STEVEN MUNGER

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Heterogeneous sensory innervation and extensive intrabulbar connections of olfactory necklace glomeruli
    Renee E Cockerham
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e4657. 2009
  2. pmc Bitter taste receptors influence glucose homeostasis
    Cedrick D Dotson
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS ONE 3:e3974. 2008
  3. pmc The receptor guanylyl cyclase type D (GC-D) ligand uroguanylin promotes the acquisition of food preferences in mice
    Hiroyuki Arakawa
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Chem Senses 38:391-7. 2013
  4. pmc Extraoral bitter taste receptors as mediators of off-target drug effects
    Adam A Clark
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    FASEB J 26:4827-31. 2012
  5. pmc Transformation of postingestive glucose responses after deletion of sweet taste receptor subunits or gastric bypass surgery
    Maartje C P Geraedts
    Division of Endocrinology, Diabetes, and Nutrition, Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Endocrinol Metab 303:E464-74. 2012
  6. pmc Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice
    Theodore M Nelson
    Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    BMC Genet 6:32. 2005
  7. pmc Inbred mouse strains C57BL/6J and DBA/2J vary in sensitivity to a subset of bitter stimuli
    John D Boughter
    Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    BMC Genet 6:36. 2005
  8. pmc An olfactory subsystem that detects carbon disulfide and mediates food-related social learning
    Steven D Munger
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Curr Biol 20:1438-44. 2010
  9. pmc Afferent activity to necklace glomeruli is dependent on external stimuli
    Renee E Cockerham
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Res Notes 2:31. 2009
  10. doi request reprint Subsystem organization of the mammalian sense of smell
    Steven D Munger
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Annu Rev Physiol 71:115-40. 2009

