Y A Lu

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. ncbi request reprint Identification of a small, naked virus in tumor-like aggregates in cell lines derived from a green turtle, Chelonia mydas, with fibropapillomas
    Y Lu
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
    J Virol Methods 86:25-33. 2000
  2. ncbi request reprint Inhibition of West Nile virus replication by short interfering RNAs
    A V Kachko
    Vektor State Scientific Center of Virology and Biotechnology, p Kol tsovo, Novosibirsk Oblast, 630559 Russia
    Dokl Biochem Biophys 410:260-2. 2006
  3. pmc Effective detection of human adenovirus in Hawaiian waters using enhanced PCR methods
    Hsin I Tong
    Departments of Public Health Sciences and Microbiology, University of Hawaii, Honolulu, Hawaii 96822, USA
    Virol J 8:57. 2011
  4. pmc In vitro evaluation of marine-microorganism extracts for anti-viral activity
    Jarred Yasuhara-Bell
    Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A, Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA
    Virol J 7:182. 2010
  5. pmc Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS
    Shengbo Cao
    Department of Public Health Sciences, University of Hawai i, Honolulu, Hawai i 96822, USA
    J Neuroinflammation 8:48. 2011
  6. ncbi request reprint Genotype and allele frequency of a 32-base pair deletion mutation in the CCR5 gene in various ethnic groups: absence of mutation among Asians and Pacific Islanders
    Y Lu
    Retrovirology Research Laboratory, Hawaii AIDS Research Consortium, and Native Hawaiian Health Research Program, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii 96816, USA
    Int J Infect Dis 3:186-91. 1999
  7. ncbi request reprint Viral susceptibility of newly established cell lines from the Hawaiian monk seal Monachus schauinslandi
    Yuanan Lu
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, Hawaii 96816, USA
    Dis Aquat Organ 57:183-91. 2003
  8. ncbi request reprint Efficient gene transfer into human monocyte-derived macrophages using defective lentiviral vectors
    Y Lu
    University of Hawaii, Retrovirology Research Laboratory, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, Hawaii 96816, USA
    Cell Mol Biol (Noisy-le-grand) 49:1151-6. 2003
  9. ncbi request reprint RT-PCR detection of the expression of the polymerase gene of a novel reptilian herpesvirus in tumor tissues of green turtles with fibropapilloma
    Y A Lu
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    Arch Virol 148:1155-63. 2003
  10. ncbi request reprint Establishment, cryopreservation, and growth of 11 cell lines prepared from a juvenile Hawaiian monk seal, Monachus schauinslandi
    Y Lu
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, Hawaii 96816, USA
    Methods Cell Sci 22:115-24. 2000

