R A Nemenoff

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-gamma Ligands in Lung Cancer
    Raphael A Nemenoff
    Division of Renal Diseases, Department of Medicine, School of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    PPAR Res 2008:156875. 2008
  2. ncbi request reprint Role of nuclear receptors in lung tumourigenesis
    Raphael A Nemenoff
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Campus Box C 281, 4200 East 9th Avenue, Denver, CO 80262, USA
    Eur J Cancer 41:2561-8. 2005
  3. ncbi request reprint Peroxisome proliferator-activated receptor-gamma in lung cancer: defining specific versus "off-target" effectors
    Raphael A Nemenoff
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Thorac Oncol 2:989-92. 2007
  4. ncbi request reprint Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB
    Yvette Bren-Mattison
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Box C 281, 4200 East 9th Avenue, Denver, CO 80262, USA
    Mol Pharmacol 73:709-17. 2008
  5. ncbi request reprint Vasopressin signaling pathways in vascular smooth muscle
    R A Nemenoff
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Front Biosci 3:d194-207. 1998
  6. ncbi request reprint Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth
    Marilee Wick
    Department of Medicine, University of Colorado Health Science Center, Denver, Colorado 80262, USA
    Mol Pharmacol 62:1207-14. 2002
  7. ncbi request reprint Subendothelial cells from normal bovine arteries exhibit autonomous growth and constitutively activated intracellular signaling
    M G Frid
    Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262, USA
    Arterioscler Thromb Vasc Biol 19:2884-93. 1999
  8. ncbi request reprint Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinases
    M Das
    Cardiovascular Pulmonary and Developmental Lung Biology Research Labs and the Department of Renal Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 276:15631-40. 2001
  9. pmc Peroxisome proliferator-activated receptor-gamma inhibits transformed growth of non-small cell lung cancer cells through selective suppression of Snail
    Rashmi Choudhary
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, 12700 E 19th Ave, Aurora, CO 80045, USA
    Neoplasia 12:224-34. 2010
  10. ncbi request reprint Peroxisome proliferator-activated receptor-gamma (PPAR(gamma)) inhibits tumorigenesis by reversing the undifferentiated phenotype of metastatic non-small-cell lung cancer cells (NSCLC)
    Yvette Bren-Mattison
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Oncogene 24:1412-22. 2005

