Shin ichi Sekizawa

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, 95616 0635, USA
    J Neurosci 29:11807-16. 2009
  2. pmc Distinct tachykinin NK(1) receptor function in primate nucleus tractus solitarius neurons is dysregulated after second-hand tobacco smoke exposure
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, CA, USA
    Br J Pharmacol 163:782-91. 2011
  3. doi request reprint House-dust mite allergen and ozone exposure decreases histamine H3 receptors in the brainstem respiratory nuclei
    Shin ichi Sekizawa
    Department of Pharmacology, School of Medicine, University of California Davis, GBSF Rm 3617, 451 Health Sciences Drive, Davis, CA 95616 0635, USA
    Toxicol Appl Pharmacol 247:204-10. 2010
  4. doi request reprint Secondhand tobacco smoke exposure differentially alters nucleus tractus solitarius neurons at two different ages in developing non-human primates
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 242:199-208. 2010
  5. pmc Substance P presynaptically depresses the transmission of sensory input to bronchopulmonary neurons in the guinea pig nucleus tractus solitarii
    Shin ichi Sekizawa
    Department of Pharmacology and Toxicology and Department of Pediatrics, University of California Davis, Davis, CA 95616, USA
    J Physiol 552:547-59. 2003
  6. ncbi request reprint Plasticity in the nucleus tractus solitarius and its influence on lung and airway reflexes
    Ann C Bonham
    Department of Medical Pharmacology, University of California, Davis, CA, USA
    J Appl Physiol (1985) 101:322-7. 2006
  7. doi request reprint Secondhand smoke exposure alters K+ channel function and intrinsic cell excitability in a subset of second-order airway neurons in the nucleus tractus solitarius of young guinea pigs
    Shin ichi Sekizawa
    Department of Pharmacology, School of Medicine, GBSF Room 3617, 451 Health Sciences Drive, University of California Davis, Davis, CA 95616 0635, USA
    Eur J Neurosci 31:673-84. 2010
  8. pmc Realignment of signal processing within a sensory brainstem nucleus as brain temperature declines in the Syrian hamster, a hibernating species
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, GBSF 3617, 451 Health Sciences Drive, Davis, CA 95616, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 198:267-82. 2012
  9. doi request reprint Extended secondhand tobacco smoke exposure induces plasticity in nucleus tractus solitarius second-order lung afferent neurons in young guinea pigs
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, Davis, CA 95616, USA
    Eur J Neurosci 28:771-81. 2008
  10. pmc Protection of signal processing at low temperature in baroreceptive neurons in the nucleus tractus solitarius of Syrian hamsters, a hibernating species
    Shin ichi Sekizawa
    Department of Pharmacology, University of California, Davis, California
    Am J Physiol Regul Integr Comp Physiol 305:R1153-62. 2013

