Hugh S Taylor

Summary

Affiliation: Yale University
Country: USA

Publications

  1. doi request reprint HOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling.
    Amanda N Kallen
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Reprod Sci 21:892-897. 2014
  2. doi request reprint Failure of the stem cell niche rather than loss of oocyte stem cells in the aging ovary.
    Efi Massasa
    Yale University School of Medicine, New Haven, CT 06510, USA
    Aging (Albany NY) 2:1-2. 2010
  3. pmc Fetal radiofrequency radiation exposure from 800-1900 mhz-rated cellular telephones affects neurodevelopment and behavior in mice
    Tamir S Aldad
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA
    Sci Rep 2:312. 2012
  4. doi request reprint Using bazedoxifene plus conjugated estrogens for treating postmenopausal women: a comprehensive review
    Hugh S Taylor
    Division of Reproductive Endocrinology and Infertility, Yale School of Medicine, New Haven, CT 06520, USA
    Menopause 19:479-85. 2012
  5. ncbi request reprint A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes
    H S Taylor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Reprod 57:1338-45. 1997
  6. ncbi request reprint A regulatory element of the empty spiracles homeobox gene is composed of three distinct conserved regions that bind regulatory proteins
    H S Taylor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Mol Reprod Dev 49:246-53. 1998
  7. pmc HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium
    H S Taylor
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 101:1379-84. 1998
  8. ncbi request reprint Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium
    H S Taylor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 84:1129-35. 1999
  9. ncbi request reprint Mutation analysis of the EMX2 gene in Kallmann's syndrome
    H S Taylor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    Fertil Steril 72:910-4. 1999
  10. ncbi request reprint The role of HOX genes in human implantation
    H S Taylor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    Hum Reprod Update 6:75-9. 2000

