Qian Zhang

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cells
    Michal Marzec
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 68:1083-91. 2008
  2. pmc IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:11977-82. 2011
  3. pmc Lack of TNFalpha expression protects anaplastic lymphoma kinase-positive T-cell lymphoma (ALK+ TCL) cells from apoptosis
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:15843-8. 2009
  4. ncbi STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104 4283, USA
    Nat Med 13:1341-8. 2007
  5. pmc Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Blood 118:3062-71. 2011
  6. pmc STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 7 103 Founders, Philadelphia, 19104, USA
    Blood 108:1058-64. 2006
  7. pmc STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:6948-53. 2005
  8. pmc Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming
    Michal Marzec
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104
    J Immunol 191:6200-7. 2013
  9. pmc Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
    Michal Marzec
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:20852-7. 2008
  10. ncbi PU.1 activates transcription of SHP-1 gene in hematopoietic cells
    Pawel Wlodarski
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:6316-23. 2007

Collaborators

Detail Information

Publications60

  1. doi Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cells
    Michal Marzec
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 68:1083-91. 2008
    ....
  2. pmc IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:11977-82. 2011
    ..These results demonstrate that the oncogenic tyrosine kinase NPM-ALK induces epigenetic silencing of the IL-2Rγ gene and that IL-2Rγ acts as a tumor suppressor by reciprocally inhibiting expression of NPM-ALK...
  3. pmc Lack of TNFalpha expression protects anaplastic lymphoma kinase-positive T-cell lymphoma (ALK+ TCL) cells from apoptosis
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:15843-8. 2009
    ..These findings provide additional rationale for the therapeutic inhibition of DNA methyltransferases in ALK+ TCL. They also suggest that treatment with TNFalpha may be highly effective in this type of lymphoma...
  4. ncbi STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104 4283, USA
    Nat Med 13:1341-8. 2007
    ..These results show that NPM1-ALK induces epigenetic silencing of STAT5A gene and that STAT5A protein can act as a key tumor suppressor by reciprocally inhibiting expression of NPM1-ALK...
  5. pmc Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Blood 118:3062-71. 2011
    ..These data also show that the DNA methylation status of the intronic CpG island affects transcriptional activity of the ICOS gene and, consequently, modulates the concentration of the expressed ICOS protein...
  6. pmc STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 7 103 Founders, Philadelphia, 19104, USA
    Blood 108:1058-64. 2006
    ..Finally, these data provide further rationale for therapeutically targeting STAT3 in T-cell lymphomas and, possibly, other malignancies...
  7. pmc STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:6948-53. 2005
    ..Reversal of such gene silencing represents an attractive aim for novel anticancer therapies...
  8. pmc Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming
    Michal Marzec
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104
    J Immunol 191:6200-7. 2013
    ..These findings indicate that NPM/ALK transforms the target CD4(+) T lymphocytes, at least in part, by using the pre-existing, IL-2-dependent signaling pathways. ..
  9. pmc Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
    Michal Marzec
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:20852-7. 2008
    ..Finally, they suggest that future immunotherapeutic protocols for this type of lymphoma may need to include the inhibition of NPM/ALK and STAT3 to achieve optimal clinical efficacy...
  10. ncbi PU.1 activates transcription of SHP-1 gene in hematopoietic cells
    Pawel Wlodarski
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:6316-23. 2007
    ..1. These findings provide an insight into the structure of the hematopoietic cell-specific P2 promoter of the SHP-1 gene and identify PU.1 as the transcriptional activator of the P2 promoter...
  11. pmc Cutaneous T cell lymphoma expresses immunosuppressive CD80 (B7-1) cell surface protein in a STAT5-dependent manner
    Qian Zhang
    Department of Pathology and Laboratory Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104
    J Immunol 192:2913-9. 2014
    ..These data identify a new mechanism of immune evasion in CTCL and suggest that the CD80-CD152 axis may become a therapeutic target in this type of lymphoma. ..
  12. pmc Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes
    Monika Kasprzycka
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
    Am J Pathol 168:1631-41. 2006
    ..Furthermore, our results indicate that Brk may play a key role in lymphomagenesis, hence identifying the kinase as a potential therapeutic target in lymphomas...
  13. pmc TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
    Arthritis Res Ther 10:R37. 2008
    ..The objective of the present study was to investigate the role of the stromal cell-derived factor 1 (SDF-1)/CXCR4 axis in TNF-induced mobilization of osteoclast precursors (OCPs) from bone marrow...
  14. pmc Increased lymphangiogenesis in joints of mice with inflammatory arthritis
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 9:R118. 2007
    ..The lymphatic system may play an important role in the pathogenesis of inflammatory arthritis...
  15. pmc Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes
    Monika Kasprzycka
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 181:2506-12. 2008
    ....
