R Civitelli

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Genomic approaches to identifying transcriptional regulators of osteoblast differentiation
    Joseph P Stains
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Barnes Jewish Hospital, North Campus, 216 S, Kingshighway Blvd, St, Louis, MO 63110, USA
    Genome Biol 4:222. 2003
  2. ncbi request reprint Use of intravenous bisphosphonates in osteoporosis
    Roberto Civitelli
    Division of Bone and Mineral Diseases, Washington University in St Louis, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Curr Osteoporos Rep 5:8-13. 2007
  3. ncbi request reprint Epidemiology of glucocorticoid-induced osteoporosis
    R Civitelli
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis MO 63110, USA
    J Endocrinol Invest 31:2-6. 2008
  4. ncbi request reprint Alveolar and postcranial bone density in postmenopausal women receiving hormone/estrogen replacement therapy: a randomized, double-blind, placebo-controlled trial
    Roberto Civitelli
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, MO 63110, USA
    Arch Intern Med 162:1409-15. 2002
  5. ncbi request reprint Regulation of connexin43 expression and function by prostaglandin E2 (PGE2) and parathyroid hormone (PTH) in osteoblastic cells
    R Civitelli
    Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 68:8-21. 1998
  6. ncbi request reprint Gap junctional communication modulates gene transcription by altering the recruitment of Sp1 and Sp3 to connexin-response elements in osteoblast promoters
    Joseph P Stains
    Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 278:24377-87. 2003
  7. doi request reprint Bone turnover markers: understanding their value in clinical trials and clinical practice
    R Civitelli
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, 660 S Euclid Ave, PO Box 8301, St Louis, MO 63110, USA
    Osteoporos Int 20:843-51. 2009
  8. ncbi request reprint Differential regulation of cadherins by dexamethasone in human osteoblastic cells
    F Lecanda
    Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 77:499-506. 2000
  9. ncbi request reprint Alveolar bone height and postcranial bone mineral density: negative effects of cigarette smoking and parity
    C F Hildebolt
    Department of Radiology, Washington University School of Medicine, St Louis, MO, USA
    J Periodontol 71:683-9. 2000
  10. ncbi request reprint Connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cells
    J G Laing
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 276:23051-5. 2001

Collaborators

Detail Information

Publications53

  1. pmc Genomic approaches to identifying transcriptional regulators of osteoblast differentiation
    Joseph P Stains
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Barnes Jewish Hospital, North Campus, 216 S, Kingshighway Blvd, St, Louis, MO 63110, USA
    Genome Biol 4:222. 2003
    ..These findings help unravel the pattern of gene-expression changes that underly the complex process of bone formation...
  2. ncbi request reprint Use of intravenous bisphosphonates in osteoporosis
    Roberto Civitelli
    Division of Bone and Mineral Diseases, Washington University in St Louis, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Curr Osteoporos Rep 5:8-13. 2007
    ..This alternative approach holds promise for improved outcomes of osteoporosis treatment and ultimately for reduced health care costs related to caring for people with fragility fractures...
  3. ncbi request reprint Epidemiology of glucocorticoid-induced osteoporosis
    R Civitelli
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis MO 63110, USA
    J Endocrinol Invest 31:2-6. 2008
    ..The rapid and profound bone loss that occurs after initiation of glucocorticoid therapy has some very practical implications with regards to the site and the timing of bone mineral density measurements and fracture prevention strategies...
  4. ncbi request reprint Alveolar and postcranial bone density in postmenopausal women receiving hormone/estrogen replacement therapy: a randomized, double-blind, placebo-controlled trial
    Roberto Civitelli
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, MO 63110, USA
    Arch Intern Med 162:1409-15. 2002
    ....
  5. ncbi request reprint Regulation of connexin43 expression and function by prostaglandin E2 (PGE2) and parathyroid hormone (PTH) in osteoblastic cells
    R Civitelli
    Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 68:8-21. 1998
    ..Modulation of intercellular communication represents a novel mechanism by which osteotropic factors regulate the activity of bone forming cells...
