R W Sidwell

Summary

Affiliation: Utah State University
Country: USA

Publications

  1. ncbi request reprint Treatment of lethal cowpox virus respiratory infections in mice with 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine and its orally active diacetate ester prodrug
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, 84322 5600, Logan, UT 84322 5600, USA
    Antiviral Res 54:113-20. 2002
  2. ncbi request reprint Peramivir (BCX-1812, RWJ-270201): potential new therapy for influenza
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Expert Opin Investig Drugs 11:859-69. 2002
  3. pmc In vivo influenza virus-inhibitory effects of the cyclopentane neuraminidase inhibitor RJW-270201
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Antimicrob Agents Chemother 45:749-57. 2001
  4. ncbi request reprint Primary immune system effects of the orally administered cyclopentane neuraminidase inhibitor RWJ-270201 in influenza virus-infected mice
    R W Sidwell
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Int Immunopharmacol 1:1211-8. 2001
  5. ncbi request reprint Influence of treatment schedule and viral challenge dose on the in vivo influenza virus-inhibitory effects of the orally administered neuraminidase inhibitor GS 4104
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan 84322 5600, USA
    Antivir Chem Chemother 10:187-93. 1999
  6. ncbi request reprint Influence of virus strain, challenge dose, and time of therapy initiation on the in vivo influenza inhibitory effects of RWJ-270201
    R W Sidwell
    Institute for Antiviral Research, Utah State University, 84322 5600, Logan, UT, USA
    Antiviral Res 51:179-87. 2001
  7. ncbi request reprint Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan 84322 5600, USA
    Antiviral Res 37:107-20. 1998
  8. pmc Inhibitory effects of recombinant manganese superoxide dismutase on influenza virus infections in mice
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan 84322 5600, USA
    Antimicrob Agents Chemother 40:2626-31. 1996
  9. ncbi request reprint Utilization of alpha-1-acid glycoprotein levels in the serum as a parameter for in vivo assay of influenza virus inhibitors
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, USA
    Antivir Chem Chemother 12:359-65. 2001
  10. ncbi request reprint Viruses of the Bunya- and Togaviridae families: potential as bioterrorism agents and means of control
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, UT 94322 5600, USA
    Antiviral Res 57:101-11. 2003

Detail Information

Publications89

  1. ncbi request reprint Treatment of lethal cowpox virus respiratory infections in mice with 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine and its orally active diacetate ester prodrug
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, 84322 5600, Logan, UT 84322 5600, USA
    Antiviral Res 54:113-20. 2002
    ..Since, HOE961 was orally active, it may have advantages over the other parenterally administered compounds for treating orthopoxvirus infections...
  2. ncbi request reprint Peramivir (BCX-1812, RWJ-270201): potential new therapy for influenza
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Expert Opin Investig Drugs 11:859-69. 2002
    ..In clinical trials with patients experimentally infected with influenza A or B viruses, oral treatment with peramivir significantly reduced nasal wash virus titres with no adverse effects. Phase III clinical trials are underway...
  3. pmc In vivo influenza virus-inhibitory effects of the cyclopentane neuraminidase inhibitor RJW-270201
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Antimicrob Agents Chemother 45:749-57. 2001
    ..RWJ-270201 was nontoxic at doses as high as 1,000 mg/kg/day. These data indicate potential for the oral use of RWJ-270201 in the treatment of influenza virus infections in humans...
  4. ncbi request reprint Primary immune system effects of the orally administered cyclopentane neuraminidase inhibitor RWJ-270201 in influenza virus-infected mice
    R W Sidwell
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Int Immunopharmacol 1:1211-8. 2001
    ....
  5. ncbi request reprint Influence of treatment schedule and viral challenge dose on the in vivo influenza virus-inhibitory effects of the orally administered neuraminidase inhibitor GS 4104
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan 84322 5600, USA
    Antivir Chem Chemother 10:187-93. 1999
    ..These data provide further insights into how the maximum therapeutic benefit can be derived from use of this orally effective influenza virus neuraminidase inhibitor...
