D Lavelle

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Oral decitabine reactivates expression of the methylated gamma-globin gene in Papio anubis
    Donald Lavelle
    Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    Am J Hematol 82:981-5. 2007
  2. pmc Effect of AGM and fetal liver-derived stromal cell lines on globin expression in adult baboon (P. anubis) bone marrow-derived erythroid progenitors
    Donald Lavelle
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e36846. 2012
  3. pmc S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)
    Donald Lavelle
    Department of Medicine, University of Illinois at Chicago, 840 S, Wood St, Chicago, Illinois 60612 7323, USA
    J Transl Med 8:92. 2010
  4. ncbi request reprint Effect of 5-aza-2'-deoxycytidine (Dacogen) on covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin promoters in Papio anubis
    Donald Lavelle
    Jesse Brown VA Medical Center and Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Exp Hematol 34:339-47. 2006
  5. ncbi request reprint Developmental changes in DNA methylation and covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin gene promoters in Papio anubis
    Donald Lavelle
    Jesse Brown VA Medical Center and Department of Medicine, University of Illinois, MP151C, 820 S Damen Ave, Chicago, IL 60612, USA
    Blood Cells Mol Dis 36:269-78. 2006
  6. ncbi request reprint The molecular mechanism of fetal hemoglobin reactivation
    Donald E Lavelle
    Department of Medicine, University of Illinois at Chicago, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA
    Semin Hematol 41:3-10. 2004
  7. ncbi request reprint Decitabine induces cell cycle arrest at the G1 phase via p21(WAF1) and the G2/M phase via the p38 MAP kinase pathway
    Donald Lavelle
    VA Chicago, Westside Division, Hematology Research MP151C, 820 South Damen Avenue, Chicago, IL 60612, USA
    Leuk Res 27:999-1007. 2003
  8. ncbi request reprint Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression
    D Lavelle
    VA Chicago, Westside Division, Chicago, Illinois 60612, USA
    Am J Hematol 68:170-8. 2001
  9. ncbi request reprint Effects of hydroxurea, stem cell factor, and erythropoietin in combination on fetal hemoglobin in the baboon
    D Lavelle
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Exp Hematol 29:156-62. 2001
  10. ncbi request reprint Inhibition of myeloma cell growth by all-trans retinoic acid is associated with upregulation of p21WAF1 and dephosphorylation of the retinoblastoma protein
    D Lavelle
    VA Westside Medical Center, Chicago, Illinois 60612, USA
    Leuk Lymphoma 35:261-8. 1999

Detail Information

Publications12

  1. ncbi request reprint Oral decitabine reactivates expression of the methylated gamma-globin gene in Papio anubis
    Donald Lavelle
    Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    Am J Hematol 82:981-5. 2007
    ....
  2. pmc Effect of AGM and fetal liver-derived stromal cell lines on globin expression in adult baboon (P. anubis) bone marrow-derived erythroid progenitors
    Donald Lavelle
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e36846. 2012
    ..We conclude that γ-globin expression in adult-derived erythroid cells can be influenced by the micro-environment, suggesting new potential targets for HbF induction...
  3. pmc S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)
    Donald Lavelle
    Department of Medicine, University of Illinois at Chicago, 840 S, Wood St, Chicago, Illinois 60612 7323, USA
    J Transl Med 8:92. 2010
    ..In these experiments the effect of S110 on HbF levels in baboons and its ability to reduce DNA methylation of the γ-globin gene promoter in vivo were evaluated...
  4. ncbi request reprint Effect of 5-aza-2'-deoxycytidine (Dacogen) on covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin promoters in Papio anubis
    Donald Lavelle
    Jesse Brown VA Medical Center and Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Exp Hematol 34:339-47. 2006
    ..anubis) pre- and posttreatment...
  5. ncbi request reprint Developmental changes in DNA methylation and covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin gene promoters in Papio anubis
    Donald Lavelle
    Jesse Brown VA Medical Center and Department of Medicine, University of Illinois, MP151C, 820 S Damen Ave, Chicago, IL 60612, USA
    Blood Cells Mol Dis 36:269-78. 2006
    ..These studies demonstrate that coordinated epigenetic modifications in the chromatin structure of the beta-like globin gene promoters accompany the highly regulated changes in expression patterns of these genes during development...
  6. ncbi request reprint The molecular mechanism of fetal hemoglobin reactivation
    Donald E Lavelle
    Department of Medicine, University of Illinois at Chicago, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA
    Semin Hematol 41:3-10. 2004
    ....
  7. ncbi request reprint Decitabine induces cell cycle arrest at the G1 phase via p21(WAF1) and the G2/M phase via the p38 MAP kinase pathway
    Donald Lavelle
    VA Chicago, Westside Division, Hematology Research MP151C, 820 South Damen Avenue, Chicago, IL 60612, USA
    Leuk Res 27:999-1007. 2003
    ..Thus, decitabine inhibited growth by inducing cell cycle arrest at the G1 phase mediated by p21(WAF1) and the G2/M phase through activation of the p38 MAP kinase pathway...
  8. ncbi request reprint Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression
    D Lavelle
    VA Chicago, Westside Division, Chicago, Illinois 60612, USA
    Am J Hematol 68:170-8. 2001
    ..Thus, HDAC inhibitors appear to activate multiple cellular pathways, leading to growth arrest and apoptosis, and their use in the treatment of myeloma, particularly in combination with other agents, warrants further investigation...
  9. ncbi request reprint Effects of hydroxurea, stem cell factor, and erythropoietin in combination on fetal hemoglobin in the baboon
    D Lavelle
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Exp Hematol 29:156-62. 2001
    ..The objective of this study was to determine the effect of treatment with a combination of erythropoietin (Epo), stem cell factor (SCF), and hydroxyurea (HU) on HbF levels...
  10. ncbi request reprint Inhibition of myeloma cell growth by all-trans retinoic acid is associated with upregulation of p21WAF1 and dephosphorylation of the retinoblastoma protein
    D Lavelle
    VA Westside Medical Center, Chicago, Illinois 60612, USA
    Leuk Lymphoma 35:261-8. 1999
    ..Increased levels of p21 have recently been observed in human myeloma cells exposed to dexamethasone, and we suggest that the common ability of these two agents to inhibit myeloma cell growth depends on their induction of p21...
  11. ncbi request reprint 2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia
    M Koshy
    University of Illinois at Chicago, Chicago, IL, USA
    Blood 96:2379-84. 2000
    ..Demonstration of sustained F levels with additional treatment cycles without toxicity is currently being performed...
  12. pmc A homeodomain protein binds to gamma-globin gene regulatory sequences
    D Lavelle
    Department of Medicine, University of Illinois, Chicago
    Proc Natl Acad Sci U S A 88:7318-22. 1991
    ..The cDNA clone encodes a homeodomain homologous to the Drosophila antennapedia protein...