GERALD DORN

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint Gone fission…: diverse consequences of cardiac Drp1 deficiency.
    Gerald W Dorn
    From the Department of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St Louis, MO
    Circ Res 116:225-8. 2015
  2. pmc Central Parkin: The evolving role of Parkin in the heart
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, United States Electronic address
    Biochim Biophys Acta 1857:1307-12. 2016
  3. pmc Parkin-dependent mitophagy in the heart
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, United States Electronic address
    J Mol Cell Cardiol 95:42-9. 2016
  4. pmc Mitochondrial dynamism and heart disease: changing shape and shaping change
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    EMBO Mol Med 7:865-77. 2015
  5. pmc The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble
    Gerald W Dorn
    From the Department of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St Louis, MO G W D and Departments of Medicine Cardiology and Cell Biology and Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY R N K
    Circ Res 116:167-82. 2015
  6. pmc Functional implications of mitofusin 2-mediated mitochondrial-SR tethering
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA Electronic address
    J Mol Cell Cardiol 78:123-8. 2015
  7. pmc MicroRNAs and the butterfly effect
    Gerald W Dorn
    Center for Pharmacogenomics Department of Internal Medicine Washington University School of Medicine St Louis, MO USA
    Cell Cycle 12:707-8. 2013
  8. pmc Two rare human mitofusin 2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology in Drosophila
    William H Eschenbacher
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e44296. 2012
  9. ncbi request reprint Mitochondrial dynamism and cardiac fate--a personal perspective
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ J 77:1370-9. 2013
  10. pmc miR-34a and the cardiomyopathy of senescence: SALT PNUTS, SALT PNUTS!
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Metab 17:629-30. 2013

Collaborators

Detail Information

Publications57

  1. doi request reprint Gone fission…: diverse consequences of cardiac Drp1 deficiency.
    Gerald W Dorn
    From the Department of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St Louis, MO
    Circ Res 116:225-8. 2015
  2. pmc Central Parkin: The evolving role of Parkin in the heart
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, United States Electronic address
    Biochim Biophys Acta 1857:1307-12. 2016
    ..This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016. ..
  3. pmc Parkin-dependent mitophagy in the heart
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, United States Electronic address
    J Mol Cell Cardiol 95:42-9. 2016
    ..Recent findings have also uncovered an unsuspected role for Parkin-mediated mitochondrial turnover in the normal perinatal transformation of myocardial metabolism. ..
  4. pmc Mitochondrial dynamism and heart disease: changing shape and shaping change
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    EMBO Mol Med 7:865-77. 2015
    ....
  5. pmc The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble
    Gerald W Dorn
    From the Department of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St Louis, MO G W D and Departments of Medicine Cardiology and Cell Biology and Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY R N K
    Circ Res 116:167-82. 2015
    ....
  6. pmc Functional implications of mitofusin 2-mediated mitochondrial-SR tethering
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA Electronic address
    J Mol Cell Cardiol 78:123-8. 2015
    ..This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease."..
  7. pmc MicroRNAs and the butterfly effect
    Gerald W Dorn
    Center for Pharmacogenomics Department of Internal Medicine Washington University School of Medicine St Louis, MO USA
    Cell Cycle 12:707-8. 2013
    ..Comment on: Hu X, et al. Proc Natl Acad Sci USA 2012; 109:19864-9...
  8. pmc Two rare human mitofusin 2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology in Drosophila
    William H Eschenbacher
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e44296. 2012
    ....
  9. ncbi request reprint Mitochondrial dynamism and cardiac fate--a personal perspective
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ J 77:1370-9. 2013
    ....
  10. pmc miR-34a and the cardiomyopathy of senescence: SALT PNUTS, SALT PNUTS!
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Metab 17:629-30. 2013
    ..In a recent Nature paper, Boon et al. (2013) describe DNA damage mechanisms and cardiac senescence provoked by miR-34a and its target, PNUTS. Interrupting this pathway may prevent age- and stress-induced cardiac degeneration...
  11. doi request reprint Molecular mechanisms that differentiate apoptosis from programmed necrosis
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Toxicol Pathol 41:227-34. 2013
    ..Here, the different molecular mechanisms, effects, and pathophysiological implications of apoptosis and programmed necrosis are reviewed as they relate to heart failure and diabetes mediated by the Bcl-2 family protein, Nix...
