BARRY ROUSE

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. pmc CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses
    Susmit Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Exp Med 198:889-901. 2003
  2. pmc Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response
    Sharvan Sehrawat
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA
    PLoS Pathog 6:e1000882. 2010
  3. pmc Controlling viral immuno-inflammatory lesions by modulating aryl hydrocarbon receptor signaling
    Tamara Veiga-Parga
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America
    PLoS Pathog 7:e1002427. 2011
  4. ncbi request reprint Regulatory T cells and immunity to pathogens
    Barry T Rouse
    University of Tennessee, College of Veterinary Medicine, Department of Pathobiology, Knoxville, TN 37996 0845, USA
    Expert Opin Biol Ther 7:1301-9. 2007
  5. ncbi request reprint Regulatory T cells in health and disease
    B T Rouse
    Department of Pathobiology, University of Tennessee, Knoxville, TN, USA
    J Intern Med 262:78-95. 2007
  6. ncbi request reprint Regulatory cells and infectious agents: detentes cordiale and contraire
    Barry T Rouse
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 173:2211-5. 2004
  7. pmc Immunity and immunopathology to viruses: what decides the outcome?
    Barry T Rouse
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 0845, USA
    Nat Rev Immunol 10:514-26. 2010
  8. ncbi request reprint Viruses and autoimmunity: an affair but not a marriage contract
    Barry T Rouse
    Department of Microbiology, The University of Tennessee, Knoxville, TN 37996 0845, USA
    Rev Med Virol 12:107-13. 2002
  9. pmc Some unmet challenges in the immunology of viral infections
    Barry T Rouse
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Discov Med 10:363-70. 2010
  10. ncbi request reprint A tale of 2 alpha-herpesviruses: lessons for vaccinologists
    Barry T Rouse
    Department of Microbiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Clin Infect Dis 42:810-7. 2006

Research Grants

  1. VACCINATION AGAINST HERPES SIMPLEX VIRUS
    BARRY ROUSE; Fiscal Year: 2004
  2. IMMUNITY MECHANISMS IN HERPESVIRUS INFECTIONS
    BARRY ROUSE; Fiscal Year: 2005

Collaborators

Detail Information

Publications70

  1. pmc CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses
    Susmit Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Exp Med 198:889-901. 2003
    ..Thus, controlling suppressor effects at the time of vaccination could result in more effective immunity...
  2. pmc Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response
    Sharvan Sehrawat
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA
    PLoS Pathog 6:e1000882. 2010
    ..Our results indicate that manipulating galectin signals, as can be achieved using appropriate sugars, may represent a convenient and inexpensive approach to enhance acute and memory responses to a virus infection...
  3. pmc Controlling viral immuno-inflammatory lesions by modulating aryl hydrocarbon receptor signaling
    Tamara Veiga-Parga
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America
    PLoS Pathog 7:e1002427. 2011
    ..Since a single TCDD administration given after the disease process had been initiated generated long lasting anti-inflammatory effects, the approach holds promise as a therapeutic means of controlling virus induced inflammatory lesions...
  4. ncbi request reprint Regulatory T cells and immunity to pathogens
    Barry T Rouse
    University of Tennessee, College of Veterinary Medicine, Department of Pathobiology, Knoxville, TN 37996 0845, USA
    Expert Opin Biol Ther 7:1301-9. 2007
    ..Treg responses to pathogens may also act to hamper the efficacy of immune control. This review discusses these issues as well as the likely mechanisms by which various pathogens can signal the participation of Treg during infection...
  5. ncbi request reprint Regulatory T cells in health and disease
    B T Rouse
    Department of Pathobiology, University of Tennessee, Knoxville, TN, USA
    J Intern Med 262:78-95. 2007
    ..The current status of therapeutic approaches that modulate regulatory T-cell responses on the outcome of experimental animal and human disease is also discussed...
  6. ncbi request reprint Regulatory cells and infectious agents: detentes cordiale and contraire
    Barry T Rouse
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 173:2211-5. 2004
    ..Finally, emerging approaches are discussed that either blunt or activate Treg and that could be used practically to manage host-pathogen interaction...
