WALLACE BRUCE THORESON

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint A2 adenosine receptors inhibit calcium influx through L-type calcium channels in rod photoreceptors of the salamander retina
    Salvatore L Stella
    Department of Pharmacology and Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5540, USA
    J Neurophysiol 87:351-60. 2002
  2. pmc Inner retinal mechanisms engaged by retinal electrical stimulation
    Eyal Margalit
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha 68198 5540, USA
    Invest Ophthalmol Vis Sci 47:2606-12. 2006
  3. ncbi request reprint Neural stem cell properties of Müller glia in the mammalian retina: regulation by Notch and Wnt signaling
    Ani V Das
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198 5840, USA
    Dev Biol 299:283-302. 2006
  4. pmc Anion-sensitive regions of L-type CaV1.2 calcium channels expressed in HEK293 cells
    Norbert Babai
    Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 5:e8602. 2010
  5. pmc Quantal amplitude at the cone ribbon synapse can be adjusted by changes in cytosolic glutamate
    Theodore M Bartoletti
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198 5840, USA
    Mol Vis 17:920-31. 2011
  6. pmc Lateral mobility of L-type calcium channels in synaptic terminals of retinal bipolar cells
    Wallace B Thoreson
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE 68198 5840, USA
    Mol Vis 19:16-24. 2013
  7. pmc Lateral interactions in the outer retina
    Wallace B Thoreson
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Prog Retin Eye Res 31:407-41. 2012
  8. pmc Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca(2+) channels
    Theodore M Bartoletti
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198 5840, USA
    J Neurophysiol 106:2922-35. 2011
  9. pmc Regulation of presynaptic strength by controlling Ca2+ channel mobility: effects of cholesterol depletion on release at the cone ribbon synapse
    Aaron J Mercer
    Dept of Ophthalmology and Visual Sciences, Univ of Nebraska Medical Center, Omaha, NE 68198 5840, USA
    J Neurophysiol 107:3468-78. 2012
  10. pmc Feedback from horizontal cells to rod photoreceptors in vertebrate retina
    Wallace B Thoreson
    Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Neurosci 28:5691-5. 2008

Collaborators

Detail Information

Publications46

  1. ncbi request reprint A2 adenosine receptors inhibit calcium influx through L-type calcium channels in rod photoreceptors of the salamander retina
    Salvatore L Stella
    Department of Pharmacology and Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5540, USA
    J Neurophysiol 87:351-60. 2002
    ..The results suggest that activation of A2 receptors stimulates PKA to inhibit L-type Ca(2+) channels in rods resulting in a decreased Ca(2+) influx that should suppress glutamate release...
  2. pmc Inner retinal mechanisms engaged by retinal electrical stimulation
    Eyal Margalit
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha 68198 5540, USA
    Invest Ophthalmol Vis Sci 47:2606-12. 2006
    ..Retinal prosthetic devices are being developed to bypass degenerated retinal photoreceptors by directly activating retinal neurons with electrical stimulation. However, little is known about retinal activity during such stimulation...
  3. ncbi request reprint Neural stem cell properties of Müller glia in the mammalian retina: regulation by Notch and Wnt signaling
    Ani V Das
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198 5840, USA
    Dev Biol 299:283-302. 2006
    ..Together, these results identify Müller cells as latent NSCs in the mammalian retina and hence, may serve as a potential target for cellular manipulation for treating retinal degeneration...
  4. pmc Anion-sensitive regions of L-type CaV1.2 calcium channels expressed in HEK293 cells
    Norbert Babai
    Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 5:e8602. 2010
    ..2 currents mediated by changes in channel open probability involving beta subunit interactions with the N terminus and a short C terminal region...
  5. pmc Quantal amplitude at the cone ribbon synapse can be adjusted by changes in cytosolic glutamate
    Theodore M Bartoletti
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198 5840, USA
    Mol Vis 17:920-31. 2011
    ..Vision is encoded at photoreceptor synapses by the number of released vesicles and size of the post-synaptic response. We hypothesized that elevating cytosolic glutamate could enhance quantal size by increasing glutamate in vesicles...
  6. pmc Lateral mobility of L-type calcium channels in synaptic terminals of retinal bipolar cells
    Wallace B Thoreson
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE 68198 5840, USA
    Mol Vis 19:16-24. 2013
    ..We investigated whether Ca(2+) channels at bipolar cell ribbon synapses are fixed in position or capable of moving in the membrane...
  7. pmc Lateral interactions in the outer retina
    Wallace B Thoreson
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Prog Retin Eye Res 31:407-41. 2012
    ..Finally, we examine the mechanisms and functions of two other forms of lateral interaction in the outer retina: negative feedback from horizontal cells to rods and positive feedback from horizontal cells to cones...