  12. doi request reprint SR and mitochondria: calcium cross-talk between kissing cousins
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Mol Cell Cardiol 55:42-9. 2013
    ..This article is part of a Special Issue entitled "Focus on Cardiac Metabolism"...
  13. pmc Mitochondrial dynamics in heart disease
    Gerald W Dorn
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Biochim Biophys Acta 1833:233-41. 2013
    ..This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology...
  14. pmc A human 3' miR-499 mutation alters cardiac mRNA targeting and function
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine and Center for Pharmacogenomics, 660 S Euclid Ave, Campus Box 8220, St Louis, MO 63110, USA
    Circ Res 110:958-67. 2012
    ..Sequence complementarity between miRs and their mRNA targets determines miR effects, but the functional consequences of human myomiR sequence variants are unknown...
  15. pmc Decoding the cardiac message: the 2011 Thomas W. Smith Memorial Lecture
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Circ Res 110:755-63. 2012
    ....
  16. pmc Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factors
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Cardiovasc Transl Res 3:374-83. 2010
    ....
  17. pmc Mitochondrial fusion is essential for organelle function and cardiac homeostasis
    Yun Chen
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 109:1327-31. 2011
    ..Mitochondrial fusion has not been observed in postmitotic myocytes of adult hearts, and its occurrence and function in this context are controversial...
  18. pmc The genomic architecture of sporadic heart failure
    Gerald W Dorn
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 108:1270-83. 2011
    ..It is likely that common gene polymorphisms account for only a fraction of individual genetic heart failure risk, and future studies using deep resequencing are likely to identify rare gene variants with larger biological effects...
  19. doi request reprint Genetics of common forms of heart failure
    Gerald W Dorn
    Department of Internal Medicine, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Curr Opin Cardiol 26:204-8. 2011
    ..Here, new results from candidate gene and genome-wide polymorphism studies that have delineated associations between polymorphic genes and heart failure are reviewed in the context of their likely clinical translation and implementation...
  20. pmc MicroRNAs in cardiac disease
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA
    Transl Res 157:226-35. 2011
    ..These advances establish a foundation for novel diagnostics and new therapeutic approaches for myocardial infarction, cardiac hypertrophy, and heart failure...
  21. pmc MicroRNAs: redefining mechanisms in cardiac disease
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Cardiovasc Pharmacol 56:589-95. 2010
    ....
  22. pmc MARF and Opa1 control mitochondrial and cardiac function in Drosophila
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 108:12-7. 2011
    ..The role of mitochondrial fusion in functioning of the heart, where mitochondria comprise ≈30% of cardiomyocyte volume and their intermyofilament spatial arrangement with other mitochondria is highly ordered, is unknown...
  23. pmc Nix Nought Nothing: fairy tale or real deal
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Mol Cell Cardiol 51:497-500. 2011
    ..This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure."..
  24. pmc Two close, too close: sarcoplasmic reticulum-mitochondrial crosstalk and cardiomyocyte fate
    Gerald W Dorn
    Washington University Center for Pharmacogenomics, Campus Box 8220, 660 S Euclid Ave, St Louis, MO 63110, USA
    Circ Res 107:689-99. 2010
    ..Here, we review our present understanding of the structural basis and the functional consequences of the close interaction between sarcoplasmic reticulum and mitochondria on cardiomyocyte function and death...
  25. pmc Mechanisms of non-apoptotic programmed cell death in diabetes and heart failure
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Cell Cycle 9:3442-8. 2010
    ..The current state of research in this area is reviewed, focusing upon new findings describing the role of programmed necrosis induced by the mitochondrial permeability transition in mouse models of heart failure and diabetes...
  26. doi request reprint Adrenergic signaling polymorphisms and their impact on cardiovascular disease
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Physiol Rev 90:1013-62. 2010
    ....
  27. doi request reprint Therapeutic potential of microRNAs in heart failure
    Gerald W Dorn
    Washington University Center for Pharmacogenomics, 660 South Euclid Avenue, Campus Box 8220, St Louis, MO 63110, USA
    Curr Cardiol Rep 12:209-15. 2010
    ..miRs are attractive nodal therapeutic targets, and stable miR mimetics (agomiRs) and antagonists (antagomiRs) are being evaluated to prevent or reverse heart failure...
  28. pmc Pharmacogenetic profiling in the treatment of heart disease
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Transl Res 154:295-302. 2009
    ....