Collaborators

Detail Information

Publications126 found, 100 shown here

  1. doi request reprint HOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling.
    Amanda N Kallen
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Reprod Sci 21:892-897. 2014
    ..Alterations in CK15 likely facilitate these cytoskeletal changes, ultimately promoting endometrial receptivity...
  2. doi request reprint Failure of the stem cell niche rather than loss of oocyte stem cells in the aging ovary.
    Efi Massasa
    Yale University School of Medicine, New Haven, CT 06510, USA
    Aging (Albany NY) 2:1-2. 2010
  3. pmc Fetal radiofrequency radiation exposure from 800-1900 mhz-rated cellular telephones affects neurodevelopment and behavior in mice
    Tamir S Aldad
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA
    Sci Rep 2:312. 2012
    ..We present the first experimental evidence of neuropathology due to in-utero cellular telephone radiation. Further experiments are needed in humans or non-human primates to determine the risk of exposure during pregnancy...
  4. doi request reprint Using bazedoxifene plus conjugated estrogens for treating postmenopausal women: a comprehensive review
    Hugh S Taylor
    Division of Reproductive Endocrinology and Infertility, Yale School of Medicine, New Haven, CT 06520, USA
    Menopause 19:479-85. 2012
    ....
  5. ncbi request reprint A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes
    H S Taylor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Reprod 57:1338-45. 1997
    ..The late establishment of a Hox axis and persistent expression of Hox genes in the adult may play an important role in preserving this plasticity...
  6. ncbi request reprint A regulatory element of the empty spiracles homeobox gene is composed of three distinct conserved regions that bind regulatory proteins
    H S Taylor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Mol Reprod Dev 49:246-53. 1998
    ..Conserved discrete areas within a homeobox gene regulatory element, which function as homeodomain protein transcription factor binding sites, are used in a combinatorial fashion to regulate these developmentally important genes...
  7. pmc HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium
    H S Taylor
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 101:1379-84. 1998
    ..HOXA10 may have an important function in regulating endometrial development during the menstrual cycle and in establishing conditions necessary for implantation in the human...
  8. ncbi request reprint Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium
    H S Taylor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 84:1129-35. 1999
    ..Steroids are novel regulators HOX gene expression. The spatial and temporal pattern of HOXA11 expression in the human endometrium suggests a role in endometrial development, implantation, and maintenance of pregnancy...
  9. ncbi request reprint Mutation analysis of the EMX2 gene in Kallmann's syndrome
    H S Taylor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    Fertil Steril 72:910-4. 1999
    ..To investigate the possibility that a mutation in the human EMX2 gene may be involved in Kallmann's syndrome...
  10. ncbi request reprint The role of HOX genes in human implantation
    H S Taylor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    Hum Reprod Update 6:75-9. 2000
    ..HOX genes are likely key regulators of human implantation. This paper will review the role of HOX genes in the reproductive tract, specifically the evidence that HOX genes are important for human endometrial development and receptivity...
  11. ncbi request reprint Transcriptional regulation of implantation by HOX genes
    Hugh S Taylor
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Yale University School of Medicine, 333 Cedar Street, P O Box 2008063, New Haven, CT 06520, USA
    Rev Endocr Metab Disord 3:127-32. 2002
  12. ncbi request reprint Endometrial HOXA10 expression after controlled ovarian hyperstimulation with recombinant follicle-stimulating hormone
    Hugh S Taylor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Fertil Steril 80:839-43. 2003
    ..To determine the effects of controlled ovarian hyperstimulation and resultant high levels of E(2) on endometrial HOXA10 expression (a marker of endometrial receptivity)...
  13. ncbi request reprint Endometrial cells derived from donor stem cells in bone marrow transplant recipients
    Hugh S Taylor
    Division of Reproductive Endocrinology, Yale University School of Medicine, New Haven, Conn 06520 8063, USA
    JAMA 292:81-5. 2004
    ..Endogenous endometrial stem cells reside in the basalis layer and serve as a source of cells that differentiate to form the endometrium. Bone marrow-derived cells have been shown to take on functions outside the hematopoietic system...
  14. ncbi request reprint Emx2 regulates mammalian reproduction by altering endometrial cell proliferation
    Hugh S Taylor
    Division of Reproductive Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Mol Endocrinol 19:2839-46. 2005
    ..Emx2 controls mammalian reproduction by adjusting endometrial cell proliferation without effecting differentiation. Regulated uterine Emx2 expression is necessary during reproduction for maximal implantation and litter size...
