Douglas Wright

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. pmc Peripheral nervous system insulin resistance in ob/ob mice
    Caleb W Grote
    Department of Anatomy and Cell Biology, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Acta Neuropathol Commun 1:15. 2013
  2. pmc Phenotypic changes in diabetic neuropathy induced by a high-fat diet in diabetic C57BL/6 mice
    B L Guilford
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Exp Diabetes Res 2011:848307. 2011
  3. pmc Insulin receptor substrate 2 expression and involvement in neuronal insulin resistance in diabetic neuropathy
    C W Grote
    Department of Anatomy and Cell Biology, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Exp Diabetes Res 2011:212571. 2011
  4. ncbi request reprint Muscle-derived neurotrophin-3 reduces injury-induced proprioceptive degeneration in neonatal mice
    D E Wright
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurobiol 50:198-208. 2002
  5. ncbi request reprint Selective changes in nocifensive behavior despite normal cutaneous axon innervation in leptin receptor-null mutant (db/db) mice
    Douglas E Wright
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA
    J Peripher Nerv Syst 12:250-61. 2007
  6. ncbi request reprint Diabetes-induced expression of activating transcription factor 3 in mouse primary sensory neurons
    Douglas E Wright
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Peripher Nerv Syst 9:242-54. 2004
  7. ncbi request reprint Overexpression of neurotrophin-3 in skeletal muscle alters normal and injury-induced limb control
    M D Taylor
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160, USA
    Somatosens Mot Res 18:286-94. 2001
  8. ncbi request reprint Postnatal regulation of limb proprioception by muscle-derived neurotrophin-3
    M D Taylor
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Comp Neurol 432:244-58. 2001
  9. ncbi request reprint Glial cell line-derived neurotrophic factor-responsive and neurotrophin-3-responsive neurons require the cytoskeletal linker protein dystonin for postnatal survival
    J A Carlsten
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Comp Neurol 432:155-68. 2001
  10. ncbi request reprint Beneficial actions of neurotrophin treatment on diabetes-induced hypoalgesia in mice
    Julie A Christianson
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Pain 4:493-504. 2003

Research Grants

  1. NEUROTROPHIN 3 IN NEURONAL INJURY AND DISEASE
    Douglas Wright; Fiscal Year: 2002

Collaborators

  • Julie A Christianson
  • Ardem Patapoutian
  • Amy J Wagers
  • Eva Feldman
  • Eric Frank
  • Janelle M Ryals
  • Michael D Taylor
  • Caleb W Grote
  • M D Taylor
  • C W Grote
  • J M Ryals
  • B L Guilford
  • Karra A Muller
  • Melinda G Arnett
  • Zhi Wang
  • Megan S Johnson
  • Aziz Moqrich
  • Rohan Gandhi
  • Wenbin Tan
  • Francis J Sun
  • Derek C Molliver
  • Paige C Geiger
  • Anna L Groover
  • J M Williams
  • J A Carlsten
  • R Vancura
  • J T Riekhof
  • J K Morris
  • P C Geiger
  • Ling Ying Li
  • Simeon G Weltmer
  • Angela S Holdeman
  • Carey Backus
  • James Watson
  • Louis F Reichardt
  • Mary Andahazy
  • Dionisio Martin-Zanca
  • Taryn J Earley
  • Kristin M Barkus
  • Rick T Dobrowsky
  • Shefali Rouen
  • Dongwei Hui
  • Sung Ok Yoon
  • Yelena S Dremina
  • David M Pinson
  • Edwin W McCleskey
  • Julie A Carlsten
  • Sean P Cook
  • R Kothary
  • B K Taylor
  • C L Patterson

