Hide Tsukamoto

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation
    Hidekazu Tsukamoto
    Department of Pathology, Keck School of Medicine of the University of Southern California, California, USA
    J Gastroenterol Hepatol 21:S102-5. 2006
  2. ncbi A rat model reproducing key pathological responses of alcoholic chronic pancreatitis
    Ilya Gukovsky
    UCLA VA Greater Los Angeles Healthcare System, West Los Angeles VA Healthcare Center, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 294:G68-79. 2008
  3. pmc PPAR Gamma and Hepatic Stellate Cells
    Saswati Hazra
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Comp Hepatol 3:S7. 2004
  4. pmc Signaling role of iron in NF-kappa B activation in hepatic macrophages
    Shigang Xiong
    Department of Pathology, Keck School of Medicine, University of Southern California, USA
    Comp Hepatol 3:S36. 2004
  5. pmc Alcohol, TLR4-TGF-β antagonism, and liver cancer
    Hidekazu Tsukamoto
    Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR 402, Los Angeles, CA, USA
    Hepatol Int 8:408-12. 2014
  6. pmc Morphogens and hepatic stellate cell fate regulation in chronic liver disease
    Hidekazu Tsukamoto
    Southern California Research Center for ALPD and Cirrhosis, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    J Gastroenterol Hepatol 27:94-8. 2012
  7. pmc "Second hit" models of alcoholic liver disease
    Hidekazu Tsukamoto
    Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA
    Semin Liver Dis 29:178-87. 2009
  8. doi Fat paradox of steatohepatitis
    Hidekazu Tsukamoto
    USC UCLA Research Center of ALPD and Cirrhosis, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Gastroenterol Hepatol 23:S104-7. 2008
  9. ncbi Fat paradox in liver disease
    Hide Tsukamoto
    Department of Pathology, Keck School of Medicine of the University of Southern California and the Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Keio J Med 54:190-2. 2005
  10. ncbi Adipogenic phenotype of hepatic stellate cells
    Hide Tsukamoto
    Research Center for Alcoholic Liver and Pancreatic Diseases and Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9141, USA
    Alcohol Clin Exp Res 29:132S-133S. 2005

Collaborators

Detail Information

Publications49

  1. ncbi Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation
    Hidekazu Tsukamoto
    Department of Pathology, Keck School of Medicine of the University of Southern California, California, USA
    J Gastroenterol Hepatol 21:S102-5. 2006
    ..They also provide insights into the molecular basis for the use of PPAR-gamma agonists, which has been advocated for treatment of liver fibrosis...
  2. ncbi A rat model reproducing key pathological responses of alcoholic chronic pancreatitis
    Ilya Gukovsky
    UCLA VA Greater Los Angeles Healthcare System, West Los Angeles VA Healthcare Center, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 294:G68-79. 2008
    ..The results indicate that alcohol impairs recovery from acute pancreatitis, suggesting a mechanism by which alcohol sensitizes pancreas to chronic injury...
  3. pmc PPAR Gamma and Hepatic Stellate Cells
    Saswati Hazra
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Comp Hepatol 3:S7. 2004
    ..Expression of PPAR gamma, per se, also inhibits HSC activation. These findings support the role of PPAR gamma in reversion of activated HSC toward their quiescent state...
  4. pmc Signaling role of iron in NF-kappa B activation in hepatic macrophages
    Shigang Xiong
    Department of Pathology, Keck School of Medicine, University of Southern California, USA
    Comp Hepatol 3:S36. 2004
    ..We propose that iron acts as an independent proinflammatory molecule via induction of the intracellular signaling for NF-kappa B activation in HM and primes the liver for chronic inflammation and injury...
  5. pmc Alcohol, TLR4-TGF-β antagonism, and liver cancer
    Hidekazu Tsukamoto
    Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR 402, Los Angeles, CA, USA
    Hepatol Int 8:408-12. 2014
    ..This reciprocal antagonism between TLR4 and TGF-β pathways may serve as a novel therapeutic target for HCC. ..
  6. pmc Morphogens and hepatic stellate cell fate regulation in chronic liver disease
    Hidekazu Tsukamoto
    Southern California Research Center for ALPD and Cirrhosis, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    J Gastroenterol Hepatol 27:94-8. 2012
    ..Implications of HSC-derived morphogens in these possibilities are discussed...
  7. pmc "Second hit" models of alcoholic liver disease
    Hidekazu Tsukamoto
    Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA
    Semin Liver Dis 29:178-87. 2009
    ..Additionally, animal models of comorbidities are urgently needed particularly for synergistic liver disease and oncogenesis caused by alcohol, obesity, and hepatitis virus...