  6. ncbi request reprint Influence of virus strain, challenge dose, and time of therapy initiation on the in vivo influenza inhibitory effects of RWJ-270201
    R W Sidwell
    Institute for Antiviral Research, Utah State University, 84322 5600, Logan, UT, USA
    Antiviral Res 51:179-87. 2001
    ....
  7. ncbi request reprint Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan 84322 5600, USA
    Antiviral Res 37:107-20. 1998
    ..These data provide strong evidence of the potential of orally administered GS4104 for treatment of influenza A and B virus infections in humans...
  8. pmc Inhibitory effects of recombinant manganese superoxide dismutase on influenza virus infections in mice
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan 84322 5600, USA
    Antimicrob Agents Chemother 40:2626-31. 1996
    ..A combination of MnSOD and ribavirin, each administered with small-particle aerosol, resulted in a generally mild improvement of the disease induced by the influenza A virus compared with use of either material alone...
  9. ncbi request reprint Utilization of alpha-1-acid glycoprotein levels in the serum as a parameter for in vivo assay of influenza virus inhibitors
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, USA
    Antivir Chem Chemother 12:359-65. 2001
    ..These data indicate murine AGP levels to be markedly stimulated by infection with influenza A and B viruses, and the level of the protein to be an additional measure of antiviral efficacy...
  10. ncbi request reprint Viruses of the Bunya- and Togaviridae families: potential as bioterrorism agents and means of control
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, UT 94322 5600, USA
    Antiviral Res 57:101-11. 2003
    ..Against infections induced by viruses in the Togaviridae family, interferon-alpha would appear to currently be the most useful for therapy...
  11. pmc Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 51:845-51. 2007
    ..These data indicate that T-705 may be useful for the treatment of avian influenza virus infections...
  12. ncbi request reprint Inhibition of influenza virus infections in immunosuppressed mice with orally administered peramivir (BCX-1812)
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 60:17-25. 2003
    ..These data indicate that peramivir may have potential for treatment of influenza virus-infected immunosuppressed patients...
  13. ncbi request reprint Respiratory syncytial virus infections: recent prospects for control
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, United States
    Antiviral Res 71:379-90. 2006
    ..In this review, updates on the status of the approved anti-RSV antibodies, ribavirin, and recent results of studies with potential new anti-RSV compounds are summarized and discussed...
  14. ncbi request reprint In vitro and in vivo influenza virus-inhibitory effects of viramidine
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 68:10-7. 2005
    ..While both compounds appear to have similar efficacy against influenza virus infections, when one considers the lesser toxicity, viramidine may warrant further evaluation as a possible therapy for influenza...
  15. ncbi request reprint In vitro and in vivo assay systems for study of influenza virus inhibitors
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 48:1-16. 2000
    ..This review has described the systems which have been used most frequently by antiviral investigators, using, as examples, recent studies with the clinically approved influenza virus neuraminidase inhibitors oseltamivir and zanamivir...
  16. ncbi request reprint Treatment of cowpox virus respiratory infections in mice with ribavirin as a single agent or followed sequentially by cidofovir
    D F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, USA
    Antivir Chem Chemother 11:303-9. 2000
    ..These results suggest that many individuals infected with an orthopoxvirus by aerosol route would benefit by a course of ribavirin therapy. Later, the fewer number of very sick individuals could be treated with intravenous cidofovir...
  17. ncbi request reprint Immunological effects of the orally administered neuraminidase inhibitor oseltamivir in influenza virus-infected and uninfected mice
    R A Burger
    Center for Persons with Disabilities, Utah State University, Logan, UT 84322 6895, USA
    Immunopharmacology 47:45-52. 2000
    ....
  18. ncbi request reprint Treatment of lethal vaccinia virus respiratory infections in mice with cidofovir
    D F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan 84322 5600, USA
    Antivir Chem Chemother 12:71-6. 2001
    ..Although it has been known for many years that the WR strain of vaccinia virus can cause lethal infections by intranasal route, its application to antiviral therapy represents a new model for studying anti-orthopoxvirus agents...