  7. pmc Immunity and immunopathology to viruses: what decides the outcome?
    Barry T Rouse
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 0845, USA
    Nat Rev Immunol 10:514-26. 2010
    ....
  8. ncbi request reprint Viruses and autoimmunity: an affair but not a marriage contract
    Barry T Rouse
    Department of Microbiology, The University of Tennessee, Knoxville, TN 37996 0845, USA
    Rev Med Virol 12:107-13. 2002
    ....
  9. pmc Some unmet challenges in the immunology of viral infections
    Barry T Rouse
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Discov Med 10:363-70. 2010
    ..In this review, we highlight some of the major challenges we face in unraveling this complexity and summarize current efforts under way to improve the efficacy of viral vaccines...
  10. ncbi request reprint A tale of 2 alpha-herpesviruses: lessons for vaccinologists
    Barry T Rouse
    Department of Microbiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Clin Infect Dis 42:810-7. 2006
    ....
  11. ncbi request reprint A strategy for selective, CD4+ T cell-independent activation of virus-specific memory B cells for limiting dilution analysis
    Xiaofeng Li
    Department of Microbiology, M409 Walters Life Sciences Bldg, University of Tennessee, Knoxville, 37996, USA
    J Immunol Methods 313:110-8. 2006
    ..This strategy eliminates the influence of poorly defined T cell-associated factors on MBC frequency determinations...
  12. pmc Enhanced viral immunoinflammatory lesions in mice lacking IL-23 responses
    Bumseok Kim
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Microbes Infect 10:302-12. 2008
    ..Our results indicate that the severity of HSV induced immunopathological lesions may be mainly the consequence of IL-12 driven Th1 T cell reactions rather than the action of IL-17 producing cells controlled by IL-23...
  13. pmc Immunization with chaperone-peptide complex induces low-avidity cytotoxic T lymphocytes providing transient protection against herpes simplex virus infection
    Udayasankar Kumaraguru
    Department of Microbiology and Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996 0845, USA
    J Virol 76:136-41. 2002
    ..Mice challenged soon after immunization showed excellent immunity, but by 90 days postimmunization this had waned to be significantly less than the level of immunity in both VvgB- and HSV-immunized mice...
  14. ncbi request reprint Herpetic stromal keratitis in the absence of viral antigen recognition
    Kaustuv Banerjee
    Department of Microbiology, College of Veterinary Medicine, University of Tennessee, M409 Walter Life Science Bldg, Knoxville, TN 37996 0845, USA
    Cell Immunol 219:108-18. 2002
    ..The results support the role of bystander activation as a mechanism of T cell mediated immunopathology and show that CD8(+) as well as CD4(+) T cells can participate in HSK lesion development...
  15. pmc An intranasal heat shock protein based vaccination strategy confers protection against mucosal challenge with herpes simplex virus
    Christopher D Pack
    Department of Microbiology, The University of Tennessee, Knoxville, Tennessee 37996, USA
    Hum Vaccin 4:360-4. 2008
    ..These studies demonstrate that Hsp70 can be used as an effective mucosal adjuvant capable of generating a protective cell-mediated immune response against HSV-1...
  16. pmc Non-mitogenic anti-CD3F(ab')2 monoclonal antibody: a novel approach to control herpetic stromal keratitis
    Pranita P Sarangi
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Invest Ophthalmol Vis Sci 49:5425-33. 2008
    ..The purpose of this study is to assess the therapeutic potential of non-Fc receptor (FcR) binding anti-CD3 monoclonal antibody (mAb), CD3F(ab')(2), for the treatment of herpes simplex virus (HSV)-induced stromal keratitis (SK)...
  17. ncbi request reprint Rescue of memory CD8+ T cell reactivity in peptide/TLR9 ligand immunization by codelivery of cytokines or CD40 ligation
    Felix N Toka
    Department of Microbiology, M 409 Walter s Life Sciences Building, University of Tennessee, Knoxville, TN 37996 0845, USA
    Virology 331:151-8. 2005
    ..Our results indicate that good memory CD8(+) T cell response to peptide immunization can be achieved by using costimulatory procedures at the time of priming or recall immunization...
