Alexander M Simon

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, 85724, USA
    Dev Biol 251:206-20. 2002
  2. pmc Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice
    Stephanie J Munger
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA Electronic address
    Dev Biol 412:173-90. 2016
  3. ncbi request reprint Role of connexin37 and connexin40 in vascular development
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, Arizona, USA
    Cell Commun Adhes 10:379-85. 2003
  4. ncbi request reprint Decreased intercellular dye-transfer and downregulation of non-ablated connexins in aortic endothelium deficient in connexin37 or connexin40
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    J Cell Sci 116:2223-36. 2003
  5. pmc Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling
    John D Kanady
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA Electronic address
    Dev Biol 405:33-46. 2015
  6. pmc Cx40 is required for, and cx37 limits, postischemic hindlimb perfusion, survival and recovery
    Jennifer S Fang
    Department of Physiology, University of Arizona Health Sciences Center, Tucson, Ariz, USA
    J Vasc Res 49:2-12. 2012
  7. ncbi request reprint Cx37 and Cx43 localize to zona pellucida in mouse ovarian follicles
    Alexander M Simon
    Department of Physiology, College of Medicine, University of Arizona, Tucson, 85724, USA
    Cell Commun Adhes 13:61-77. 2006
  8. ncbi request reprint Decreased intercellular communication and connexin expression in mouse aortic endothelium during lipopolysaccharide-induced inflammation
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, Ariz 85724 5051, USA
    J Vasc Res 41:323-33. 2004
  9. pmc Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax
    John D Kanady
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    Dev Biol 354:253-66. 2011
  10. pmc Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice
    Jennifer S Fang
    Department of Physiology, University of Arizona, Tucson, AZ 85718, USA
    Am J Physiol Heart Circ Physiol 304:H816-27. 2013

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, 85724, USA
    Dev Biol 251:206-20. 2002
    ..These results provide evidence of a critical role for endothelial gap junction-mediated communication in the development and/or functional maintenance of segments of the mouse vasculature...
  2. pmc Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice
    Stephanie J Munger
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA Electronic address
    Dev Biol 412:173-90. 2016
    ..The partition of Foxc2 and NFATc1 expression at VV leaflets makes it unlikely that these factors directly cooperate during the leaflet elongation stage of VV development. ..
  3. ncbi request reprint Role of connexin37 and connexin40 in vascular development
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, Arizona, USA
    Cell Commun Adhes 10:379-85. 2003
    ..In addition, Cx37 and Cx40 appear to be mutually dependent on each other for normal expression in vascular endothelium...
  4. ncbi request reprint Decreased intercellular dye-transfer and downregulation of non-ablated connexins in aortic endothelium deficient in connexin37 or connexin40
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    J Cell Sci 116:2223-36. 2003
    ..Furthermore, Cx37 and Cx40 are codependent on each other for optimal expression in vascular endothelium...
  5. pmc Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling
    John D Kanady
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA Electronic address
    Dev Biol 405:33-46. 2015
    ..These data provide further evidence suggesting that Foxc2 and Cx37 are elements in a common molecular pathway directing lymphangiogenesis. ..
  6. pmc Cx40 is required for, and cx37 limits, postischemic hindlimb perfusion, survival and recovery
    Jennifer S Fang
    Department of Physiology, University of Arizona Health Sciences Center, Tucson, Ariz, USA
    J Vasc Res 49:2-12. 2012
    ..Vascular endothelium predominantly expresses two connexin (Cx) isoforms: Cx37 and Cx40. The relevance of these Cxs to postischemic limb recovery remains unclear...
  7. ncbi request reprint Cx37 and Cx43 localize to zona pellucida in mouse ovarian follicles
    Alexander M Simon
    Department of Physiology, College of Medicine, University of Arizona, Tucson, 85724, USA
    Cell Commun Adhes 13:61-77. 2006
    ..We suggest that in addition to its role in oocyte-granulosa cell communication, Cx37 could enable a distinct communication pathway between those granulosa cells that are in direct contact with the oocyte...