  19. ncbi request reprint Intranasal treatment of cowpox virus respiratory infections in mice with cidofovir
    D F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 47:171-7. 2000
    ..The data suggest the possibility that aerosol delivery of cidofovir to human lungs may be a viable alternative to intravenous dosing...
  20. ncbi request reprint Transgenic mice as a chemotherapeutic model for hepatitis B virus infection
    J D Morrey
    Institute for Antiviral Research, Utah State University, Logan 84322 5600, USA
    Antivir Ther 3:59-68. 1998
    ....
  21. pmc Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activities
    D F Smee
    Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Antimicrob Agents Chemother 45:743-8. 2001
    ..This is consistent with its effect as a neuraminidase inhibitor. RWJ-270201 shows promise in the treatment of human influenza virus infections...
  22. ncbi request reprint Effects of cidofovir on the pathogenesis of a lethal vaccinia virus respiratory infection in mice
    D F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, 84322 5600, USA
    Antiviral Res 52:55-62. 2001
    ..These results illustrate the ability of a single cidofovir treatment to control the pathogenesis of an acute lethal infection in various tissues during the vaccinia virus infection in mice...
  23. ncbi request reprint Characterization of an influenza A (H3N2) virus resistant to the cyclopentane neuraminidase inhibitor RWJ-270201
    D F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 52:251-9. 2001
    ..Mice infected with a lethal dose of the resistant virus could still be effectively treated with RWJ-270201. Thus, the HA mutation may allow for the spread of the virus in cell culture in the presence of the NA inhibitor, but not in mice...
  24. ncbi request reprint Effect of immunomodulators in the hu-PBL-SCID mouse model
    J R Mead
    Institute for Antiviral Research, Utah State University, Logan 84322 5600
    Biotechnol Ther 4:133-43. 1993
    ..The T-cell population results using human cells in SCID mice were similar to the effects of these immunomodulators on murine cells in immunologically competent mice...
  25. ncbi request reprint Antiviral and immunomodulating inhibitors of experimentally-induced Punta Toro virus infections
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan 84322 5600
    Antiviral Res 25:105-22. 1994
    ..The active immunomodulators were significantly effective when therapy was initiated as late as 48 h after virus inoculation, at a time when clinical signs of the PTV disease were being manifested in the animal...
  26. ncbi request reprint Potential role of immunomodulators for treatment of phlebovirus infections of animals
    R W Sidwell
    Institute for Antiviral Research, Utah State University, Logan 84322 5600
    Ann N Y Acad Sci 653:344-55. 1992
    ..As a next step, studies need to be run to compare the immunologic profiles induced by each substance in domestic animals and in mice...
  27. pmc Efficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virus
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 76:124-9. 2007
    ..p. cidofovir (100 mg/(kg day)). Significant reductions in tissue virus titers occurred with both treatment regimens. (N)-MCT could be further pursued for its potential to treat orthopoxvirus infections in humans...
  28. ncbi request reprint Antiviral activities of tragacanthin polysaccharides on Punta Toro virus infections in mice
    D F Smee
    Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan 84322 5600, USA
    Chemotherapy 42:286-93. 1996
    ..These compounds should be considered for the potential treatment of significant human infections induced by bunyaviruses and hantaviruses...
  29. ncbi request reprint Effect of methionine enkephalin on natural killer cell and cytotoxic T lymphocyte activity in mice infected with influenza A virus
    R A Burger
    Department of Biology, Utah State University, Logan 84322-6895, USA
    Immunopharmacol Immunotoxicol 17:323-34. 1995
    ..The results of this study demonstrate the immunomodulatory effects of Met-Enk on NK and CTL in influenza infected mice and suggest a potential for therapeutic applications...
  30. ncbi request reprint Resistance to Friend leukemia virus in transgenic mice expressing the native Fv-4 gene
    M K Jackson
    Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan 84322 5700, USA
    Acta Virol 43:19-23. 1999
    ..These results indicate that the native gene confers the resistance in homozygous transgenic mice or double integrants derived from different founders but not hemizygotes...