  18. ncbi request reprint CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions
    Susmit Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 172:4123-32. 2004
    ..Our results decipher the in vivo role of T(reg) in a virus-induced immunopathology and imply that manipulation of regulatory cell function represents a useful approach to control viral-induced immunoinflammatory disease...
  19. pmc In vitro-generated antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells control the severity of herpes simplex virus-induced ocular immunoinflammatory lesions
    Sharvan Sehrawat
    Comparative and Experimental Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee 37996 0845, USA
    J Virol 82:6838-51. 2008
    ..The suppression effect in vivo appeared to be polyspecific. The protocol we have developed could provide a useful additional approach to control virus-induced inflammatory disease...
  20. ncbi request reprint Heat-shock protein 70 acts as an effective adjuvant in neonatal mice and confers protection against challenge with herpes simplex virus
    Christopher D Pack
    Department of Microbiology, The University of Tennessee, Knoxville, TN 37996, USA
    Vaccine 23:3526-34. 2005
    ....
  21. pmc Natural killer cells as novel helpers in anti-herpes simplex virus immune response
    Subhadra Nandakumar
    Department of Microbiology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Virol 82:10820-31. 2008
    ..Hence, NK cells may well be exploited for enhancing and rescuing the T-cell response in situations where the CD4 helper response is affected...
  22. ncbi request reprint Elucidating the protective and pathologic T cell species in the virus-induced corneal immunoinflammatory condition herpetic stromal keratitis
    Kaustuv Banerjee
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Leukoc Biol 77:24-32. 2005
    ..These observations have the potential to yield important treatment strategies by targeting specific cell types in HSK...
  23. ncbi request reprint CXCR2-/- mice show enhanced susceptibility to herpetic stromal keratitis: a role for IL-6-induced neovascularization
    Kaustuv Banerjee
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 172:1237-45. 2004
    ..Our results serve to further demonstrate the critical role of angiogenesis in the pathogenesis of ocular lesions...
  24. ncbi request reprint Role of Stat4-mediated signal transduction events in the generation of aggressor CD4+ T cells in herpetic stromal keratitis pathogenesis
    Kaustuv Banerjee
    Comparative and Experimental Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37916, USA
    J Interferon Cytokine Res 27:65-75. 2007
    ..The data imply a significant role of Stat4-mediated signaling events in the generation of an aggressor CD4(+) T cell population in stromal keratitis pathogenesis...
  25. ncbi request reprint Mucosal application of plasmid-encoded IL-15 sustains a highly protective anti-Herpes simplex virus immunity
    Felix N Toka
    Department of Microbiology, University of Tennessee, Knoxville, 37996, USA
    J Leukoc Biol 78:178-86. 2005
    ..Therefore, a mucosal immunization strategy that incorporates a potent cytokine such as IL-15 as an adjuvant might induce protective mucosal immune responses that constitute the initial barrier at mucosal portals of pathogen entry...
  26. ncbi request reprint Mice transgenic for IL-1 receptor antagonist protein are resistant to herpetic stromal keratitis: possible role for IL-1 in herpetic stromal keratitis pathogenesis
    Partha S Biswas
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 172:3736-44. 2004
    ..Targeting IL-1 could prove to be a worthwhile therapeutic approach to control SK, an important cause of human blindness...
  27. ncbi request reprint Protective and pathological roles of virus-specific and bystander CD8+ T cells in herpetic stromal keratitis
    Kaustuv Banerjee
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 173:7575-83. 2004
    ..A case is made that CD8(+) T cell control is expressed in the trigeminal ganglion, serving to curtail a source of virus to the cornea...
  28. pmc Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis
    Bumseok Kim
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 0845, USA
    Am J Pathol 165:2177-85. 2004
    ..These results indicate that the use of VEGF pathway-specific siRNAs represents a useful therapy against neovascularization-related eye diseases...
