Audrey O T Lau

Summary

Affiliation: Washington State University
Country: USA

Publications

  1. pmc Comparative transcriptome analysis of geographically distinct virulent and attenuated Babesia bovis strains reveals similar gene expression changes through attenuation
    Monica J Pedroni
    Program of Genomics, Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, ADBF 4043, Pullman, WA, 99164, USA
    BMC Genomics 14:763. 2013
  2. pmc Comparative genomic analysis and phylogenetic position of Theileria equi
    Lowell S Kappmeyer
    Animal Disease Research Unit, Agricultural Research Service, USDA, Pullman, WA 99164 7030, USA
    BMC Genomics 13:603. 2012
  3. pmc Genome-wide analysis of peptidase content and expression in a virulent and attenuated Babesia bovis strain pair
    Maria Mesplet
    Instituto de Patobiologia, CICVyA, INTA Castelar, Buenos Aires, Argentina
    Mol Biochem Parasitol 179:111-3. 2011
  4. ncbi request reprint Babesia bovis: the development of an expression oligonucleotide microarray
    Audrey O T Lau
    Program in Microbial Genomics, Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, United States
    Exp Parasitol 117:93-8. 2007
  5. doi request reprint An overview of the Babesia, Plasmodium and Theileria genomes: a comparative perspective
    Audrey O T Lau
    Program in Genomics, Department of Veterinary Microbiology and Pathology, School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Mol Biochem Parasitol 164:1-8. 2009
  6. doi request reprint Babesia bovis: a comprehensive phylogenetic analysis of plastid-encoded genes supports green algal origin of apicoplasts
    Audrey O T Lau
    Program in Genomics, Department of Veterinary Microbiology and Pathology, School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Exp Parasitol 123:236-43. 2009
  7. pmc Genotypic diversity of merozoite surface antigen 1 of Babesia bovis within an endemic population
    Audrey O T Lau
    Programs in Genomics and Vector borne Diseases, Department of Veterinary Microbiology and Pathology and School for Global Animal Health, Washington State University, Pullman, WA 99164 7040, USA
    Mol Biochem Parasitol 172:107-12. 2010
  8. pmc Attenuation of virulence in an apicomplexan hemoparasite results in reduced genome diversity at the population level
    Audrey Ot Lau
    Programs in Genomics and Vector borne Diseases, Department of Veterinary Microbiology and Pathology and Paul G, Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, USA
    BMC Genomics 12:410. 2011
  9. pmc Characterization of acyl carrier protein and LytB in Babesia bovis apicoplast
    Marina C Caballero
    Program of Genomics, Department of Veterinary Microbiology and Pathology and Paul G Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Mol Biochem Parasitol 181:125-33. 2012
  10. pmc Expression and strain variation of the novel "small open reading frame" (smorf) multigene family in Babesia bovis
    Lucas M Ferreri
    Department of Veterinary Microbiology and Pathology and School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6040, USA
    Int J Parasitol 42:131-8. 2012

