Mohammad Shahidullah

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Damage to lens fiber cells causes TRPV4-dependent Src family kinase activation in the epithelium
    M Shahidullah
    Dept of Physiology, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ, 85724, USA Electronic address
    Exp Eye Res 140:85-93. 2015
  2. pmc Connexins form functional hemichannels in porcine ciliary epithelium
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA Electronic address
    Exp Eye Res 118:20-9. 2014
  3. pmc TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, 85724, USA
    Am J Physiol Cell Physiol 302:C1751-61. 2012
  4. pmc Responses of sodium-hydrogen exchange to nitric oxide in porcine cultured nonpigmented ciliary epithelium
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona 85724, USA
    Invest Ophthalmol Vis Sci 50:5851-8. 2009
  5. pmc Studies on bicarbonate transporters and carbonic anhydrase in porcine nonpigmented ciliary epithelium
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona 85724, USA
    Invest Ophthalmol Vis Sci 50:1791-800. 2009
  6. doi request reprint Hyposmotic stress causes ATP release and stimulates Na,K-ATPase activity in porcine lens
    M Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona 85724, USA
    J Cell Physiol 227:1428-37. 2012
  7. pmc Primary culture of porcine nonpigmented ciliary epithelium
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona 85724, USA
    Curr Eye Res 32:511-22. 2007
  8. doi request reprint Nitric oxide regulation of Na, K-ATPase activity in ocular ciliary epithelium involves Src family kinase
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona
    J Cell Physiol 229:343-52. 2014
  9. pmc DIDS inhibits Na-K-ATPase activity in porcine nonpigmented ciliary epithelial cells by a Src family kinase-dependent mechanism
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona, USA
    Am J Physiol Cell Physiol 305:C492-501. 2013
  10. pmc Hydrostatic pressure-induced release of stored calcium in cultured rat optic nerve head astrocytes
    Amritlal Mandal
    Department of Physiology, University of Arizona, Tucson, Arizona 85724, USA
    Invest Ophthalmol Vis Sci 51:3129-38. 2010