  31. ncbi request reprint Inhibition of measles virus replication by 5'-nor carbocyclic adenosine analogues
    D L Barnard
    Institute for Antiviral Research, Utah State University, Logan, USA
    Antivir Chem Chemother 12:241-50. 2001
    ..Most compounds tested were also not toxic at concentrations >100 mg/ml in actively growing and stationary-phase cells. Results suggest that these compounds may be clinically useful anti-MV virus agents...
  32. ncbi request reprint Utilization of transgenic mice replicating high levels of hepatitis B virus for antiviral evaluation of lamivudine
    J D Morrey
    Institute for Antiviral Research, Utah State University, Logan 84322 5600, USA
    Antiviral Res 42:97-108. 1999
    ....
  33. ncbi request reprint Characterizing antiviral activity of adefovir dipivoxil in transgenic mice expressing hepatitis B virus
    Justin G Julander
    Animal, Dairy, and Veterinary Sciences Department, Institute for Antiviral Research, Utah State University, 4700 Old Main Hill, Logan, UT 84322 4700, USA
    Antiviral Res 55:27-40. 2002
    ..ADV was identified to have potent anti-HBV activity in this HBV transgenic mouse model and could serve as a suitable positive control for future drug discovery experiments...
  34. pmc In vitro activity of expanded-spectrum pyridazinyl oxime ethers related to pirodavir: novel capsid-binding inhibitors with potent antipicornavirus activity
    D L Barnard
    Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Antimicrob Agents Chemother 48:1766-72. 2004
    ..Both compounds were relatively nontoxic in actively growing cells (50% cytotoxic doses, >/=4,588 nM). These data suggest that these oxime ethers warrant further investigation as potential agents for treating selected PV infections...
  35. ncbi request reprint Error-prone replication of West Nile virus caused by ribavirin
    Craig W Day
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, 4700 Old Main Hill, Utah State University, Logan, UT 84322 4700, USA
    Antiviral Res 67:38-45. 2005
    ..These data support the hypothesis that error catastrophe is one of the modes of action for ribavirin against WNV...
  36. ncbi request reprint Effects of zidovudine on Friend virus complex infection in Rfv-3r/s genotype-containing mice used as a model for HIV infection
    J D Morrey
    AIDS Research Program, Utah State University, Logan
    J Acquir Immune Defic Syndr 3:500-10. 1990
    ....
  37. ncbi request reprint TLR3 deletion limits mortality and disease severity due to Phlebovirus infection
    Brian B Gowen
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main, Logan, UT 84322, USA
    J Immunol 177:6301-7. 2006
    ....
  38. pmc Comparison of the inhibitory effects of interferon alfacon-1 and ribavirin on yellow fever virus infection in a hamster model
    Justin G Julander
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, United States
    Antiviral Res 73:140-6. 2007
    ..Pre- and post-virus exposure treatment with IFN alfacon-1 was efficacious in improving disease in YFV-infected hamsters...
  39. pmc Correlation between breakdown of the blood-brain barrier and disease outcome of viral encephalitis in mice
    Aaron L Olsen
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antiviral Res 75:104-12. 2007
    ..In general, it was found that evaluation of BBB permeability was a more sensitive indicator of disease outcome and the antiviral efficacy Ampligen than either weight change or brain viral titers...
  40. pmc Recombinant Eimeria protozoan protein elicits resistance to acute phlebovirus infection in mice but not hamsters
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, 84322, USA
    Antimicrob Agents Chemother 50:2023-9. 2006
    ..Further investigation into the immunostimulatory capacity of rEA in other mammalian systems is necessary...
  41. ncbi request reprint Cell line dependency for antiviral activity and in vivo efficacy of N-methanocarbathymidine against orthopoxvirus infections in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 73:69-77. 2007
    ..Cidofovir (100mg/kg/day) protected animals from death in all three infections...
