    Genet Med 5:322-7. 2003
    ..To illustrate an approach of deriving haplotypes for genetic association studies, using the lipoprotein lipase (LPL) gene and coronary artery disease...
  56. ncbi request reprint Minireview: adiposity, inflammation, and atherogenesis
    Christopher J Lyon
    Division of Endocrinology, Diabetes, and Hypertension, University of California at Los Angeles, Los Angeles, California 90095 7073, USA
    Endocrinology 144:2195-200. 2003
    ....
  57. ncbi request reprint Carotid intima-media thickness (cIMT) cosegregates with blood pressure and renal function in hypertensive Hispanic families
    Yi Chun Chen
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Atherosclerosis 198:160-5. 2008
    ..Since cIMT is correlated with hypertension and microalbuminuria, we tested the hypothesis that there is a genetic basis for the observed relationship between cIMT, blood pressure (BP), and renal function within high risk families...
  58. ncbi request reprint A genome-wide scan for carotid artery intima-media thickness: the Mexican-American Coronary Artery Disease family study
    Dai Wang
    Medical Genetics Institute, Steven Spielberg Pediatric Research Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, SSB 378, Los Angeles, Calif 90048, USA
    Stroke 36:540-5. 2005
    ..To systematically identify the genetic determinants of CIMT, we performed a genome-wide scan using data from 91 2-generation Mexican American families ascertained via a parent with CAD diagnosed...
  59. ncbi request reprint TGF-beta(1) induces peroxisome proliferator-activated receptor gamma1 and gamma2 expression in human THP-1 monocytes
    Ulrich Kintscher
    Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 297:794-9. 2002
    ..TGF-beta(1) also induced the expression of three C/EBPisoforms (alpha, beta, and delta). Induction of PPARgamma1 and gamma2 in monocytes by TGF-beta(1) may contribute to the anti-inflammatory effects of this growth factor...
  60. ncbi request reprint Polycystic ovary syndrome in Mexican-Americans: prevalence and association with the severity of insulin resistance
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Fertil Steril 84:766-9. 2005
    ..Hyperinsulinemic euglycemic clamp studies showed greater insulin resistance in the women with PCOS...
  61. ncbi request reprint Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait
    Mark O Goodarzi
    Medical Genetics Institute, Department of Pediatrics, Steven Spielberg Pediatric Research Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Diabetes 54:1222-7. 2005
    ..We postulated that the processes of insulin action and insulin clearance in skeletal muscle are highly regulated and that AMPD1 function may play an important role in these phenomena...
  62. ncbi request reprint Genetic effects on obesity assessed by bivariate genome scan: the Mexican-American coronary artery disease study
    Xiaohui Li
    Genetic Epidemiology, Medical Genetic Institute, Steven Spielberg Pediatric Research Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Obesity (Silver Spring) 14:1192-200. 2006
    ..To identify the genetic determinants of obesity using univariate and bivariate models in a genome scan...
  63. ncbi request reprint Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway
    Chia Yu Lin
    Larry Hillblom Islet Research Center, Division of Endocrinology, David Geffen School of Medicine at University of California Los Angeles, 900A Weyburn Place North, Los Angeles, California 90095 7073, USA
    J Clin Endocrinol Metab 90:6678-86. 2005
    ..Human IAPP (h-IAPP) applied to beta-cells forms toxic oligomers that induce apoptosis. Thiazolidinediones, ligands of peroxisome proliferator-activated receptor-gamma (PPAR-gamma), can delay the onset of T2DM...
  64. ncbi request reprint C-reactive protein induces apoptosis in human coronary vascular smooth muscle cells
    Florian Blaschke
    Division of Endocrinology, Diabetes, and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Circulation 110:579-87. 2004
    ....
  65. pmc Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages
    Bardia Askari
    Department of Pathology, 1959 NE Pacific St, University of Washington School of Medicine, Seattle, WA 98195 7470, USA
    Diabetes 56:1143-52. 2007
    ..Therefore, rosiglitazone might alter the biological effects of fatty acids in these cells and in atherosclerosis...
  66. ncbi request reprint Metabolic syndrome-interdependence of the cardiovascular and metabolic pathways
    Evren Caglayan
    Klinik III fur Innere Medizin, Klinikum der Universität zu Köln, Joseph Stelzmann Str 9, D 50924 Koln, Germany
    Curr Opin Pharmacol 5:135-42. 2005
    ..Further studies are needed to determine whether they have synergistic effects to protect the vasculature...
  67. ncbi request reprint Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways
    Daisuke Ogawa
    Division of Endocrinology and Molecular Medicine, University of Kentucky College of Medicine, Lexington, Ken 40536 0200, USA
    Circ Res 96:e59-67. 2005
    ..The full text of this article is available online at http://circres.ahajournals.org...
  68. doi request reprint Pharmacologic treatment options for prediabetes
    Willa A Hsueh
    Diabetes Research Center, Division of Diabetes, Obesity and Lipids, Methodist Hospital Research Institute, Houston, TX 77030, USA
    Nat Clin Pract Endocrinol Metab 4:380-1. 2008
  69. ncbi request reprint Heritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parent
    Anny H Xiang
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    Arterioscler Thromb Vasc Biol 22:843-8. 2002
    ..Heritability is particularly evident in younger family members, suggesting that acquired factors contribute progressively to IMT variability with aging...
  70. ncbi request reprint Genetic markers: progress and potential for cardiovascular disease
    Gary H Gibbons
    Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA, USA
    Circulation 109:IV47-58. 2004
  71. ncbi request reprint Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: Section 5: gender-related risk factors for ischemic heart disease
    Leslee J Shaw
    Circulation 109:e56-8. 2004