  8. pmc Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca(2+) channels
    Theodore M Bartoletti
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198 5840, USA
    J Neurophysiol 106:2922-35. 2011
    ..This may improve detection of small light decrements when cones are hyperpolarized by bright light...
  9. pmc Regulation of presynaptic strength by controlling Ca2+ channel mobility: effects of cholesterol depletion on release at the cone ribbon synapse
    Aaron J Mercer
    Dept of Ophthalmology and Visual Sciences, Univ of Nebraska Medical Center, Omaha, NE 68198 5840, USA
    J Neurophysiol 107:3468-78. 2012
    ....
  10. pmc Feedback from horizontal cells to rod photoreceptors in vertebrate retina
    Wallace B Thoreson
    Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Neurosci 28:5691-5. 2008
    ..HC-to-rod feedback counters light-evoked decreases in synaptic output and thus shapes the transmission of rod responses to downstream visual neurons...
  11. pmc Kinetics of synaptic transmission at ribbon synapses of rods and cones
    Wallace B Thoreson
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, 4th Floor, Durham Research Center, 985840 Nebraska Medical Center, Omaha, NE 68198 5840, USA
    Mol Neurobiol 36:205-23. 2007
    ..Thus, multiple synaptic mechanisms help to shape the responses of second-order horizontal and bipolar cells...
  12. ncbi request reprint Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells
    Wallace B Thoreson
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5540, USA
    Invest Ophthalmol Vis Sci 43:2450-61. 2002
    ..LPA receptor transduction was analyzed in human and rat RPE cells...
  13. pmc Chloride equilibrium potential in salamander cones
    Wallace B Thoreson
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE, USA
    BMC Neurosci 5:53. 2004
    ..To assess the impact of these and other chloride-dependent mechanisms on release from cones, the chloride equilibrium potential (ECl) was determined in red-sensitive, large single cones from the tiger salamander retinal slice...
  14. pmc A highly Ca2+-sensitive pool of vesicles contributes to linearity at the rod photoreceptor ribbon synapse
    Wallace B Thoreson
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Neuron 42:595-605. 2004
    ..The low-order [Ca(2+)] dependence of release promotes a linear relationship between Ca(2+) entry and exocytosis that permits rods to relay information about small changes in illumination with high fidelity at the first synapse in vision...
  15. ncbi request reprint Kinetics of synaptic transfer from rods and cones to horizontal cells in the salamander retina
    W B Thoreson
    Department of Ophthalmology, 985540 University of Nebraska Medical Center, Omaha, NE 68198 5540, USA
    Neuroscience 122:785-98. 2003
    ..The match between model and response was not improved by including an estimate of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor desensitization or by making glutamate uptake voltage dependent...
  16. ncbi request reprint Chloride efflux inhibits single calcium channel open probability in vertebrate photoreceptors: chloride imaging and cell-attached patch-clamp recordings
    W B Thoreson
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha 68198 5540, USA
    Vis Neurosci 17:197-206. 2000
    ..Examination of the open and closed time distributions suggests that the reduction in open probability arises from increases in closed-state dwell times. Changes in intracellular [Cl-] may thus modulate photoreceptor Ca2+ channels...
  17. ncbi request reprint Contrast encoding in retinal bipolar cells: current vs. voltage
    Wallace B Thoreson
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha 68198 5540, USA
    Vis Neurosci 20:19-28. 2003
    ....
  18. pmc Removal of extracellular chloride suppresses transmitter release from photoreceptor terminals in the mudpuppy retina
    W B Thoreson
    Department of Ophthalmology, Gifford Laboratory of Ophthalmology, University of Nebraska Medical Center, Omaha 68198, USA
    J Gen Physiol 107:631-42. 1996
    ..Thus, it is possible that control of [Cl-] in and around photoreceptors may regulate glutamate release from these cells...
  19. ncbi request reprint Dihydropyridine-sensitive calcium currents in bipolar cells of salamander retina are inhibited by reductions in extracellular chloride
    W B Thoreson
    Departments of Ophthalmology and Pharmacology, University of Nebraska Medical Center, 985540, Omaha, NE 68198 5540, USA
    Neurosci Lett 280:155-8. 2000
    ..Thus, sensitivity to Cl(-) may be a more general property of L-type Ca(2+) channel subtypes that mediate sustained neurotransmission...
  20. ncbi request reprint Reciprocal interactions between calcium and chloride in rod photoreceptors
    Wallace B Thoreson
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Neurophysiol 90:1747-53. 2003
    ..These findings support the hypothesis that feedback interactions between Ca2+- and Ca2+-activated Cl- channels may contribute to the regulation of presynaptic Ca2+ currents involved in synaptic transmission from rod photoreceptors...