Collaborators

Detail Information

Publications24

  1. pmc Damage to lens fiber cells causes TRPV4-dependent Src family kinase activation in the epithelium
    M Shahidullah
    Dept of Physiology, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ, 85724, USA Electronic address
    Exp Eye Res 140:85-93. 2015
    ..Increased Na,K-ATPase activity gives the lens greater capacity to control ion concentrations in the fiber mass and the Na,K-ATPase response may reflect the critical contribution of the epithelium to lens ion homeostasis. ..
  2. pmc Connexins form functional hemichannels in porcine ciliary epithelium
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA Electronic address
    Exp Eye Res 118:20-9. 2014
    ..The results point to functional hemichannels at the NPE basolateral surface. It is feasible that hemichannels might contribute to the transfer of substances between the ciliary epithelium cytoplasm and aqueous humor. ..
  3. pmc TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, 85724, USA
    Am J Physiol Cell Physiol 302:C1751-61. 2012
    ..The results point to TRPV4-mediated calcium entry that causes a cytoplasmic calcium increase which is an essential early step in the mechanism used by the lens to sense and respond to hyposmotic stress...
  4. pmc Responses of sodium-hydrogen exchange to nitric oxide in porcine cultured nonpigmented ciliary epithelium
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona 85724, USA
    Invest Ophthalmol Vis Sci 50:5851-8. 2009
    ..To better understand how nitric oxide (NO) alters the function of the nonpigmented ciliary epithelium (NPE), studies were performed to determine the influence of NO on sodium-hydrogen exchanger (NHE) activity...
  5. pmc Studies on bicarbonate transporters and carbonic anhydrase in porcine nonpigmented ciliary epithelium
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona 85724, USA
    Invest Ophthalmol Vis Sci 50:1791-800. 2009
    ..Bicarbonate transport plays a role in aqueous humor (AH) secretion. The authors examined bicarbonate transport mechanisms and carbonic anhydrase (CA) in porcine nonpigmented ciliary epithelium (NPE)...
  6. doi request reprint Hyposmotic stress causes ATP release and stimulates Na,K-ATPase activity in porcine lens
    M Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona 85724, USA
    J Cell Physiol 227:1428-37. 2012
    ..The responses might signify an autoregulatory loop initiated by mechanical stress or osmotic swelling...
  7. pmc Primary culture of porcine nonpigmented ciliary epithelium
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona 85724, USA
    Curr Eye Res 32:511-22. 2007
    ..Here we report development of a method of growing and maintaining primary cultures of NPE from porcine eye. Studies were conducted to confirm that the cultured NPE expressed proteins characteristic of native NPE...
  8. doi request reprint Nitric oxide regulation of Na, K-ATPase activity in ocular ciliary epithelium involves Src family kinase
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona
    J Cell Physiol 229:343-52. 2014
    ..Taken together, the results suggest that NO activates guanylate cyclase to cause a rise in cGMP and subsequent PKG-dependent SFK activation. Inhibition of Na,K-ATPase activity depends on SFK activation...
  9. pmc DIDS inhibits Na-K-ATPase activity in porcine nonpigmented ciliary epithelial cells by a Src family kinase-dependent mechanism
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona, USA
    Am J Physiol Cell Physiol 305:C492-501. 2013
    ..The evidence points to an inhibitory influence of DIDS on NPE Na-K-ATPase activity by a mechanism that hinges on SFK activation associated with a reduction of cytoplasmic pH. ..
  10. pmc Hydrostatic pressure-induced release of stored calcium in cultured rat optic nerve head astrocytes
    Amritlal Mandal
    Department of Physiology, University of Arizona, Tucson, Arizona 85724, USA
    Invest Ophthalmol Vis Sci 51:3129-38. 2010
    ..Recently, the authors reported ERK1/2, p90(RSK) and NHE1 phosphorylation after 2 hours. Here they examine calcium responses at the onset of HP to determine what precedes ERK1/2 phosphorylation...
  11. pmc Nonpigmented ciliary epithelial cells respond to acetazolamide by a soluble adenylyl cyclase mechanism
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona
    Invest Ophthalmol Vis Sci 55:187-97. 2014
    ..Here, we examine the contribution of sAC to an increase in cyclic AMP (cAMP) and changes in a key ion transporter, H(+)-ATPase, in NPE exposed to acetazolamide, a carbonic anhydrase inhibitor (CAI)...
  12. pmc Ouabain-induced stimulation of sodium-hydrogen exchange in rat optic nerve astrocytes
    Amritlal Mandal
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Cell Physiol 295:C100-10. 2008
    ..Taken together, the results are consistent with increased capacitative calcium entry and subsequent cAMP-PKA-dependent stimulation of NHE1 in ouabain-treated cells...