  16. pmc Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3
    Monika Kasprzycka
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Proc Natl Acad Sci U S A 103:9964-9. 2006
    ..These results also provide an additional rationale to therapeutically target the chimeric kinase and/or STAT3 in ALK+TCL...
  17. pmc Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins
    Ruolin Guo
    Department of Pathology and Laboratory Medicine, and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 283:23084-92. 2008
    ..Inhibition of ubiquitin-mediated Smad1 and Runx2 degradation in osteoblasts could help to treat inflammation-induced osteoporosis...
  18. doi Anaplastic lymphoma kinase (ALK)-induced malignancies: novel mechanisms of cell transformation and potential therapeutic approaches
    Mariusz A Wasik
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Semin Oncol 36:S27-35. 2009
    ..They also suggest that immunotherapeutic approaches to ALK(+)TCL and, possibly, other ALK-driven malignancies may require inhibition of ALK and STAT3 to achieve the optimal clinical efficacy...
  19. pmc VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 283:13491-9. 2008
    ....
  20. ncbi Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
    Michal Marzec
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Lab Invest 85:1544-54. 2005
    ..The above results represent the 'proof-of-principle' experiments with regard to the ALK enzymatic activity as an attractive therapeutic target in T-cell lymphomas and other malignancies that express the kinase in an active form...
  21. pmc Detection of protein tyrosine-kinase (PTK) gene expression pattern in normal and malignant T lymphocytes by combined PTK-specific polymerase chain reaction and parallel denaturing gradient gel electrophoresis
    Zhi Yong Wang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Mol Diagn 5:113-20. 2003
    ....
  22. ncbi New roles for osteoclasts in bone
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1116:245-54. 2007
    ..In this article, we review these findings, which support new roles for osteoclasts and OCPs in the growing field of osteoimmunology and in common pathologic conditions affecting bones and joints...
  23. ncbi Loss of SHP-1 tyrosine phosphatase expression correlates with the advanced stages of cutaneous T-cell lymphoma
    Agnieszka Witkiewicz
    Department of Pathology, Jefferson Medical College, Philadelphia, PA 19107, USA
    Hum Pathol 38:462-7. 2007
    ..In turn, SHP-1 loss correlates with, and may contribute to, progression of CTCL...
  24. ncbi Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 168:466-74. 2002
    ..These results also suggest that activated STAT3, which is known to display oncogenic properties, as well as its regulatory molecules may represent attractive targets for novel therapies in ALK+ TCL...
  25. pmc The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma
    Ronnie M Abraham
    Departments of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Cancer Biol Ther 12:1019-22. 2011
    ..Novel therapeutic agents may potentially exploit the phenotypic plasticity of CTCL such that the malignant T cells become vulnerable to antitumor immunity...
  26. ncbi Expression of SHP-1 phosphatase indicates post-germinal center cell derivation of B-cell posttransplant lymphoproliferative disorders
    Michele Paessler
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Lab Invest 82:1599-606. 2002
    ..By being expressed earlier, SHP-1 is a more sensitive marker of post-germinal center B cells than CD138, which is seen on the terminally differentiated immunoblasts and plasma cells...
  27. ncbi Diminished expression of the type II receptor for TGFbeta (TGFbetaRII) in T lymphocytes from patients with Sezary syndrome is not due to mutations in the receptor's poly-A tract: limitations of the standard RT-PCR in cDNA sequence analysis of homopolymeri
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Arch Immunol Ther Exp (Warsz) 50:421-9. 2002
    ....
  28. ncbi Nucleophosmin-Anaplastic Lymphoma Kinase (NPM-ALK): the ultimate oncogene and therapeutic target
    Michael T Werner
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States
    Blood . 2016
    ..Combining ALK inhibition with other novel therapeutic modalities should prove even more effective...
  29. ncbi TNF-alpha and pathologic bone resorption
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Keio J Med 54:127-31. 2005
    ..Here we review our current understanding of the mechanisms whereby TNFa increases osteoclastogenesis in vitro and in vivo...
  30. ncbi Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding
    George S Sheppard
    Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Department R47A, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
    J Med Chem 49:3832-49. 2006
    ....
  31. pmc Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers
    Hongchuan Jin
    State Key Laboratory in Oncology in South China, Sir Y K Pao Center for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong
    Proc Natl Acad Sci U S A 104:12353-8. 2007
    ....
  32. doi Nocturnal behavior and rhythmic period gene expression in a lancelet, Branchiostoma lanceolatum
    Christof Schomerus
    Fachbereich Medizin der Johann Wolfgang Goethe Universität, Dr Senckenbergische Anatomie, Institut für Anatomie II, Frankfurt, Germany
    J Biol Rhythms 23:170-81. 2008
    ..The amphiPer mRNA levels fluctuated in a rhythmic manner, being high early in the day and low late at night. The authors' data suggest a homology of the amphiPer expessing cells to the suprachiasmatic nucleus of vertebrates...
