Judith Woodfolk

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Trichophyton antigens associated with IgE antibodies and delayed type hypersensitivity. Sequence homology to two families of serine proteinases
    J A Woodfolk
    Department of Internal Medicine, Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 273:29489-96. 1998
  2. ncbi request reprint T-cell responses to allergens
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 119:280-94; quiz 295-6. 2007
  3. ncbi request reprint Cytokines as a therapeutic target for allergic diseases: a complex picture
    J A Woodfolk
    Asthma and Allergic Diseases Center, PO Box 801355, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Curr Pharm Des 12:2349-63. 2006
  4. ncbi request reprint Selective roles and dysregulation of interleukin-10 in allergic disease
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville 22908 1355, USA
    Curr Allergy Asthma Rep 6:40-6. 2006
  5. ncbi request reprint Epitope-specific T-cell responses and allergic phenotypes: implications for T-cell peptide therapy
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, University of Virginia Health System, PO Box 801355, Charlottesville, VA 22908 1355 USA
    Expert Rev Clin Immunol 2:309-18. 2006
  6. ncbi request reprint A new paradigm for immunoglobulin E in allergic diseases
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville 22908 1355, USA
    Curr Allergy Asthma Rep 5:227-32. 2005
  7. ncbi request reprint High-dose allergen exposure leads to tolerance
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, USA
    Clin Rev Allergy Immunol 28:43-58. 2005
  8. pmc Allergy and dermatophytes
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, P O Box 801355, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Clin Microbiol Rev 18:30-43. 2005
  9. ncbi request reprint Distinct human T cell repertoires mediate immediate and delayed-type hypersensitivity to the Trichophyton antigen, Tri r 2
    J A Woodfolk
    Asthma and Allergic Diseases Center, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 165:4379-87. 2000
  10. ncbi request reprint Diversity of the human allergen-specific T cell repertoire associated with distinct skin test reactions: delayed-type hypersensitivity-associated major epitopes induce Th1- and Th2-dominated responses
    J A Woodfolk
    Asthma and Allergic Diseases Center, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 167:5412-9. 2001