  8. doi Fat paradox of steatohepatitis
    Hidekazu Tsukamoto
    USC UCLA Research Center of ALPD and Cirrhosis, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Gastroenterol Hepatol 23:S104-7. 2008
    ..Our recent work suggests that defective insulin signaling in activated HSC may be responsible for this paradox. Further, activated Wnt signaling is implicated in 'anti-adipogenic' stellate cell transdifferentiation in liver fibrogenesis...
  9. ncbi Fat paradox in liver disease
    Hide Tsukamoto
    Department of Pathology, Keck School of Medicine of the University of Southern California and the Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Keio J Med 54:190-2. 2005
    ..It further suggests, activated HSC in steatotic livers may have defective insulin signaling or lipogenic regulation...
  10. ncbi Adipogenic phenotype of hepatic stellate cells
    Hide Tsukamoto
    Research Center for Alcoholic Liver and Pancreatic Diseases and Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9141, USA
    Alcohol Clin Exp Res 29:132S-133S. 2005
    ..These findings establish a new conceptual framework for the treatment of liver fibrosis and propose an intriguing notion concerning the plasticity of HSC...
  11. ncbi Adipogenic transcriptional regulation of hepatic stellate cells
    Hongyun She
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 280:4959-67. 2005
    ..These results support the importance of adipogenic transcriptional regulation in HSC quiescence and provide a new framework for identifying novel molecular targets for the treatment of liver cirrhosis...
  12. pmc Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis
    Shigang Xiong
    Department of Pathology, Keck School of Medicine, University of Southern California, 1333 San Pablo St, MMR 402, Los Angeles, CA 90033 9141, USA
    Am J Physiol Gastrointest Liver Physiol 295:G512-21. 2008
    ..Our results suggest enhanced iron uptake as a mechanism of KC iron loading in ALD and demonstrate the ILI response as a function acquired by differentiated macrophages in humans and as a priming mechanism for ALD...
  13. ncbi Iron activates NF-kappaB in Kupffer cells
    Hongyun She
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033 9141, USA
    Am J Physiol Gastrointest Liver Physiol 283:G719-26. 2002
    ..We propose that this finding offers a molecular basis for iron-mediated accentuation of TNF-alpha-dependent liver injury...
  14. doi Intragastric ethanol infusion model in rodents
    Hide Tsukamoto
    Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 447:33-48. 2008
    ..The model is best used by alcohol researchers through a center-supported core facility and its tissue sharing program...
  15. ncbi Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells
    Chin K Sung
    Dept of Pathology, Keck School of Medicine of the Univ of Southern California, 1333 San Pablo St, MMR 412, Los Angeles, CA 90089 9141, USA
    Am J Physiol Gastrointest Liver Physiol 286:G722-9. 2004
    ....
  16. ncbi Signaling role of intracellular iron in NF-kappaB activation
    Shigang Xiong
    Department of Pathology and Molecular Microbiology and Immunology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 278:17646-54. 2003
    ..These results support a novel signaling role for [LMW.Fe](i) in IKK activation, which appears to be induced by ONOO(-) and selectively operative in macrophages...
  17. pmc Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression
    Shuping Zhong
    Department of Biochemistry and Molecular Biology and the Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 286:2393-401. 2011
    ..Together, these results identify a new class of genes that are regulated by alcohol through the co-regulation of TFIIIB components and define a central role for c-Jun in this process...
  18. ncbi Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption
    Masahiro Minagawa
    Department of Molecular Microbiology, Norris Comprehensive Cancer Center, University of Southern California Los Angeles, 1441 Eastlake Avenue, M S 73, Los Angeles, CA 90033 0800, USA
    Gastroenterology 126:1387-99. 2004
    ..This report analyzes the role of natural killer T cells, Fas, and TNF-alpha in a model of chronic alcohol consumption...
  19. ncbi Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine
    Nary Veal
    Keck School of Medicine of the Univ of Southern California, 1333 San Pablo St, MMR 402, Los Angeles, CA 90033, USA
    Am J Physiol Gastrointest Liver Physiol 287:G352-62. 2004
    ..Furthermore, our study is the first to demonstrate a potent inhibitory effect on NF-kappaB promoter activity and TNF-alpha expression by a SAM's metabolite, MTA...
  20. pmc Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1
    Samantha M Yeligar
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 183:5964-76. 2009
    ..The identification of HIF-1alpha and AP-1 in ethanol-induced RANTES expression provides new strategies to ameliorate ethanol-induced inflammatory responses...
  21. ncbi Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease
    Shigang Xiong
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Alcohol 30:107-13. 2003
    ....
