Hong Bo Zhao

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Expression and function of pannexins in the inner ear and hearing
    Hong Bo Zhao
    Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY, 40536, USA
    BMC Cell Biol 17:16. 2016
  2. pmc Pannexin 1 deficiency can induce hearing loss
    Hong Bo Zhao
    Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, United States Electronic address
    Biochem Biophys Res Commun 463:143-7. 2015
  3. pmc Connexin26 is responsible for anionic molecule permeability in the cochlea for intercellular signalling and metabolic communications
    Hong Bo Zhao
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, Kentucky, 40536, USA
    Eur J Neurosci 21:1859-68. 2005
  4. pmc Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear
    Hong Bo Zhao
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, KY 40536 0293, USA
    Proc Natl Acad Sci U S A 102:18724-9. 2005
  5. pmc Distinct and gradient distributions of connexin26 and connexin30 in the cochlear sensory epithelium of guinea pigs
    Hong Bo Zhao
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Comp Neurol 499:506-18. 2006
  6. pmc Active cochlear amplification is dependent on supporting cell gap junctions
    Yan Zhu
    Department of Otolaryngology, University of Kentucky Medical School, Lexington, Kentucky 40536, USA
    Nat Commun 4:1786. 2013
  7. pmc Modulation of outer hair cell electromotility by cochlear supporting cells and gap junctions
    Ning Yu
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, Kentucky, United States of America
    PLoS ONE 4:e7923. 2009
  8. pmc Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing
    Jin Chen
    1 Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, Kentucky, 40536, USA 2 Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P R of China
    Sci Rep 5:10762. 2015
  9. pmc Deafness induced by Connexin 26 (GJB2) deficiency is not determined by endocochlear potential (EP) reduction but is associated with cochlear developmental disorders
    Jin Chen
    Dept of Otolaryngology, University of Kentucky Medical School, Lexington, KY 40536, USA Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Biochem Biophys Res Commun 448:28-32. 2014
  10. doi request reprint Hemichannel-mediated inositol 1,4,5-trisphosphate (IP3) release in the cochlea: a novel mechanism of IP3 intercellular signaling
    David G Gossman
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0293, USA
    Cell Commun Adhes 15:305-15. 2008