Research Grants

Collaborators

Detail Information

Publications20

  1. pmc Heterogeneous sensory innervation and extensive intrabulbar connections of olfactory necklace glomeruli
    Renee E Cockerham
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e4657. 2009
    ..The heterogeneous sensory innervation of individual necklace glomeruli by multiple, functionally distinct, OSN subtypes precludes a similar combinatorial coding strategy in this olfactory subsystem...
  2. pmc Bitter taste receptors influence glucose homeostasis
    Cedrick D Dotson
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS ONE 3:e3974. 2008
    ..Together, these findings suggest that a functionally compromised TAS2R receptor negatively impacts glucose homeostasis, providing an important link between alimentary chemosensation and metabolic disease...
  3. pmc The receptor guanylyl cyclase type D (GC-D) ligand uroguanylin promotes the acquisition of food preferences in mice
    Hiroyuki Arakawa
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Chem Senses 38:391-7. 2013
    ....
  4. pmc Extraoral bitter taste receptors as mediators of off-target drug effects
    Adam A Clark
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    FASEB J 26:4827-31. 2012
    ..If our hypothesis is confirmed, it would offer a new paradigm for understanding the off-target actions of diverse drugs and could reveal potential new therapeutic targets...
  5. pmc Transformation of postingestive glucose responses after deletion of sweet taste receptor subunits or gastric bypass surgery
    Maartje C P Geraedts
    Division of Endocrinology, Diabetes, and Nutrition, Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Endocrinol Metab 303:E464-74. 2012
    ..Our results demonstrate that the small and large intestines utilize distinct mechanisms for GSGS and suggest novel large intestine targets that could mimic the improved glycemic control seen after RYGB...
  6. pmc Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice
    Theodore M Nelson
    Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    BMC Genet 6:32. 2005
    ..However, there is evidence for both receptor-dependent and -independent transduction mechanisms for a number of bitter stimuli, including quinine hydrochloride (QHCl) and denatonium benzoate (DB)...
  7. pmc Inbred mouse strains C57BL/6J and DBA/2J vary in sensitivity to a subset of bitter stimuli
    John D Boughter
    Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    BMC Genet 6:36. 2005
    ..Here, we used a taste-salient brief-access procedure to measure taste sensitivity to eight stimuli characterized as bitter or aversive in C57BL/6J (B6) and DBA/2J (D2) mice...
  8. pmc An olfactory subsystem that detects carbon disulfide and mediates food-related social learning
    Steven D Munger
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Curr Biol 20:1438-44. 2010
    ..Our findings indicate that GC-D(+) OSNs detect chemosignals that facilitate food-related social interactions...
  9. pmc Afferent activity to necklace glomeruli is dependent on external stimuli
    Renee E Cockerham
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Res Notes 2:31. 2009
    ....
  10. doi request reprint Subsystem organization of the mammalian sense of smell
    Steven D Munger
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Annu Rev Physiol 71:115-40. 2009
    ..An integrative approach that includes gene targeting methods, optical and electrophysiological recording, and behavioral analysis has helped to elucidate the functional significance of this subsystem organization for the sense of smell...
  11. ncbi request reprint Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli
    Yiling Nie
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Biol 15:1948-52. 2005
    ..Thus, individual T1R subunits increase the receptive range of the sweet taste receptor, offering a functional mechanism for phenotypic variations in sweet taste...
  12. ncbi request reprint Taste sensitivities to PROP and PTC vary independently in mice
    Theodore M Nelson
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201 1509, USA
    Chem Senses 28:695-704. 2003
    ..Most strikingly, these results demonstrate that in mice, unlike in humans, PTC and PROP taste sensitivities vary independently, thereby suggesting a subtle functional diversity of bitter-taste mechanisms across mammalian species...
  13. pmc Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women
    Cedrick D Dotson
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Appetite 54:93-9. 2010
    ..Therefore, our results indicate that a polymorphism in TAS2R38 is associated with differences in ingestive behavior...
  14. ncbi request reprint Expression and purification of functional ligand-binding domains of T1R3 taste receptors
    Yiling Nie
    Department of Anatomy and Neurobiology, Graduate Programs in Life Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Chem Senses 31:505-13. 2006
    ..This methodology should not only facilitate the characterization of T1R ligand interactions but may also be useful for dissecting the function of other class C GPCRs such as the large family of orphan V2R vomeronasal receptors...
  15. pmc Glucagon signaling modulates sweet taste responsiveness
    Amanda E T Elson
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 S Penn St, Rm S251, Baltimore, MD 21201, USA
    FASEB J 24:3960-9. 2010
    ..Together, these data indicate a role for local glucagon signaling in the peripheral modulation of sweet taste responsiveness...
  16. pmc Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice
    Kevin R Kelliher
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 100:4299-304. 2003
    ....
  17. pmc Functional analysis of the guanylyl cyclase type D signaling system in the olfactory epithelium
    Renee E Cockerham
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1170:173-6. 2009
    ..Together, these findings suggest that neurons expressing GC-D are part of a specialized olfactory subsystem that is responsive to semiochemicals...
  18. pmc Modulation of taste sensitivity by GLP-1 signaling in taste buds
    Bronwen Martin
    National Institute on Aging NIH, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1170:98-101. 2009
    ..Together, these findings suggest a novel paracrine mechanism for the hormonal modulation of taste function in mammals...
  19. pmc Modulation of taste sensitivity by GLP-1 signaling
    Yu Kyong Shin
    National Institute on Aging NIH, Baltimore, Maryland 21224, USA
    J Neurochem 106:455-63. 2008
    ..A modest increase in citric acid taste sensitivity in these knockout mice suggests GLP-1 signaling may modulate sour taste, as well. Together, these findings suggest a novel paracrine mechanism for the regulation of taste function...
  20. pmc T1R and T2R receptors: the modulation of incretin hormones and potential targets for the treatment of type 2 diabetes mellitus
    Cedrick D Dotson
    University of Maryland School of Medicine, Department of Anatomy and Neurobiology, Baltimore, MD 21201, USA
    Curr Opin Investig Drugs 11:447-54. 2010
    ..This review focuses on the intriguing finding that taste receptors may be involved in modulating the incretin response, and considers T1Rs and T2Rs as potential targets for new hypoglycemic drugs...

Research Grants2

  1. CHARACTERIZING SPECIALIZED CHEMOSENSORY NEURONS
    STEVEN MUNGER; Fiscal Year: 2002
    ..In addition, GC-D transgenic mice will be used to examine the ability of neonates to attach to nipples and suckle. ..
  2. Chemosensory receptors and the basis of specificity
    STEVEN MUNGER; Fiscal Year: 2009
    ..abstract_text> ..