Siba K Samal

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging pathogens
    Joshua M DiNapoli
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:9788-93. 2007
  2. pmc Mutation of the f-protein cleavage site of avian paramyxovirus type 7 results in furin cleavage, fusion promotion, and increased replication in vitro but not increased replication, tissue tropism, or virulence in chickens
    Sa Xiao
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 86:3828-38. 2012
  3. pmc Sequence analysis of fusion protein gene of Newcastle disease virus isolated from outbreaks in Egypt during 2006
    Mahmoud H A Mohamed
    Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt
    Virol J 8:237. 2011
  4. pmc Role of intergenic sequences in newcastle disease virus RNA transcription and pathogenesis
    Yongqi Yan
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Virol 82:1323-31. 2008
  5. pmc Complete genome sequence of avian paramyxovirus (APMV) serotype 5 completes the analysis of nine APMV serotypes and reveals the longest APMV genome
    Arthur S Samuel
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 5:e9269. 2010
  6. pmc Experimental infection of hamsters with avian paramyxovirus serotypes 1 to 9
    Arthur S Samuel
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    Vet Res 42:38. 2011
  7. pmc A recombinant Newcastle disease virus (NDV) expressing VP2 protein of infectious bursal disease virus (IBDV) protects against NDV and IBDV
    Zhuhui Huang
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Dr, College Park, MD 20742
    J Virol 78:10054-63. 2004
  8. doi request reprint A single amino acid change, Q114R, in the cleavage-site sequence of Newcastle disease virus fusion protein attenuates viral replication and pathogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Gen Virol 92:2333-8. 2011
  9. pmc Generation by reverse genetics of an effective, stable, live-attenuated newcastle disease virus vaccine based on a currently circulating, highly virulent Indonesian strain
    Sa Xiao
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, USA
    PLoS ONE 7:e52751. 2012
  10. pmc Complete genome sequences of avian paramyxovirus serotype 6 prototype strain Hong Kong and a recent novel strain from Italy: evidence for the existence of subgroups within the serotype
    Sa Xiao
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Virus Res 150:61-72. 2010

Collaborators

Detail Information

Publications76

  1. pmc Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging pathogens
    Joshua M DiNapoli
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:9788-93. 2007
    ..NDV has the potential for further development as a pretested, highly attenuated, intranasal vector to be available for expedited vaccine development for humans, who generally lack preexisting immunity against NDV...
  2. pmc Mutation of the f-protein cleavage site of avian paramyxovirus type 7 results in furin cleavage, fusion promotion, and increased replication in vitro but not increased replication, tissue tropism, or virulence in chickens
    Sa Xiao
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 86:3828-38. 2012
    ..Thus, the acquisition of furin cleavability by APMV-7 resulted in syncytium formation and increased virus yield in vitro but did not alter virus yield, tropism, or virulence in chickens...
  3. pmc Sequence analysis of fusion protein gene of Newcastle disease virus isolated from outbreaks in Egypt during 2006
    Mahmoud H A Mohamed
    Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt
    Virol J 8:237. 2011
    ..In this study, the sequences of fusion protein (F) gene of three Newcastle disease virus (NDV) strains isolated from outbreak in chickens in the Al-Sharkia province of Egypt in 2006 were determined...
  4. pmc Role of intergenic sequences in newcastle disease virus RNA transcription and pathogenesis
    Yongqi Yan
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Virol 82:1323-31. 2008
    ..The level of attenuation increased as the length of the IGS increased. Interestingly, decreased IGS length also attenuated the viruses. These findings can have significant applications in NDV vaccine development...
  5. pmc Complete genome sequence of avian paramyxovirus (APMV) serotype 5 completes the analysis of nine APMV serotypes and reveals the longest APMV genome
    Arthur S Samuel
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 5:e9269. 2010
    ..The genomes of representatives of all APMV serotypes except APMV type 5 have recently been fully sequenced. Here, we report the complete genome sequence of the APMV-5 prototype strain budgerigar/Kunitachi/74...
  6. pmc Experimental infection of hamsters with avian paramyxovirus serotypes 1 to 9
    Arthur S Samuel
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    Vet Res 42:38. 2011
    ..Taken together, these results demonstrate that all nine known APMV serotypes are capable of replicating in hamsters with minimal disease and pathology...
