Isidro Hötzel

Summary

Affiliation: Washington State University
Country: USA

Publications

  1. ncbi request reprint Dimorphic sequences of rap-1 genes encode B and CD4+ T helper lymphocyte epitopes in the Babesia bigemina rhoptry associated protein-1
    I Hotzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164 7040, USA
    Mol Biochem Parasitol 81:89-99. 1996
  2. ncbi request reprint Conservation of the human immunodeficiency virus type 1 gp120 V1/V2 stem/loop structure in the equine infectious anemia virus (EIAV) gp90
    Isidro Hötzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    AIDS Res Hum Retroviruses 19:923-4. 2003
  3. pmc Caprine arthritis-encephalitis virus envelope surface glycoprotein regions interacting with the transmembrane glycoprotein: structural and functional parallels with human immunodeficiency virus type 1 gp120
    Isidro Hötzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    J Virol 77:11578-87. 2003
  4. ncbi request reprint Differential receptor usage of small ruminant lentiviruses in ovine and caprine cells: host range but not cytopathic phenotype is determined by receptor usage
    Isidro Hötzel
    Department of Veterinary Microbiology and Pathology, Washington State University Pullman, Washington, 99164 7040, USA
    Virology 301:21-31. 2002
  5. ncbi request reprint A maedi-visna virus strain K1514 receptor gene is located in sheep chromosome 3p and the syntenic region of human chromosome 2
    Isidro Hötzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    J Gen Virol 83:1759-64. 2002
  6. ncbi request reprint Rapid evolution of two discrete regions of the caprine arthritis-encephalitis virus envelope surface glycoprotein during persistent infection
    Isidro Hötzel
    Department of Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Virus Res 84:17-25. 2002
  7. pmc Host range of small-ruminant lentivirus cytopathic variants determined with a selectable caprine arthritis- encephalitis virus pseudotype system
    I Hotzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    J Virol 75:7384-91. 2001
  8. pmc Conservation of human immunodeficiency virus type 1 gp120 inner-domain sequences in lentivirus and type A and B retrovirus envelope surface glycoproteins
    I Hotzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    J Virol 75:2014-8. 2001
  9. ncbi request reprint Sequence similarity between the envelope surface unit (SU) glycoproteins of primate and small ruminant lentiviruses
    I Hotzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Virus Res 69:47-54. 2000
  10. ncbi request reprint Genetic variation in the dimorphic regions of RAP-1 genes and rap-1 loci of Babesia bigemina
    I Hotzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164 7040, USA
    Mol Biochem Parasitol 90:479-89. 1997