  21. ncbi request reprint Anion modulation of calcium current voltage dependence and amplitude in salamander rods
    W B Thoreson
    Department of Ophthalmology, University of Nebraska Medical Center, 985540 Nebraska Medical Center, Omaha, NE 68198 5540, USA
    Biochim Biophys Acta 1464:142-50. 2000
    ..Because of the overlap between the physiological voltage range and the lower part of the I(Ca) activation curve, anion effects on amplitude and activation may influence synaptic transmission at the first retinal synapse...
  22. ncbi request reprint D2-like dopamine receptors promote interactions between calcium and chloride channels that diminish rod synaptic transfer in the salamander retina
    Wallace B Thoreson
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha 68198 5540, USA
    Vis Neurosci 19:235-47. 2002
    ..The net result is a Cl- efflux that inhibits depolarization-evoked increases in [Ca2+]i and synaptic transmission from rods...
  23. pmc Quantal mEPSCs and residual glutamate: how horizontal cell responses are shaped at the photoreceptor ribbon synapse
    Lucia Cadetti
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Durham Research Center Room 4050, Omaha, NE 68198 5840, USA
    Eur J Neurosci 27:2575-86. 2008
    ....
  24. pmc Horizontal cell feedback regulates calcium currents and intracellular calcium levels in rod photoreceptors of salamander and mouse retina
    Norbert Babai
    Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, NE 68198 5840, USA
    J Physiol 587:2353-64. 2009
    ..The finding that HC to rod feedback is present in both amphibian and mammalian species shows that this mechanism is highly conserved across vertebrate retinas...
  25. ncbi request reprint Calcium-dependent inactivation and depletion of synaptic cleft calcium ions combine to regulate rod calcium currents under physiological conditions
    Katalin Rabl
    Department of Ophthalmology, University of Nebraska Medical Center, 985540 Nebraska Medical Center, Omaha, NE 68198 5540, USA
    Eur J Neurosci 16:2070-7. 2002
    ..These findings suggest that Ca2+-dependent inactivation and depletion of synaptic cleft Ca2+ may combine to regulate I(Ca) in response to light-evoked changes in rod membrane potential...
  26. ncbi request reprint Activation of glutamate transporters in rods inhibits presynaptic calcium currents
    Katalin Rabl
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha 68198 5540, USA
    Vis Neurosci 20:557-66. 2003
    ..The neurotransmitter L-Glu released from rod terminals might thus provide a negative feedback signal to inhibit further L-Glu release...
  27. ncbi request reprint Endogenous adenosine reduces glutamatergic output from rods through activation of A2-like adenosine receptors
    Salvatore L Stella
    Department of Pharmacology and Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5540, USA
    J Neurophysiol 90:165-74. 2003
    ..The effects of these drugs suggest that endogenous adenosine activates an A2-like adenosine receptor on rods leading to inhibition of ICa, which in turn inhibits l-glutamate release from rod photoreceptors...
  28. pmc Calcium-induced calcium release in rod photoreceptor terminals boosts synaptic transmission during maintained depolarization
    Lucia Cadetti
    Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, 68198 5840, USA
    Eur J Neurosci 23:2983-90. 2006
    ..These results indicate that CICR enhances calcium increases in rod terminals evoked by sustained depolarization, which in turn acts to boost synaptic exocytosis from rods...
  29. pmc Paired-pulse depression at photoreceptor synapses
    Katalin Rabl
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198 5840, USA
    J Neurosci 26:2555-63. 2006
    ..Thus, depression of release is not likely to contribute to differences in the kinetics of transmission from rods and cones...
  30. pmc Vesicle pool size at the salamander cone ribbon synapse
    Theodore M Bartoletti
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, 4050 Durham Research Center, Omaha, NE 68198 5840, USA
    J Neurophysiol 103:419-23. 2010
    ..EPSCs evoked by lengthy depolarization suggest a reserve pool of approximately 90 vesicles per ribbon, similar to the number of additional docking sites further up the ribbon...
  31. pmc A comparison of release kinetics and glutamate receptor properties in shaping rod-cone differences in EPSC kinetics in the salamander retina
    Lucia Cadetti
    Department of Ophthalmology, University of Nebraska Medical Center, Durham Research Center, Omaha, NE 68198 5840, USA
    J Physiol 569:773-88. 2005
    ..Rod-cone differences in the rates of exocytosis are thus a major factor in producing faster cone-driven responses in second-order retinal neurones...
  32. pmc Feedback effects of horizontal cell membrane potential on cone calcium currents studied with simultaneous recordings
    Lucia Cadetti
    Dept of Ophthalmology, Univ of Nebraska Medical Center, Durham Research Center, Omaha, NE 68198 5840, USA
    J Neurophysiol 95:1992-5. 2006
    ..These results support the hypothesis that changes in the HC membrane potential alter the voltage dependence and amplitude of cone ICa by altering extracellular pH levels at the synapse...