  15. pmc Endocrine disruptors affect developmental programming of HOX gene expression
    Hugh S Taylor
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Fertil Steril 89:e57-8. 2008
    ..Diethylstilbestrol and several environmental xenoestrogens disrupt the development of the female reproductive tract by altering HOX gene expression, leading to structural and functional defects...
  16. pmc Designing the ideal selective estrogen receptor modulator--an achievable goal?
    Hugh S Taylor
    Division of Reproductive Endocrinology, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Menopause 16:609-15. 2009
    ..Further clinical investigation will help to clarify the relative benefits and risks of novel SERMs in development within specific indications...
  17. pmc Novel therapies targeting endometriosis
    Hugh S Taylor
    Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
    Reprod Sci 18:814-23. 2011
    ..The most promising of these potential therapies are currently slated for further testing in both rodent and nonhuman primate trials...
  18. pmc Transcriptional repression of peri-implantation EMX2 expression in mammalian reproduction by HOXA10
    Patrick J Troy
    Division of Reproductive Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Mol Cell Biol 23:1-13. 2003
    ..These findings demonstrate conservation of the transcription factor-target gene relationship, although the direction of regulation is reversed with possible evolutionary implications...
  19. ncbi request reprint EMX2 gene expression in the female reproductive tract and aberrant expression in the endometrium of patients with endometriosis
    Gaurang S Daftary
    Division of Reproductive Endocrinology, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 89:2390-6. 2004
    ..Reporter expression was increased, indicating reversal of HOXA10-mediated transcriptional repression. Endometrial EMX2 expression is aberrant in women with endometriosis and is mediated by altered HOXA10 expression...
  20. pmc WT1 represses HOX gene expression in the regulation of gynaecologic tumour histologic type
    Vaagn Andikyan
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, CT, USA
    J Cell Mol Med 13:4522-31. 2009
    ..This suggests that Gynaecologic epithelial histologic type is regulated by WT1 expression through its selective repression of HOX genes...
  21. doi request reprint Effects of Oral vs Transdermal Estrogen Therapy on Sexual Function in Early Postmenopause: Ancillary Study of the Kronos Early Estrogen Prevention Study (KEEPS)
    Hugh S Taylor
    Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut
    JAMA Intern Med 177:1471-1479. 2017
    ..Sexual dysfunction, an important determinant of women's health and quality of life, is commonly associated with declining estrogen levels around the menopausal transition...
  22. pmc Endometriosis impairs bone marrow-derived stem cell recruitment to the uterus whereas bazedoxifene treatment leads to endometriosis regression and improved uterine stem cell engraftment
    Sharif Sakr
    Department of Obstetrics, Gynecology and Reproductive Sciences S S, H N, H S T, Department of Molecular, Cellular and Developmental Biology H S T, Yale University, New Haven Connecticut and Pfizer B K, Collegeville, Pennsylvania
    Endocrinology 155:1489-97. 2014
    ..BZA/CE not only treats lesions of endometriosis, it also dramatically reduces stem cell recruitment to the lesions and restores stem cell engraftment of the uterine endometrium. ..
  23. ncbi request reprint Differential cell-specific modulation of HOXA10 by estrogen and specificity protein 1 response elements
    Ryan Martin
    Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8063, USA
    J Clin Endocrinol Metab 92:1920-6. 2007
    ..HOX genes are highly evolutionarily conserved regulators of embryonic development. HOXA10 also regulates differentiation of the adult reproductive tract and mammary gland in response to sex steroids...
  24. pmc A novel role for the AAA ATPase spastin as a HOXA10 transcriptional corepressor in Ishikawa endometrial cells
    Gaurang S Daftary
    Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55902, USA
    Mol Endocrinol 25:1539-49. 2011
    ..Endometrial spastin, therefore, likely has a novel function downstream of estrogen and progesterone in implantation biology as a cofactor of HOXA10...
  25. ncbi request reprint Pleiotropic effects of Hoxa10 on the functional development of peri-implantation endometrium
    Gaurang S Daftary
    Laboratory of Developmental Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA
    Mol Reprod Dev 67:8-14. 2004
    ..Functional differentiation in regenerative adult tissues may depend on timed expression of embryonic selector genes. Mol. Reprod. Dev. 67: 8-14, 2004...
  26. ncbi request reprint Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells
    Hongling DU
    Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Mol Endocrinol 19:2222-33. 2005
    ..1,25-(OH)2D3 up-regulates HOXA10 expression by binding VDR and interacting with a VDRE in the HOXA10 regulatory region. Direct regulation of HOXA10 by vitamin D has implications for fertility and myeloid differentiation...
  27. ncbi request reprint Endocrine regulation of HOX genes