Collaborators

Detail Information

Publications40

  1. pmc Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-gamma Ligands in Lung Cancer
    Raphael A Nemenoff
    Division of Renal Diseases, Department of Medicine, School of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    PPAR Res 2008:156875. 2008
    ..This article reviews the existing biological and mechanistic experiments focusing on the role of PPARgamma in lung cancer, focusing specifically on nonsmall cell lung cancer...
  2. ncbi request reprint Role of nuclear receptors in lung tumourigenesis
    Raphael A Nemenoff
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Campus Box C 281, 4200 East 9th Avenue, Denver, CO 80262, USA
    Eur J Cancer 41:2561-8. 2005
    ....
  3. ncbi request reprint Peroxisome proliferator-activated receptor-gamma in lung cancer: defining specific versus "off-target" effectors
    Raphael A Nemenoff
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Thorac Oncol 2:989-92. 2007
    ..This review examines these pathways with a specific focus on the role of TZDs and PPAR gamma in lung cancer...
  4. ncbi request reprint Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB
    Yvette Bren-Mattison
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Box C 281, 4200 East 9th Avenue, Denver, CO 80262, USA
    Mol Pharmacol 73:709-17. 2008
    ..These data indicate that high levels of PGE(2) as a result of elevated COX-2 expression are critical for promoting lung tumorigenesis and that the antitumorigenic effects of PPARgamma are mediated in part through blocking this pathway...
  5. ncbi request reprint Vasopressin signaling pathways in vascular smooth muscle
    R A Nemenoff
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Front Biosci 3:d194-207. 1998
    ..Recent studies suggesting a role for c-Jun amino terminal kinases in the regulation of smooth muscle-alpha-actin expression are described...
  6. ncbi request reprint Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth
    Marilee Wick
    Department of Medicine, University of Colorado Health Science Center, Denver, Colorado 80262, USA
    Mol Pharmacol 62:1207-14. 2002
    ..We propose that PPARgamma serves as a target for NSAIDs that accounts for COX-independent inhibition of lung cancer cell growth...
  7. ncbi request reprint Subendothelial cells from normal bovine arteries exhibit autonomous growth and constitutively activated intracellular signaling
    M G Frid
    Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262, USA
    Arterioscler Thromb Vasc Biol 19:2884-93. 1999
    ..Our data suggest that unique arterial cells with autonomous growth potential and constitutively activated signaling pathways exist in normal arteries and may contribute selectively to the pathogenesis of vascular diseases...
  8. ncbi request reprint Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinases
    M Das
    Cardiovascular Pulmonary and Developmental Lung Biology Research Labs and the Department of Renal Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 276:15631-40. 2001
    ....
  9. pmc Peroxisome proliferator-activated receptor-gamma inhibits transformed growth of non-small cell lung cancer cells through selective suppression of Snail
    Rashmi Choudhary
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, 12700 E 19th Ave, Aurora, CO 80045, USA
    Neoplasia 12:224-34. 2010
    ..These findings suggest that selective regulation of Snail may be critical in mediating the antitumorigenic effects of PPARgamma activators...
  10. ncbi request reprint Peroxisome proliferator-activated receptor-gamma (PPAR(gamma)) inhibits tumorigenesis by reversing the undifferentiated phenotype of metastatic non-small-cell lung cancer cells (NSCLC)
    Yvette Bren-Mattison
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Oncogene 24:1412-22. 2005
    ..These data indicate that inhibitory effects of PPAR(gamma) on lung tumorigenesis involve selective inhibition of invasive metastasis, and activation of pathways that promote a more differentiated epithelial phenotype...
  11. ncbi request reprint Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth
    Shingo Ameshima
    Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver, Colo, USA
    Circ Res 92:1162-9. 2003
    ..We conclude that fluid shear stress decreases the expression of PPARgamma in endothelial cells and that loss of PPARgamma expression characterizes an abnormal, proliferating, apoptosis-resistant endothelial cell phenotype...
  12. ncbi request reprint Induction of cytosolic phospholipase A2 by oncogenic Ras is mediated through the JNK and ERK pathways in rat epithelial cells
    Z Refaat
    Department of Medicine and Pharmacology, University of Colorado Health Science Center, Denver, Colorado 80262, USA
    J Biol Chem 276:1226-32. 2001
    ..We conclude that expression of oncogenic forms of Ras directly increases cPLA(2) expression in normal epithelial cells through activation of the JNK and ERK pathways...
  13. pmc Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9
    Xue Qing Wang
    Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    Mol Biol Cell 20:791-800. 2009
    ....
  14. pmc Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1
    Meredith A Tennis
    Department of Medicine, University of Colorado Health Sciences Center, 12700 E 19th Ave, Aurora, CO 80045, USA
    Neoplasia 12:244-53. 2010
    ....
  15. ncbi request reprint Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2
    Amy M Meyer
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    Carcinogenesis 25:1517-24. 2004
    ..These results demonstrate a role for cPLA2 in mouse lung tumorigenesis that may be mediated by decreased prostaglandin synthesis...
  16. pmc Lung Kr├╝ppel-like factor (LKLF) is a transcriptional activator of the cytosolic phospholipase A2 alpha promoter
    Marilee J Wick
    Department of Medicine, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Biochem J 387:239-46. 2005
    ..These results indicate that LKLF is an important regulator of cPLA2 expression and participates in the induction of this protein, which is critical for increased eicosanoid production associated with lung tumorigenesis...
  17. ncbi request reprint Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation
    Robert A Winn
    Veterans Affairs Medical Center, Denver, Colorado 80220, USA
    J Biol Chem 280:19625-34. 2005
    ....
  18. ncbi request reprint Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma
    Robert A Winn
    Veterans Administration Medical Center, Denver, and Department of Medicine, University of Colorado Health Sciences Center, 80220, USA
    J Biol Chem 281:26943-50. 2006
    ..These data suggest that ERK5-dependent activation of PPARgamma represents a major effector pathway mediating the anti-tumorigenic effects of Wnt 7a and Fzd 9 in NSCLC...
  19. ncbi request reprint C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion
    Joshua M Thurman
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 178:1819-28. 2007
    ..This innate immune system thereby recognizes hypoxic injury and triggers a systemic inflammatory response through the generation of C3a and subsequent activation of the NF-kappaB system...
  20. ncbi request reprint Prostacyclin in human non-small cell lung cancers
    Patrick Nana-Sinkam