  7. pmc A recombinant Newcastle disease virus (NDV) expressing VP2 protein of infectious bursal disease virus (IBDV) protects against NDV and IBDV
    Zhuhui Huang
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Dr, College Park, MD 20742
    J Virol 78:10054-63. 2004
    ..These results indicate that the recombinant NDV can be used as a vaccine vector for other avian pathogens...
  8. doi request reprint A single amino acid change, Q114R, in the cleavage-site sequence of Newcastle disease virus fusion protein attenuates viral replication and pathogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Gen Virol 92:2333-8. 2011
    ..The pathogenicity was further reduced when the isoleucine at position 118 was substituted for valine...
  9. pmc Generation by reverse genetics of an effective, stable, live-attenuated newcastle disease virus vaccine based on a currently circulating, highly virulent Indonesian strain
    Sa Xiao
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, USA
    PLoS ONE 7:e52751. 2012
    ..These results suggest that Ban/AF can provide better protection than commercial vaccines and is a promising vaccine candidate against NDV strains circulating in Indonesia...
  10. pmc Complete genome sequences of avian paramyxovirus serotype 6 prototype strain Hong Kong and a recent novel strain from Italy: evidence for the existence of subgroups within the serotype
    Sa Xiao
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Virus Res 150:61-72. 2010
    ..Taken together, our results indicated that the APMV-6 strains represents a single serotype with two subgroups that differ substantially based on nt and aa sequences and can be distinguished by HI assay...
  11. pmc Phylogenetic and pathotypic characterization of newcastle disease viruses circulating in west Africa and efficacy of a current vaccine
    Arthur Samuel
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Clin Microbiol 51:771-81. 2013
    ..A vaccine efficacy study showed that the LaSota vaccine protected birds from morbidity and mortality but did not prevent shedding of West African challenge viruses...
  12. pmc Molecular characterization and complete genome sequence of avian paramyxovirus type 4 prototype strain duck/Hong Kong/D3/75
    Baibaswata Nayak
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    Virol J 5:124. 2008
    ..Newcastle disease virus represents APMV-1 and is the most characterized among all APMV types. Very little is known about the molecular characteristics and pathogenicity of APMV 2-9...
  13. pmc Complete genome sequence of avian paramyxovirus-3 strain Wisconsin: evidence for the existence of subgroups within the serotype
    Sachin Kumar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Virus Res 149:78-85. 2010
    ..Taken together, our results indicate that the two APMV-3 strains represent a single serotype with two subgroups that differ substantially based on nt and aa sequences, but with only a modest antigenic difference...
  14. pmc Evaluation of the genetic diversity of avian paramyxovirus type 4
    Baibaswata Nayak
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Virus Res 171:103-10. 2013
    ..Reciprocal cross-HI assay using post infection chicken sera also failed to detect significant antigenic variation among the available APMV-4 strains...
  15. pmc Mutations in the fusion protein cleavage site of avian paramyxovirus serotype 4 confer increased replication and syncytium formation in vitro but not increased replication and pathogenicity in chickens and ducks
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, USA
    PLoS ONE 8:e50598. 2013
    ..These results suggested that the cleavage site sequence of the F protein is not a limiting determinant of APMV-4 pathogenicity in chickens and ducks...
  16. pmc Replication, neurotropism, and pathogenicity of avian paramyxovirus serotypes 1-9 in chickens and ducks
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 7:e34927. 2012
    ..The link between the presence of a furin cleavage site in the F protein, syncytium formation, systemic spread, and virulence that has been well-established with APMV-1 pathotypes was not evident with the other APMV serotypes...
  17. pmc Avian paramyxovirus serotypes 2-9 (APMV-2-9) vary in the ability to induce protective immunity in chickens against challenge with virulent Newcastle disease virus (APMV-1)
    Baibaswata Nayak
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Vaccine 30:2220-7. 2012
    ..The induction of NDV-neutralizing antibodies was a marker for efficient protection, but partial protection also was observed in their absence...
  18. pmc Complete sequence of the genome of avian paramyxovirus type 2 (strain Yucaipa) and comparison with other paramyxoviruses
    Madhuri Subbiah
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742 USA
    Virus Res 137:40-8. 2008
    ....
  19. pmc Complete genome sequence of avian paramyxovirus type 7 (strain Tennessee) and comparison with other paramyxoviruses
    Sa Xiao
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Virus Res 145:80-91. 2009
    ..The mean death time in embryonated chicken eggs was found to be more than 144h, indicating APMV-7 to be avirulent for chickens...