  33. pmc Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor
    Jieyi Wang
    Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Proc Natl Acad Sci U S A 105:1838-43. 2008
    ..The sulfonamide MetAP2 inhibitor and GAPDH biomarker in circulating leukocytes may be used for the development of a cancer treatment...
  34. doi Establishment and characterization of conditions required for tumor colonization by intravenously delivered bacteria
    Yong A Yu
    Genelux Corporation, San Diego Science Center, 3030 Bunker Hill Street, Suite 310, San Diego, California 92109, USA
    Biotechnol Bioeng 100:567-78. 2008
    ..Bacterial colonization of tumors could be achieved without any specific gene modifications either in bacteria or in the host...
  35. ncbi Anti-AIDS agents. Part 58: synthesis and anti-HIV activity of 1-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (1-thia-DCK) analogues
    Peng Xia
    Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 200032, China
    Bioorg Med Chem Lett 14:3341-3. 2004
    ..Compound 9b was less active with EC(50) and TI values of 3.11 microM and 62.3, respectively. The bioassay results indicated that thia-DCK analogues merit attention as potential HIV-1 inhibitors...
  36. ncbi Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation. Role of eNOS phosphorylation at Tyr83
    David Fulton
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912 2500, USA
    Circ Res 102:497-504. 2008
    ..Moreover, our results demonstrate an important role for Src-mediated phosphorylation of eNOS at Tyr83 in agonist stimulation of eNOS activation and vascular relaxation...
  37. pmc Paradoxical activation of endothelial nitric oxide synthase by NADPH oxidase
    Qian Zhang
    Department of Pharmacology, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Arterioscler Thromb Vasc Biol 28:1627-33. 2008
    ..However, the specific contribution of ROS to endothelial function is not well understood...
  38. pmc Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues
    Carrie E Johnson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 104:20820-5. 2007
    ..Moreover, they raise the possibility that this phenomenon could be exploited therapeutically to selectively kill brain cancer cells while sparing the surrounding brain parenchyma...
  39. pmc Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation
    Julie L Wilsbacher
    Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    J Biol Chem 283:23721-30. 2008
    ..Thus, targeting both IGF-1R and ErbB receptors simultaneously results in cell cycle arrest and apoptosis through combined effects on Akt, cyclin D1, and Bax activation...
  40. ncbi Treatment of anaplastic thyroid carcinoma in vitro with a mutant vaccinia virus
    Shu Fu Lin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Surgery 142:976-83; discussion 976-83. 2007
    ..Anaplastic thyroid carcinoma (ATC) is a fatal disease resistant to all conventional treatments. Novel therapies are needed to improve dismal outcomes...
  41. ncbi Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties
    Megumi Kawai
    Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 16:3574-7. 2006
    ..The micromolar hits were quickly improved to potent nanomolar inhibitors by chemical modifications guided by insights from X-ray crystallography...
  42. pmc Importance of uterine cell death, renewal, and their hormonal regulation in hamsters that show progesterone-dependent implantation
    Qian Zhang
    Division of Reproductive and Developmental Biology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Endocrinology 147:2215-27. 2006
    ..The overall results indicate that uterine cell apoptosis and proliferation patterns are highly ordered cell-specific phenomena that play an important role in maintaining the sexual cycle and pregnancy-associated uterine changes...
  43. ncbi Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression
    Zhenqiang Yao
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 281:11846-55. 2006
    ..Therefore, the first step of TNF-induced osteoclastogenesis is at the level of OCP genesis in the bone marrow, which represents another layer of regulation to control erosive disease...
  44. ncbi The subcellular localization of syntaxin 17 varies among different cell types and is altered in some malignant cells
    Qian Zhang
    Department of Gastrointestinal Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Histochem Cytochem 53:1371-82. 2005
    ....
  45. ncbi Cloning and functional study of porcine parotid hormone, a novel proline-rich protein
    Qian Zhang
    Department of Biochemistry, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    J Biol Chem 280:22233-44. 2005
    ..In addition, the 30-amino acid parotid hormone was synthesized. Both the expressed and the synthetic proteins were biologically active in that they enhanced intradentinal fluid movement as measured by intradentinal dye penetration...
  46. ncbi Regulation of activities of NK cells and CD4 expression in T cells by human HNP-1, -2, and -3
    Kun Zhang
    Cancer Institute, The Second Affiliated Hospital, Zhejiang University Medical College, 88 Jiefang Road, Hangzhou, Zhejiang Province, PR China
    Biochem Biophys Res Commun 323:437-44. 2004
    ..The elevated HNPs in cancer tissues may create a microenvironment unfavorable for adaptive immune reaction, implicating the cancer evasion...