  42. ncbi request reprint Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, 84322 5600, USA
    Antiviral Res 71:53-63. 2006
    ..Our data do not support the use of ribavirin or other IMP dehydrogenase inhibitors for treating SARS infections in humans...
  43. ncbi request reprint Protective immunity against acute phleboviral infection elicited through immunostimulatory cationic liposome-DNA complexes
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT 84322, United States
    Antiviral Res 69:165-72. 2006
    ..Taken together, our findings indicate that non-specific immunotherapy with CLDC appears to be an effective treatment for blocking PTV-induced disease and suggests that further exploration in other viral disease models may be warranted...
  44. ncbi request reprint Combinatorial ribavirin and interferon alfacon-1 therapy of acute arenaviral disease in hamsters
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 17:175-83. 2006
    ..Further, combination therapy reduces the effective dosage of ribavirin, which would serve to limit its toxicity...
  45. ncbi request reprint Activities of oseltamivir and ribavirin used alone and in combination against infections in mice with recent isolates of influenza A (H1N1) and B viruses
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah 84321 5600, USA
    Antivir Chem Chemother 17:185-92. 2006
    ..These activities differed from published results with older, more established virus strains as oseltamivir was less effective and ribavirin was more active than previously reported...
  46. pmc In vitro and in vivo activities of T-705 against arenavirus and bunyavirus infections
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA
    Antimicrob Agents Chemother 51:3168-76. 2007
    ..Our results suggest that T-705 may be a viable alternative for the treatment of life-threatening bunyaviral and arenaviral infections...
  47. pmc Activity of T-1106 in a hamster model of yellow Fever virus infection
    Justin G Julander
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 51:1962-6. 2007
    ....
  48. ncbi request reprint TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, Utah 84341, USA
    J Immunol 178:5200-8. 2007
    ..We conclude that TLR3 is essential to the induction of antiviral activity elicited by poly(I:C(12)U), which does not appear to be recognized by the cytosolic sensor of poly(I:C), melanoma differentiation-associated gene-5...
  49. pmc Is the anti-psychotic, 10-(3-(dimethylamino)propyl)phenothiazine (promazine), a potential drug with which to treat SARS infections? Lack of efficacy of promazine on SARS-CoV replication in a mouse model
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antiviral Res 79:105-13. 2008
    ..Thus, promazine did not affect SARS-CoV replication in vitro or in vivo, nor were any other phenothiazines efficacious in reducing virus replication. Therefore, treating SARS infections with compounds like promazine is not warranted...
  50. pmc Prophylactic treatment with recombinant Eimeria protein, alone or in combination with an agonist cocktail, protects mice from Banzi virus infection
    Justin G Julander
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, United States
    Antiviral Res 75:14-9. 2007
    ..Treatment with rEA, alone or in combination with an agonist cocktail, is efficacious for the prophylaxis of BV infection in mice...
  51. pmc Differential pathogenesis of cowpox virus intranasal infections in mice induced by low and high inoculum volumes and effects of cidofovir treatment
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA
    Int J Antimicrob Agents 31:352-9. 2008
    ..Cidofovir effectively treated both infections and slowed viral replication sufficiently to subdue the exaggerated release of pro-inflammatory mediators...
  52. ncbi request reprint Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 17:275-84. 2006
    ..In summary, the data suggest that induction of IFN by mismatched dsRNA or actual treatment with exogenous IFN-alpha can inhibit SARS-CoV replication in the lungs of mice...
  53. pmc Prophylactic and therapeutic intervention of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with interferon alfacon-1
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antiviral Res 77:215-24. 2008
    ..These studies suggest that IFN alfacon-1 may be an effective treatment for early intervention following infection with RVFV...
  54. ncbi request reprint Effect of oral gavage treatment with ZnAL42 and other metallo-ion formulations on influenza A H5N1 and H1N1 virus infections in mice
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 18:125-32. 2007
    ..The data suggest that the prophylactic use of ZnAL42 is effective against avian influenza H5N1 or H1N1 virus infection in mice and should be further explored as an option for treating human influenza virus infections...