  8. ncbi request reprint Decreased intercellular communication and connexin expression in mouse aortic endothelium during lipopolysaccharide-induced inflammation
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, Ariz 85724 5051, USA
    J Vasc Res 41:323-33. 2004
    ..These results suggest that LPS mediates changes in endothelial gap junction-mediated communication, at least in part, through modulation of Cx40 and Cx37 levels...
  9. pmc Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax
    John D Kanady
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    Dev Biol 354:253-66. 2011
    ..These results show that at least three Cxs are expressed in the developing lymphatic vasculature and, when defective, are associated with clinically manifest lymphatic disorders in mice and man...
  10. pmc Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice
    Jennifer S Fang
    Department of Physiology, University of Arizona, Tucson, AZ 85718, USA
    Am J Physiol Heart Circ Physiol 304:H816-27. 2013
    ..Our data suggest that Cx40(-/-) mice are at significantly greater risk for poor recovery from ischemic insult due to compromised regulation of tissue perfusion, vascular remodeling, and prolonged inflammatory response...
  11. pmc Absence of venous valves in mice lacking Connexin37
    Stephanie J Munger
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    Dev Biol 373:338-48. 2013
    ..Because Cxs are necessary for the development of valves in lymphatic vessels as well, our results support the notion of common molecular pathways controlling valve development in veins and lymphatic vessels...
  12. pmc A functional channel is necessary for growth suppression by Cx37
    Miranda E Good
    Department of Physiology, University of Arizona, PO Box 245051, Tucson, AZ 85724, USA
    J Cell Sci 124:2448-56. 2011
    ....
  13. pmc Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice
    Michael W Bobbie
    Departments of Medicine, University of Arizona, Tucson, Arizona, USA
    Invest Ophthalmol Vis Sci 51:3758-63. 2010
    ..Diabetes-induced inhibition of Cx43 expression contributes to vascular cell apoptosis in retinas of diabetic mice. This suggests that reduced Cx43 expression plays a critical role in the development of AC and PL associated with DR...
  14. ncbi request reprint Heart and head defects in mice lacking pairs of connexins
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    Dev Biol 265:369-83. 2004
    ..Moreover, ablating different pairs of cardiac connexins results in distinct heart defects, suggesting both common and unique functions for Cx40, Cx43, and Cx37 during cardiac morphogenesis...
  15. pmc Cx37 deletion enhances vascular growth and facilitates ischemic limb recovery
    Jennifer S Fang
    Department of Physiology, University of Arizona, Tucson, Arizona, USA
    Am J Physiol Heart Circ Physiol 301:H1872-81. 2011
    ..These results are consistent with Cx37 exerting a growth-suppressive effect in the vasculature that limits embryonic vasculogenesis as well as arteriogenic and angiogenic responses to ischemic injury in the adult animal...
  16. pmc Connexin 37 profoundly slows cell cycle progression in rat insulinoma cells
    Janis M Burt
    Dept of Physiology, P O Box 245051, Univ of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Cell Physiol 295:C1103-12. 2008
    ..Our results indicate that Cx37 expression suppresses cell proliferation by significantly increasing cell cycle time by extending all phases of the cell cycle and accumulating cells at the G(1)/S checkpoint...
  17. pmc Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43
    Stephanie J Munger
    Department of Physiology, University of Arizona, Tucson AZ 85724, USA Electronic address
    Dev Biol . 2016
    ..These results demonstrate that the expression of Cx43 is specifically required in LECs for normal development of LVs...
  18. ncbi request reprint Lipopolysaccharide reduces electrical coupling in microvascular endothelial cells by targeting connexin40 in a tyrosine-, ERK1/2-, PKA-, and PKC-dependent manner
    Michael L Bolon
    The Centre for Critical Illness Research and Children s Health Research Institute, Lawson Health Research Institute, London, Canada
    J Cell Physiol 211:159-66. 2007
    ..We suggest that this mechanism contributes to compromised arteriolar function following LPS exposure...
  19. ncbi request reprint Central role of connexin40 in the propagation of electrically activated vasodilation in mouse cremasteric arterioles in vivo
    Xavier F Figueroa
    Dept of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, PO Box 800736, Charlottesville, VA 22908 0736, USA
    Circ Res 92:793-800. 2003
    ..Moreover, electrical stimulation activates a nonneuronal, Cx40-dependent vasodilator response that spreads along the vessel length without decay...