  6. ncbi request reprint Gap junctional communication modulates gene transcription by altering the recruitment of Sp1 and Sp3 to connexin-response elements in osteoblast promoters
    Joseph P Stains
    Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 278:24377-87. 2003
    ..Thus, regulation of Sp1/Sp3 recruitment to the promoter may represent a potential general mechanism for transcriptional control of target genes by signals passing through gap junctions...
  7. doi request reprint Bone turnover markers: understanding their value in clinical trials and clinical practice
    R Civitelli
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, 660 S Euclid Ave, PO Box 8301, St Louis, MO 63110, USA
    Osteoporos Int 20:843-51. 2009
    ..Thus, although BTMs are currently confined to clinical research applications, further improvement in assay precision may extend their diagnostic value in clinical settings...
  8. ncbi request reprint Differential regulation of cadherins by dexamethasone in human osteoblastic cells
    F Lecanda
    Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 77:499-506. 2000
    ..Dexamethasone effects on certain osteoblast differentiated features, such as induction of alkaline phosphatase activity are not strictly dependent on cadherin function...
  9. ncbi request reprint Alveolar bone height and postcranial bone mineral density: negative effects of cigarette smoking and parity
    C F Hildebolt
    Department of Radiology, Washington University School of Medicine, St Louis, MO, USA
    J Periodontol 71:683-9. 2000
    ....
  10. ncbi request reprint Connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cells
    J G Laing
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 276:23051-5. 2001
    ....
  11. ncbi request reprint Connexin45 interacts with zonula occludens-1 in osteoblastic cells
    J G Laing
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Commun Adhes 8:209-12. 2001
    ..Furthermore we found that ZO-1 could bind to peptides derived from the carboxyl terminal of Cx45 that had been covalently bound to an agarose resin. These data suggests that Cx45 and ZO-1 directly interact in ROS/Cx45 cells...
  12. ncbi request reprint Regulation of alphaVbeta3 and alphaVbeta5 integrins by dexamethasone in normal human osteoblastic cells
    S L Cheng
    Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 77:265-76. 2000
    ....
  13. pmc Serotonin-norepinephrine reuptake inhibitor therapy in late-life depression is associated with increased marker of bone resorption
    M L O Shea
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Osteoporos Int 24:1741-9. 2013
    ..Bone resorption increased after antidepressant treatment, which may increase fracture risk...
  14. ncbi request reprint Calcium and phosphate homeostasis: concerted interplay of new regulators
    R Civitelli
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Endocrinol Invest 34:3-7. 2011
    ..Transgenic mouse models have been of great value in the elucidation of Klotho and FGF23 function. This review highlights current knowledge into calcium and phosphate homeostasis in health and disease...
  15. ncbi request reprint Sequence and structure of the mouse connexin45 gene
    D Baldridge
    Department of Internal Medicine, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri, USA
    Biosci Rep 21:683-9. 2001
    ....
  16. ncbi request reprint Proliferation, differentiation and apoptosis in connexin43-null osteoblasts
    F Furlan
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Cell Commun Adhes 8:367-71. 2001
    ..These observations suggest that Cx43 is important for a normal and timely development of the osteoblastic phenotype. Delayed differentiation and increase programmed cell death may explain the skeletal phenotype of Cx43-null mice...
  17. pmc Alveolar bone measurement precision for phosphor-plate images
    Charles F Hildebolt
    Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:e96-107. 2009
    ..The aim was to demonstrate methods for determining measurement precision and to determine the precision of alveolar bone measurements made with a vacuum-coupled positioning device and phosphor plate images...
  18. pmc Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction
    F Lecanda
    Divisions of Bone and Mineral and Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Cell Biol 151:931-44. 2000
    ..Cell to cell signaling, mediated by Cx43 gap junctions, was critical for normal osteogenesis, craniofacial development, and osteoblastic function...
  19. ncbi request reprint Accentuated ovariectomy-induced bone loss and altered osteogenesis in heterozygous N-cadherin null mice
    Chung Fang Lai
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington School of Medicine, St Louis, Missouri 63110, USA
    J Bone Miner Res 21:1897-906. 2006
    ....