  22. pmc Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease
    Simon W Beaven
    Howard Hughes Medical Institute, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Gastroenterology 140:1052-62. 2011
    ..We investigated the role of LXR signaling stellate cell activation and susceptibility to fibrotic liver disease...
  23. pmc Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen
    Yuan Ping Han
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 279:4820-8. 2004
    ..Thus, this study provides a novel model to enlighten the role of MMPs, particularly that of MMP-9, in HSC activation regulated by a specific cytokine in liver fibrogenesis...
  24. pmc c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair
    Keigo Machida
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Hepatology 52:480-92. 2010
    ..The core protein also suppresses apoptosis mediated by Fas ligand because of c-Jun-dependent Fas down-regulation...
  25. pmc Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation
    Komal Ramani
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, HMR Bldg, 413, Department of Medicine, Keck School of Medicine USC, 2011 Zonal Ave, Los Angeles, CA 90033, USA
    Hepatology 51:986-95. 2010
    ..MAT2A knockdown decreased intracellular SAMe levels in LX-2 cells. Activation of extracellular signal-regulated kinase and phosphatidylinositol-3-kinase signaling in LX-2 cells required the expression of MAT2beta but not that of MAT2A...
  26. pmc Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development
    Kinji Asahina
    Department of Pathology, Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033 9141, USA
    Hepatology 49:998-1011. 2009
    ..Finally, we demonstrated that fetal HSCs, submesothelial cells, and perivascular mesenchymal cells are all derived from mesoderm by using MesP1-Cre and ROSA26 reporter mice...
  27. pmc Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver
    Kinji Asahina
    Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA
    Hepatology 53:983-95. 2011
    ..On the other hand, the Wt1(+) STM and MC/SubMCs do not contribute to sinusoidal endothelial cells, Kupffer cells, and hepatoblasts...
  28. ncbi Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis
    Jason H Cheng
    Department of Pathology, Keck School of Medicine of the Univ of Southern California, Los Angeles, CA 90033 9141, USA
    Am J Physiol Gastrointest Liver Physiol 294:G39-49. 2008
    ..These results demonstrate antiadipogenic Wnt signaling in HSC activation and therapeutic potential of Wnt antagonism for liver fibrosis...
  29. ncbi Role of abnormal methionine metabolism in alcoholic liver injury
    Shelly C Lu
    USC Liver Disease Research Center, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Alcohol 27:155-62. 2002
    ..These changes can lead to impaired antioxidant defense, altered gene expression, promotion of fibrogenesis, and even hepatocarcinogenesis...
  30. pmc A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix
    Yuan Ping Han
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 4680, USA
    J Biol Chem 282:12928-39. 2007
    ....
  31. ncbi Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages
    Li Chen
    Department of Pathology and Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 9141, USA
    J Biol Chem 282:5582-8. 2007
    ..In conclusion, MEK1, TAK1, NF-kappa-inducing kinase, and PI3K are required for iron-induced IKK activation in hepatic macrophages and TAK1, PI3K, and p21ras physically interact in caveolae to initiate signal transduction...
  32. ncbi A pilot study of an alcoholic liver disease recurrence prevention education program in hospitalized patients with advanced liver disease
    Steve Sussman
    Preventive Medicine and IPR, University of Southern California, 1000 South Fremont Avenue, Unit 8, Building A 4, Alhambra, CA 91803, USA
    Addict Behav 30:465-73. 2005
    ..For those ALD inpatients that are able and willing to participate, the program shows promising effects on self-reported lifestyle change...
  33. ncbi Steatohepatitis induced by intragastric overfeeding in mice
    Qing Gao Deng
    Research Center for Alcoholic Liver and Pancreatic Diseases and Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Hepatology 42:905-14. 2005
    ..TNF type I receptor deficiency did not prevent obesity and SH. In conclusion, forced overfeeding with a high-fat diet in mice induces obesity, insulin resistance, and SH in the absence of TNF signaling or Cyp2e1 induction...
  34. ncbi Iron regulation of hepatic macrophage TNFalpha expression
    Hidekazu Tsukamoto
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases and USC Research Center for Liver Diseases, Keck School of Medicine of University of Southern California, Los Angeles, CA 90089, USA
    Free Radic Biol Med 32:309-13. 2002
    ..Recent evidence also suggests a role of intracellular low molecular weight iron in the early signal transduction for LPS-mediated NF-kappaB activation...
  35. ncbi Redox regulation of cytokine expression in Kupffer cells
    Hidekazu Tsukamoto
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, CA 90033, USA
    Antioxid Redox Signal 4:741-8. 2002
    ..This article reviews the literature on redox regulation of cytokine gene expression by Kupffer cells...
