Genomes and Genes
Affiliation: University of Rochester
- Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expressionTirumalai Rangasamy
Division of Pulmonary and Critical Care Medicine, Univ of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8692, USA
Am J Physiol Lung Cell Mol Physiol 296:L888-900. 2009..Many of the genes discovered in this study could rationally play an important role in the susceptibility to CS-induced emphysema...
- Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammationJason Emo
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14610, USA
J Immunol 188:3784-90. 2012..Taken together, these findings identify LPA acting via lpa2 as a novel negative regulatory pathway that inhibits DC activation and allergic airway inflammation...
- T-cell activation under hypoxic conditions enhances IFN-gamma secretionJessica Roman
University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642 8692, USA
Am J Respir Cell Mol Biol 42:123-8. 2010..We conclude that hypoxia is a previously underappreciated modulator of effector cytokine secretion in CD4(+) T cells...
- Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matterMarc A Williams
Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Immunol 181:4545-59. 2008....