  55. pmc Effect of exogenous interferon and an interferon inducer on western equine encephalitis virus disease in a hamster model
    Justin G Julander
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Virology 360:454-60. 2007
    ..This model of WEEV infection in hamsters appears to serve as a suitable model for the evaluation of potential therapeutic agents for the treatment of WEE disease...
  56. ncbi request reprint Characterization and treatment of cidofovir-resistant vaccinia (WR strain) virus infections in cell culture and in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 16:203-11. 2005
    ..Cidofovir, HDP-cidofovir and arabinofuranosyladenine treatments reduced lung virus titres <fourfold, and snout virus titres > or = eight-fold. The animal model appears to have limited utility in drug efficacy testing...
  57. pmc Interferon alfacon-1 protects hamsters from lethal pichinde virus infection
    Brian B Gowen
    Institute for Antiviral Research, 5600 Old Main Hill, Utah State University, Logan, UT 84322, USA
    Antimicrob Agents Chemother 49:2378-86. 2005
    ..These data are the first report demonstrating efficacious treatment of acute arenaviral disease with alpha interferon therapy, and further study is warranted...
  58. ncbi request reprint Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Int J Antimicrob Agents 23:430-7. 2004
    ..These data indicate the utility of parenteral cidofovir, oral HDP-CDV and oral HOE961 in treating severe respiratory infections caused by this virus...
  59. ncbi request reprint Comparison of colorimetric, fluorometric, and visual methods for determining anti-influenza (H1N1 and H3N2) virus activities and toxicities of compounds
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    J Virol Methods 106:71-9. 2002
    ..These methods should also be applicable to evaluating antiviral effects against other lytic virus infections...
  60. ncbi request reprint Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 15:15-22. 2004
    ..These compounds or analogues warrant further evaluation as potential therapies for treating SARS or could be used as lead compounds for discovery of more potent SARSCoV inhibitors...
  61. ncbi request reprint Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah 84322 5600, USA
    Nucleosides Nucleotides Nucleic Acids 23:375-83. 2004
    ..None of the other compounds, including IDU, prevented death nor delayed the time to death. Cidofovir had the best potential for treating orthopoxvirus infections of those tested...
  62. ncbi request reprint Identification of active antiviral compounds against a New York isolate of West Nile virus
    John D Morrey
    Department of Animal, Dairy, and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 4700, USA
    Antiviral Res 55:107-16. 2002
    ....
  63. ncbi request reprint Characterization of antiviral activity of entecavir in transgenic mice expressing hepatitis B virus
    Justin G Julander
    Institute for Antiviral Research, Animal, Dairy, and Veterinary Sciences Department and Biotechnology Center, Utah State University, 4700 Old Main Hill, Logan, UT 84322 4700, USA
    Antiviral Res 59:155-61. 2003
    ..ETV was well tolerated and no morbidity or mortality was observed during the 10-day study. Similar to other animal models, ETV displayed potent anti-HBV activity in this transgenic mouse model...
  64. ncbi request reprint Coumarins and pyranocoumarins, potential novel pharmacophores for inhibition of measles virus replication
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, USA
    Antivir Chem Chemother 13:39-59. 2002
    ..This and related compounds may be valuable leads in the development of a potent and selective class of MV inhibitors that could be used in future in the clinic...
  65. ncbi request reprint Comparative effects of cidofovir and cyclic HPMPC on lethal cowpox and vaccinia virus respiratory infections in mice
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Chemotherapy 49:126-31. 2003
    ..Thus, it was deemed important to directly compare the activities of cidofovir and cyclic HPMPC against poxvirus infections in mouse models...
  66. ncbi request reprint A review of compounds exhibiting anti-orthopoxvirus activity in animal models
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 57:41-52. 2003
    ....
  67. ncbi request reprint Effect of interferon-alpha and interferon-inducers on West Nile virus in mouse and hamster animal models
    John D Morrey
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 15:101-9. 2004
    ....