  13. pmc The Na+/H+ exchanger controls deoxycholic acid-induced apoptosis by a H+-activated, Na+-dependent ionic shift in esophageal cells
    Aaron Goldman
    Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 6:e23835. 2011
    ..Cells tolerate acidification but evade DCA-induced apoptosis if NHE is inhibited. Our data suggests that suppression of NHE by endogenous or exogenous inhibitors may lead to apoptosis resistance during GI tumorigenesis...
  14. pmc Elevated hydrostatic pressure activates sodium/hydrogen exchanger-1 in rat optic nerve head astrocytes
    Amritlal Mandal
    Dept of Physiology, Univ of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Cell Physiol 297:C111-20. 2009
    ..These responses may precede long-term changes of protein expression known to occur in pressure-stressed astrocytes...
  15. pmc A novel mechanism of acid and bile acid-induced DNA damage involving Na+/H+ exchanger: implication for Barrett's oesophagus
    Aaron Goldman
    Arizona Cancer Center, University of Arizona, USA
    Gut 59:1606-16. 2010
    ....
  16. pmc Localization of multidrug resistance-associated protein 2 in the nonpigmented ciliary epithelium of the eye
    Ryan M Pelis
    Department of Physiology, University of Arizona, College of Medicine, Tucson, Arizona, USA
    J Pharmacol Exp Ther 329:479-85. 2009
    ..MRP2 at the apical membrane of NPE cells may be involved in protecting intraocular tissues from exposure to potentially harmful toxins...
  17. doi request reprint A renal-like organic anion transport system in the ciliary epithelium of the bovine and human eye
    Jonghwa Lee
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada J L, A H, R M P Department of Physiology, University of Arizona, Tucson, Arizona M S, N A D and Department of Ophthalmology and Visual Sciences, Yale University, New Haven, Connecticut M C P
    Mol Pharmacol 87:697-705. 2015
    ..These data indicate that the ciliary body expresses a variety of OA transporters, including those common to the kidney. They are likely involved in clearing potentially harmful endobiotic and xenobiotic OAs from the eye. ..
  18. pmc The Significance of TRPV4 Channels and Hemichannels in the Lens and Ciliary Epithelium
    Nicholas A Delamere
    Department of Physiology, University of Arizona, Tucson, Arizona
    J Ocul Pharmacol Ther 32:504-508. 2016
    ....
  19. doi request reprint Src Family Kinase Links Insulin Signaling to Short Term Regulation of Na,K-ATPase in Nonpigmented Ciliary Epithelium
    Mohammad Shahidullah
    Department of Physiology and Ophthalmology and Vision Science, University of Arizona, Tucson, Arizona
    J Cell Physiol . 2016
    ..The findings are consistent with previous studies that indicate a link between Na,K-ATPase activity and SFK signaling. J. Cell. Physiol. 9999: 1-12, 2016. © 2016 Wiley Periodicals, Inc...
  20. pmc Calcium entry via connexin hemichannels in lens epithelium
    Amritlal Mandal
    Dept of Physiology, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Exp Eye Res 132:52-8. 2015
    ..Even though connexins form channels with a large carrying capacity, calcium entry does not increase the cytoplasmic calcium concentration beyond a tolerable physiological range. ..
  21. pmc NO donors inhibit Na,K-ATPase activity by a protein kinase G-dependent mechanism in the nonpigmented ciliary epithelium of the porcine eye
    Mohammad Shahidullah
    Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky 40202, USA
    Br J Pharmacol 148:871-80. 2006
    ..These findings suggest that Na,K-ATPase inhibition in NPE may contribute to the ability of NO donors to reduce aqueous humor secretion...
  22. pmc Cyclic GMP, sodium nitroprusside and sodium azide reduce aqueous humour formation in the isolated arterially perfused pig eye
    Mohammad Shahidullah
    The Laboratory of Experimental Optometry, Department of Optometry and Radiography, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China
    Br J Pharmacol 145:84-92. 2005
    ..None of the drugs had any significant effect on ocular vasculature. The reduction of the AHF and IOP in the arterially perfused pig eye by nitrovasodilators is likely to involve the NO-cGMP pathway...
  23. ncbi request reprint Effects of ion transport and channel-blocking drugs on aqueous humor formation in isolated bovine eye
    Mohammad Shahidullah
    Laboratory of Experimental Optometry, Department of Optometry and Radiography, The Hong Kong Polytechnic University, Kowloon, Hong Kong
    Invest Ophthalmol Vis Sci 44:1185-91. 2003
    ..To investigate the role of active chloride secretion by the ciliary epithelium in the formation of aqueous humor (AH), by using the in vitro perfused eye...
  24. ncbi request reprint The mechanism of aqueous humour formation
    Chi Ho To
    Laboratory of Experimental Optometry, Department of Optometry and Radiography, The Hong Kong Polytechnic University, Hung Hom, Kowloon, China
    Clin Exp Optom 85:335-49. 2002
    ..It also examines the current ionic models for AH formation and its regulation from a cellular transport perspective...