  29. ncbi request reprint Influence of CCR7 ligand DNA preexposure on the magnitude and duration of immunity
    Yunsang Lee
    Laboratory of Viral Immunology, Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    Virology 312:169-80. 2003
    ..Moreover, CCL21- and CCL19-treated mice showed less severe disease and better survival following challenge. Our results are discussed in terms of the relevance of CCR7 ligand preimmunization to improve vaccine...
  30. ncbi request reprint IL-12 suppresses the expression of ocular immunoinflammatory lesions by effects on angiogenesis
    Sujin Lee
    Department of Microbiology, Walters Life Sciences Building, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Leukoc Biol 71:469-76. 2002
    ..The use of antiangiogenesis therapy might represent a useful control measure against HSK...
  31. pmc Induction of CD8 T-cell-specific systemic and mucosal immunity against herpes simplex virus with CpG-peptide complexes
    Malgorzata Gierynska
    Department of Microbiology, Walters Life Sciences Building, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Virol 76:6568-76. 2002
    ..Still, our results indicate that the CpG ODN-peptide immunization system holds promise as a means of selectively inducing a CD8+ T-cell response against HSV...
  32. ncbi request reprint Counteracting corneal immunoinflammatory lesion with interleukin-1 receptor antagonist protein
    Partha Sarathi Biswas
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, USA
    J Leukoc Biol 76:868-75. 2004
    ..Our results show the importance of targeting early proinflammatory molecules such as IL-1 to counteract HSK and advocate IL-1 ra as an effective agent to achieve this...
  33. pmc CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1
    Felix N Toka
    Department of Microbiology, University of Tennessee, Walter s Life Science Bldg M409, 1414 Cumberland Ave, Knoxville, TN 37996, USA
    J Virol 78:13082-9. 2004
    ..However, it remains to be seen if all types of vaccines against HSV are similarly affected by CD25(+) T(reg) cells and if it is possible to devise means of limiting T(reg) cell activity to enhance vaccine efficacy...
  34. ncbi request reprint Depletion of MCP-1 increases development of herpetic stromal keratitis by innate immune modulation
    Bumseok Kim
    Department of Microbiology and Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Leukoc Biol 80:1405-15. 2006
    ..These results indicate that MCP-1 in the SK cornea might regulate the expression of other chemokines, as well as the infiltration of inflammatory cells and control development of SK...
  35. pmc Quantitative analysis of herpes simplex virus type 1-specific memory B cells generated by different routes of infection
    Daisy J Vanitha
    Department of Microbiology, M409 Walters Life Sciences Bldg, 1414 W Cumberland Ave, University of Tennessee, Knoxville, TN 37996, USA
    Virology 360:136-42. 2007
    ..Our findings indicate that the widespread dispersion of MBCs to lymphoid tissues throughout the body is largely independent of the route of infection, but may be influenced by tissue-specific factors...
  36. ncbi request reprint Application of FGF-2 to modulate herpetic stromal keratitis
    Bumseok Kim
    Department of Microbiology and Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996 0845, USA
    Curr Eye Res 31:1021-8. 2006
    ..The current study examined the effect of FGF-2 application on the outcome of ocular HSV infection...
  37. pmc Antigenic peptides complexed to phylogenically diverse Hsp70s induce differential immune responses
    Udayasankar Kumaraguru
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    Cell Stress Chaperones 8:134-43. 2003
    ..The difference in immune response generated by the various Hsp70s could possibly be due to their differential ability to interact productively with other coreceptors and different regulatory cochaperones...
  38. ncbi request reprint Mechanisms of pathogenesis in herpetic immunoinflammatory ocular lesions
    Shilpa P Deshpande
    Department of Microbiology, University of Tennessee, M409, Walter Life Sciences Building, Knoxville, TN 37996 0845, USA
    Vet Microbiol 86:17-26. 2002
    ..We conclude that this immunoinflammatory response involves multiple immune mechanisms including autoimmunity...
  39. ncbi request reprint Anti-inflammatory effects of FTY720 against viral-induced immunopathology: role of drug-induced conversion of T cells to become Foxp3+ regulators
    Sharvan Sehrawat
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Immunol 180:7636-47. 2008
    ....