Research Grants

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Trichophyton antigens associated with IgE antibodies and delayed type hypersensitivity. Sequence homology to two families of serine proteinases
    J A Woodfolk
    Department of Internal Medicine, Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 273:29489-96. 1998
    ..Our results define two distinct antigens derived from the dermatophyte Trichophyton that serve as targets for diverse immune responses in humans...
  2. ncbi request reprint T-cell responses to allergens
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 119:280-94; quiz 295-6. 2007
    ..Experimental techniques and approaches for analyzing allergen-specific T cells and identifying novel T-cell epitopes are described that may lead to new T-cell-based therapies...
  3. ncbi request reprint Cytokines as a therapeutic target for allergic diseases: a complex picture
    J A Woodfolk
    Asthma and Allergic Diseases Center, PO Box 801355, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Curr Pharm Des 12:2349-63. 2006
    ..Taken together, existing data suggest that a multi-faceted approach, which is tailored to each patient, will be required in order to attain clinical benefit...
  4. ncbi request reprint Selective roles and dysregulation of interleukin-10 in allergic disease
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville 22908 1355, USA
    Curr Allergy Asthma Rep 6:40-6. 2006
    ..Knowledge of the targeted patient population and design of an immunogen (ie, peptide or modified allergen) within this context are likely to provide improved results over conventional immunotherapy...
  5. ncbi request reprint Epitope-specific T-cell responses and allergic phenotypes: implications for T-cell peptide therapy
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, University of Virginia Health System, PO Box 801355, Charlottesville, VA 22908 1355 USA
    Expert Rev Clin Immunol 2:309-18. 2006
    ..Further investigation of allergen-derived T-cell epitopes is warranted in order to optimize the design of peptide vaccines for the treatment of allergic disease...
  6. ncbi request reprint A new paradigm for immunoglobulin E in allergic diseases
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville 22908 1355, USA
    Curr Allergy Asthma Rep 5:227-32. 2005
    ..This may be important for advancing our understanding of the response to immunotherapy and anti-IgE, and for defining immune mechanisms that drive allergic responses...
  7. ncbi request reprint High-dose allergen exposure leads to tolerance
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, USA
    Clin Rev Allergy Immunol 28:43-58. 2005
    ..Identification of Fel d 1 epitopes that induce interleukin-10 may provide new targets for treatment...
  8. pmc Allergy and dermatophytes
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, P O Box 801355, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Clin Microbiol Rev 18:30-43. 2005
    ..Characterization of additional molecular targets by using new techniques may aid not only in the eradication of infection but also in the resolution of allergic symptoms...
  9. ncbi request reprint Distinct human T cell repertoires mediate immediate and delayed-type hypersensitivity to the Trichophyton antigen, Tri r 2
    J A Woodfolk
    Asthma and Allergic Diseases Center, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 165:4379-87. 2000
    ..We conclude that different immune responses to Trichophyton are mediated by distinct T cell repertoires between individuals with IH and DTH reactions to Tri r 2...
  10. ncbi request reprint Diversity of the human allergen-specific T cell repertoire associated with distinct skin test reactions: delayed-type hypersensitivity-associated major epitopes induce Th1- and Th2-dominated responses
    J A Woodfolk
    Asthma and Allergic Diseases Center, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 167:5412-9. 2001
    ..We conclude that T cell repertoires associated with distinct immune responses to Tri r 2 can be distinguished based on Th2 cytokine induction by DTH-associated major epitopes localizing to the amino-terminal region of the molecule...
  11. ncbi request reprint T cell epitope-specific defects in the immune response to cat allergen in patients with atopic dermatitis
    Raquel Carneiro
    Asthma and Allergic Diseases Center, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908 1355, USA
    J Invest Dermatol 122:927-36. 2004
    ..Control of IFN-gamma production to chain 2 epitopes by IL-10 may be relevant to sensitization status. Development of high titer IgE ab in AD could reflect a failure of this mechanism...
  12. ncbi request reprint Quantitative measurement of airborne allergens from dust mites, dogs, and cats using an ion-charging device
    N J Custis
    Asthma and Allergic Diseases Center, University of Virginia, VA, USA
    Clin Exp Allergy 33:986-91. 2003
    ..Increasing evidence suggests that children raised with an animal(s) in the house have a decreased risk of becoming sensitized. However, it is not clear whether this phenomenon is related to airborne exposure...
  13. ncbi request reprint Asthma and indoor air: contrasts in the dose response to cat and dust-mite
    E A Erwin
    University of Virginia, Asthma and Allergic Diseases Center, Charlottesville, VA 22908 1355, USA
    Indoor Air 15:33-9. 2005
    ..Equally the results may give insight into a form of tolerance that could be a target for protecting patients against allergic disease...
  14. ncbi request reprint Cat and dust mite sensitivity and tolerance in relation to wheezing among children raised with high exposure to both allergens
    Elizabeth A Erwin
    University of Virginia Asthma and Allergic Diseases Center, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 115:74-9. 2005
    ..Recent evidence has suggested that high exposure to cat allergens is associated with decreased prevalence of sensitization to cat and, in some studies, decreased asthma...
  15. ncbi request reprint Targeting Fel d 1 to FcgammaRI induces a novel variation of the T(H)2 response in subjects with cat allergy
    Kathryn E Hulse
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 121:756-762.e4. 2008
    ..Induction of CD4+ T cells that produce IL-10 or IFN-gamma is central to the protective effects of conventional allergen immunotherapy...
  16. ncbi request reprint Prevalence and titer of IgE antibodies to mouse allergens
    Thomas A E Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 120:1058-64. 2007
    ..Positive skin tests to allergens derived from mouse urine have been reported among patients with asthma. Very few data are available detailing the titer of IgE Ab to mouse allergen and how it varies by location and population...
  17. doi request reprint Analysis of CD25hiCD4+ "regulatory" T-cell subtypes in atopic dermatitis reveals a novel T(H)2-like population
    Amanda J Reefer
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 121:415-422.e3. 2008
    ..It is unresolved whether circulating CD25hiCD4+ T cells in patients with atopic dermatitis who have elevated IgE (IgE(high)) are regulatory or effector in nature...
  18. ncbi request reprint The immune response to intrinsic and extrinsic allergens: determinants of allergic disease
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville 22908 1355, USA
    Int Arch Allergy Immunol 129:277-85. 2002
    ..The relevance of Th1/Th2 and regulatory cytokines to development of new allergen-specific therapies is also discussed...
  19. ncbi request reprint Environmental factors influencing allergy and asthma
    Thomas A E Platts-Mills
    Asthma and Allergic Disease Center, University of Virginia, Charlottesville, VA 22908, USA
    Chem Immunol Allergy 91:3-15. 2006
    ..Although there have been many changes in our environment, none of these alone explains the consistency or the scale of the rise in asthma over the 40 years between 1960 and 2000...
  20. pmc Markers for host-induced gene expression in Trichophyton dermatophytosis
    Gil Kaufman
    Faculty of Medicine, Technion Israel Institute of Technology, Haifa
    Infect Immun 73:6584-90. 2005
    ..Upregulation of several newly identified T. mentagrophytes genes on protein substrates suggests that these genes encode proteins which are relevant to the dermatophyte-skin interaction...
  21. ncbi request reprint Airborne endotoxin in homes with domestic animals: implications for cat-specific tolerance
    James A Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, VA, USA
    J Allergy Clin Immunol 116:384-9. 2005
    ..Similarly, the presence of an animal in the home has been associated with decreased sensitization to animal allergens. It has been suggested that the effect of animals could be explained by increased endotoxin exposure...
  22. ncbi request reprint Animal danders
    Elizabeth A Erwin
    Asthma and Allergic Diseases Center, University of Virginia, PO Box 801355, Charlottesville, VA 22908, USA
    Immunol Allergy Clin North Am 23:469-81. 2003
    ..The most probable explanations are related to the form and quantity of airborne allergens...
  23. ncbi request reprint A role for IL-10-mediated HLA-DR7-restricted T cell-dependent events in development of the modified Th2 response to cat allergen
    Amanda J Reefer
    Asthma and Allergic Diseases Center, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 172:2763-72. 2004
    ..We conclude that IL-10-producing T cells specific for chain 2 epitopes are relevant to tolerance induction, and that DR7-restricted recognition of these epitopes favors a modified Th2 response...
  24. ncbi request reprint Specific IgE and IgG antibody-binding patterns to recombinant cockroach allergens
    Shama M Satinover
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 115:803-9. 2005
    ..The specificity of serum antibody responses to different cockroach allergens has not been studied...
  25. ncbi request reprint Mechanisms of tolerance to inhalant allergens: the relevance of a modified Th2 response to allergens from domestic animals
    Thomas A E Platts-Mills
    Asthma and Allergic Disease Center, University of Virginia, University Health Systems, Charlottesville 22908 1355, USA
    Springer Semin Immunopathol 25:271-9. 2004
    ..Dust mite and cockroach differ from cat (and rat) allergens not only in the quantity inhaled and the particles' sizes but also in the biochemistry of the molecule...
  26. ncbi request reprint Quantitative measurement of IgE antibodies to purified allergens using streptavidin linked to a high-capacity solid phase
    Elizabeth A Erwin
    University of Virginia Astma and Allergic Diseases Center, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 115:1029-35. 2005
    ..Commercially available assays for IgE antibody provide results in international units per milliliter for many allergen extracts, but this is not easily achieved with purified or novel allergens...
  27. ncbi request reprint Bla g 6: a troponin C allergen from Blattella germanica with IgE binding calcium dependence
    James Hindley
    School of Biosciences, Cardiff University, VA 22903, USA
    J Allergy Clin Immunol 117:1389-95. 2006
    ..The known cockroach allergens do not appear to account for the full repertoire of IgE responses...
  28. ncbi request reprint The relevance of microbial allergens to the IgE antibody repertoire in atopic and nonatopic eczema
    Amanda J Reefer
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 120:156-63. 2007
    ..However, the relationship between antimicrobial IgE antibodies and nonatopic disease is unclear...

