Patrick Y Jay

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Transgenerational cardiology: One way to a baby's heart is through the mother
    Patrick Y Jay
    Departments of Pediatrics, Washington University School of Medicine, Box 8208, 660 South Euclid Avenue, St Louis, MO, 63110, USA Departments of Genetics, Washington University School of Medicine, Box 8208, 660 South Euclid Avenue, St Louis, MO, 63110, USA Electronic address
    Mol Cell Endocrinol 435:94-102. 2016
  2. ncbi request reprint Function follows form: cardiac conduction system defects in Nkx2-5 mutation
    Patrick Y Jay
    Department of Cardiology, Children s Hospital, Boston, Massachusetts, USA
    Anat Rec A Discov Mol Cell Evol Biol 280:966-72. 2004
  3. ncbi request reprint Absence of Msx2 does not affect cardiac conduction or rescue conduction defects associated with Nkx2-5 mutation
    Patrick Y Jay
    Department of Cardiology, Children s Hospital, Boston, Massachusetts 02139, USA
    J Cardiovasc Electrophysiol 16:82-5. 2005
  4. ncbi request reprint Haploinsufficiency of the cardiac transcription factor Nkx2-5 variably affects the expression of putative target genes
    Patrick Y Jay
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    FASEB J 19:1495-7. 2005
  5. pmc Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system
    Patrick Y Jay
    Department of Cardiology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 113:1130-7. 2004
  6. pmc Heterogeneity of genetic modifiers ensures normal cardiac development
    Julia B Winston
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 121:1313-21. 2010
  7. pmc Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies
    Bin Zhang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 4:e5232. 2009
  8. pmc GATA4 deficiency impairs ovarian function in adult mice
    Antti Kyrönlahti
    Department of Pediatrics, Washington University and St Louis Children s Hospital, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Biol Reprod 84:1033-44. 2011
  9. pmc Complex trait analysis of ventricular septal defects caused by Nkx2-5 mutation
    Julia B Winston
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Circ Cardiovasc Genet 5:293-300. 2012
  10. pmc GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice
    Justyna Krachulec
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Endocrinology 153:2599-611. 2012