  68. ncbi request reprint Modeling hamsters for evaluating West Nile virus therapies
    John D Morrey
    Department of Animal, Dairy, and Veterinary Sciences, Institute for Antiviral Research, Biotechnology Center, Utah State University, 4700 Old Main Hill, Room 305, Logan, UT 84322 4700, USA
    Antiviral Res 63:41-50. 2004
    ..The use of older hamsters is another WNV-infectious model, in addition to mice, for evaluating potential antiviral therapies...
  69. ncbi request reprint Topical cidofovir is more effective than is parenteral therapy for treatment of progressive vaccinia in immunocompromised mice
    Donald F Smee
    Department of Animal, Dairy, and Veterinary Sciences, Institute for Antiviral Research, Utah State University, 5600 University Boulevard, Logan, UT 84322 5600, USA
    J Infect Dis 190:1132-9. 2004
    ..We developed a new mouse model for studying the effects of antiviral agents on progressive vaccinia virus infections...
  70. ncbi request reprint Treatment of mannan-enhanced influenza B virus infections in mice with oseltamivir, ribavirin and viramidine
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 15:261-8. 2004
    ..The overall results demonstrate that mannan can be used to enhance certain non-lethal influenza virus infections sufficiently to allow antiviral studies...
  71. ncbi request reprint Combination treatment of influenza A virus infections in cell culture and in mice with the cyclopentane neuraminidase inhibitor RWJ-270201 and ribavirin
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah 84322 5600, USA
    Chemotherapy 48:88-93. 2002
    ..Treatment of influenza infections in the clinical setting may benefit by these two agents in combination...
  72. pmc Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Antimicrob Agents Chemother 46:1329-35. 2002
    ..Studies will need to be conducted with cidofovir-resistant monkeypox virus in monkeys to further support these hypotheses...
  73. pmc Selective cytotoxicity of ricin A chain immunotoxins towards murine cytomegalovirus-infected cells
    B B Barnett
    Department of Biology, Utah State University, Logan 84322 5305, USA
    Antimicrob Agents Chemother 40:470-2. 1996
    ....
  74. ncbi request reprint West Nile virus infection of the placenta
    Justin G Julander
    The Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA
    Virology 347:175-82. 2006
    ..These results suggest that embryos are susceptible to WNV infection after the formation of the trophectoderm around 3.5 dpc through the formation of the functional placenta around 10.5 dpc...
  75. ncbi request reprint Treatment of West Nile virus-infected mice with reactive immunoglobulin reduces fetal titers and increases dam survival
    Justin G Julander
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 4700, USA
    Antiviral Res 65:79-85. 2005
    ..5 and 13.5dpc also resulted in reduction of viral titer on 14.5dpc, indicating that later treatment may also be efficacious. This suggests that Ig treatment may be useful in treating fetal WNV infection in women...
  76. ncbi request reprint Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity
    Peiyuan Wang
    Pharmasset Inc, Tucker, Georgia 30084, Utah State University, Logan, Utah 84322, USA
    J Med Chem 47:6100-3. 2004
    ..A novel anti-hepatitis C virus (HCV) agent, N(3),5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridinin-5-one, was identified, and the structure was confirmed by chemical synthesis from 2-hydroxy-5-nitropyridine...
  77. ncbi request reprint in vitro inhibition of the measles virus by novel ring-expanded ('fat') nucleoside analogues containing the imidazo[4,5-e]diazepine ring system
    Ning Zhang
    Laboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County 21250, USA
    Bioorg Med Chem Lett 12:3391-4. 2002
    ..Both compounds showed higher anti-MV activity than the control drug ribavirin...
  78. pmc Neutralizing viruses in suspensions by copper oxide-based filters
    Gadi Borkow
    Ruth Ben Ari Institute of Clinical Immunology, Kaplan Medical Center, Rehovot 76100, Israel
    Antimicrob Agents Chemother 51:2605-7. 2007
    ..Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses found in filterable suspensions...
  79. pmc Viral regulation of aquaporin 4, connexin 43, microcephalin and nucleolin
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware Ave SE, MMC 392, Minneapolis, MN 55455, USA
    Schizophr Res 98:163-77. 2008
    ....