  20. pmc Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 86:2501-11. 2012
    ..These results illustrate the effects of N-glycosylation of the F protein on NDV pathobiology and suggest that the N-glycans in HR1 and HR2 coordinately downregulate viral fusion and virulence...
  21. pmc Evaluation of the replication, pathogenicity, and immunogenicity of avian paramyxovirus (APMV) serotypes 2, 3, 4, 5, 7, and 9 in rhesus macaques
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 8:e75456. 2013
    ..This suggests that they are not likely to significantly infect primates in nature, and represent promising attenuated candidates for vector development. ..
  22. pmc Complete genome sequences of avian paramyxovirus type 8 strains goose/Delaware/1053/76 and pintail/Wakuya/20/78
    Anandan Paldurai
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Virus Res 142:144-53. 2009
    ....
  23. pmc Complete genome sequences of avian paramyxovirus serotype 2 (APMV-2) strains Bangor, England and Kenya: evidence for the existence of subgroups within serotype 2
    Madhuri Subbiah
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    Virus Res 152:85-95. 2010
    ..These differences in antigenic relatedness suggest that these four APMV-2 strains represent a single serotype with two antigenic subgroups, and this is strongly supported by the dimorphism in nt and aa sequence identity...
  24. pmc Pathogenesis of two strains of avian paramyxovirus serotype 2, Yucaipa and Bangor, in chickens and turkeys
    Madhuri Subbiah
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    Avian Dis 54:1050-7. 2010
    ..There also was evidence of systemic spread even though the cleavage site of the viral fusion glycoprotein does not contain the canonical furin protease cleavage site...
  25. pmc Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 8:e74022. 2013
    ..Our findings showed that genotype-matched vaccines can provide protection to chickens by efficiently preventing spread of virus, primarily due to the F protein. ..
  26. pmc Role of C596 in the C-terminal extension of the haemagglutinin-neuraminidase protein in replication and pathogenicity of a highly virulent Indonesian strain of Newcastle disease virus
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, USA
    J Gen Virol 95:331-6. 2014
    ..These results indicate that this attenuating mechanism in avirulent strains such as Ulster can be applied directly to a highly virulent strain recently in circulation. ..
  27. pmc The hemagglutinin-neuraminidase protein of Newcastle disease virus determines tropism and virulence
    Zhuhui Huang
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA
    J Virol 78:4176-84. 2004
    ..These results are consistent with the hypothesis that the virulence of NDV is multigenic and that the cleavability of F protein alone does not determine the virulence of a strain...
  28. pmc Immunization of cattle with recombinant Newcastle disease virus expressing bovine herpesvirus-1 (BHV-1) glycoprotein D induces mucosal and serum antibody responses and provides partial protection against BHV-1
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    Vaccine 28:3159-70. 2010
    ....
  29. pmc Roles of the fusion and hemagglutinin-neuraminidase proteins in replication, tropism, and pathogenicity of avian paramyxoviruses
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Virol 85:8582-96. 2011
    ....
  30. ncbi request reprint Contribution of the attachment G glycoprotein to pathogenicity and immunogenicity of avian metapneumovirus subgroup C
    Dhanasekaran Govindarajan
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    Avian Dis 54:59-66. 2010
    ..Our results suggest that the G glycoprotein is an important determinant for the pathogenicity and immunogenicity of AMPV...
  31. pmc Experimental infection of mice with avian paramyxovirus serotypes 1 to 9
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 6:e16776. 2011
    ..Taken together, these results demonstrate that all APMV serotypes except APMV-5 are capable of replicating in mice with minimal disease and pathology...
  32. pmc Evaluation of the Newcastle disease virus F and HN proteins in protective immunity by using a recombinant avian paramyxovirus type 3 vector in chickens
    Sachin Kumar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 85:6521-34. 2011
    ..rAMPV3 represents an avirulent vaccine vector that can be used against NDV and other poultry pathogens...
  33. pmc Mutations in the cytoplasmic domain of the Newcastle disease virus fusion protein confer hyperfusogenic phenotypes modulating viral replication and pathogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 87:10083-93. 2013
    ..We conclude that these wild-type residues in the NDV F CT have an effect on regulating F protein biological functions and thus modulating viral replication and pathogenesis. ..
  34. pmc Complete sequence of the genome of avian paramyxovirus type 9 and comparison with other paramyxoviruses
    Arthur S Samuel
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, MD 20742, USA
    Virus Res 142:10-8. 2009
    ..The mean death time in embryonated chicken eggs was found to be more than 120h, indicating APMV-9 to be avirulent for chickens...
