Jean Xin Jiang

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Cataract-causing mutation of human connexin 46 impairs gap junction, but increases hemichannel function and cell death
    Qian Ren
    First Hospital of Lanzhou University, Lanzhou, China Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas, United States of America
    PLoS ONE 8:e74732. 2013
  2. pmc "INTEGRINating" the connexin hemichannel function in bone osteocytes through the action of integrin α5
    Nidhi Batra
    Department of Biochemistry University of Texas Heath Science Center San Antonio, TX USA
    Commun Integr Biol 5:516-8. 2012
  3. pmc Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter
    Rugmani Padmanabhan Iyer
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas, United States of America
    PLoS ONE 8:e56792. 2013
  4. pmc Glucocorticoid-induced autophagy in osteocytes
    Xuechun Xia
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Bone Miner Res 25:2479-88. 2010
  5. ncbi Gap junctions or hemichannel-dependent and independent roles of connexins in cataractogenesis and lens development
    J X Jiang
    Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Curr Mol Med 10:851-63. 2010
  6. pmc Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress
    Jean Xin Jiang
    Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Front Biosci 12:1450-62. 2007
  7. pmc Gap junction- and hemichannel-independent actions of connexins
    Jean X Jiang
    Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Biochim Biophys Acta 1711:208-14. 2005
  8. ncbi Hemichannels formed by connexin 43 play an important role in the release of prostaglandin E(2) by osteocytes in response to mechanical strain
    Jean X Jiang
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Cell Commun Adhes 10:259-64. 2003
  9. ncbi Stimulation of lens cell differentiation by gap junction protein connexin 45.6
    Sumin Gu
    Department of Biochemistry, University of Texas Health Science Center San Antonio, San Antonio, Texas 78229 3900, USA
    Invest Ophthalmol Vis Sci 44:2103-11. 2003
  10. ncbi Mechanical stimulation of gap junctions in bone osteocytes is mediated by prostaglandin E2
    J X Jiang
    Department of Biochemistry, University of Texas Health Science Center, San Antonio 78229 3900, USA
    Cell Commun Adhes 8:283-8. 2001