Detail Information

Publications22

  1. pmc Peripheral nervous system insulin resistance in ob/ob mice
    Caleb W Grote
    Department of Anatomy and Cell Biology, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Acta Neuropathol Commun 1:15. 2013
    ....
  2. pmc Phenotypic changes in diabetic neuropathy induced by a high-fat diet in diabetic C57BL/6 mice
    B L Guilford
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Exp Diabetes Res 2011:848307. 2011
    ..These results provide new insight as to how dyslipidemia may alter the development and phenotype of diabetic neuropathy...
  3. pmc Insulin receptor substrate 2 expression and involvement in neuronal insulin resistance in diabetic neuropathy
    C W Grote
    Department of Anatomy and Cell Biology, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Exp Diabetes Res 2011:212571. 2011
    ....
  4. ncbi request reprint Muscle-derived neurotrophin-3 reduces injury-induced proprioceptive degeneration in neonatal mice
    D E Wright
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurobiol 50:198-208. 2002
    ..Our results demonstrate that in addition to its early actions on sensory neuron generation and naturally occurring cell death, NT-3 has important neuroprotective effects on muscle afferents during postnatal development...
  5. ncbi request reprint Selective changes in nocifensive behavior despite normal cutaneous axon innervation in leptin receptor-null mutant (db/db) mice
    Douglas E Wright
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA
    J Peripher Nerv Syst 12:250-61. 2007
    ....
  6. ncbi request reprint Diabetes-induced expression of activating transcription factor 3 in mouse primary sensory neurons
    Douglas E Wright
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Peripher Nerv Syst 9:242-54. 2004
    ..Finally, the ability to detect sensory deficits in diabetic mice occurs after the expression of injury-related gene ATF3, suggesting that nerve damage may be underway prior to the appearance of behavioral deficits...
  7. ncbi request reprint Overexpression of neurotrophin-3 in skeletal muscle alters normal and injury-induced limb control
    M D Taylor
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160, USA
    Somatosens Mot Res 18:286-94. 2001
    ....
  8. ncbi request reprint Postnatal regulation of limb proprioception by muscle-derived neurotrophin-3
    M D Taylor
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Comp Neurol 432:244-58. 2001
    ..However, our results also show that NT-3 may be therapeutic for proprioceptive axons immediately after nerve injury by delaying axon degeneration...
  9. ncbi request reprint Glial cell line-derived neurotrophic factor-responsive and neurotrophin-3-responsive neurons require the cytoskeletal linker protein dystonin for postnatal survival
    J A Carlsten
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Comp Neurol 432:155-68. 2001
    ..Moreover, we show that dystonin is critical for the maintenance of certain DRG neurons, and its function may be related to neurotrophic support...
  10. ncbi request reprint Beneficial actions of neurotrophin treatment on diabetes-induced hypoalgesia in mice
    Julie A Christianson
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Pain 4:493-504. 2003
    ..Furthermore, these studies show that dorsal root ganglion neurons in diabetic mice are responsive to treatment with either NGF or GDNF; however, these 2 neurotrophins differ in their ability to affect distinct somatosensations...
  11. doi request reprint Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic mice
    Karra A Muller
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Diabetes 57:1693-701. 2008
    ..In addition, diabetic mice were treated with insulin to assess whether sensorimotor and spindle deficits were reversible...
  12. ncbi request reprint Restorative effects of neurotrophin treatment on diabetes-induced cutaneous axon loss in mice
    Julie A Christianson
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160, USA
    Exp Neurol 179:188-99. 2003
    ..Importantly, intrathecal treatment using GDNF or NTN strongly stimulated axon growth and branching, suggesting that administration of these trophic factors can improve cutaneous innervation deficits caused by diabetes...
  13. ncbi request reprint Neurotrophin-3 reverses chronic mechanical hyperalgesia induced by intramuscular acid injection
    Rohan Gandhi
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurosci 24:9405-13. 2004
    ..The attenuation of hyperalgesia suggests that NT-3 may be a modulator of muscle-derived pain, and NT-3 may suppress events that lead to secondary hyperalgesia triggered by insult to muscle afferents...
  14. pmc Prenatal exposure to elevated NT3 disrupts synaptic selectivity in the spinal cord
    Zhi Wang
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Neurosci 27:3686-94. 2007
    ..These results indicate that prenatal exposure to elevated levels of NT3 disrupts the normal mechanisms responsible for synaptic selectivity in the stretch reflex circuit...
  15. ncbi request reprint Modulation of muscle spindle innervation by neurotrophin-3 following nerve injury
    Michael D Taylor
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Exp Neurol 191:211-22. 2005
    ..Finally, exposure of muscle afferent fibers to NT-3 prior to injury alters axonal responses both in vitro and in vivo...
  16. pmc Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate
    Aziz Moqrich
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Neurosci 7:812-8. 2004
    ..The surviving presumptive TrkA-expressing neurons adopted a proprioceptive phenotype, indicating that neurotrophin signaling can specify sensory neuron subtypes...
  17. ncbi request reprint Nerve growth factor blocks the glucose-induced down-regulation of caveolin-1 expression in Schwann cells via p75 neurotrophin receptor signaling
    Wenbin Tan
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045, USA
    J Biol Chem 278:23151-62. 2003
    ....
  18. pmc Pro-NGF, sortilin, and p75NTR: potential mediators of injury-induced apoptosis in the mouse dorsal root ganglion
    Melinda G Arnett
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Brain Res 1183:32-42. 2007
    ..These results propose pro-NGF-induced, p75NTR-sortilin-mediated neuronal death as a critical aspect of nerve injury-induced death in the DRG...
  19. ncbi request reprint Comparison of ketamine versus combination of ketamine and medetomidine in injectable anesthetic protocols: chemical immobilization in macaques and tissue reaction in rats
    Francis J Sun
    Department of Laboratory Animal Resources, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Contemp Top Lab Anim Sci 42:32-7. 2003
    ..Histological evaluation of tissue inflammation and muscle necrosis in rats indicated that the lower dose of ketamine afforded by combination with medetomidine caused markedly less damage to muscle tissue at injection sites...
  20. ncbi request reprint ATP and UTP excite sensory neurons and induce CREB phosphorylation through the metabotropic receptor, P2Y2
    Derek C Molliver
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    Eur J Neurosci 16:1850-60. 2002
    ..These findings suggest that P2Y2 contributes to the transduction of ATP-mediated sensory signalling, and may be involved in the activity-dependent regulation of nociceptor phenotype...
  21. pmc Hematopoietic stem cells are uniquely selective in their migratory response to chemokines
    Douglas E Wright
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 195:1145-54. 2002
    ..The sharply restricted chemotactic responsiveness of HSC is unique among leukocytes and may be necessary for the specific homing of circulating HSC to bone marrow, as well as for the maintenance of HSC in hematopoietic microenvironments...
  22. pmc Diabetes-induced chemogenic hypoalgesia is paralleled by attenuated stimulus-induced fos expression in the spinal cord of diabetic mice
    Megan S Johnson
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Pain 8:637-49. 2007
    ..This murine model may be better suited to understanding the insensate symptoms of diabetic patients in the absence of chronic pain...

Research Grants1

  1. NEUROTROPHIN 3 IN NEURONAL INJURY AND DISEASE
    Douglas Wright; Fiscal Year: 2002
    ..Results from these studies will define new biological actions of NT-3 and reveal how manipulation of the trophic support of neurons may be useful to treat pathologic neural conditions. ..