Susan E Sweeney

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3
    Susan E Sweeney
    University of California San Diego, School of Medicine, La Jolla, CA 92093, USA
    Arthritis Rheum 56:743-52. 2007
  2. pmc Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases
    Toshio Yoshizawa
    Division of Rheumatology, Allergy and Immunology, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA
    J Immunol 181:3252-8. 2008
  3. ncbi request reprint Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon complex in fibroblast-like synoviocytes
    Susan E Sweeney
    Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    J Immunol 174:6424-30. 2005
  4. pmc Synoviocyte innate immune responses: II. Pivotal role of IFN regulatory factor 3
    Susan E Sweeney
    Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    J Immunol 184:7162-8. 2010
  5. ncbi request reprint Signal transduction in rheumatoid arthritis
    Susan E Sweeney
    Division of Rheumatology, Allergy, and Immunology, University of California San Diego, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Curr Opin Rheumatol 16:231-7. 2004
  6. pmc Role of interferon regulatory factor 7 in serum-transfer arthritis: regulation of interferon-β production
    Susan E Sweeney
    University of California San Diego, La Jolla, CA 92093 0663, USA
    Arthritis Rheum 64:1046-56. 2012
  7. ncbi request reprint Rheumatoid arthritis: regulation of synovial inflammation
    Susan E Sweeney
    Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Int J Biochem Cell Biol 36:372-8. 2004
  8. ncbi request reprint Primer: signal transduction in rheumatic disease--a clinician's guide
    Susan E Sweeney
    Division of Rheumatology, Allergy and Immunology, University of California San Diego, Department of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0656, USA
    Nat Clin Pract Rheumatol 3:651-60. 2007
  9. pmc Targeting interferon regulatory factors to inhibit activation of the type I IFN response: implications for treatment of autoimmune disorders
    Susan E Sweeney
    Division of Rheumatology, Allergy, and Immunology, University of California, San Diego, La Jolla, CA 92093, United States
    Cell Immunol 271:342-9. 2011

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3
    Susan E Sweeney
    University of California San Diego, School of Medicine, La Jolla, CA 92093, USA
    Arthritis Rheum 56:743-52. 2007
    ..This study was designed to investigate the role of the IKK-related kinase IKKepsilon and IFN regulatory factor 3 (IRF-3) in the activation of antiviral genes in rheumatoid arthritis (RA)...
  2. pmc Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases
    Toshio Yoshizawa
    Division of Rheumatology, Allergy and Immunology, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA
    J Immunol 181:3252-8. 2008
    ..MKK7 is the primary activator of JNK in TNF, LPS, and PGN responses. However, TLR3 requires both MKK4 and MKK7, with the former activating c-Jun and the latter activating both c-Jun and IRF3 through JNK-dependent mechanisms...
  3. ncbi request reprint Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon complex in fibroblast-like synoviocytes
    Susan E Sweeney
    Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    J Immunol 174:6424-30. 2005
    ..These data suggest a novel role for the IKKepsilon complex in synovial inflammation, extracellular matrix destruction, and activation of the viral program and innate immune response in RA...
  4. pmc Synoviocyte innate immune responses: II. Pivotal role of IFN regulatory factor 3
    Susan E Sweeney
    Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    J Immunol 184:7162-8. 2010
    ..Targeting synoviocyte IRF3 represents a potential approach to suppress diverse mediators while limiting suppression of IRF7-mediated immune responses...
  5. ncbi request reprint Signal transduction in rheumatoid arthritis
    Susan E Sweeney
    Division of Rheumatology, Allergy, and Immunology, University of California San Diego, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Curr Opin Rheumatol 16:231-7. 2004
    ..Understanding the critical networks in diseases like rheumatoid arthritis can potentially identify novel therapeutic targets...
  6. pmc Role of interferon regulatory factor 7 in serum-transfer arthritis: regulation of interferon-β production
    Susan E Sweeney
    University of California San Diego, La Jolla, CA 92093 0663, USA
    Arthritis Rheum 64:1046-56. 2012
    ..The purpose of this study was to examine the effect of genetic deficiency of IRF-7 in a passive K/BxN serum-transfer model of arthritis...
  7. ncbi request reprint Rheumatoid arthritis: regulation of synovial inflammation
    Susan E Sweeney
    Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Int J Biochem Cell Biol 36:372-8. 2004
    ....
  8. ncbi request reprint Primer: signal transduction in rheumatic disease--a clinician's guide
    Susan E Sweeney
    Division of Rheumatology, Allergy and Immunology, University of California San Diego, Department of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0656, USA
    Nat Clin Pract Rheumatol 3:651-60. 2007
    ..Understanding these intracellular pathways might lead to new approaches to the treatment of inflammatory disease, including the use of orally bioavailable small molecules that regulate cytokine function and production...
  9. pmc Targeting interferon regulatory factors to inhibit activation of the type I IFN response: implications for treatment of autoimmune disorders
    Susan E Sweeney
    Division of Rheumatology, Allergy, and Immunology, University of California, San Diego, La Jolla, CA 92093, United States
    Cell Immunol 271:342-9. 2011
    ..IRF regulation of inflammation and induction of the IFN signature might contribute to the pathogenesis of autoimmune diseases and therefore represent novel therapeutic targets...