  20. ncbi request reprint Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43
    Dong Jin Chung
    Division of Bone and Mineral Diseases, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Cell Sci 119:4187-98. 2006
    ..In conclusion, lack of Cx43 in osteoblasts leads to suboptimal acquisition of peak bone mass, and hinders the bone anabolic effect of PTH. Cx43 represents a potential target for modulation of bone anabolism...
  21. ncbi request reprint Role of connexin43 in osteoblast response to physical load
    Susan K Grimston
    Division of Bone and Mineral Diseases, Washington University in St Louis, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1068:214-24. 2006
    ..Taken together, these results indicate that deficiency of Cx43 in osteoblasts attenuates but does not abolish anabolic responses to mechanical strain...
  22. ncbi request reprint Bone loss after temporarily induced muscle paralysis by Botox is not fully recovered after 12 weeks
    Susan K Grimston
    Division of Bone and Mineral Diseases, Washington University in Saint Louis, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1116:444-60. 2007
    ..These results underscore the significance of normal muscle function in the maintenance of bone mass...
  23. ncbi request reprint Effects of dietary calcium compared with calcium supplements on estrogen metabolism and bone mineral density
    Nicola Napoli
    Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 85:1428-33. 2007
    ..High calcium intake has been associated with both high bone mineral density (BMD) and high urinary estrogen metabolites. However, the role of dietary calcium and calcium supplements on estrogen metabolism and BMD remains unknown...
  24. ncbi request reprint Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment
    Stine D Ohlendorff
    Department of Endocrinology, The Osteoporosis and Metabolic Research Unit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
    Pharmacogenet Genomics 17:555-67. 2007
    ..The aim of this study was to determine the presence of polymorphisms in exon 13 of the P2X7 gene and the association with osteoclast apoptosis in vitro and bone status in vivo...
  25. ncbi request reprint Safety considerations with bisphosphonates for the treatment of osteoporosis
    William Strampel
    Michigan State University College of Osteopathic Medicine, East Lansing, Michigan 48824 1316, USA
    Drug Saf 30:755-63. 2007
    ..By being aware of other potential safety issues, such as renal impairment, influenza-like illness and osteonecrosis of the jaw, physicians can detect these AEs early in the course of treatment...
  26. pmc The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans
    Radoslaw Dobrowolski
    Institute of Genetics, University of Bonn, Germany
    Hum Mol Genet 17:539-54. 2008
    ..Our results suggest that the increased activity of ATP-releasing channels in Cx43G138R mutated cardiomyocytes may further reduce the already decreased gap junctional communication and thus aggravate arrhythmogenesis in the mouse mutant...
  27. ncbi request reprint Efficacy and tolerability of intravenous ibandronate injections in postmenopausal osteoporosis: 2-year results from the DIVA study
    John A Eisman
    Garvan Institute of Medical Research, St Vincent s Campus and University of New South Wales, Sydney, Australia
    J Rheumatol 35:488-97. 2008
    ..We report the effects on lumbar spine and proximal femur bone mineral density (BMD) and bone resorption markers over 2 years...
  28. pmc Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1)
    Susan K Grimston
    Division of Bone and Mineral Disease, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bone Miner Res 23:879-86. 2008
    ..We tested this hypothesis in vivo in a model of genetic deficiency of the Cx43 gene (Gja1)...
  29. ncbi request reprint Weightlessness and skeleton homeostasis
    Konstantinos Ziambaras
    Department of Endocrinology, University of Crete Medical School, Iraklion, Grete, Greece
    Hormones (Athens) 4:18-27. 2005
    ..Although negative calcium balance and bone loss have been observed in all the aforementioned models of skeletal unloading, the exact mechanism(s) by which this occurs are still unknown and mainly speculative...
  30. ncbi request reprint Gap junctions in skeletal development and function
    Joseph P Stains
    University of Maryland School of Medicine, Department of Orthopaedics, Baltimore, MD 21201, USA
    Biochim Biophys Acta 1719:69-81. 2005
    ..A common theme is that without connexins none of the cells of bone function properly. Thus, connexins play an important role in skeletal form and function...