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 125:141S. 2004
  21. ncbi request reprint Hypoxic activation of adventitial fibroblasts: role in vascular remodeling
    Kurt R Stenmark
    Developmental Lung Biology Research Laboratory, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 122:326S-334S. 2002
    ....
  22. ncbi request reprint Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer
    Robert L Keith
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, Denver VA Medical Center, Denver, CO 80220, USA
    Cancer Res 62:734-40. 2002
    ....
  23. pmc Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation
    Seth B Furgeson
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Cardiovasc Res 86:274-82. 2010
    ..We tested if selective depletion of PTEN only in SMC is sufficient to promote SMC phenotypic modulation, cytokine production, and enhanced neointima formation...
  24. ncbi request reprint Prostacyclin synthase promoter regulation and familial pulmonary arterial hypertension
    Patrick Nana-Sinkam
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 128:612S. 2005
  25. pmc Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model
    Robert S Stearman
    Department of Medicine Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, USA
    Am J Pathol 167:1763-75. 2005
    ..Thus, the A/J mouse-urethane model reflects significant molecular details of human lung AC, and comparison of changes in orthologous gene expression may provide novel insights into lung carcinogenesis...
  26. ncbi request reprint Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice
    Robert L Keith
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, Denver VA Medical Center, Denver, Colorado, USA
    Cancer Res 64:5897-904. 2004
    ....
  27. ncbi request reprint Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor
    Nihal Kaplan-Albuquerque
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 278:39830-8. 2003
    ..This was associated with appearance of serum response factor in the cytoplasm. These data indicate that activation of p85/p110 alpha/Akt mediates suppression of SM gene expression by PDGF...
  28. ncbi request reprint Induction of cPLA2 in lung epithelial cells and non-small cell lung cancer is mediated by Sp1 and c-Jun
    S A Blaine
    Department of Medicine and Pharmacology, University of Colorado Health Science Center, Denver, Colorado 80262, USA
    J Biol Chem 276:42737-43. 2001
    ..Expression of Ha-Ras led to induction of c-Jun protein, which showed functional cooperation with Sp1 in driving promoter activity. Additional unidentified transcription factors bound to the regions from -55/-53 and -37/-34...
  29. ncbi request reprint Targeted over-expression of mPGES-1 and elevated PGE2 production is not sufficient for lung tumorigenesis in mice
    Stacy A Blaine
    Department of Pharmacology, University of Colorado Health Science Center, Denver, CO 80262, USA
    Carcinogenesis 26:209-17. 2005
    ..Cyclooxygenase-2 levels were elevated in tumors in both groups. From these studies we conclude that over-expression of mPGES-1 and highly elevated PGE2 production are not sufficient to induce lung tumors...
  30. ncbi request reprint Induction of SM-alpha-actin expression by mechanical strain in adult vascular smooth muscle cells is mediated through activation of JNK and p38 MAP kinase
    Jenny Tock
    Department of Pediatrics, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Box C 281, 4200 E Ninth Ave, Denver, CO 80262, USA
    Biochem Biophys Res Commun 301:1116-21. 2003
    ..These studies indicate that in adult VSMC, mechanical strain leads to increased expression of smooth muscle markers, resulting in a more contractile phenotype...
  31. ncbi request reprint Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells
    Lindsay Marek
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Cell Physiol 201:459-69. 2004
    ..Thus, multiple signaling conduits control global differentiation-specific gene expression in PC12 cells...
  32. ncbi request reprint Patterns of gene expression differentially regulated by platelet-derived growth factor and hypertrophic stimuli in vascular smooth muscle cells: markers for phenotypic modulation and response to injury
    Nihal Kaplan-Albuquerque
    Department of Medicine, University of Colorado Health Sciences Center, Denver, 80262, USA
    J Biol Chem 280:19966-76. 2005
    ..These data indicate that genes that are differentially regulated by PDGF and hypertrophic stimuli may represent families of genes and potentially be biomarkers for vascular injury...
  33. pmc Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis
    Mary C M Weiser-Evans
    Division of Renal Diseases and Hypertension and Pulmonary Sciences, University of Colorado Denver, Denver, Colorado 80262, USA
    Cancer Res 69:1733-8. 2009
    ..Correspondingly, IL-6 staining was decreased in tumors grown in cPLA(2)-KO mice. These data suggest that stromal cPLA(2) plays a critical role in tumor progression by altering tumor-macrophage interactions and cytokine production...
  34. ncbi request reprint Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice
    Amy M Meyer
    University of Colorado Health Sciences Center, School of Pharmacy, Box C238, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1260-6. 2006
    ....
  35. ncbi request reprint Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development
    Janet M Wenzlau
    Department of Renal Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Circ Res 98:846-55. 2006
    ..These data suggest the EGAP NAT complex is an essential regulatory enzyme controlling the function of a subset of proteins required for embryonic growth control and vessel development...
  36. pmc Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms
    Jason R Neil
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Carcinogenesis 29:2227-35. 2008
    ....
  37. doi request reprint Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha
    Raphael A Nemenoff
    Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Denver, Denver, CO 80262, USA
    Circ Res 102:1036-45. 2008
    ....
  38. ncbi request reprint Depletion of serum response factor by RNA interference mimics the mitogenic effects of platelet derived growth factor-BB in vascular smooth muscle cells
    Nihal Kaplan-Albuquerque
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Circ Res 97:427-33. 2005
    ..These data indicate that loss of SRF transactivation in VSMC, in this case through suppression via RNAi, induces biological responses similar to that seen with PDGF...
  39. pmc Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling
    Heather A Walker
    Department of Pediatrics, Renal Division, University of Colorado Health Sciences Center, Denver 80262, USA
    Mol Biol Cell 14:1941-52. 2003
    ..FRNK, in turn, may control SMC growth by downregulating FAK-dependent signaling events...
  40. ncbi request reprint Regulation of SM22 alpha expression by arginine vasopressin and PDGF-BB in vascular smooth muscle cells
    Nihal Kaplan-Albuquerque
    Department of Medicine, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262, USA
    Am J Physiol Heart Circ Physiol 285:H1444-52. 2003
    ..These data indicate that AVP and PDGF initiate specific signaling pathways that control expression of multiple SM genes leading to phenotypic modulation...