  35. ncbi request reprint Role of fusion protein cleavage site in the virulence of Newcastle disease virus
    Aruna Panda
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    Microb Pathog 36:1-10. 2004
    ....
  36. pmc Experimental avian paramyxovirus serotype-3 infection in chickens and turkeys
    Sachin Kumar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Vet Res 41:72. 2010
    ..Furthermore, there was little or no disease despite systemic viral spread and abundant viral replication in all the tissues tested...
  37. pmc Comparative immunogenicity of HIV-1 gp160, gp140 and gp120 expressed by live attenuated newcastle disease virus vector
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 8:e78521. 2013
    ..These studies illustrate that rLaSota/gp140S is a promising vaccine candidate to elicit potent mucosal, humoral and cellular immune responses to the HIV-1 Env protein. ..
  38. ncbi request reprint Sequence analysis of the large polymerase (L) protein of the US strain of avian metapneumovirus indicates a close resemblance to that of the human metapneumovirus
    Dhanasekaran Govindarajan
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, Maryland 20742, USA
    Virus Res 105:59-66. 2004
    ..Phylogenetic analysis of the different L proteins also revealed a closer relationship between APV-C and hMPV...
  39. pmc Mutations in the fusion protein cleavage site of avian paramyxovirus serotype 2 increase cleavability and syncytium formation but do not increase viral virulence in chickens
    Madhuri Subbiah
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 85:5394-405. 2011
    ..Furthermore, cleavage of the F protein is not a determinant of APMV-2 pathogenicity in chickens...
  40. pmc Contributions of the avian influenza virus HA, NA, and M2 surface proteins to the induction of neutralizing antibodies and protective immunity
    Baibaswata Nayak
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 84:2408-20. 2010
    ..Thus, there was no indication that M2 is immunogenic or protective. Furthermore, inclusion of NA in addition to HA in a vaccine preparation for chickens may not enhance the high level of protection provided by HA...
  41. pmc Prostate-specific antigen-retargeted recombinant newcastle disease virus for prostate cancer virotherapy
    Raghunath Shobana
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
    J Virol 87:3792-800. 2013
    ..Prostate-specific antigen targeting is likely to enhance the therapeutic index of rNDV owing to tumor-restricted replication and enhanced fusogenicity...
  42. pmc A Y526Q mutation in the Newcastle disease virus HN protein reduces its functional activities and attenuates virus replication and pathogenicity
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 83:7779-82. 2009
    ..While most of the mutations had surprisingly little effect, mutation at conserved residue Y526 reduced the neuraminidase, receptor binding, and fusion activities and attenuated viral virulence in eggs and young birds...
  43. pmc Role of untranslated regions of the hemagglutinin-neuraminidase gene in replication and pathogenicity of newcastle disease virus
    Yongqi Yan
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA
    J Virol 83:5943-6. 2009
    ..This indicates that the 5' UTR of HN mRNA plays an important role in replication and pathogenicity of NDV in vivo...
  44. pmc Complete genome sequence of avian paramyxovirus type 3 reveals an unusually long trailer region
    Sachin Kumar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Virus Res 137:189-97. 2008
    ....
  45. pmc Complete genome sequences of Newcastle disease virus strains circulating in chicken populations of Indonesia
    Sa Xiao
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 86:5969-70. 2012
    ..This is the first report of complete genome sequences of NDV strains isolated from chickens in Indonesia...
  46. doi request reprint Complete genome sequence of a virulent Newcastle disease virus isolated from an outbreak in chickens in Egypt
    Mahmoud H A Mohamed
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Virus Genes 39:234-7. 2009
    ..Determination of complete genome sequences of additional NDV strains from Africa is necessary to understand the epidemiology of currently circulating viruses in Africa...
  47. doi request reprint Complete genome sequence of highly virulent neurotropic Newcastle disease virus strain Texas GB
    Anandan Paldurai
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Virus Genes 41:67-72. 2010
    ..The phylogenetic analysis showed that strain Texas GB is closely related to the neurovirulent mesogenic strain Beaudette C (BC) and to NDV viruses isolated in China and Egypt than to other strains of NDV...