Research Grants

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Identification of a small, naked virus in tumor-like aggregates in cell lines derived from a green turtle, Chelonia mydas, with fibropapillomas
    Y Lu
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
    J Virol Methods 86:25-33. 2000
    ..Further characterization of this small naked virus will clarify its role in etiology of green turtle fibropapilloma, a life-threatening disease of this endangered marine species...
  2. ncbi request reprint Inhibition of West Nile virus replication by short interfering RNAs
    A V Kachko
    Vektor State Scientific Center of Virology and Biotechnology, p Kol tsovo, Novosibirsk Oblast, 630559 Russia
    Dokl Biochem Biophys 410:260-2. 2006
  3. pmc Effective detection of human adenovirus in Hawaiian waters using enhanced PCR methods
    Hsin I Tong
    Departments of Public Health Sciences and Microbiology, University of Hawaii, Honolulu, Hawaii 96822, USA
    Virol J 8:57. 2011
    ..To explore the possibility of direct use of human enteric viruses as improved human fecal contamination indicators, human adenovirus (HAdV) was tested as a model in this study...
  4. pmc In vitro evaluation of marine-microorganism extracts for anti-viral activity
    Jarred Yasuhara-Bell
    Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A, Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA
    Virol J 7:182. 2010
    ....
  5. pmc Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS
    Shengbo Cao
    Department of Public Health Sciences, University of Hawai i, Honolulu, Hawai i 96822, USA
    J Neuroinflammation 8:48. 2011
    ..We therefore hypothesized that a soluble TNF-α antagonist might have potential utility as a neuroprotective effecter molecule, and conducted proof-of-concept studies to test this hypothesis...
  6. ncbi request reprint Genotype and allele frequency of a 32-base pair deletion mutation in the CCR5 gene in various ethnic groups: absence of mutation among Asians and Pacific Islanders
    Y Lu
    Retrovirology Research Laboratory, Hawaii AIDS Research Consortium, and Native Hawaiian Health Research Program, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii 96816, USA
    Int J Infect Dis 3:186-91. 1999
    ....
  7. ncbi request reprint Viral susceptibility of newly established cell lines from the Hawaiian monk seal Monachus schauinslandi
    Yuanan Lu
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, Hawaii 96816, USA
    Dis Aquat Organ 57:183-91. 2003
    ..The wide range of viral susceptibility of these monk seal cell lines suggests their potential value in studying viruses of monk seals and other marine mammals...
  8. ncbi request reprint Efficient gene transfer into human monocyte-derived macrophages using defective lentiviral vectors
    Y Lu
    University of Hawaii, Retrovirology Research Laboratory, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, Hawaii 96816, USA
    Cell Mol Biol (Noisy-le-grand) 49:1151-6. 2003
    ..Given the previously reported antiviral activities of these DLV and their lack of cytopathic effects on primary MDM, it may be possible to use these vectors to inhibit HIV-1 replication within the CNS...
  9. ncbi request reprint RT-PCR detection of the expression of the polymerase gene of a novel reptilian herpesvirus in tumor tissues of green turtles with fibropapilloma
    Y A Lu
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    Arch Virol 148:1155-63. 2003
    ..These findings extend and substantiate the pathogenic association of GTHV with FP...
  10. ncbi request reprint Establishment, cryopreservation, and growth of 11 cell lines prepared from a juvenile Hawaiian monk seal, Monachus schauinslandi
    Y Lu
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, Hawaii 96816, USA
    Methods Cell Sci 22:115-24. 2000
    ..These newly established cell lines are currently being used for the investigation of an eye disease occurring in captive monk seal pups in Oahu and will be available for future isolation and study of monk seal viruses...
  11. ncbi request reprint Sequencing and characterization of the full-length gene encoding the single-stranded DNA binding protein of a novel Chelonian herpesvirus
    O Nigro
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii Manoa, Hawaii, USA
    Arch Virol 149:337-47. 2004
    ....
  12. ncbi request reprint Rapid acquisition of entire DNA polymerase gene of a novel herpesvirus from green turtle fibropapilloma by a genomic walking technique
    Q Yu
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, HI 96816, USA
    J Virol Methods 91:183-95. 2001
    ..The sequence and location of the DNA pol gene in the GTHV genome should greatly facilitate future studies of the viral life cycle...
  13. ncbi request reprint Establishment, characterization and viral susceptibility of 3 new cell lines from snakehead, Channa striatus (Blooch)
    Zhengshan Zhao
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii 96816, USA
    Methods Cell Sci 25:155-66. 2003
    ..These newly established cell lines are currently being used for the investigation of snakehead viral diseases in Hawaii and will be available for future isolation and study of snakehead viruses...
  14. pmc Effective transduction of primary mouse blood- and bone marrow-derived monocytes/macrophages by HIV-based defective lentiviral vectors
    Lingbing Zeng
    Retrovirology Research Laboratory, Pacific Biosciences Research Center, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    J Virol Methods 134:66-73. 2006
    ..Overall, these results establish a new and efficient method for gene transfer into primary mouse monocytes/macrophages. This may be of utility in the preclinical development of gene therapies that target this important cell type...
  15. pmc HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1
    Lingbing Zeng
    Pacific Biosciences Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    J Gene Med 8:18-28. 2006
    ..In this study we established a lentiviral vector-based technique for improved gene transfer into human MDM cultures in vitro and demonstrated significant protection of transduced MDM from super-infection with wild-type HIV-1...
  16. ncbi request reprint Nucleotide sequence of an ICP18.5 assembly protein (UL28) gene of green turtle herpesvirus pathogenically associated with green turtle fibropapilloma
    Olivia Nigro
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    J Virol Methods 120:107-12. 2004
    ..Identification of the genomic sequences of GTHV provides a molecular base for the development of diagnostic immunoassay and also for the determination of the pathogenic role of GTHV infection...
  17. pmc Quantitative evaluation of monocyte transmigration into the brain following chemical opening of the blood-brain barrier in mice
    Jianmei Wu
    Pacific Biosciences Research Center, University of Hawaii, Honolulu, HI 96822, USA
    Brain Res 1098:79-85. 2006
    ..This opens the way for the future use of vector-transduced monocytes as a novel delivery system to achieve effective gene transfer into the CNS...
  18. ncbi request reprint Establishment, characterization, and viral susceptibility of two cell lines derived from goldfish Carassius auratus muscle and swim bladder
    Luc Rougée
    Kewalo Marine Laboratory, Pacific Biosciences Research Center, University of Hawaii at Manoa, 41 Ahui Street, Honolulu, Hawaii 96813, USA
    Dis Aquat Organ 77:127-35. 2007
    ..These newly established cell lines will be used as a diagnostic tool for viral diseases in this fish species and also for the isolation and study of goldfish viruses in the future...
  19. ncbi request reprint TT virus: preferential distribution in CD19(+) peripheral blood mononuclear cells and lack of viral integration
    Qigui Yu
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    J Med Virol 66:276-84. 2002
    ..Our data indicate that PBMC and PBMC subsets are not the major sites of TTV replication...
  20. ncbi request reprint Establishment and characterization of two cell lines from bluefin trevally Caranx melampygus
    Zhengshan Zhao
    Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, Hawaii 96816, USA
    Dis Aquat Organ 68:91-100. 2006
    ..These newly established cell lines are currently being used to facilitate the diagnosis of viral disease affecting marine fish aquaculture in Hawaii, and will be available for future isolation and study of bluefin trevally fish viruses...

Research Grants1

  1. Development of gene transfer approaches for neuroAIDS
    Yuanan Lu; Fiscal Year: 2006
    ..Overall, the work is expected to result in significant insight into new approaches for treatment of neuroAIDS and other neurologic diseases. ..