Donald A Vessey

Summary

Country: USA

Publications

  1. pmc FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning
    Donald A Vessey
    Liver Study Unit, Veterans Affairs Medical Center, San Francisco, CA, USA
    Med Sci Monit Basic Res 19:126-32. 2013
  2. pmc A sphingosine kinase form 2 knockout sensitizes mouse myocardium to ischemia/reoxygenation injury and diminishes responsiveness to ischemic preconditioning
    Donald A Vessey
    Liver Study Unit, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Oxid Med Cell Longev 2011:961059. 2011
  3. doi request reprint P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X₇ channels
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 301:H881-7. 2011
  4. doi request reprint Ischemic preconditioning requires opening of pannexin-1/P2X(7) channels not only during preconditioning but again after index ischemia at full reperfusion
    Donald A Vessey
    Department of Veterans Affairs Medical Center, Liver Study Unit 151 K, 4150 Clement St, San Francisco, CA 94121, USA
    Mol Cell Biochem 351:77-84. 2011
  5. pmc Sphingosine protects aging hearts from ischemia/reperfusion injury: Superiority to sphingosine 1-phosphate and ischemic pre- and post-conditioning
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Oxid Med Cell Longev 2:146-51. 2009
  6. doi request reprint Pannexin-I/P2X 7 purinergic receptor channels mediate the release of cardioprotectants induced by ischemic pre- and postconditioning
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA, USA
    J Cardiovasc Pharmacol Ther 15:190-5. 2010
  7. pmc Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 297:H1429-35. 2009
  8. doi request reprint Sphingosine can pre- and post-condition heart and utilizes a different mechanism from sphingosine 1-phosphate
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Biochem Mol Toxicol 22:113-8. 2008
  9. ncbi request reprint A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury
    Zhu Qiu Jin
    Cardiology Section, VA Medical Center and University of California, San Francisco, CA 94121, USA
    Cardiovasc Res 76:41-50. 2007
  10. ncbi request reprint Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Biochem Mol Toxicol 21:273-9. 2007