  40. pmc Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators
    Sharvan Sehrawat
    Comparative and Experimental Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 182:3191-201. 2009
    ..Our results indicate that galectin-9 therapy may represent a useful approach to control HSV-induced lesions, the most common cause of infectious blindness in the Western world...
  41. ncbi request reprint Concomitant helper response rescues otherwise low avidity CD8+ memory CTLs to become efficient effectors in vivo
    Udayasankar Kumaraguru
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 172:3719-24. 2004
    ..Our results emphasize that peptide immunization remains a viable approach to induce long-term CD8+ T cell function, providing steps are taken to assure appropriate stimulation of Th cell responses...
  42. ncbi request reprint Qa-1b and CD94-NKG2a interaction regulate cytolytic activity of herpes simplex virus-specific memory CD8+ T cells in the latently infected trigeminal ganglia
    Susmit Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 176:1703-11. 2006
    ..Our results demonstrate the operation of a regulatory system in vivo that serves to protect irreplaceable neurons from destruction by the immune system...
  43. pmc In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology
    Susmit Suvas
    Department of Microbiology, M409, Walters Life Sciences Building, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Virol 79:11935-42. 2005
    ..Our results are the first observations to determine in vivo kinetics of GITR and GITR-L expression after virus infection, and they emphasize the role of GITR-GITR-L interaction to regulate virus-induced immuno-inflammatory lesions...
  44. ncbi request reprint Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects
    Bumseok Kim
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 175:509-16. 2005
    ..Our results could mean that IL-18 administration may represent a useful approach to manage unwanted angiogenesis...
  45. ncbi request reprint In vivo rescue of defective memory CD8+ T cells by cognate helper T cells
    Udayasankar Kumaraguru
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    J Leukoc Biol 78:879-87. 2005
    ..Our results could mean that therapeutic vaccine approaches could be designed to compensate situations that have defective CD8(+) T cell function...
  46. ncbi request reprint A novel flow cytometry based assay for quantification of corneal angiogenesis in the mouse model of herpetic stromal keratitis
    Partha S Biswas
    Department of Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Exp Eye Res 80:73-81. 2005
    ..The flow cytometry analysis used in this present study is a useful, accurate and cost effective method for quantifying corneal angiogenesis...
  47. ncbi request reprint Toll-like receptor ligand links innate and adaptive immune responses by the production of heat-shock proteins
    Udayasankar Kumaraguru
    Department of Microbiology, University of Tennessee, Knoxville 37996, USA
    J Leukoc Biol 73:574-83. 2003
    ..The cross-priming, shown also to occur in vivo, may be particularly useful when Ag doses are low and have minimal opportunity for delivery to DCs for consequent direct priming...
  48. ncbi request reprint Involvement of IL-6 in the paracrine production of VEGF in ocular HSV-1 infection
    Partha Sarathi Biswas
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Exp Eye Res 82:46-54. 2006
    ..Thus, our results further demonstrate the close relationship between proinflammatory cytokines and VEGF-induced corneal neovascularisation...
  49. ncbi request reprint Influence of DNA encoding cytokines on systemic and mucosal immunity following genetic vaccination against herpes simplex virus
    Sujin Lee
    Department of Microbiology, The University of Tennessee, M409 Walters Life Sciences Building, Knoxville, TN 37996 0845, USA
    Microbes Infect 5:571-8. 2003
    ..The approach of using DNA vaccines combined with DNA encoding cytokines holds promise and represents a potentially useful approach for vaccines...
  50. ncbi request reprint Blocking mouse MMP-9 production in tumor cells and mouse cornea by short hairpin (sh) RNA encoding plasmids
    Ahmet Kursat Azkur
    Department of Microbiology, University of Tennessee, Knoxville, 37996, USA
    Oligonucleotides 15:72-84. 2005
    ..However, interferon-alpha (IFN-alpha) and IFN- beta induced by pshRNA might also contribute to inhibition of herpetic simplex keratitis (HSK) in the cornea...