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Dimorphic sequences of rap-1 genes encode B and CD4+ T helper lymphocyte epitopes in the Babesia bigemina rhoptry associated protein-1
    I Hotzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164 7040, USA
    Mol Biochem Parasitol 81:89-99. 1996
    ..These data indicate that dimorphic regions of RAP-1 encode unique B and T helper lymphocyte epitopes and may be required for enhanced protective immune responses in cattle...
  2. ncbi request reprint Conservation of the human immunodeficiency virus type 1 gp120 V1/V2 stem/loop structure in the equine infectious anemia virus (EIAV) gp90
    Isidro Hötzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    AIDS Res Hum Retroviruses 19:923-4. 2003
  3. pmc Caprine arthritis-encephalitis virus envelope surface glycoprotein regions interacting with the transmembrane glycoprotein: structural and functional parallels with human immunodeficiency virus type 1 gp120
    Isidro Hötzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    J Virol 77:11578-87. 2003
    ..Our results indicate structural and functional parallels between CAEV gp135 and HIV-1 gp120 that may be more broadly applicable to the SU of other lentiviruses...
  4. ncbi request reprint Differential receptor usage of small ruminant lentiviruses in ovine and caprine cells: host range but not cytopathic phenotype is determined by receptor usage
    Isidro Hötzel
    Department of Veterinary Microbiology and Pathology, Washington State University Pullman, Washington, 99164 7040, USA
    Virology 301:21-31. 2002
    ..Therefore, our results indicate that the differential species tropism of SRLV is determined by receptor usage. However, receptor usage is unrelated to cytopathic phenotype...
  5. ncbi request reprint A maedi-visna virus strain K1514 receptor gene is located in sheep chromosome 3p and the syntenic region of human chromosome 2
    Isidro Hötzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    J Gen Virol 83:1759-64. 2002
    ..These regions do not include any known lentivirus receptor or coreceptor gene, indicating that MVV-K1514 uses a new lentivirus receptor to infect human cells...
  6. ncbi request reprint Rapid evolution of two discrete regions of the caprine arthritis-encephalitis virus envelope surface glycoprotein during persistent infection
    Isidro Hötzel
    Department of Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Virus Res 84:17-25. 2002
    ..Our results define two discrete regions of CAEV SU that undergo rapid sequence variation in persistently infected goats which may have important roles in virus-host interactions...
  7. pmc Host range of small-ruminant lentivirus cytopathic variants determined with a selectable caprine arthritis- encephalitis virus pseudotype system
    I Hotzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    J Virol 75:7384-91. 2001
    ..The results indicate a differential receptor recognition by MVV strains which is unrelated to cytopathic phenotype...
  8. pmc Conservation of human immunodeficiency virus type 1 gp120 inner-domain sequences in lentivirus and type A and B retrovirus envelope surface glycoproteins
    I Hotzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    J Virol 75:2014-8. 2001
    ..Thus, the antiparallel beta-strands 5 and 25 of gp120 form an SU surface highly conserved among the lentiviruses and at least partially conserved in the type A and B retroviral envelope glycoproteins...
  9. ncbi request reprint Sequence similarity between the envelope surface unit (SU) glycoproteins of primate and small ruminant lentiviruses
    I Hotzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Virus Res 69:47-54. 2000
    ..The results indicate that SU glycoproteins from primate and small ruminant lentiviruses have structurally related domains...
  10. ncbi request reprint Genetic variation in the dimorphic regions of RAP-1 genes and rap-1 loci of Babesia bigemina
    I Hotzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164 7040, USA
    Mol Biochem Parasitol 90:479-89. 1997
    ..Collectively, the data suggest that gene conversion and unequal recombination events contribute to overall rap-1 sequence conservation among gene variants and strains but may also generate new rap-1 variants...
  11. ncbi request reprint Seven new ovine progressive pneumonia virus (OPPV) field isolates from Dubois Idaho sheep comprise part of OPPV clade II based on surface envelope glycoprotein (SU) sequences
    Lynn M Herrmann
    US Department of Agriculture, Animal Disease Research Unit, Agricultural Research Service, 3003 ADBF, Washington State University, Pullman, WA 99164 6630, USA
    Virus Res 102:215-20. 2004
    ..These data indicate that the seven new Dubois OPPV field isolates along with WLC1 OPPV are part of the OPPV clade II and are distinct from CAEVs and MVVs...
  12. pmc Surface envelope glycoprotein is B-lymphocyte immunodominant in sheep naturally infected with ovine progressive pneumonia virus
    Lynn M Herrmann
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, Washington 99164 6630, USA
    Clin Diagn Lab Immunol 12:797-800. 2005
    ..Since these data indicate that SU is the immunodominant protein in most mature sheep persistently infected with OPPV, SU-specific diagnostic serological assays can be utilized for OPPV diagnosis...
  13. ncbi request reprint Mutations increasing exposure of a receptor binding site epitope in the soluble and oligomeric forms of the caprine arthritis-encephalitis lentivirus envelope glycoprotein
    Isidro Hötzel
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Virology 339:261-72. 2005
    ....
  14. ncbi request reprint Organization, transcription, and expression of rhoptry associated protein genes in the Babesia bigemina rap-1 locus
    Carlos E Suarez
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Mol Biochem Parasitol 127:101-12. 2003
    ..Immunoblot analysis of merozoites revealed the expected RAP-1a expression but failed to detect expressed RAP-1b and RAP-1c, indicating that expression of the rap-1 genes is regulated both at the transcriptional and translational levels...
  15. ncbi request reprint TNFalpha and GM-CSF-induced activation of the CAEV promoter is independent of AP-1
    Brian G Murphy
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 0001, USA
    Virology 352:188-99. 2006
    ..A set of progressive deletion mutants was utilized to show that TNFalpha-induced expression depends on an element or elements within the U3 70-bp repeat...