Research Grants

  1. Functional Analysis of Inner Ear Gap Junctions
    Hong Bo Zhao; Fiscal Year: 2008

Collaborators

Detail Information

Publications24

  1. pmc Expression and function of pannexins in the inner ear and hearing
    Hong Bo Zhao
    Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY, 40536, USA
    BMC Cell Biol 17:16. 2016
    ..However, detailed information about pannexin function in the cochlea and Panx mutation induced hearing loss still remain largely undetermined. Further studies are required. ..
  2. pmc Pannexin 1 deficiency can induce hearing loss
    Hong Bo Zhao
    Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, United States Electronic address
    Biochem Biophys Res Commun 463:143-7. 2015
    ..These data indicate that like connexins Panx1 deficiency can also induce hearing loss. These data also suggest that pannexins play important rather than redundant roles in the cochlea and hearing. ..
  3. pmc Connexin26 is responsible for anionic molecule permeability in the cochlea for intercellular signalling and metabolic communications
    Hong Bo Zhao
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, Kentucky, 40536, USA
    Eur J Neurosci 21:1859-68. 2005
    ..g. IP3, ATP, cAMP and cGMP) are anions...
  4. pmc Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear
    Hong Bo Zhao
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, KY 40536 0293, USA
    Proc Natl Acad Sci U S A 102:18724-9. 2005
    ..The data also demonstrated a potential source of ATP in the cochlea...
  5. pmc Distinct and gradient distributions of connexin26 and connexin30 in the cochlear sensory epithelium of guinea pigs
    Hong Bo Zhao
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Comp Neurol 499:506-18. 2006
    ..This further supports our previous reports that Cx26 and Cx30 can solely and concertedly perform different functions in the cochlea...
  6. pmc Active cochlear amplification is dependent on supporting cell gap junctions
    Yan Zhu
    Department of Otolaryngology, University of Kentucky Medical School, Lexington, Kentucky 40536, USA
    Nat Commun 4:1786. 2013
    ..Our study demonstrates that active cochlear amplification in vivo is dependent on supporting cell gap junctions. These new findings also show that connexin 26 deficiency can reduce active cochlear amplification to induce hearing loss...
  7. pmc Modulation of outer hair cell electromotility by cochlear supporting cells and gap junctions
    Ning Yu
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, Kentucky, United States of America
    PLoS ONE 4:e7923. 2009
    ..Our findings reveal a new mechanism of cochlear supporting cells and gap junctional coupling to modulate OHC electromotility and eventually hearing sensitivity in the inner ear...
  8. pmc Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing
    Jin Chen
    1 Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, Kentucky, 40536, USA 2 Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P R of China
    Sci Rep 5:10762. 2015
    ..These data demonstrate that Panx1 channels dominate ATP release in the cochlea ensuring EP and auditory receptor potential generation and hearing. Panx1 deficiency can reduce ATP release and EP generation causing hearing loss. ..
  9. pmc Deafness induced by Connexin 26 (GJB2) deficiency is not determined by endocochlear potential (EP) reduction but is associated with cochlear developmental disorders
    Jin Chen
    Dept of Otolaryngology, University of Kentucky Medical School, Lexington, KY 40536, USA Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Biochem Biophys Res Commun 448:28-32. 2014
    ..These data suggest that congenital deafness induced by Cx26 deficiency is not determined by EP reduction and may result from cochlear developmental disorders...
  10. doi request reprint Hemichannel-mediated inositol 1,4,5-trisphosphate (IP3) release in the cochlea: a novel mechanism of IP3 intercellular signaling
    David G Gossman
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0293, USA
    Cell Commun Adhes 15:305-15. 2008
    ..This hemichannel-mediated extracellular pathway may play an important role in long-distance intercellular communication in the cochlea, given that IP(3) only has a short lifetime in the cytoplasm...
  11. pmc ATP activates P2X receptors to mediate gap junctional coupling in the cochlea
    Yan Zhu
    Dept of Otolaryngology, University of Kentucky Medical Center, Lexington, KY 40536 0293, United States
    Biochem Biophys Res Commun 426:528-32. 2012
    ....
  12. doi request reprint ATP activates P2x receptors and requires extracellular Ca(++) participation to modify outer hair cell nonlinear capacitance
    Ning Yu
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, KY 40536 0293, USA
    Pflugers Arch 457:453-61. 2008
    ..Our findings indicate that ATP activates P2x receptors instead of P2y receptors to modify OHC electromotility. Extracellular Ca(++) is required for this modification...
  13. pmc Cell degeneration is not a primary causer for Connexin26 (GJB2) deficiency associated hearing loss
    Chun Liang
    Department of Otolaryngology, University of Kentucky Medical School, Lexington, KY 40536, USA
    Neurosci Lett 528:36-41. 2012
    ..Some mechanisms other than cell degeneration, such as cochlear development disorders, may play an essential role in this common hereditary deafness...
  14. pmc Prestin is expressed on the whole outer hair cell basolateral surface
    Ning Yu
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, 40536 0293, USA
    Brain Res 1095:51-8. 2006
    ..Prestin in the basal plasma membrane may provide a reservoir on the OHC surface for prestin-recycling and may also facilitate performing its hypothesized transporter function...
  15. pmc Cellular characterization of Connexin26 and Connnexin30 expression in the cochlear lateral wall
    Ying Peng Liu
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, KY 40536 0293, USA
    Cell Tissue Res 333:395-403. 2008
    ..Thus, Cx26 and Cx30 have distinct cell-specific distributions in the SV and SPL, suggesting that they can form different pathways for transporting ions/nutrients in the cochlear lateral wall...
  16. pmc Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development
    Yan Zhu
    Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536
    Sci Rep 5:15647. 2015
    ....
  17. pmc Identification and characterization of pannexin expression in the mammalian cochlea
    Xiao Hui Wang
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Comp Neurol 512:336-46. 2009
    ..Thus, Panx1, 2, and 3 are abundantly expressed in the mammalian cochlea and demonstrate distinct cellular distributions. Like connexins, they may play an important role in hearing...
  18. pmc Gap junction mediated miRNA intercellular transfer and gene regulation: A novel mechanism for intercellular genetic communication
    Liang Zong
    Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536 U S A
    Sci Rep 6:19884. 2016
    ....
  19. pmc ATP-mediated potassium recycling in the cochlear supporting cells
    Yan Zhu
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536 0293 USA
    Purinergic Signal 6:221-9. 2010
    ..ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11302-010-9184-9) contains supplementary material, which is available to authorized users...
  20. pmc Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise
    Denise Yan
    Department of Otolaryngology, University of Miami School of Medicine, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 110:2228-33. 2013
    ..V60L, noise exposure exacerbated high-frequency hearing loss in young adulthood. Our results suggest that P2X(2) function is required for life-long normal hearing and for protection from exposure to noise...
  21. ncbi request reprint Paradoxical enhancement of active cochlear mechanics in long-term administration of salicylate
    Zhi Wu Huang
    Department of Otolaryngology, People s Hospital, Faculty of Medicine, Wuhan University, Wuhan, China
    J Neurophysiol 93:2053-61. 2005
    ..The data revealed that long-term administration of salicylate could paradoxically enhance active cochlear mechanics. The data also suggested that salicylate-induced tinnitus might be generated at the OHC level...
  22. ncbi request reprint Polysaccharide extract isolated from ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury
    Hong Bo Zhao
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    J Pharmacol Sci 95:294-8. 2004
    ..These findings suggest that Gl-PS might be useful in treating H/R-induced oxidative stress and Mn-SOD might play a critical role in the neuroprotective effect of Gl-PS against H/R injury...
  23. ncbi request reprint Effects of intense noise exposure on the outer hair cell plasma membrane fluidity
    Guang Di Chen
    Center for Hearing and Deafness, 137 Cary Hall, 3435 Main Street, SUNY at Buffalo, Buffalo, NY 14214, USA
    Hear Res 226:14-21. 2007
    ..The reduction of the lateral diffusion in the OHC lateral wall indicated that noise could impair the micromechanics of the OHC lateral wall and might consequently impair OHC electromotility to induce threshold shift...
  24. ncbi request reprint Excitation of fluorescent dyes inactivates the outer hair cell integral membrane motor protein prestin and betrays its lateral mobility
    Joseph Santos-Sacchi
    Surgery Otolaryngology and Neurobiology, BML 244, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Pflugers Arch 446:617-22. 2003
    ..These data indicate that lateral diffusion of prestin occurs within the cell's lateral plasma membrane...

Research Grants1

  1. Functional Analysis of Inner Ear Gap Junctions
    Hong Bo Zhao; Fiscal Year: 2008
    ....