Collaborators

Detail Information

Publications18

  1. pmc Cataract-causing mutation of human connexin 46 impairs gap junction, but increases hemichannel function and cell death
    Qian Ren
    First Hospital of Lanzhou University, Lanzhou, China Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas, United States of America
    PLoS ONE 8:e74732. 2013
    ..This combination leads to the development of human congenital cataracts. ..
  2. pmc "INTEGRINating" the connexin hemichannel function in bone osteocytes through the action of integrin α5
    Nidhi Batra
    Department of Biochemistry University of Texas Heath Science Center San Antonio, TX USA
    Commun Integr Biol 5:516-8. 2012
    ..These results suggest a critical regulatory mechanism for Cx43 hemichannel opening through the association of integrin α5, resulting in release of bone anabolic factors required for bone development...
  3. pmc Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter
    Rugmani Padmanabhan Iyer
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas, United States of America
    PLoS ONE 8:e56792. 2013
    ..Together, these results suggest that cysteine residues 249 and 321 form a disulfide bridge, which plays an important role in substrate transport but has no effect on trafficking of SNAT4 to the cell surface...
  4. pmc Glucocorticoid-induced autophagy in osteocytes
    Xuechun Xia
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Bone Miner Res 25:2479-88. 2010
    ..Together this study reveals a novel mechanism for the effect of GC on osteocytes, shedding new insight into mechanisms responsible for bone loss in patients receiving GC therapy...
  5. ncbi Gap junctions or hemichannel-dependent and independent roles of connexins in cataractogenesis and lens development
    J X Jiang
    Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Curr Mol Med 10:851-63. 2010
    ..Recent advances in basic research of lens connexins and the discoveries of clinical disorders as a result of lens connexin dysfunctions are summarized and discussed here...
  6. pmc Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress
    Jean Xin Jiang
    Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Front Biosci 12:1450-62. 2007
    ....
  7. pmc Gap junction- and hemichannel-independent actions of connexins
    Jean X Jiang
    Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Biochim Biophys Acta 1711:208-14. 2005
    ..In this review, gap junction- and hemichannel-independent functions of connexins are summarized, and the molecular mechanisms underlying these connexin functions are speculated and discussed...
  8. ncbi Hemichannels formed by connexin 43 play an important role in the release of prostaglandin E(2) by osteocytes in response to mechanical strain
    Jean X Jiang
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Cell Commun Adhes 10:259-64. 2003
    ..Our results suggest that hemichannels formed by Cx43, instead of intercellular channels, are likely to play a predominant role in the release of intracellular PGE(2) in response to FFSS...
  9. ncbi Stimulation of lens cell differentiation by gap junction protein connexin 45.6
    Sumin Gu
    Department of Biochemistry, University of Texas Health Science Center San Antonio, San Antonio, Texas 78229 3900, USA
    Invest Ophthalmol Vis Sci 44:2103-11. 2003
    ..The present study was undertaken to explore the roles gap junctions play in lens epithelial cell differentiation...
  10. ncbi Mechanical stimulation of gap junctions in bone osteocytes is mediated by prostaglandin E2
    J X Jiang
    Department of Biochemistry, University of Texas Health Science Center, San Antonio 78229 3900, USA
    Cell Commun Adhes 8:283-8. 2001
    ..Gap junctions may serve as channels for the signals generated by osteocytes in response to mechanical loading...
  11. ncbi Phosphorylation of lens-fiber connexins in lens organ cultures
    J X Jiang
    Department of Biochemistry, University of Texas Health Science Center at San Antonio, 78284 7760, USA
    Eur J Biochem 255:37-44. 1998
    ..6 and connexin56. Comparison of the phosphopeptide patterns by two-dimensional mapping suggested that protein kinase C was involved in the phosphorylation of connexin45.6 and that it phosphorylated the C-terminus of connexin45.6 in vitro...
  12. ncbi PGE(2) is essential for gap junction-mediated intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanical strain
    B Cheng
    Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
    Endocrinology 142:3464-73. 2001
    ..Hence, PGE(2) is an essential mediator between mechanical strain and gap junctions in osteocyte-like cells...
  13. ncbi Regulation of lens connexin 45.6 by apoptotic protease, caspase-3
    X Yin
    Department of Biochemistry, University of Texas Health Science Center, San Antonio 78229-3900, USA
    Cell Commun Adhes 8:373-6. 2001
    ..6. Finally, caspase-3 mediated truncation can be modulated by the specific connexin phosphorylation...
  14. ncbi Expression of functional gap junctions and regulation by fluid flow in osteocyte-like MLO-Y4 cells
    B Cheng
    Department of Biochemistry, University of Texas Health Science Center, San Antonio 78229-3900, USA
    J Bone Miner Res 16:249-59. 2001
    ..These studies indicate that gap junctions may serve as channels for signals generated by osteocytes in response to mechanical loading...
  15. ncbi Casein kinase II phosphorylates lens connexin 45.6 and is involved in its degradation
    X Yin
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas 78284 7760, USA
    J Biol Chem 275:6850-6. 2000
    ..6. The connexin degradation induced by phosphorylation has a broad functional significance in the regulation of gap junctions in vivo...
  16. ncbi The development-associated cleavage of lens connexin 45.6 by caspase-3-like protease is regulated by casein kinase II-mediated phosphorylation
    X Yin
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 276:34567-72. 2001
    ..Finally, caspase-3-mediated cleavage can be regulated by casein kinase II-mediated phosphorylation, suggesting that Cx45.6 turnover and specific cleavage by caspase-3-like protease is alternatively modulated...
  17. ncbi Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport
    S Gu
    Department of Biochemistry and Physiology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 276:24137-44. 2001
    ..The unique expression pattern and selective glutamine transport properties of mNAT2 suggest that it plays a specific role in the uptake of glutamine involved in the generation of the neurotransmitter glutamate in retina...
  18. pmc Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by glycogen synthase kinase 3/beta-catenin signaling
    Xuechun Xia
    Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Mol Cell Biol 30:206-19. 2010
    ..beta-Catenin binds to the Cx43 promoter, stimulating Cx43 expression and functional gap junctions between osteocytes...