  31. pmc Cell-cell communication in the osteoblast/osteocyte lineage
    Roberto Civitelli
    Washington University in St Louis, Department of Internal Medicine, Division of Bone and Mineral Diseases, 660 S Euclid Avenue, P O Box 8301, St Louis, MO 63110, USA
    Arch Biochem Biophys 473:188-92. 2008
    ..Hence, Cx43 is involved in skeletal responsiveness to anabolic signals, as those provided by parathyroid hormone and physical load, the latter function probably involving osteocyte-osteoblast communication...
  32. ncbi request reprint Relationships between clinical attachment level and spine and hip bone mineral density: data from healthy postmenopausal women
    Thomas K Pilgram
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Periodontol 73:298-301. 2002
    ..There are physiological reasons to expect an association between bone mineral density of the spine and hip and attachment loss. To this point, however, most studies have found no correlation...
  33. ncbi request reprint The pattern of alveolar crest height change in healthy postmenopausal women after 3 years of hormone/estrogen replacement therapy
    Charles F Hildebolt
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Periodontol 73:1279-84. 2002
    ..The objective of the study was to determine if the positive effect of HRT/ERT on alveolar crest height (ACH) is generalized or site specific...
  34. ncbi request reprint Development of mice with osteoblast-specific connexin43 gene deletion
    Charles H M Castro
    Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Commun Adhes 10:445-50. 2003
    ..Selective Cre mediated Cx43 gene inactivation in bone forming cells will be useful to determine the role of Cx43 in adult skeletal homeostasis and overcome the perinatal lethality of the conventional null model...
  35. ncbi request reprint Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis
    Charlles H M Castro
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, 216 S Kingshighway Blvd, St Louis, MO 63110, USA
    J Cell Sci 117:2853-64. 2004
    ..This results in decreased bone formation, delayed acquisition of peak bone mass and increased body fat...
  36. ncbi request reprint Estrogen and/or calcium plus vitamin D increase mandibular bone mass
    Charles F Hildebolt
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Periodontol 75:811-6. 2004
    ..Here we report on mandibular bone mass for 49 women (of the original cohort of 135) who continued in an additional 2-year, open-label extension...
  37. ncbi request reprint The oxidative metabolism of estrogen modulates response to ERT/HRT in postmenopausal women
    Reina C Armamento-Villareal
    Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Bone 35:682-8. 2004
    ..Thus, women with estrogen metabolism favoring the 2-hydroxylation pathway respond favorably to ERT/HRT...
  38. ncbi request reprint Intravenous ibandronate injections in postmenopausal women with osteoporosis: one-year results from the dosing intravenous administration study
    Pierre D Delmas
    Université Claude Bernard Lyon 1 and INSERM Research Unit 403, Lyon, France
    Arthritis Rheum 54:1838-46. 2006
    ..The aim of this study was to identify the optimal intravenous dosing regimen for ibandronate in postmenopausal women with osteoporosis...
  39. pmc Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription
    Joseph P Stains
    Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, MO 63110, USA
    Mol Biol Cell 16:64-72. 2005
    ....
  40. pmc Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation
    Gabriel Mbalaviele
    Division of Bone and Mineral Diseases, Department of Internal Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 94:403-18. 2005
    ..In vivo, this synergism leads to increased new bone formation...
  41. ncbi request reprint Cell-to-cell interactions in bone
    Joseph P Stains
    Division of Bone and Mineral Diseases, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, MO, USA
    Biochem Biophys Res Commun 328:721-7. 2005
    ..This review examines the current knowledge of how direct cell-to-cell interactions modulate osteoblast function...
  42. ncbi request reprint Increased prevalence of celiac disease and need for routine screening among patients with osteoporosis
    William F Stenson
    Divisions of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 165:393-9. 2005
    ..However, the relative prevalence of celiac disease among osteoporotic and nonosteoporotic populations is not known, and the benefit of screening the osteoporotic population for celiac disease remains controversial...