Research Grants6

  1. Immune Respone to Cat: Regulatory and Effector T Cells
    Judith Woodfolk; Fiscal Year: 2004
    ..Defining cellular mechanisms which govern tolerance to cat is fundamental to understanding the factors that control the prevalence and severity of asthma and to the rational design of new therapies. ..
  2. Immune Respone to Cat: Regulatory and Effector T Cells
    Judith Woodfolk; Fiscal Year: 2005
    ..Defining cellular mechanisms which govern tolerance to cat is fundamental to understanding the factors that control the prevalence and severity of asthma and to the rational design of new therapies. ..
  3. Immune Respone to Cat: Regulatory and Effector T Cells
    Judith Woodfolk; Fiscal Year: 2006
    ..Defining cellular mechanisms which govern tolerance to cat is fundamental to understanding the factors that control the prevalence and severity of asthma and to the rational design of new therapies. ..
  4. Immune Respone to Cat: Regulatory and Effector T Cells
    Judith Woodfolk; Fiscal Year: 2007
    ..Defining cellular mechanisms which govern tolerance to cat is fundamental to understanding the factors that control the prevalence and severity of asthma and to the rational design of new therapies. ..
  5. Immune Response to Cat: Regulatory and Effector T Cells
    Judith Woodfolk; Fiscal Year: 2009
    ..The proposed studies, which investigate how Tregs function in AD skin, are highly relevant to the development of T cell-based treatments for this debilitating disease. ..
  6. Immune Response to Cat: Regulatory and Effector T Cells
    Judith A Woodfolk; Fiscal Year: 2010
    ..The proposed studies, which investigate how Tregs function in AD skin, are highly relevant to the development of T cell-based treatments for this debilitating disease. ..