  51. ncbi request reprint Vascular endothelial growth factor receptor 2-based DNA immunization delays development of herpetic stromal keratitis by antiangiogenic effects
    Bumseok Kim
    Department of Microbiology and Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 177:4122-31. 2006
    ..These results indicate a role for CD8+ T cells in the antiangiogenic effects. Our results may also imply that the anti-VEGFR-2 vaccination approach might prove useful to control pathological ocular angiogenesis and its consequences...
  52. pmc Role of inflammatory cytokine-induced cyclooxygenase 2 in the ocular immunopathologic disease herpetic stromal keratitis
    Partha S Biswas
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Virol 79:10589-600. 2005
    ..COX-2 stimulation by HSV infection represents a critical early event accessible for therapy and the control of SK severity...
  53. pmc Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus
    Sujin Lee
    Department of Microbiology, The University of Tennessee, Knoxville, Tennessee 37996 0845, USA
    J Clin Invest 110:1105-11. 2002
    ..Since angiogenesis appears to represent a vital step in the pathogenesis of herpetic stromal keratitis, these results indicate that targeting MMP-9 for inhibition should prove useful for the therapy of herpetic stromal keratitis...
  54. doi request reprint Control of viral immunoinflammatory lesions by manipulating CD200:CD200 receptor interaction
    Pranita P Sarangi
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Clin Immunol 131:31-40. 2009
    ..Treatment of animals in the chronic phase was minimally effective. Our data are the first to demonstrate the use of CD200R stimulation to control lesion severity in a viral induced inflammatory disease...
  55. ncbi request reprint IL-10 and natural regulatory T cells: two independent anti-inflammatory mechanisms in herpes simplex virus-induced ocular immunopathology
    Pranita P Sarangi
    Comparative and Experimental Medicine Program, College of Veterinary Medicine, University of Tennessee, 1414 Cumberland Avenue, Knoxville, TN 37996, USA
    J Immunol 180:6297-306. 2008
    ..Our current investigations indicate that at least two independent anti-inflammatory mechanisms are involved in limiting the corneal lesions in SK, both of which may need to be modulated to control SK therapeutically...
  56. pmc Codelivery of CCR7 ligands as molecular adjuvants enhances the protective immune response against herpes simplex virus type 1
    Felix N Toka
    Department of Microbiology, University of Tennessee, Knoxville, Tennessee 37996, USA
    J Virol 77:12742-52. 2003
    ..Thus CCR7L expressed ectopically may serve as a molecular adjuvant to boost the immune response to a codelivered antigen in mucosal surfaces...
  57. pmc Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis
    Pranita P Sarangi
    Department of Microbiology, The University of Tennessee, M409 Walters Life Sciences Bldg, 1414 Cumberland Avenue, Knoxville, TN 37996, USA
    J Virol 81:11128-38. 2007
    ..We discuss the possible mechanisms by which early recognition of HSV constituents impacts the subsequent development of immunopathological lesions...
  58. ncbi request reprint Regulation of microbial immunity: the suppressor cell renaissance
    Susmit Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996 0854, USA
    Viral Immunol 18:411-8. 2005
    ..The mechanisms by which Treg are induced, recognize microbes, and exert their function is also discussed. Finally, we examine approaches that might prove useful to manipulate regulatory cell response against infections...
  59. ncbi request reprint Herpetic eye disease: immunopathogenesis and therapeutic measures
    Shilpa Deshpande
    Department of Microbiology, M 409, Walters Life Sciences Bldg, 1414 Cumberland Avenue, College of Arts and Sciences, University of Tennessee, Knoxville, TN 37996, USA
    Expert Rev Mol Med 6:1-14. 2004
    ..This article reviews understanding of HSK, both in humans and in the mouse model, with an emphasis on possible future therapeutic strategies to counteract this blinding immunoinflammatory disease...
  60. ncbi request reprint Viruses and autoimmunity
    Bumseok Kim
    College of Veterinary Medicine, University of Tennessee, Comparative and Experimental Medicine, Knoxville, TN 37996, USA
    Autoimmunity 39:71-7. 2006
    ..This review briefly discusses examples where viruses are involved, taking the view point that molecular mimicry is over emphasized as a critical mechanism during AID pathogenesis...