  80. ncbi request reprint Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring
    Limin Shi
    Biology Division, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 23:297-302. 2003
    ..Therefore, maternal viral infection has a profound effect on the behavior of adult offspring, probably via an effect of the maternal immune response on the fetus...
  81. pmc Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype
    Richard S Kornbluth
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0676, USA
    Antimicrob Agents Chemother 50:4038-43. 2006
    ..These findings suggest that drug therapy for poxviruses may be complicated by drug resistance but that treatment of the infection with currently known compounds is possible...
  82. ncbi request reprint An orally bioavailable oxime ether capsid binder with potent activity against human rhinovirus
    Keith G Watson
    Biota Chemistry Laboratory, School of Chemistry, Monash University, PO Box 23 Victoria, Australia 3800
    J Med Chem 46:3181-4. 2003
    ..Compound 14 illustrates that an oxime ether group can act as a metabolically stable bioisostere for an ester functionality...
  83. ncbi request reprint Antiviral activity of nucleoside analogues against SARS-coronavirus (SARS-coV)
    Chung K Chu
    The University of Georgia, College of Pharmacy, Athens, GA, USA
    Antivir Chem Chemother 17:285-9. 2006
    ..Herein we describe the antiviral activity of several classes of nucleoside analogues evaluated against SARS-CoV in Vero 76 cells, some of which exhibited moderate activity...
  84. ncbi request reprint Anti-influenza virus activities of 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N-(4,6-dimethyl-2-pyrimidin-2-yl)benzenesulphonamide and its derivatives
    Periyasamy Selvam
    Arumigu Kalasalingam College of Pharmacy, Krishnankoil 626 190, India
    Antivir Chem Chemother 17:269-74. 2006
    ..The basic molecule is amenable to diverse chemical modifications, which may improve water solubility and antiviral potency...
  85. ncbi request reprint Glial fibrillary acidic protein and glutamic acid decarboxylase 65 and 67 kDa proteins are increased in brains of neonatal BALB/c mice following viral infection in utero
    S Hossein Fatemi
    Schizophr Res 69:121-3. 2004
  86. pmc Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection
    Michael P Malakhov
    NexBio, Inc, 6330 Nancy Ridge Dr, Suite 105, San Diego, CA 92121, USA
    Antimicrob Agents Chemother 50:1470-9. 2006
    ..04 to 0.9 nM. Mouse and ferret studies confirmed significant in vivo efficacy of the sialidase fusion in both prophylactic and treatment modes...
  87. ncbi request reprint Synthesis of cyclopentenyl carbocyclic nucleosides as potential antiviral agents against orthopoxviruses and SARS
    Jong Hyun Cho
    The University of Georgia College of Pharmacy, Athens, GA 30602, USA
    J Med Chem 49:1140-8. 2006
    ..The 1,2,4-triazole analogue (17a) also exhibited moderate antiviral activity (EC(50) 21 microM) against SARSCoV...
  88. ncbi request reprint Broad-spectrum inhibitor of viruses in the Flaviviridae family
    Joshua O Ojwang
    ZymeTx Inc, 655 Research Parkway, Suite 554 Oklahoma City, OK 73104, USA
    Antiviral Res 68:49-55. 2005
    ..The data described herein suggest that ZX-2401 is a broad-spectrum inhibitor of the RNA viruses, which has merit for development of treatments for the emerging infections caused by the viruses in the Flaviviridae family...
  89. doi request reprint Potent in vitro activity of the albumin fusion type 1 interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agents of bioterrorism and the severe acute respiratory syndrome (SARS) virus
    G Mani Subramanian
    Human Genome Sciences, Inc, Rockville, MD 20850, USA
    Chemotherapy 54:176-80. 2008
    ..The type 1 interferons (INF-alpha and INF-beta) are potent antiviral agents. Albumin-INF-alpha and albumin-INF-beta are novel recombinant proteins consisting of IFN-alpha or IFN-beta genetically fused to human albumin...