  29. pmc Having a change of heart: reversing the suicidal proclivities of cardiac myocytes
    Gerald W Dorn
    Washington University Center for Pharmacogenomics, 660 S Euclid Ave, Campus Box 8086, St Louis, MO 63110, USA
    Trans Am Clin Climatol Assoc 120:189-98. 2009
    ..Since these apoptotic genes are similarly dysregulated in human heart disease, the stage is set for a new era of therapeutics targeting cardiac suicide genes and their products...
  30. doi request reprint GRK mythology: G-protein receptor kinases in cardiovascular disease
    Gerald W Dorn
    Center for Pharmacogenomics, Washington University, 660 S Euclid Ave, Campus Box 8086, St Louis, MO 63110, USA
    J Mol Med (Berl) 87:455-63. 2009
    ..Here, recent developments are reviewed, with an emphasis on novel GRK functions and signaling pathways...
  31. doi request reprint Novel pharmacotherapies to abrogate postinfarction ventricular remodeling
    Gerald W Dorn
    Center for Pharmacogenomics, Washington University, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Nat Rev Cardiol 6:283-91. 2009
    ..Therapeutic targeting of multiple organ systems involved in recovery after myocardial infarction might prove to be the best approach to improve patients' cardiac outcome...
  32. doi request reprint The rationale for cardiomyocyte resuscitation in myocardial salvage
    Gerald W Dorn
    Center for Pharmacogenomics, Washington University, St Louis, MO 63110, USA
    J Mol Med (Berl) 86:1085-95. 2008
    ..Cardiomyocyte resuscitation by preventing programmed cell death shows promise as an additive approach to minimizing necrosis for long-term prevention of heart failure...
  33. pmc Receptor-independent cardiac protein kinase Calpha activation by calpain-mediated truncation of regulatory domains
    Min Young Kang
    Washington University Center for Pharmacogenomics, St Louis, MO 63110, USA
    Circ Res 107:903-12. 2010
    ..Ischemia produces calcium overload that activates calpains and conventional PKCs. However, calpains can proteolytically process PKCs, and the potential in vivo consequences of this interaction are unknown...
  34. pmc G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure
    Philip W Raake
    Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, 1025 Walnut St, Philadelphia, PA 19107, USA
    Circ Res 103:413-22. 2008
    ....
  35. pmc Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling
    Gerald W Dorn
    Center for Pharmacogenomics and Cardiovascular Division, Department of Internal Medicine, Washington University, 660 S Euclid Ave, Campus Box 8086, St Louis, MO 63110, USA
    Cardiovasc Res 81:465-73. 2009
    ..The major focus of this review is on apoptosis in heart failure, with a discussion of molecular cross-talk between apoptosis, autophagy, and programmed necrosis...
  36. pmc Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death
    Abhinav Diwan
    Center for Pharmacogenomics, Washington University in St Louis, St Louis, MO 63110, USA
    J Clin Invest 119:203-12. 2009
    ..These results establish a new function for NIX as an integrator of transcriptional and calcium-mediated signals for programmed cell death...
  37. ncbi request reprint Distinct pathways regulate proapoptotic Nix and BNip3 in cardiac stress
    Anita S Galvez
    Department of Internal Medicine, University of Cincinnati, Cincinnati Ohio 45267 0542, USA
    J Biol Chem 281:1442-8. 2006
    ..BNip3 is hypoxia-inducible, whereas Nix expression was induced by G alpha(q)-mediated hypertrophic stimuli. PKC alpha, a G(q) effector, transduced Nix transcriptional induction via Sp1...
  38. pmc A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure
    Stephen B Liggett
    Department of Internal Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, Ohio 45267, USA
    Nat Med 14:510-7. 2008
    ....
  39. pmc Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support
    Scot J Matkovich
    Center for Pharmacogenomics, Washington University, St Louis, MO 63110, USA
    Circulation 119:1263-71. 2009
    ....
  40. pmc Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University, St Louis, Missouri, USA
    Mol Pharmacol 76:466-80. 2009
    ....
  41. ncbi request reprint Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy
    Harvey S Hahn
    Department of Internal Medicine, University of Cincinnati Medical Center, 231 Albert B Sabin Way, Cincinnati, Ohio 45267 0542, USA
    Circ Res 93:1111-9. 2003
    ..These results define pathological roles for PKCalpha as a negative regulator of ventricular systolic and diastolic function...