  61. ncbi request reprint Molecular adjuvants for mucosal immunity
    Felix N Toka
    Department of Microbiology, University of Tennessee, Walter s Life Sciences Building, Knoxville, TN 37996, USA
    Immunol Rev 199:100-12. 2004
    ..This review summarizes the progress in the use of genetic vaccines to achieve mucosal immunity and discusses the needed strategies to maximize long-term prospective immunity at this vulnerable entry site...
  62. ncbi request reprint Early events in HSV keratitis--setting the stage for a blinding disease
    Partha S Biswas
    Comaprative and Experimental Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37916, USA
    Microbes Infect 7:799-810. 2005
    ..We also comment on events ongoing during chronic SK, debating whether or not these represent virus-induced or autoimmune lesions...
  63. pmc DNA containing CpG motifs induces angiogenesis
    Mei Zheng
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996 0845, USA
    Proc Natl Acad Sci U S A 99:8944-9. 2002
    ..These findings establish that DNA containing bioactive CpG motifs induces angiogenesis, and suggest that CpG motifs in HSV DNA may contribute to the blinding lesions of stromal keratitis...
  64. ncbi request reprint Viruses and autoimmunity
    Bumseok Kim
    College of Veterinary Medicine, University of Tennessee, Comparative and Experimental Medicine, Knoxville, TN 37996, USA
    Autoimmunity 38:559-65. 2005
    ..This review briefly discusses examples where viruses are involved, taking the viewpoint that molecular mimicry is over emphasized as a critical mechanism during AID pathogenesis...
  65. pmc An anti-inflammatory role of VEGFR2/Src kinase inhibitor in herpes simplex virus 1-induced immunopathology
    Shalini Sharma
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 1414 Cumberland Avenue, Knoxville, TN 37996 0845, USA
    J Virol 85:5995-6007. 2011
    ....
  66. pmc Herpes keratitis in the absence of anterograde transport of virus from sensory ganglia to the cornea
    Katarina Polcicova
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 102:11462-7. 2005
    ..Nevertheless, US9- HSV caused keratitis. Therefore, herpes keratitis can occur without anterograde transport from ganglia to the cornea, probably mediated by virus persistent in the cornea...
  67. ncbi request reprint Regulatory T cells in virus infections
    Barry T Rouse
    Department of Microbiology, The University of Tennessee, Knoxville, TN 37996, USA
    Immunol Rev 212:272-86. 2006
    ..This review also discusses how virus infections become recognized by nTreg responses and how such responses might be manipulated to increase immunity or to limit virus-induced immunopathology...
  68. ncbi request reprint Natural regulatory T cells in infectious disease
    Yasmine Belkaid
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Nat Immunol 6:353-60. 2005
    ..We describe here various situations in which the balance between natural T(reg) cells and effector immune functions influences the outcome of infection and discuss how manipulating this equilibrium might be exploited therapeutically...
  69. pmc Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression
    Henry Radziewicz
    Emory University School of Medicine, 954 Gatewood Road N E, Atlanta, GA 30329, USA
    J Virol 81:2545-53. 2007
    ....
  70. ncbi request reprint Differentiation of memory B and T cells
    Vandana Kalia
    Rollins Research Center G211, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA
    Curr Opin Immunol 18:255-64. 2006
    ..Detailed definition of the molecular and cellular signals involved in the development of immunological memory, and the relative contributions of different memory subsets to protective immunity, remains an important goal...

Research Grants2

  1. VACCINATION AGAINST HERPES SIMPLEX VIRUS
    BARRY ROUSE; Fiscal Year: 2004
    ..Our results should be applicable to the future design of vaccines against HSV and may have application to other situations that require immunomodulation. ..
  2. IMMUNITY MECHANISMS IN HERPESVIRUS INFECTIONS
    BARRY ROUSE; Fiscal Year: 2005
    ..Our experiments may identify better methods of generating protective immunity against HSV. ..