gerald mizejewski

Summary

Affiliation: Wadsworth research Center
Location: Albany, New York, United States
Summary:
Physiology, Embryology, Biochemistry, Peptides, Fetal Proteins,Alpha-fetoprotein
Grants:
NONE
Publications:
1) Mizejewski, GJ, Mechanism of Cancer Growth of Alpha-fetoprotein Derived Growth Inhibitory Peptides(GIP): Comparison of GIP-34 versus GIP-8 (AFPep). Updates and Prospects. Cancers Vol-3: 2709-2733,2011.

Publications

  1. ncbi request reprint Fatty acids, alpha-fetoprotein, and cystic fibrosis
    G J Mizejewski
    Division of Molecular Medicine, Wadsworth Center, Department of Health, Albany, NY 12201, USA
    Pediatrics 108:1370-3. 2001
  2. ncbi request reprint Biological role of alpha-fetoprotein in cancer: prospects for anticancer therapy
    Gerald J Mizejewski
    Division of Molecular Medicine, Wadsworth Center for Laboratory and Research, NYS Health Dept, Empire State Plaza, Albany, NY 02201, USA
    Expert Rev Anticancer Ther 2:709-35. 2002
  3. ncbi request reprint Studies on a growth-inhibitory peptide derived from alpha-fetoprotein and some analogs
    L E Eisele
    Wadsworth Center, New York State Department of Health, Albany 12201-0509, USA
    J Pept Res 57:29-38. 2001
  4. ncbi request reprint Review of Growth Inhibitory Peptide as a biotherapeutic agent for tumor growth, adhesion, and metastasis
    M Muehlemann
    Serometrix Biotechnology, Syracuse, NY, USA
    Cancer Metastasis Rev 24:441-67. 2005
  5. ncbi request reprint Studies on analogs of a peptide derived from alpha-fetoprotein having antigrowth properties
    L E Eisele
    Wadsworth Center, New York State Department of Health, Albany, NY 12201-0500, USA
    J Pept Res 57:539-46. 2001
  6. ncbi request reprint Human alpha-fetoprotein peptides bind estrogen receptor and estradiol, and suppress breast cancer
    D Vakharia
    Division of Environmental Disease Prevention and Molecular Medicine, Wadsworth Center, NYS Department of Health, Albany, NY, USA
    Breast Cancer Res Treat 63:41-52. 2000
  7. ncbi request reprint Interrelationships among biological activity, disulfide bonds, secondary structure, and metal ion binding for a chemically synthesized 34-amino-acid peptide derived from alpha-fetoprotein
    R MacColl
    Wadsworth Center, New York State Department of Health, P O Box 509, Albany, NY 12201 0509, USA
    Biochim Biophys Acta 1528:127-34. 2001
  8. ncbi request reprint Phycoerythrin 545: monomers, energy migration, bilin topography, and monomer/dimer equilibrium
    R MacColl
    Wadsworth Center, New York State Department of Health, Albany, New York 12201 0509, USA
    Biochemistry 37:417-23. 1998
  9. ncbi request reprint Alpha-fetoprotein structure and function: relevance to isoforms, epitopes, and conformational variants
    G J Mizejewski
    Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany 12201, USA
    Exp Biol Med (Maywood) 226:377-408. 2001
  10. doi request reprint The adenocarcinoma cell surface mucin receptor for alpha-fetoprotein: is the same receptor present on circulating monocytes and macrophages? A commentary
    G J Mizejewski
    Division of Translational Medicine, Molecular Diagnostics Laboratory, New York State Department of Health, Wadsworth Center, Empire State Plaza, Albany, NY, 12201, USA
    Tumour Biol 35:7397-402. 2014