  42. pmc Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes
    Kei Fujimoto
    Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 120:4031-9. 2010
    ..These results establish Nix as a critical mediator of β cell apoptosis and programmed necrosis in Pdx1-deficient diabetes...
  43. ncbi request reprint Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure
    Jeanne Mialet Perez
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Nat Med 9:1300-5. 2003
    ....
  44. ncbi request reprint Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic mice
    Yukihiro Hayakawa
    Program in Molecular Cardiology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Circulation 108:3036-41. 2003
    ..To test whether apoptosis is causally linked to heart failure, we assessed whether inhibiting this cell death would improve left ventricular function and survival in the Galpha(q) peripartum cardiomyopathy model...
  45. ncbi request reprint Manipulating cardiac contractility in heart failure: data from mice and men
    Gerald W Dorn
    Department of Internal Medicine, Division of Cardiology, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
    Circulation 109:150-8. 2004
  46. ncbi request reprint Adrenergic pathways and left ventricular remodeling
    Gerald W Dorn
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0542, USA
    J Card Fail 8:S370-3. 2002
    ..These catecholamines activate cardiomyocyte alpha- and beta-adrenergic receptors which, although responsive to the same hormonal ligands, stimulate almost entirely distinct signaling pathways with different end organ results...
  47. ncbi request reprint Ischemic protection and myofibrillar cardiomyopathy: dose-dependent effects of in vivo deltaPKC inhibition
    Harvey S Hahn
    Department of Internal Medicine, Division of Cardiology, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0542, USA
    Circ Res 91:741-8. 2002
    ....
  48. ncbi request reprint Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia
    Faisal M Syed
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Circ Res 96:1103-9. 2005
    ....
  49. ncbi request reprint Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy
    Martin G Yussman
    Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
    Nat Med 8:725-30. 2002
    ..Thus, Nix/Bnip3L is upregulated in myocardial hypertrophy, and is both necessary and sufficient for Gq-mediated apoptosis of cardiomyocytes and resulting hypertrophy decompensation...
  50. pmc Clinical and genetic modifiers of long-term survival in heart failure
    Sharon Cresci
    Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Coll Cardiol 54:432-44. 2009
    ..This study sought to identify genetic modifiers of beta-blocker response and long-term survival in heart failure (HF)...
  51. pmc MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts
    Scot J Matkovich
    Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 106:166-75. 2010
    ..Because miR-133a levels decrease during reactive cardiac hypertrophy, some have considered that restoring miR-133a levels could suppress hypertrophic remodeling...
  52. pmc Deep mRNA sequencing for in vivo functional analysis of cardiac transcriptional regulators: application to Galphaq
    Scot J Matkovich
    Department of Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 106:1459-67. 2010
    ..Transcriptional profiling can detect subclinical heart disease and provide insight into disease etiology and functional status. Current microarray-based methods are expensive and subject to artifact...
  53. pmc Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy
    Yun Chen
    Department of Medicine, Center for Pharmacogenomics, and Departments of Medicine and Pathology and Immunology, Division of Molecular Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:9035-42. 2010
    ..Complete protection against programmed cell death mediated by Nix and related factors can be achieved by simultaneous inhibition of both pathways...
  54. pmc RISC RNA sequencing for context-specific identification of in vivo microRNA targets
    Scot J Matkovich
    Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 108:18-26. 2011
    ..One miR can target hundreds of individual mRNAs, but existing methodologies are not sufficient to accurately and comprehensively identify these mRNA targets in vivo...
  55. ncbi request reprint A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure
    Stephen B Liggett
    Department of Medicine, Cardiopulmonary Genomics Program, University of Maryland, Baltimore, MD, USA
    Hum Mol Genet 16:2740-50. 2007
    ..Thus, the GNAQ -694/-695 promoter polymorphism alters transcription factor binding, increases promoter activity and adversely affects outcome in human heart failure...
  56. pmc An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice
    Farah Sheikh
    Department of Medicine, UCSD, La Jolla, California 92093, USA
    J Clin Invest 118:3870-80. 2008
    ..These studies shed light on the physiological regulation of the sarcomere in response to hypertrophic stress...
  57. ncbi request reprint Signaling pathways involved in left ventricular remodeling: summation
    Gerald W Dorn
    Section of Cardiology, Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    J Card Fail 8:S387-8. 2002