  48. pmc Immunization of chickens with Newcastle disease virus expressing H5 hemagglutinin protects against highly pathogenic H5N1 avian influenza viruses
    Baibaswata Nayak
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 4:e6509. 2009
    ..We have previously developed a reverse genetics system to produce low-virulent NDV vaccine strain LaSota from cloned cDNA. This system allows us to use NDV as a vaccine vector for other avian pathogens...
  49. pmc Loss of N-linked glycosylation from the hemagglutinin-neuraminidase protein alters virulence of Newcastle disease virus
    Aruna Panda
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Virol 78:4965-75. 2004
    ..In standard tests to assess virulence in chickens, all of the glycosylation mutants were less virulent than the parental BC virus, but the G4 and G12 mutants were the least virulent...
  50. pmc The large polymerase protein is associated with the virulence of Newcastle disease virus
    Subrat N Rout
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Virol 82:7828-36. 2008
    ..Our findings offer new insights into the pathogenesis of NDV infection...
  51. pmc Recovery of avian metapneumovirus subgroup C from cDNA: cross-recognition of avian and human metapneumovirus support proteins
    Dhanasekaran Govindarajan
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 80:5790-7. 2006
    ..These results indicate a close functional relationship between AMPV/CO and HMPV...
  52. pmc Effects of naturally occurring six- and twelve-nucleotide inserts on Newcastle disease virus replication and pathogenesis
    Anandan Paldurai
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 9:e103951. 2014
    ..Thus, although these inserts had no evident effect on gene expression, protein function, or replication in vivo, they did affect virulence in two of the three tested strains. ..
  53. pmc Complete genome sequence of a novel Newcastle disease virus strain isolated from a chicken in West Africa
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 86:11394-5. 2012
    ..Sequence divergence relative to vaccine strains was substantial, likely contributes to outbreaks, and illustrates the continued evolution of new NDV strains in West Africa...
  54. pmc Cell-type-specific innate immune response to oncolytic Newcastle disease virus
    Moanaro Biswas
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Viral Immunol 25:268-76. 2012
    ..Our results suggest that tumor selectivity is dependent on variations in the cellular antiviral response to infection with NDV and RIG-I expression...
  55. pmc Role of untranslated regions in regulation of gene expression, replication, and pathogenicity of Newcastle disease virus expressing green fluorescent protein
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA
    J Virol 84:2629-34. 2010
    ..In particular, UTRs of the M and F genes enhanced levels of GFP expression at the junction of the P and M genes without altering replication of NDV, suggesting that UTRs could be used for enhanced expression of a foreign gene by NDV...
  56. pmc A host-restricted viral vector for antigen-specific immunization against Lyme disease pathogen
    Sa Xiao
    Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Vaccine 29:5294-303. 2011
    ..Taken together, our studies highlighted the importance of NDV as vaccine vector that can be used for simple yet effective immunization of hosts against bacterial infections including Lyme disease...
  57. pmc Evaluation of the contributions of individual viral genes to newcastle disease virus virulence and pathogenesis
    Anandan Paldurai
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 88:8579-96. 2014
    ..The leader and trailer regions did not appear to contribute to the difference in virulence between BC and GBT...
  58. doi request reprint Inhibition of host innate immune responses and pathogenicity of recombinant Newcastle disease viruses expressing NS1 genes of influenza A viruses
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Gen Virol 91:1996-2001. 2010
    ..Our study also demonstrated that expression of H1N1/09 NS1 resulted in enhanced replication of rNDV in human cells, indicating that function of the NS1 proteins can be host-species-specific...
  59. doi request reprint Experimental infection of calves with Newcastle disease virus induces systemic and mucosal antibody responses
    Madhuri Subbiah
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Arch Virol 153:1197-200. 2008
    ..These results suggest that NDV has the potential for development as a host-range-restricted, intranasal vaccine vector for cattle that lack preexisting immunity to NDV...
  60. pmc Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 90:1682-6. 2015
    ..Additionally, these responses were higher after the gp120 than after the SOSIP gp140 protein boost...
  61. pmc Role of the cytoplasmic tail amino acid sequences of Newcastle disease virus hemagglutinin-neuraminidase protein in virion incorporation, cell fusion, and pathogenicity
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Virol 83:10250-5. 2009
    ....
  62. doi request reprint Induction of type I interferons by a novel porcine reproductive and respiratory syndrome virus isolate
    Yuchen Nan
    Molecular Virology Laboratory, VA MD Regional College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
    Virology 432:261-70. 2012
    ..8% at the nucleotide level. The identification of this IFN-inducing PRRSV isolate may be beneficial for vaccine development against PRRS...