  43. ncbi request reprint Cell-cell interactions in regulating osteogenesis and osteoblast function
    Joseph P Stains
    Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Birth Defects Res C Embryo Today 75:72-80. 2005
    ..This review examines the role of cell-cell interactions mediated by adherens junctions formed by cadherins and communicative gap junctions formed by connexins in regulating bone development and osteogenic function...
  44. ncbi request reprint A new concept for bisphosphonate therapy: a rationale for the development of monthly oral dosing of ibandronate
    Jean Yves Reginster
    Unite d Exploration du Metabolisme de l Os et du Cartilage, CHU Centre Ville, Liege, Belgium
    Osteoporos Int 17:159-66. 2006
    ..Greater convenience and tolerability may enhance the therapy adherence and, hence, improve long-term therapeutic outcomes in PMO...
  45. ncbi request reprint A new selective estrogen receptor modulator, CHF 4227.01, preserves bone mass and microarchitecture in ovariectomized rats
    Reina Armamento-Villareal
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Bone Miner Res 20:2178-88. 2005
    ..01, given to 6-month-old female rats immediately after ovariectomy, preserved bone mass and bone microarchitecture without affecting uterus weight. It also decreased serum cholesterol and fat mass in estrogen-deficient rats...
  46. pmc Heterogeneous nuclear ribonucleoprotein K represses transcription from a cytosine/thymidine-rich element in the osteocalcin promoter
    Joseph P Stains
    Division of Bone and Mineral Diseases, Washington University School of Medicine, and Barnes Jewish Hospital, St Louis, MO, USA
    Biochem J 385:613-23. 2005
    ..Rather, hnRNP K represses osteocalcin gene transcription by inhibiting the formation of a transcriptional complex on the CT element of the osteocalcin promoter...
  47. ncbi request reprint Activation of L-type calcium channels is required for gap junction-mediated intercellular calcium signaling in osteoblastic cells
    Niklas Rye Jørgensen
    Osteoporosis and Metabolic Bone Unit, Department of Endocrinology, Copenhagen University Hospitals, Copenhagen Hospital Corporation DK 2650 Hvidovre, Denmark
    J Biol Chem 278:4082-6. 2003
    ..In human osteoblastic cells, gap junction-dependent ICW also required activation of L-type calcium channels and influx of extracellular calcium...
  48. ncbi request reprint Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass
    Michael R McClung
    Oregon Osteoporosis Center, Providence Portland Medical Center, Portland, OR 97213, USA
    Arch Intern Med 165:1762-8. 2005
    ..We contrasted the effects of once-daily doses of 20 mug of teriparatide and 10 mg of alendronate sodium on bone mineral density (BMD) and markers of bone turnover...
  49. ncbi request reprint Cell-cell adhesion and signaling through cadherins: connecting bone cells in their microenvironment
    Gabriel Mbalaviele
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University, St Louis, Missouri 63110, USA
    J Bone Miner Res 21:1821-7. 2006
  50. ncbi request reprint Intercellular calcium signaling occurs between human osteoblasts and osteoclasts and requires activation of osteoclast P2X7 receptors
    Niklas R Jørgensen
    Osteoporosis Research Clinic, Dept 545, Copenhagen University Hospital Hvidovre, Kettegaard Alle 30, Hvidovre DK 2650, Denmark
    J Biol Chem 277:7574-80. 2002
    ..P2 receptors may be important drug targets for the modulation of bone turnover...
  51. pmc The pro-osteogenic action of beta-catenin requires interaction with BMP signaling, but not Tcf/Lef transcriptional activity
    Valerie S Salazar
    Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 104:942-52. 2008
    ..These data suggest that cooperative interactions between beta-catenin and BMP signaling systems drive osteoblast cell fate specification and differentiation...
  52. ncbi request reprint Dominant negative N-cadherin inhibits osteoclast differentiation by interfering with beta-catenin regulation of RANKL, independent of cell-cell adhesion
    Chan Soo Shin
    Department of Internal Medicine, Seoul National University College of Medicine, Korea
    J Bone Miner Res 20:2200-12. 2005
    ..NCadDeltaC inhibited beta-catenin/TCF signaling, resulting in decreased RANKL expression, which could contribute to the reduced osteoclast formation...