  47. ncbi Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins
    Yong A Yu
    Department of Biochemistry, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Nat Biotechnol 22:313-20. 2004
    ..Based on their 'tumor-finding' nature, bacteria and viruses may be designed to carry multiple genes for detection and treatment of cancer...
  48. ncbi Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammation
    Azhar bin Ali
    National University Medical Institutes, The National University of Singapore, Singapore, Singapore
    Free Radic Biol Med 34:824-9. 2003
    ..Therefore, antioxidant PON-1 is regulated at the mRNA level in a gender-specific manner by proinflammatory LPS and anti-inflammatory dexamethasone...
  49. ncbi Indian hedgehog, but not histidine decarboxylase or amphiregulin, is a progesterone-regulated uterine gene in hamsters
    Atanu Khatua
    Division of Reproductive and Developmental Biology, D4124 Medical Center North, 1161 21st Avenue South, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Endocrinology 147:4079-92. 2006
    ..We conclude that similarities and dissimilarities exist in uterine expression pattern of implantation-related genes, including hormonal regulation and their event-specific importance...
  50. ncbi Aberrant methylation of the 8p22 tumor suppressor gene DLC1 in renal cell carcinoma
    Qian Zhang
    Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, Beijing, China
    Cancer Lett 249:220-6. 2007
    ..Thus, our results demonstrated that DLC1 methylation occurs in a subset of RCC tumors and may play a role in renal carcinogenesis...
  51. ncbi Apoptosis profiles in benign prostatic hyperplasia: close associations of cell kinetics with percent area density of histologic composition
    Xianghua Zhang
    Department of Urology, Peking University First Hospital, Institute of Urology, Beijing, China
    Urology 68:905-10. 2006
    ....
  52. ncbi Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus
    Qian Zhang
    Genelux Corporation, San Diego Science Center, San Diego, California 92109, USA
    Cancer Res 67:10038-46. 2007
    ..These findings suggest that immune activation may combine with viral oncolysis to induce tumor eradication in this model, providing a novel perspective for the design of oncolytic viral therapies for human cancers...
  53. ncbi Spectrophotometric and calorimetric titration studies on molecular recognition of camphor and borneol by nucleobase-modified beta-cyclodextrins
    Yu Liu
    Department of Chemistry, State Key Laboratory of Elemento organic Chemistry, Nankai University, Tianjin 300071, P R China
    J Phys Chem B 111:12211-8. 2007
    ....
  54. ncbi Pyrazolo[3,4-d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR)
    Robert D Hubbard
    Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 17:5406-9. 2007
    ..The synthesis and subsequent optimization of this class of compounds led to the discovery of 14, a compound that possesses in vivo IGF-IR inhibitory activity...
  55. ncbi Comparison between gene expression of conidia and germinating phase in Trichophyton rubrum
    Li Yang
    College of Life Sciences, Wuhan University, Wuhan, 430072, China
    Sci China C Life Sci 50:377-84. 2007
    ..rubrum conidial germination, and possess significant meaning to the study of other superficial dermatophytes...
  56. pmc IK1 and cardiac hypoxia: after the long and short QT syndromes, what else can go wrong with the inward rectifier K+ currents?
    Yanfang Xu
    J Mol Cell Cardiol 43:15-7. 2007
  57. ncbi Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen
    Susan E Morgan-Lappe
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Cancer Res 67:4390-8. 2007
    ..Given our observations that Ran and TPX2 depletion preferentially reduces the survival of activated K-Ras-transformed cells, these two proteins may serve as useful anticancer targets in tumors expressing the activated K-Ras oncogene...
  58. pmc The use of global transcriptional analysis to reveal the biological and cellular events involved in distinct development phases of Trichophyton rubrum conidial germination
    Tao Liu
    State Key Lab for Molecular Virology and Genetic Engineering, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China
    BMC Genomics 8:100. 2007
    ..Conidia are considered to be the primary cause of infections by Trichophyton rubrum...
  59. pmc Nonmalignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins
    Anders Woetmann
    Institute of Molecular Biology, University of Copenhagen, Blegdamsvej 3C, DK 2200 Copenhagen N, Denmark
    Blood 109:3325-32. 2007
    ..This represents a novel mechanism by which infections with SE-producing bacteria may contribute to pathogenesis of CTCL...
  60. ncbi SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells
    Johannes Lundin Brockdorff
    Institute of Medical Microbiology and Immunology, University of Copenhagen, Blegdamsvej 3C, 2200 Copenhagen N, Denmark
    Cytokine 20:141-7. 2002
    ..Furthermore, the results indicate that SHP2 may not be involved in the activation of Stat3 or Stat5 in CTCL cells...