  63. pmc Newcastle disease virus expressing human immunodeficiency virus type 1 envelope glycoprotein induces strong mucosal and serum antibody responses in Guinea pigs
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 85:10529-41. 2011
    ..3. These data illustrate that it is feasible to use NDV as a vaccine vector to elicit potent humoral and mucosal responses to the HIV-1 envelope protein...
  64. pmc Type I interferon-sensitive recombinant newcastle disease virus for oncolytic virotherapy
    Subbiah Elankumaran
    Center for Molecular Medicine and Infectious Diseases, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 1981 Kraft Drive, Blacksburg, VA 24061, USA
    J Virol 84:3835-44. 2010
    ..These findings indicate that augmentation of innate immune responses by NDV results in selective oncolysis and offer a novel and safe virotherapy platform...
  65. ncbi request reprint Analysis of the complete genome sequence of avian metapneumovirus subgroup C indicates that it possesses the longest genome among metapneumoviruses
    Dhanasekaran Govindarajan
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    Virus Genes 30:331-3. 2005
  66. ncbi request reprint Deduced amino acid sequence of the small hydrophobic protein of US avian pneumovirus has greater identity with that of human metapneumovirus than those of non-US avian pneumoviruses
    Abdul S Yunus
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Virus Res 93:91-7. 2003
    ..We also provide the sequences of transcription-signals and the M-F, F-M2, M2-SH and SH-G intergenic regions of APV/CO...
  67. pmc Newcastle disease virus exerts oncolysis by both intrinsic and extrinsic caspase-dependent pathways of cell death
    Subbiah Elankumaran
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 80:7522-34. 2006
    ..We have also shown that trackable oncolytic NDV could be developed without any reduction in oncolytic efficacy...
  68. pmc The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments
    Lilin Ye
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, College Park, MD 20742, USA
    J Immunol 181:2572-85. 2008
    ..Taken together, the intracellular trafficking of FcRn is regulated by its intrinsic sorting information and/or an interaction with Ii chain...
  69. pmc Newcastle disease virus V protein is associated with viral pathogenesis and functions as an alpha interferon antagonist
    Zhuhui Huang
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA
    J Virol 77:8676-85. 2003
    ..Pathogenicity studies showed that the V protein of NDV significantly contributes to the virus virulence...
  70. ncbi request reprint Complete sequence of the G glycoprotein gene of avian metapneumovirus subgroup C and identification of a divergent domain in the predicted protein
    Dhanasekaran Govindarajan
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Gen Virol 85:3671-5. 2004
    ..Comparison of the G protein sequences of AMPV-CO and Mn-2a identified a highly divergent domain (48 % amino acid identity) at aa 300-450...
  71. pmc Immunization of primates with a Newcastle disease virus-vectored vaccine via the respiratory tract induces a high titer of serum neutralizing antibodies against highly pathogenic avian influenza virus
    Joshua M DiNapoli
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases NIH, 50 South Drive, Bethesda, MD 20892, USA
    J Virol 81:11560-8. 2007
    ..This vaccine is a candidate for clinical evaluation in humans...
  72. pmc Recombinant newcastle disease virus expressing a foreign viral antigen is attenuated and highly immunogenic in primates
    Alexander Bukreyev
    LID, NIAID, NIH, 50 South Dr, Rm 6505, Bethesda, MD 20892 8007, USA
    J Virol 79:13275-84. 2005
    ..NDV appears to be a promising vector for the development of vaccines for humans; one application would be in controlling localized outbreaks of emerging pathogens...
  73. ncbi request reprint The pathogenesis of Newcastle disease: a comparison of selected Newcastle disease virus wild-type strains and their infectious clones
    Nobuko Wakamatsu
    Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, GA 30605, USA
    Virology 353:333-43. 2006
    ..Both pathogenicity indices and clinicopathologic examination demonstrated that the F, HN, and P genes of NDV collectively or individually can contribute to viral virulence...
  74. pmc Biological significance of the second receptor binding site of Newcastle disease virus hemagglutinin-neuraminidase protein
    Tatiana L Bousse
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Virol 78:13351-5. 2004
    ..Furthermore, the mutations at Arg516 slowed the growth rate of virus in tissue culture cells. These results suggest that the second binding site facilitates virus infection and growth by enhancing the fusion promotion activity of the HN...