Collaborators

Detail Information

Publications19

  1. pmc Comparative transcriptome analysis of geographically distinct virulent and attenuated Babesia bovis strains reveals similar gene expression changes through attenuation
    Monica J Pedroni
    Program of Genomics, Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, ADBF 4043, Pullman, WA, 99164, USA
    BMC Genomics 14:763. 2013
    ..We investigated the transcriptome profiles of two geographically distinct B. bovis virulent and attenuated strain pairs to better understand virulence loss and to gain insight into pathogen adaptation strategies...
  2. pmc Comparative genomic analysis and phylogenetic position of Theileria equi
    Lowell S Kappmeyer
    Animal Disease Research Unit, Agricultural Research Service, USDA, Pullman, WA 99164 7030, USA
    BMC Genomics 13:603. 2012
    ..equi relative to sequenced apicomplexan parasites...
  3. pmc Genome-wide analysis of peptidase content and expression in a virulent and attenuated Babesia bovis strain pair
    Maria Mesplet
    Instituto de Patobiologia, CICVyA, INTA Castelar, Buenos Aires, Argentina
    Mol Biochem Parasitol 179:111-3. 2011
    ..We conclude that while peptidases may well play a required role in B. bovis pathogenesis, neither loss of peptidase gene content nor reduced gene expression underlies the loss of virulence associated with in vivo passage and attenuation...
  4. ncbi request reprint Babesia bovis: the development of an expression oligonucleotide microarray
    Audrey O T Lau
    Program in Microbial Genomics, Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, United States
    Exp Parasitol 117:93-8. 2007
    ..bovis expression sequence tag study. Therefore, we conclude that the microarray is suitable for analyzing B. bovis gene expression, and present the complete B. bovis infected erythrocyte expression profile...
  5. doi request reprint An overview of the Babesia, Plasmodium and Theileria genomes: a comparative perspective
    Audrey O T Lau
    Program in Genomics, Department of Veterinary Microbiology and Pathology, School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Mol Biochem Parasitol 164:1-8. 2009
    ..This review, therefore, summarizes comparisons of genome structure, protein families, metabolic pathways and organelle biology in these three apicomplexans and how such knowledge has and will continue to enhance the field...
  6. doi request reprint Babesia bovis: a comprehensive phylogenetic analysis of plastid-encoded genes supports green algal origin of apicoplasts
    Audrey O T Lau
    Program in Genomics, Department of Veterinary Microbiology and Pathology, School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Exp Parasitol 123:236-43. 2009
    ..The results also substantiate earlier findings that plastids found in Heterokonts such as Odontella and Thalassiosira were derived from a separate secondary endosymbiotic event likely originating from a red algal lineage...
  7. pmc Genotypic diversity of merozoite surface antigen 1 of Babesia bovis within an endemic population
    Audrey O T Lau
    Programs in Genomics and Vector borne Diseases, Department of Veterinary Microbiology and Pathology and School for Global Animal Health, Washington State University, Pullman, WA 99164 7040, USA
    Mol Biochem Parasitol 172:107-12. 2010
    ..bovis within an individual animal in an endemic region. Co-infection with multiple diverse MSA-1 genotypes provides a basis for more extensive genotypic shifts that characterizes outbreak strains...
  8. pmc Attenuation of virulence in an apicomplexan hemoparasite results in reduced genome diversity at the population level
    Audrey Ot Lau
    Programs in Genomics and Vector borne Diseases, Department of Veterinary Microbiology and Pathology and Paul G, Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, USA
    BMC Genomics 12:410. 2011
    ..We expected virulence loss to be accompanied by consistent changes at the gene level, and that such changes would be shared among attenuated parasites of diverse geographic and genetic background...
  9. pmc Characterization of acyl carrier protein and LytB in Babesia bovis apicoplast
    Marina C Caballero
    Program of Genomics, Department of Veterinary Microbiology and Pathology and Paul G Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Mol Biochem Parasitol 181:125-33. 2012
    ..The results indicate specialized molding of apicoplast biosynthetic pathways to meet the requirements of individual apicomplexan parasites and their unique intracellular niches...
  10. pmc Expression and strain variation of the novel "small open reading frame" (smorf) multigene family in Babesia bovis
    Lucas M Ferreri
    Department of Veterinary Microbiology and Pathology and School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6040, USA
    Int J Parasitol 42:131-8. 2012
    ..The function of these novel proteins is unknown...
  11. pmc Expression of 6-Cys Gene Superfamily Defines Babesia bovis Sexual Stage Development within Rhipicephalus microplus
    Heba F Alzan
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, United States of America
    PLoS ONE 11:e0163791. 2016
    ..Within B. bovis specifically, proteins encoded by 6-Cys genes A and B are markers for sexual stages and candidate antigens for developing novel vaccines able to interfere with the development of B. bovis within the tick vector...
  12. doi request reprint ApicoAMP: the first computational model for identifying apicoplast-targeted transmembrane proteins in Apicomplexa
    Gokcen Cilingir
    School of Electrical Engineering and Computer Science, Washington State University, Pullman, WA 99164, USA
    J Microbiol Methods 95:313-9. 2013
    ....
  13. pmc Loss of neurovirulence is associated with reduction of cerebral capillary sequestration during acute Babesia bovis infection
    Kerry S Sondgeroth
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Parasit Vectors 6:181. 2013
    ..We evaluated whether serial passage also results in a loss of cerebral capillary sequestration by examining brain biopsies during acute disease and at necropsy...
  14. pmc Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa
    Kelly A Brayton
    Program in Genomics, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA
    PLoS Pathog 3:1401-13. 2007
    ..The genome sequence provides a greater understanding of B. bovis metabolism and potential avenues for drug therapies and vaccine development...
  15. pmc Babesia bovis: a bipartite signal directs the glutamyl-tRNA synthetase to the apicoplast
    Monica J Pedroni
    Program of Genomics, Department of Veterinary Microbiology and Pathology, Paul G Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Exp Parasitol 131:261-6. 2012
    ..As GltX bipartite signal successfully guided the reporter protein into the apicoplast, our finding implies that it also directs native GltX into the same organelle...
  16. doi request reprint Babesia bovis: transcriptional analysis of rRNA gene unit expression
    Jacob M Laughery
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Exp Parasitol 123:45-50. 2009
    ..Collectively, the data indicate that differential transcription of rRNA occurs in B.bovis, depending on the life stage of the parasite and on the environment...
  17. doi request reprint Target specific-trisubstituted pyrrole inhibits Babesia bovis erythrocytic growth
    Audrey O T Lau
    Program of Genomics, Department of Veterinary Microbiology and Pathology, Paul G Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA
    Exp Parasitol 133:365-8. 2013
    ..Target conservation and the in vitro efficacy support further investigation of this compound and validation of Babesia cGMP dependent protein kinase as its in vivo target...
  18. pmc ApicoAP: the first computational model for identifying apicoplast-targeted proteins in multiple species of Apicomplexa
    Gokcen Cilingir
    School of Electrical Engineering and Computer Science, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 7:e36598. 2012
    ..Attempts to define a consensus motif that universally identifies apicoplast TPs have failed...
  19. pmc Tick passage results in enhanced attenuation of Babesia bovis
    Kerry S Sondgeroth
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA
    Infect Immun 82:4426-34. 2014
    ....