Alexander Simon

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc The extracellular matrix controls gap junction protein expression and function in postnatal hippocampal neural progenitor cells
    Sophie Imbeault
    Neural Regeneration Laboratory and Ottawa Institute of Systems Biology, Dept of Biochemistry, Microbiology, and Immunology, University of Ottawa, ON, Canada
    BMC Neurosci 10:13. 2009
  2. ncbi request reprint Decreased intercellular communication and connexin expression in mouse aortic endothelium during lipopolysaccharide-induced inflammation
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, Ariz 85724 5051, USA
    J Vasc Res 41:323-33. 2004
  3. ncbi request reprint Decreased intercellular dye-transfer and downregulation of non-ablated connexins in aortic endothelium deficient in connexin37 or connexin40
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    J Cell Sci 116:2223-36. 2003
  4. ncbi request reprint Role of connexin37 and connexin40 in vascular development
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, Arizona, USA
    Cell Commun Adhes 10:379-85. 2003
  5. ncbi request reprint Heart and head defects in mice lacking pairs of connexins
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    Dev Biol 265:369-83. 2004
  6. ncbi request reprint Cx37 and Cx43 localize to zona pellucida in mouse ovarian follicles
    Alexander M Simon
    Department of Physiology, College of Medicine, University of Arizona, Tucson, 85724, USA
    Cell Commun Adhes 13:61-77. 2006
  7. pmc Connexin 37 profoundly slows cell cycle progression in rat insulinoma cells
    Janis M Burt
    Dept of Physiology, P O Box 245051, Univ of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Cell Physiol 295:C1103-12. 2008
  8. ncbi request reprint Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, 85724, USA
    Dev Biol 251:206-20. 2002
  9. pmc Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice
    Michael W Bobbie
    Departments of Medicine, University of Arizona, Tucson, Arizona, USA
    Invest Ophthalmol Vis Sci 51:3758-63. 2010
  10. ncbi request reprint Lipopolysaccharide reduces electrical coupling in microvascular endothelial cells by targeting connexin40 in a tyrosine-, ERK1/2-, PKA-, and PKC-dependent manner
    Michael L Bolon
    The Centre for Critical Illness Research and Children s Health Research Institute, Lawson Health Research Institute, London, Canada
    J Cell Physiol 211:159-66. 2007

Research Grants

  1. Gap Junction Mediated Signaling and Vascular Responses
    Alexander M Simon; Fiscal Year: 2010

Collaborators

  • Sayon Roy
  • JANIS BURT
  • Brian Duling
  • D A Goodenough
  • Gerald M Kidder
  • Michael W Bobbie
  • Sophie Imbeault
  • Michael L Bolon
  • David L Paul
  • Xavier F Figueroa
  • Kyle Trudeau
  • Stephanie J Munger
  • A Sheila Menzies
  • Steffany Al Bennett
  • Alexandra Pettit
  • Lamiaa Migahed
  • Rebecca DesRoches
  • Kiyomasa Nishii
  • Lianne G Gauvin
  • Catherine D Sorbara
  • Hadi D Toeg
  • Karel Tyml
  • David N Damon
  • Kathy H Day

Detail Information

Publications11

  1. pmc The extracellular matrix controls gap junction protein expression and function in postnatal hippocampal neural progenitor cells
    Sophie Imbeault
    Neural Regeneration Laboratory and Ottawa Institute of Systems Biology, Dept of Biochemistry, Microbiology, and Immunology, University of Ottawa, ON, Canada
    BMC Neurosci 10:13. 2009
    ..It is not known how these two signalling systems interact. Here, we examined the role of ECM components in regulating connexin expression and function in postnatal hippocampal progenitor cells...
  2. ncbi request reprint Decreased intercellular communication and connexin expression in mouse aortic endothelium during lipopolysaccharide-induced inflammation
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, Ariz 85724 5051, USA
    J Vasc Res 41:323-33. 2004
    ..These results suggest that LPS mediates changes in endothelial gap junction-mediated communication, at least in part, through modulation of Cx40 and Cx37 levels...
  3. ncbi request reprint Decreased intercellular dye-transfer and downregulation of non-ablated connexins in aortic endothelium deficient in connexin37 or connexin40
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    J Cell Sci 116:2223-36. 2003
    ..Furthermore, Cx37 and Cx40 are codependent on each other for optimal expression in vascular endothelium...
  4. ncbi request reprint Role of connexin37 and connexin40 in vascular development
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, Arizona, USA
    Cell Commun Adhes 10:379-85. 2003
    ..In addition, Cx37 and Cx40 appear to be mutually dependent on each other for normal expression in vascular endothelium...
  5. ncbi request reprint Heart and head defects in mice lacking pairs of connexins
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    Dev Biol 265:369-83. 2004
    ..Moreover, ablating different pairs of cardiac connexins results in distinct heart defects, suggesting both common and unique functions for Cx40, Cx43, and Cx37 during cardiac morphogenesis...
  6. ncbi request reprint Cx37 and Cx43 localize to zona pellucida in mouse ovarian follicles
    Alexander M Simon
    Department of Physiology, College of Medicine, University of Arizona, Tucson, 85724, USA
    Cell Commun Adhes 13:61-77. 2006
    ..We suggest that in addition to its role in oocyte-granulosa cell communication, Cx37 could enable a distinct communication pathway between those granulosa cells that are in direct contact with the oocyte...
  7. pmc Connexin 37 profoundly slows cell cycle progression in rat insulinoma cells
    Janis M Burt
    Dept of Physiology, P O Box 245051, Univ of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Cell Physiol 295:C1103-12. 2008
    ..Our results indicate that Cx37 expression suppresses cell proliferation by significantly increasing cell cycle time by extending all phases of the cell cycle and accumulating cells at the G(1)/S checkpoint...
  8. ncbi request reprint Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, 85724, USA
    Dev Biol 251:206-20. 2002
    ..These results provide evidence of a critical role for endothelial gap junction-mediated communication in the development and/or functional maintenance of segments of the mouse vasculature...
  9. pmc Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice
    Michael W Bobbie
    Departments of Medicine, University of Arizona, Tucson, Arizona, USA
    Invest Ophthalmol Vis Sci 51:3758-63. 2010
    ..Diabetes-induced inhibition of Cx43 expression contributes to vascular cell apoptosis in retinas of diabetic mice. This suggests that reduced Cx43 expression plays a critical role in the development of AC and PL associated with DR...
  10. ncbi request reprint Lipopolysaccharide reduces electrical coupling in microvascular endothelial cells by targeting connexin40 in a tyrosine-, ERK1/2-, PKA-, and PKC-dependent manner
    Michael L Bolon
    The Centre for Critical Illness Research and Children s Health Research Institute, Lawson Health Research Institute, London, Canada
    J Cell Physiol 211:159-66. 2007
    ..We suggest that this mechanism contributes to compromised arteriolar function following LPS exposure...
  11. ncbi request reprint Central role of connexin40 in the propagation of electrically activated vasodilation in mouse cremasteric arterioles in vivo
    Xavier F Figueroa
    Dept of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, PO Box 800736, Charlottesville, VA 22908 0736, USA
    Circ Res 92:793-800. 2003
    ..Moreover, electrical stimulation activates a nonneuronal, Cx40-dependent vasodilator response that spreads along the vessel length without decay...

Research Grants1

  1. Gap Junction Mediated Signaling and Vascular Responses
    Alexander M Simon; Fiscal Year: 2010
    ..Finally, these studies could also lead to new approaches to control vasculogenesis and angiogenesis in other clinically important settings, such as anti-angiogenesis treatments designed to fight cancer. ..