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Fatty acids, alpha-fetoprotein, and cystic fibrosis
    G J Mizejewski
    Division of Molecular Medicine, Wadsworth Center, Department of Health, Albany, NY 12201, USA
    Pediatrics 108:1370-3. 2001
    ....
  2. ncbi request reprint Biological role of alpha-fetoprotein in cancer: prospects for anticancer therapy
    Gerald J Mizejewski
    Division of Molecular Medicine, Wadsworth Center for Laboratory and Research, NYS Health Dept, Empire State Plaza, Albany, NY 02201, USA
    Expert Rev Anticancer Ther 2:709-35. 2002
    ....
  3. ncbi request reprint Studies on a growth-inhibitory peptide derived from alpha-fetoprotein and some analogs
    L E Eisele
    Wadsworth Center, New York State Department of Health, Albany 12201-0509, USA
    J Pept Res 57:29-38. 2001
    ..Peptide aggregation is critically important in establishing the ability of the peptide to inhibit growth and have anticancer activity, but the state of its two cysteines is of little influence...
  4. ncbi request reprint Review of Growth Inhibitory Peptide as a biotherapeutic agent for tumor growth, adhesion, and metastasis
    M Muehlemann
    Serometrix Biotechnology, Syracuse, NY, USA
    Cancer Metastasis Rev 24:441-67. 2005
    ....
  5. ncbi request reprint Studies on analogs of a peptide derived from alpha-fetoprotein having antigrowth properties
    L E Eisele
    Wadsworth Center, New York State Department of Health, Albany, NY 12201-0500, USA
    J Pept Res 57:539-46. 2001
    ..At trifluoroethanol concentrations of 20% and higher, the alanine and glycine peptides were changed into highly helical structures...
  6. ncbi request reprint Human alpha-fetoprotein peptides bind estrogen receptor and estradiol, and suppress breast cancer
    D Vakharia
    Division of Environmental Disease Prevention and Molecular Medicine, Wadsworth Center, NYS Department of Health, Albany, NY, USA
    Breast Cancer Res Treat 63:41-52. 2000
    ..The recent epidemiologic observation that high AFP levels in young pregnant women reduce their subsequent risk of postmenopausal breast cancer may be related to the growth suppressive property of AFP with the exposed P149 epitope...
  7. ncbi request reprint Interrelationships among biological activity, disulfide bonds, secondary structure, and metal ion binding for a chemically synthesized 34-amino-acid peptide derived from alpha-fetoprotein
    R MacColl
    Wadsworth Center, New York State Department of Health, P O Box 509, Albany, NY 12201 0509, USA
    Biochim Biophys Acta 1528:127-34. 2001
    ..This conformational flexibility may possibly be related to the biological activity of the peptide...
  8. ncbi request reprint Phycoerythrin 545: monomers, energy migration, bilin topography, and monomer/dimer equilibrium
    R MacColl
    Wadsworth Center, New York State Department of Health, Albany, New York 12201 0509, USA
    Biochemistry 37:417-23. 1998
    ..Ultrafast fluorescence using a two-photon method showed the fastest time for protein dimers to be 2. 4 ps and monomers had a 39-ps lifetime. Phycocyanin 645 was found to have a 550-fs lifetime...
  9. ncbi request reprint Alpha-fetoprotein structure and function: relevance to isoforms, epitopes, and conformational variants
    G J Mizejewski
    Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany 12201, USA
    Exp Biol Med (Maywood) 226:377-408. 2001
    ..In the present review, the various isoforms and variants of AFP are discussed in light of their potential biological relevance...
  10. doi request reprint The adenocarcinoma cell surface mucin receptor for alpha-fetoprotein: is the same receptor present on circulating monocytes and macrophages? A commentary
    G J Mizejewski
    Division of Translational Medicine, Molecular Diagnostics Laboratory, New York State Department of Health, Wadsworth Center, Empire State Plaza, Albany, NY, 12201, USA
    Tumour Biol 35:7397-402. 2014
    ..The secondary objective is to discuss the role of AFP and its derived peptides in the growth suppression of adenocarcinomas and lymphomas using the AFP-mucin receptor concept as a key to the mechanism of tumor growth inhibition. ..
  11. doi request reprint Review of the adenocarcinoma cell surface receptor for human alpha-fetoprotein; proposed identification of a widespread mucin as the tumor cell receptor
    G J Mizejewski
    Wadsworth Center, Division of Translational Medicine, New York State Department of Health, Empire State Plaza, Albany, NY, 12201, USA
    Tumour Biol 34:1317-36. 2013
    ....
  12. pmc Newborn screening for autism: in search of candidate biomarkers
    Gerald J Mizejewski
    Division of Translational Medicine, Wadsworth Center, NYS Department of Health, PO Box 509, Albany, NY 12201 0509, USA
    Biomark Med 7:247-60. 2013
    ..Autism is usually diagnosed in children 3-5 years of age using behavioral characteristics; thus, diagnosis shortly after birth would be beneficial for early initiation of treatment...
  13. doi request reprint Review of the putative cell-surface receptors for alpha-fetoprotein: identification of a candidate receptor protein family
    Gerald J Mizejewski
    Wadsworth Center, Division of Translational Medicine, New York State Department of Health, Empire State Plaza, Albany, NY 12201, USA
    Tumour Biol 32:241-58. 2011
    ..Present data do not support the concept that the AFP receptor is a "universal" tumor receptor and/or biomarker...