Collaborators

Detail Information

Publications19

  1. pmc FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning
    Donald A Vessey
    Liver Study Unit, Veterans Affairs Medical Center, San Francisco, CA, USA
    Med Sci Monit Basic Res 19:126-32. 2013
    ..We investigated the hypothesis that postconditioning by FTY720 (FTY) in isolated perfused mouse hearts is independent of the sphingosine 1-phosphate (S1P) pathway...
  2. pmc A sphingosine kinase form 2 knockout sensitizes mouse myocardium to ischemia/reoxygenation injury and diminishes responsiveness to ischemic preconditioning
    Donald A Vessey
    Liver Study Unit, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Oxid Med Cell Longev 2011:961059. 2011
    ..Thus, deletion of the SphK2 gene sensitizes the myocardium to IR injury and diminishes the protective effect of IPC...
  3. doi request reprint P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X₇ channels
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 301:H881-7. 2011
    ..The data point out for the first time the potential of P2X(7) agonists as cardioprotectants...
  4. doi request reprint Ischemic preconditioning requires opening of pannexin-1/P2X(7) channels not only during preconditioning but again after index ischemia at full reperfusion
    Donald A Vessey
    Department of Veterans Affairs Medical Center, Liver Study Unit 151 K, 4150 Clement St, San Francisco, CA 94121, USA
    Mol Cell Biochem 351:77-84. 2011
    ..This correlates with an inability to generate phospho-Akt at reperfusion. IPC prevents this loss and thereby primes the cell for response to cardioprotectants released at full reperfusion...
  5. pmc Sphingosine protects aging hearts from ischemia/reperfusion injury: Superiority to sphingosine 1-phosphate and ischemic pre- and post-conditioning
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Oxid Med Cell Longev 2:146-51. 2009
    ..In conclusion, POST was less affected by aging than PC; and sphingosine is a uniquely effective agent for both PC and POST of aging hearts...
  6. doi request reprint Pannexin-I/P2X 7 purinergic receptor channels mediate the release of cardioprotectants induced by ischemic pre- and postconditioning
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA, USA
    J Cardiovasc Pharmacol Ther 15:190-5. 2010
    ..Inhibitors of other P2X receptors, P2Y receptors, or connexins did not affect IPC. We conclude that a pannexin-1/P2X(7) channel is responsible for the release of cardioprotectants induced by ischemic pre- and postconditioning...
  7. pmc Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 297:H1429-35. 2009
    ..These studies reveal that S1P is an important mediator of both IPC and IPOST that is released along with adenosine during each cycle of IPC or IPOST...
  8. doi request reprint Sphingosine can pre- and post-condition heart and utilizes a different mechanism from sphingosine 1-phosphate
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Biochem Mol Toxicol 22:113-8. 2008
    ....
  9. ncbi request reprint A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury
    Zhu Qiu Jin
    Cardiology Section, VA Medical Center and University of California, San Francisco, CA 94121, USA
    Cardiovasc Res 76:41-50. 2007
    ..SphK is involved in ischemic preconditioning (IPC). To date no studies in genetically altered animals have examined the role of SphK1 in myocardial ischemia/reperfusion (IR) injury and IPC...
  10. ncbi request reprint Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Biochem Mol Toxicol 21:273-9. 2007
    ..SK2 from rat liver and spleen was also not inhibited by DMS. L-Sphingosine and to a lesser extent dihydrosphingosine and phytosphingosine were effective inhibitors of both forms...
  11. doi request reprint Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation
    Zhu Qiu Jin
    Cardiology Section, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Cardiovasc Res 79:134-40. 2008
    ..Ischaemic postconditioning (POST) has been shown to protect hearts against ischaemia/reperfusion injury (IR). To date, no studies have examined the role of SphK1 in POST...
  12. ncbi request reprint Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center San Francisco CA 94121, USA
    Med Sci Monit 12:BR318-24. 2006
    ..Sphingosine kinase (SKase) has been implicated in the protection of hearts from ischemia/reperfusion injury. This hypothesis was further examined...
  13. pmc Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction
    Che Chung Yeh
    Cardiothoracic Surgery, 4150 Clement St, 112D, San Francisco, CA 94121, USA
    Am J Physiol Heart Circ Physiol 296:H1193-9. 2009
    ....
  14. pmc Combined sphingosine, S1P and ischemic postconditioning rescue the heart after protracted ischemia
    Donald A Vessey
    Liver Study Unit 151 K, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 375:425-9. 2008
    ..The data indicate that detrimental changes are accumulating during protracted ischemia but for up to 90min this damage is not irreversible and hearts can still recover with proper treatment...
  15. ncbi request reprint Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes
    Rong Tao
    Cardiology Section, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Cardiovasc Res 74:56-63. 2007
    ....
  16. ncbi request reprint Adult cardiac fibroblasts null for sphingosine kinase-1 exhibit growth dysregulation and an enhanced proinflammatory response
    Rachid Kacimi
    Cardiology Research, Cardiology Section 111C5, VA Medical Center, San Francisco, CA 94121, USA
    J Mol Cell Cardiol 43:85-91. 2007
    ..We conclude that activation of endogenous SphK-1 serves a dual regulatory function: it is required for optimal cardiac fibroblast proliferation but is a negative modulator of proinflammatory responses during hypoxia...
  17. ncbi request reprint Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid: CoA ligases of human liver
    Donald A Vessey
    Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Biochem Mol Toxicol 18:100-6. 2004
    ..In contrast, the partial inhibition of the XM-ligases by triacsin C, which showed only a low-affinity component, did not require Mg(2+)...
  18. ncbi request reprint A rapid radioassay for sphingosine kinase
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Anal Biochem 337:136-42. 2005
    ..The utility of the assay is demonstrated by using it to conduct a complete bisubstrate kinetic analysis of rat heart SKase...
  19. ncbi request reprint Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria
    Donald A Vessey
    Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biochem Mol Toxicol 17:1-6. 2003
    ..5% homology to the bovine XL-I XM-ligase. The cDNA could be expressed in COS cells, and the expressed enzyme had greater benzoate activity than phenylacetate activity, which is consistent with the known substrate specificity of HXM-A...