  36. ncbi Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells
    Saswati Hazra
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 279:11392-401. 2004
    ..In summary, our results demonstrate that the restoration of PPARgamma reverses the activated HSC to the quiescent phenotype and suppresses AP-1 activity via a physical interaction between PPARgamma and JunD...
  37. pmc Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog
    Keigo Machida
    Southern California Research Center for Alcoholic, Liver, and Pancreatic Diseases and Cirrhosis, and Department of Molecular Microbiology, University of Southern California, Keck School of Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:1548-53. 2009
    ..Taken together, our study demonstrates a TLR4-dependent mechanism of synergistic liver disease by HCV and alcohol and an obligatory role for Nanog, a TLR4 downstream gene, in HCV-induced liver oncogenesis enhanced by alcohol...
  38. ncbi IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells
    Philippe Mathurin
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles 90089, USA
    Am J Physiol Gastrointest Liver Physiol 282:G981-90. 2002
    ..This shows concomitant induction of IL-10R but not CRF2-4 to that of IL-10 by activated HSC in vitro and in vivo and associated acquisition of the responsiveness to IL-10, entailing complex effects on HSC...
  39. pmc The Necdin-Wnt pathway causes epigenetic peroxisome proliferator-activated receptor gamma repression in hepatic stellate cells
    Nian Ling Zhu
    Department of Pathology, Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 285:30463-71. 2010
    ..Our results demonstrate a novel necdin-Wnt pathway, which serves to mediate antiadipogenic HSC trans-differentiation via epigenetic repression of PPARγ...
  40. ncbi Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells
    Sharon Yavrom
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 9141, USA
    J Biol Chem 280:40650-9. 2005
    ..The former effect is mediated by the ability of PPARgamma to inhibit p300-facilitated NF-I binding to DNA as demonstrated by chromatin immunoprecipitation assay...
  41. pmc Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199
    Samantha Yeligar
    Department of Biochemistry and Molecular Biology, The Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 183:5232-43. 2009
    ....
  42. ncbi Alcoholic liver disease (ALD): a new domain for prevention efforts
    Steve Sussman
    Institute for Health Promotion and Disease Prevention Research, University of Southern California, Alhambra, California 91803, USA
    Subst Use Misuse 37:1887-904. 2002
    ..It is hoped that new interest among health behavior researchers and practitioners will be stimulated...
  43. ncbi Action plan for enhancing global collaboration on alcoholic liver and pancreatic diseases: white paper
    Steve J Pandol
    Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    J Gastroenterol Hepatol 21:S109-10. 2006
  44. pmc S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model
    Shelly C Lu
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Los Angeles, CA 90033, USA
    Hepatology 50:462-71. 2009
    ..SAMe treatment of H4IIE cells altered the expression of several genes with the net effect of inhibiting angiogenesis. These changes were confirmed at the protein level and functionally in human umbilical vein endothelial cells...
  45. ncbi Demographic characteristics of hospitalized patients with alcoholic liver disease and pancreatitis in los angeles county
    Nico Tao
    Department of Pathology, University of Southern California University of California Los Angeles Research Center for Alcoholic Liver and Pancreatic Diseases, 90033, USA
    Alcohol Clin Exp Res 27:1798-804. 2003
    ..Another specific aim of the study was to characterize demographic and comorbid differences between patients with ALD and patients with pancreatitis, another alcohol-related disease...
  46. ncbi Conceptual importance of identifying alcoholic liver disease as a lifestyle disease
    Hidekazu Tsukamoto
    Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR 402, Los Angeles, CA 90033 9141, USA
    J Gastroenterol 42:603-9. 2007
    ..Molecular characterization of the interfaces of these interactions is essential for revelation or acquisition of new pathogenetic, preventive, and therapeutic insights...
  47. pmc Expression of carboxylesterase and lipase genes in rat liver cell-types
    Tommaso Mello
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Biochem Biophys Res Commun 374:460-4. 2008
    ....
  48. ncbi Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes
    An Sheng Zhang
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, OR 97239, USA
    Blood 103:1509-14. 2004
    ..Western blot analysis confirmed this finding. Unexpectedly, HSCs also had high levels of DMT1 and ferroportin, implicating them in either iron sensing or iron cycling...
  49. ncbi Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001
    Manuela G Neuman
    Division of Clinical Pharmacology, Sunnybrook and Women s College Health Sciences Centre, Room E235, 2075 Bayview Ave, Ontario, M4N 3M5, Toronto, Canada
    Alcohol 28:117-28. 2002