  14. doi request reprint Targeted delivery of anti-cancer growth inhibitory peptides derived from human alpha-fetoprotein: review of an International Multi-Center Collaborative Study
    G J Mizejewski
    Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, New York 12201, USA
    J Drug Target 18:575-88. 2010
    ..Following a discussion of the preceding results, a candidate cell surface receptor family was proposed which correlated with previous published reports for a putative AFP/GIP receptor...
  15. doi request reprint Can prenatal screening for fetal alcohol spectrum disorder be justified? A commentary
    G J Mizejewski
    Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201, USA
    Gynecol Obstet Invest 69:128-30. 2010
    ....
  16. doi request reprint Alpha-fetoprotein (AFP)-derived peptides as epitopes for hepatoma immunotherapy: a commentary
    Gerald J Mizejewski
    Diagnostic Oncology and Fetal Defects Section, Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    Cancer Immunol Immunother 58:159-70. 2009
    ....
  17. ncbi request reprint Physiology of alpha-fetoprotein as a biomarker for perinatal distress: relevance to adverse pregnancy outcome
    Gerald J Mizejewski
    The Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    Exp Biol Med (Maywood) 232:993-1004. 2007
    ..Hence, the present review was divided into two major sections: (I) AFP structure and function considerations and (II) the relationship of AFP levels to the distressed fetus during the third trimester and at term...
  18. ncbi request reprint The alpha-fetoprotein-derived growth inhibitory peptide 8-mer fragment: review of a novel anticancer agent
    Gerald J Mizejewski
    Diagnostic Oncology Section, Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    Cancer Biother Radiopharm 22:73-98. 2007
    ..Thus, it was proposed that the 8-mer fragment derived from GIP could potentially serve as a lead compound for targeted cancer therapeutic agents of the biologic-response modifier type...
  19. ncbi request reprint Anticancer versus antigrowth activities of three analogs of the growth-inhibitory peptide: relevance to physicochemical properties
    G J Mizejewski
    Wadsworth Center, New York State Department of Health, Albany, NY 12201 0509, USA
    Anticancer Res 26:3071-6. 2006
    ..Notably, the antigrowth assay failed to predict the marked anticancer activity of the analogs against a mammary tumor, indicating that the growth bioassay cannot always be relied upon as a screening protocol...
  20. ncbi request reprint Update of alpha fetoprotein growth-inhibitory peptides as biotherapeutic agents for tumor growth and metastasis
    G J Mizejewski
    Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    Chemotherapy 52:83-90. 2006
    ..It was concluded that the GIP derived from full-length AFP represents a growth-inhibitory motif possessing intrinsic properties that allow it to interact in cell surface events such as tumor proliferation, progression, and metastasis...
  21. ncbi request reprint Biological roles of alpha-fetoprotein during pregnancy and perinatal development
    Gerald J Mizejewski
    Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, New York 12201, USA
    Exp Biol Med (Maywood) 229:439-63. 2004
    ..The review concludes with a discussion of the place of AFP in the rapidly expanding field of proteomics...
  22. ncbi request reprint Levels of alpha-fetoprotein during pregnancy and early infancy in normal and disease states
    Gerald J Mizejewski
    Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany 12201, USA
    Obstet Gynecol Surv 58:804-26. 2003
    ..Based on its presence in so many types of birth defects, malformations, and congenital anomalies, AFP can be seen to serve as a form of molecular "duct tape" during pregnancy and postnatal development...
  23. ncbi request reprint Alpha-fetoprotein growth inhibitory peptides: potential leads for cancer therapeutics
    Gerald J Mizejewski
    Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    Mol Cancer Ther 2:1243-55. 2003
    ..Thus, it is proposed that the GIP, its analogues, and its fragment peptides can potentially serve as lead compounds for cancer therapeutics...
  24. ncbi request reprint Peptides as receptor ligand drugs and their relationship to G-coupled signal transduction
    G J Mizejewski
    Wadsworth Center, New York State Dept of Health, Empire State Plaza, Albany, NY 12201, USA
    Expert Opin Investig Drugs 10:1063-73. 2001
    ..The exploitation of such peptide-mediated signal pathways, which are of primary importance to tumour cells, may provide an attractive strategy for anticancer therapy in the future...
  25. ncbi request reprint Anti-prostate cancer and anti-breast cancer activities of two peptides derived from alpha-fetoprotein
    Gisela Caceres
    Rumbaugh Goodwin Institute for Cancer Research, Inc, 1850 NW 69th Avenue, Suite 5, Plantation, Florida 33313, USA
    Anticancer Res 22:2817-20. 2002
    ..A scrambled amino acid sequence of the peptide was used as a control in these tumor studies, and it had virtually no anti-cancer activity...
  26. ncbi request reprint Maternal serum transformed alpha-fetoprotein levels in women with intrauterine growth retardation
    Jose L Bartha
    Fetal Medicine Research Unit, Department of Obstetrics and Gynaecology, St Michael s Hospital, University of Bristol, Bristol, UK
    Fetal Diagn Ther 22:294-8. 2007
    ..To evaluate maternal serum transformed alpha-fetoprotein (t-AFP) levels in women with intrauterine growth retardation (IUGR)...