Collaborators

Detail Information

Publications30

  1. pmc Transgenerational cardiology: One way to a baby's heart is through the mother
    Patrick Y Jay
    Departments of Pediatrics, Washington University School of Medicine, Box 8208, 660 South Euclid Avenue, St Louis, MO, 63110, USA Departments of Genetics, Washington University School of Medicine, Box 8208, 660 South Euclid Avenue, St Louis, MO, 63110, USA Electronic address
    Mol Cell Endocrinol 435:94-102. 2016
    ..This suggests that an unbiased genetic approach would most efficiently lead to the relevant pathway. A genetic foundation would lay the groundwork for human studies and clinical trials. ..
  2. ncbi request reprint Function follows form: cardiac conduction system defects in Nkx2-5 mutation
    Patrick Y Jay
    Department of Cardiology, Children s Hospital, Boston, Massachusetts, USA
    Anat Rec A Discov Mol Cell Evol Biol 280:966-72. 2004
    ..Hypoplasia of the atrioventricular node, His bundle, and Purkinje system can explain in whole or in part specific conduction and electrophysiologic defects present in Nkx2-5 haploinsufficiency...
  3. ncbi request reprint Absence of Msx2 does not affect cardiac conduction or rescue conduction defects associated with Nkx2-5 mutation
    Patrick Y Jay
    Department of Cardiology, Children s Hospital, Boston, Massachusetts 02139, USA
    J Cardiovasc Electrophysiol 16:82-5. 2005
    ..Several observations support a model in which Msx2 negatively regulates formation of the conduction system and inappropriate Msx2 up-regulation causes the conduction defects associated with Nkx2-5 mutation...
  4. ncbi request reprint Haploinsufficiency of the cardiac transcription factor Nkx2-5 variably affects the expression of putative target genes
    Patrick Y Jay
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    FASEB J 19:1495-7. 2005
    ..Any dependence of gene expression on Nkx2-5 gene dosage is affected by factors specific to the individual gene and the physiologic context...
  5. pmc Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system
    Patrick Y Jay
    Department of Cardiology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 113:1130-7. 2004
    ..Postnatal conduction defects in Nkx2-5 mutation may result at least in part from a defect in the genetic program that governs the recruitment or retention of embryonic cardiac myocytes in the conduction system...
  6. pmc Heterogeneity of genetic modifiers ensures normal cardiac development
    Julia B Winston
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 121:1313-21. 2010
    ..This variability suggests that additional factors can affect or prevent the mutant phenotype. We assess here the role of genetic modifiers and their interactions...
  7. pmc Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies
    Bin Zhang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 4:e5232. 2009
    ....
  8. pmc GATA4 deficiency impairs ovarian function in adult mice
    Antti Kyrönlahti
    Department of Pediatrics, Washington University and St Louis Children s Hospital, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Biol Reprod 84:1033-44. 2011
    ..Our findings, coupled with those of other investigators, support the premise that GATA4 is a key transcriptional regulator of ovarian somatic cell function in both fetal and adult mice...
  9. pmc Complex trait analysis of ventricular septal defects caused by Nkx2-5 mutation
    Julia B Winston
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Circ Cardiovasc Genet 5:293-300. 2012
    ..The occurrence of a congenital heart defect has long been thought to have a multifactorial basis, but the evidence is indirect. Complex trait analysis could provide a more nuanced understanding of congenital heart disease...
  10. pmc GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice
    Justyna Krachulec
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Endocrinology 153:2599-611. 2012
    ..We conclude that GATA4 is a key modifier of gonadectomy-induced adrenocortical neoplasia, postovariectomy obesity, and sex steroidogenic cell differentiation...
  11. pmc Molecular genetics of congenital diaphragmatic defects
    Malgorzata Bielinska
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    Ann Med 39:261-74. 2007
    ..We discuss potential mechanisms underlying the seemingly random combination of diaphragmatic, pulmonary, cardiovascular, and gonadal defects in these patients...
  12. ncbi request reprint Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome
    Bin Zhang
    Departments of Genetics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 134:3191-201. 2007
    ....
  13. pmc Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development
    Ann Ng
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    Dev Biol 335:208-15. 2009
    ..This work has broad significance to understanding the genetic basis of coronary development and potentially to molecular mechanisms relevant to revascularization following ischemic injury to the heart...
  14. ncbi request reprint Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase
    Antje Buerger
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Card Fail 12:392-8. 2006
    ..Conditional gene inactivation in mice using the bacteriophage P1 Cre-loxP recombination system requires transgenic expression of Cre-recombinase driven by a tissue-specific or inducible promoter...
  15. pmc The maternal-age-associated risk of congenital heart disease is modifiable
    Claire E Schulkey
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110 USA
    Nature 520:230-3. 2015
    ..Thus, even when the offspring carry a causal mutation, an intervention aimed at the mother can meaningfully reduce their risk of congenital heart disease. ..
  16. pmc Enhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure
    Kai Chien Yang
    Department of Developmental Biology, Washington University Medical School, 660 South Euclid Avenue Box 8103, St Louis, MO 63110 1093, USA
    Cardiovasc Res 93:252-62. 2012
    ..The experiments here were undertaken to test the hypothesis that increased PI3Kα signalling will counteract the adverse electrophysiological remodelling associated with pathological hypertrophy and heart failure...
  17. ncbi request reprint Cardiac conduction and arrhythmia: insights from Nkx2.5 mutations in mouse and humans
    Patrick Y Jay
    Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
    Novartis Found Symp 250:227-38; discussion 238-41, 276-9. 2003
    ..We propose that consideration of the two alternative hypotheses, in addition to the traditional ICC-centric model, should lead to a richer understanding of cardiac conduction defects and arrhythmogenesis...
  18. pmc Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy
    Arpita Kalla Vyas
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 6:e17178. 2011
    ..Our current objective was to determine whether pharmacologic enhancement of insulin sensitivity and myocardial glucose uptake preserves cardiac function and survival in the setting of primary heart failure...
  19. pmc Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects
    Patrick Y Jay
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    Dev Biol 301:602-14. 2007
    ..We conclude that GATA-4, like its co-regulator FOG-2, is required for proper mesenchymal cell function in the developing diaphragm, lungs, and heart...
  20. ncbi request reprint The 16th Asian Pacific Congress of Cardiology (APCC)
    Patrick Y Jay
    Departments of Pediatrics and Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    IDrugs 11:181-3. 2008
  21. pmc Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret
    Maximiliaan Schillebeeckx
    Department of Genetics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Mol Cell Endocrinol 399:122-30. 2015
    ..These new genetic and epigenetic markers may prove useful for studies of steroidogenic cell development and for diagnostic testing. ..
  22. pmc Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis
    Mayurranjan S Mitra
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Mol Cell Cardiol 51:120-8. 2011
    ..Collectively, these data suggest that lipin 1 is the principal lipin protein in the myocardium and is regulated in response to physiologic and pathologic stimuli that impact cardiac metabolism...
  23. doi request reprint HIV protease inhibitors that block GLUT4 precipitate acute, decompensated heart failure in a mouse model of dilated cardiomyopathy
    Paul W Hruz
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    FASEB J 22:2161-7. 2008
    ..The potential for HIV protease inhibitors to contribute to or exacerbate cardiomyopathy in human patients warrants further investigation...
  24. pmc The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis
    Zhenyi Liu
    Sage Labs, A Horizon Discovery Group Company, St Louis, MO 63146, USA
    Development 142:2452-63. 2015
    ..Reinterpretation of clinical findings based on our analyses suggests that differences in outcome segregating with Notch1 or Notch2 are likely to reflect outcomes dependent on the overall strength of Notch signals. ..
  25. pmc Association of genes with physiological functions by comparative analysis of pooled expression microarray data
    Iuan Bor D Chen
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Physiol Genomics 45:69-78. 2013
    ..The results demonstrate a straightforward bioinformatic strategy to associate genes with functions. The database upon which the strategy is based is provided so that investigators can perform their own screens...
  26. pmc Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy
    Kai Chien Yang
    Department of Developmental Biology, Washington University Medical School, St Louis, MO 63110 1093, USA
    J Physiol 588:5015-32. 2010
    ....
  27. ncbi request reprint Genetic wiring diagram of the cardiac conduction system
    Patrick Y Jay
    Circulation 116:2520-2. 2007
  28. pmc Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy
    Julie R McMullen
    Experimental Cardiology and Heart Failure Division, Baker Heart Research Institute, Melbourne 8008, Australia
    Proc Natl Acad Sci U S A 104:612-7. 2007
    ..Identification of genes important for hypertrophy in the athlete's heart could offer new strategies for treating heart failure...
  29. ncbi request reprint Transcriptional regulation of cardiac conduction system development: 2004 FASEB cardiac conduction system minimeeting, Washington, DC
    Brett S Harris
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA
    Anat Rec A Discov Mol Cell Evol Biol 280:1036-45. 2004
    ..Thus, the precise spatiotemporal regulation of Nkx2.5 levels during development may be required for the progressive emergence of gene expression patterns specific to differentiated Purkinje fiber cells...
  30. ncbi request reprint Elucidating the molecular and genetic interactions responsible for congenital heart disease
    Patrick Y Jay
    Pediatr Res 51:127. 2002