  33. pmc Kinetics of exocytosis is faster in cones than in rods
    Katalin Rabl
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198 5840, USA
    J Neurosci 25:4633-40. 2005
    ..The initial rapid release of vesicles from cones can shape the postsynaptic response and may contribute to the faster responses of cone-driven cells observed at light offset...
  34. pmc Calcium regulates vesicle replenishment at the cone ribbon synapse
    Norbert Babai
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Neurosci 30:15866-77. 2010
    ..This in turn provides a mechanism for converting changes in light intensity into changes in sustained release at the cone ribbon synapse...
  35. pmc Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors
    Tamas Szikra
    Department of Ophthalmology, UCSF School of Medicine, San Francisco, CA 94143, USA
    J Physiol 586:4859-75. 2008
    ..Rods were immunopositive for TRPC1 whereas cone inner segments immunostained with TRPC6 channel antibodies. Thus, SOCE modulates Ca(2+) homeostasis and light-evoked neurotransmission at the rod photoreceptor synapse mediated by TRPC1...
  36. ncbi request reprint Direct identification and enrichment of retinal stem cells/progenitors by Hoechst dye efflux assay
    Sumitra Bhattacharya
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska 68198 7691, USA
    Invest Ophthalmol Vis Sci 44:2764-73. 2003
    ....
  37. ncbi request reprint Membrane properties of retinal stem cells/progenitors
    Ani V Das
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198 7691, USA
    Prog Retin Eye Res 24:663-81. 2005
    ..Understanding of membrane properties of retinal stem cells/progenitors is essential for the successful formulation of approaches to treat retinal degeneration and diseases by cell therapy...
  38. ncbi request reprint Retinal properties and potential of the adult mammalian ciliary epithelium stem cells
    Ani V Das
    Department of Ophthalmology, University of Nebraska Medical Center, DRC 4034, 98 5840 Nebraska Medical Center, Omaha, NE 68198 7691, USA
    Vision Res 45:1653-66. 2005
    ..Both proliferative/differential potential and transcription profiles suggest that CE stem cells may be a residual population of stem cells of optic neuroepithelium, representing a stage antecedent to retinal progenitors...
  39. pmc Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse
    A J Mercer
    University of Nebraska Medical Center, Department of Ophthalmology and Visual Sciences, 4050 Durham Research Center, Omaha, NE 68198 5840, USA
    J Neurophysiol 105:321-35. 2011
    ..A diffuse distribution of Cl(Ca) channels may allow Ca(2+) influx at one site to influence relatively distant Ca(2+) channels...
  40. doi request reprint Induced pluripotent stem cells generate both retinal ganglion cells and photoreceptors: therapeutic implications in degenerative changes in glaucoma and age-related macular degeneration
    Sowmya Parameswaran
    Department of Ophthalmology and Visual Sciences, Omaha, Nebraska, USA
    Stem Cells 28:695-703. 2010
    ..The depth of the retinal potential of iPSCs suggests that they may be used to formulate stem cell approaches to understand and treat a wide range of retinal degenerative diseases from glaucoma to age-related macular degeneration (AMD)...
  41. ncbi request reprint Adult corneal limbal epithelium: a model for studying neural potential of non-neural stem cells/progenitors
    Xing Zhao
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha 68198, USA
    Dev Biol 250:317-31. 2002
    ..Our study, therefore, draws attention toward the necessity for rigorous characterization of transdifferentiation and offers a model for characterizing neural potential of heterologous stem cells/progenitors...
  42. pmc Synaptic transmission at retinal ribbon synapses
    Ruth Heidelberger
    Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Prog Retin Eye Res 24:682-720. 2005
    ..We also consider the modulation of exocytosis at photoreceptor synapses, with an emphasis on the regulation of calcium channels...
  43. doi request reprint Derivation of neurons with functional properties from adult limbal epithelium: implications in autologous cell therapy for photoreceptor degeneration
    Xing Zhao
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Stem Cells 26:939-49. 2008
    ..These observations posit the LE as a potential source of neural progenitors for autologous cell therapy to treat photoreceptor degeneration in age-related macular degeneration and retinitis pigmentosa...
  44. pmc Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine
    Stella R Evans
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 279:41792-800. 2004
    ....
  45. pmc Overexpression of eCLCA1 in small airways of horses with recurrent airway obstruction
    Friederike Anton
    Department of Pathology, School of Veterinary Medicine Hannover, Hannover, Germany
    J Histochem Cytochem 53:1011-21. 2005
    ..The results suggest that spontaneous or experimental recurrent airway obstruction in horses may serve as a model to study the role of CLCA homologs in chronic airway disease with overproduction of mucins...