Detail Information

Publications13

  1. pmc A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, 95616 0635, USA
    J Neurosci 29:11807-16. 2009
    ..The data suggest a novel mechanism for postsynaptic group II mGluRs to fine-tune baroreceptor signal transmission in the NTS...
  2. pmc Distinct tachykinin NK(1) receptor function in primate nucleus tractus solitarius neurons is dysregulated after second-hand tobacco smoke exposure
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, CA, USA
    Br J Pharmacol 163:782-91. 2011
    ..We hypothesized that exposure to SHS in young primates changed the effect of substance P on the plasticity of neurons in the nucleus tractus solitarius (NTS), where airway sensory information is first processed in the CNS...
  3. doi request reprint House-dust mite allergen and ozone exposure decreases histamine H3 receptors in the brainstem respiratory nuclei
    Shin ichi Sekizawa
    Department of Pharmacology, School of Medicine, University of California Davis, GBSF Rm 3617, 451 Health Sciences Drive, Davis, CA 95616 0635, USA
    Toxicol Appl Pharmacol 247:204-10. 2010
    ..Histamine H3 receptors may be a therapeutic target for allergic asthma and rhinitis in children...
  4. doi request reprint Secondhand tobacco smoke exposure differentially alters nucleus tractus solitarius neurons at two different ages in developing non-human primates
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 242:199-208. 2010
    ....
  5. pmc Substance P presynaptically depresses the transmission of sensory input to bronchopulmonary neurons in the guinea pig nucleus tractus solitarii
    Shin ichi Sekizawa
    Department of Pharmacology and Toxicology and Department of Pediatrics, University of California Davis, Davis, CA 95616, USA
    J Physiol 552:547-59. 2003
    ..The data suggest a new site of action for substance P in the NTS (NK1 receptors on the central terminals of sensory fibres) and a new mechanism (depression of synaptic transmission) for regulating respiratory reflex function...
  6. ncbi request reprint Plasticity in the nucleus tractus solitarius and its influence on lung and airway reflexes
    Ann C Bonham
    Department of Medical Pharmacology, University of California, Davis, CA, USA
    J Appl Physiol (1985) 101:322-7. 2006
    ..This review focuses on existing evidence for plasticity in the NTS, potential targets for plasticity in the NTS, and the impact of this plasticity on lung and airway reflexes...
  7. doi request reprint Secondhand smoke exposure alters K+ channel function and intrinsic cell excitability in a subset of second-order airway neurons in the nucleus tractus solitarius of young guinea pigs
    Shin ichi Sekizawa
    Department of Pharmacology, School of Medicine, GBSF Room 3617, 451 Health Sciences Drive, University of California Davis, Davis, CA 95616 0635, USA
    Eur J Neurosci 31:673-84. 2010
    ..The data suggest that SHS exposure downregulates K+ channel function in a subset of NTS neurons, resulting in reduced cell excitability. The changes may help to explain the exaggerated neural reflex responses in children exposed to SHS...
  8. pmc Realignment of signal processing within a sensory brainstem nucleus as brain temperature declines in the Syrian hamster, a hibernating species
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, GBSF 3617, 451 Health Sciences Drive, Davis, CA 95616, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 198:267-82. 2012
    ..Changes were significant (P < 0.05), supporting our hypothesis by showing that, as temperature falls, rapid-onset neurons contribute more to signal processing but less to energy conservation than do delayed-onset neurons...
  9. doi request reprint Extended secondhand tobacco smoke exposure induces plasticity in nucleus tractus solitarius second-order lung afferent neurons in young guinea pigs
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, Davis, CA 95616, USA
    Eur J Neurosci 28:771-81. 2008
    ..The mechanism may help to explain some of the exaggerated respiratory responses of children exposed to SHS...
  10. pmc Protection of signal processing at low temperature in baroreceptive neurons in the nucleus tractus solitarius of Syrian hamsters, a hibernating species
    Shin ichi Sekizawa
    Department of Pharmacology, University of California, Davis, California
    Am J Physiol Regul Integr Comp Physiol 305:R1153-62. 2013
    ..The latter (shorter duration of non-NMDAR currents) would likely limit NMDAR coincidence gating and may help protect hamster NTS neurons, enabling them to contribute to signal processing at low body temperatures...
  11. ncbi request reprint Air pollutants and cough
    Jesse P Joad
    Department of Pediatrics, University of California, Davis, 2516 Stockton Blvd, Sacramento, CA 95817, USA
    Pulm Pharmacol Ther 20:347-54. 2007
    ..Ozone and allergen increased the intrinsic excitability of second-order neurones in the NTS. The animal studies suggest that the cough and wheeze experienced by humans exposed to pollutants may involve plasticity in the nervous system...
  12. ncbi request reprint Plasticity of brainstem mechanisms of cough
    Ann C Bonham
    Department of Pharmacology, University of California, Davis School of Medicine, 4150 V Street, 1104 PSSB, Sacramento, CA 95817, USA
    Respir Physiol Neurobiol 152:312-9. 2006
    ..This review integrates evidence implicating the NTS in exaggerated cough with proof of the concept that NTS neurons undergo plasticity to contribute to an exaggeration of cough...
  13. ncbi request reprint Group I metabotropic glutamate receptors on second-order baroreceptor neurons are tonically activated and induce a Na+-Ca2+ exchange current
    Shin ichi Sekizawa
    Department of Pharmacology, School of Medicine, University of California, Davis, CA 95817, USA
    J Neurophysiol 95:882-92. 2006
    ....