    Gaurang S Daftary
    Division of Reproductive Endocrinology, Yale University School of Medicine, 333 Cedar Street, P O Box 208063, New Haven, Connecticut 06520 8063, USA
    Endocr Rev 27:331-55. 2006
    ..This review discusses endocrine Hox regulation and its impact on physiology and human pathology...
  28. ncbi request reprint Regulation of HOXA10 expression by phytoestrogens
    G Eda Akbas
    Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Endocrinol Metab 292:E435-42. 2007
    ..In utero exposure to isoflavones is unlikely to result in HOXA10-mediated developmental anomalies. Adult genistein exposure alters uterine HOXA10 expression, a potential mechanism by which this agent affects fertility...
  29. pmc 3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells
    Hongling DU
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, PO Box 208063, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Reproduction 139:237-45. 2010
    ..PHGDH is necessary for serine biosynthesis, which serves as a substrate for protein synthesis. One mechanism by which HOXA10 regulates cellular differentiation may involve limiting protein synthesis in the secretary phase...
  30. pmc HOXA10 inhibits Kruppel-like factor 9 expression in the human endometrial epithelium
    Hongling DU
    Department of Obstetrics, Yale University, New Haven, Connecticut 06520, USA
    Biol Reprod 83:205-11. 2010
    ..HOXA10 directly and selectively repressed KLF9 expression in endometrial epithelial cells. HOXA10 repression of KLF9 likely contributes to the loss of sex steroid responsiveness in secretory-phase endometrial epithelium...
  31. pmc The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility
    Hongling DU
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520
    Cold Spring Harb Perspect Med 6:a023002. 2015
    ..Alteration of HOX gene expression causes both uterine developmental abnormalities and impaired adult endometrial development that prevent implantation and lead to female infertility. ..
  32. pmc In utero exposure to diethylstilbestrol (DES) or bisphenol-A (BPA) increases EZH2 expression in the mammary gland: an epigenetic mechanism linking endocrine disruptors to breast cancer
    Leo F Doherty
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Horm Cancer 1:146-55. 2010
    ..Developmental programming of EZH2 is a novel mechanism by which in utero exposure to endocrine disruptors leads to epigenetic regulation of the mammary gland...
  33. pmc Ischemia/reperfusion injury promotes and granulocyte-colony stimulating factor inhibits migration of bone marrow-derived stem cells to endometrium
    Hongling DU
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, CT, USA
    Stem Cells Dev 21:3324-31. 2012
    ..G-CSF is unlikely to be of benefit in repair of uterine injury in humans. Taken together, we demonstrate that ischemic injury drives BM MSC engraftment of the uterus, independent of estrous cycle, sex steroids, or G-CSF...
  34. pmc Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    David Resuehr
    Department of Obstetrics and Gynecology, Women s Reproductive Health Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Fertil Steril 98:948-56.e1. 2012
    ....
  35. pmc Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity
    Beth W Rackow
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Fertil Steril 93:2027-34. 2010
    ..To evaluate the effect of uterine leiomyomas on the endometrium using molecular markers of endometrial receptivity: HOXA10, HOXA11, LIF, and BTEB1...
  36. pmc Stem cells and female reproduction
    Hongling DU
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, Connecticut 06520, USA
    Reprod Sci 16:126-39. 2009
    ..While we are just beginning to understand stem cells and many key questions remain, the potential advantages of stem cells in reproductive biology and medicine are apparent...
  37. pmc HOXA11 promotes fibroblast proliferation and regulates p53 in uterosacral ligaments
    Kathleen A Connell
    Department of Obstetrics, Division of Urogynecology and Reconstructive Pelvic Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Reprod Sci 16:694-700. 2009
    ....
  38. pmc Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response
    Jason G Bromer
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    FASEB J 24:2273-80. 2010
    ..Permanent epigenetic alteration of ERE sensitivity to estrogen may be a general mechanism through which endocrine disruptors exert their action...
  39. doi request reprint Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression
    Hanyia Naqvi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA
    Reprod Sci 23:186-91. 2016
    ..Similarly, systemic effects of endometriosis on other organs may also be responsible for the widespread manifestations of the disease. ..
  40. pmc Defining the proliferative phase endometrial defect
    Jason G Bromer
    Department of Obstetrics, Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Fertil Steril 91:698-704. 2009
    ..To evaluate proliferative phase endometrial development in a heterogeneous infertility population...
  41. pmc Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors
    Megan M Wenner
    John B Pierce Laboratory, New Haven, Connecticut
    Am J Physiol Endocrinol Metab 305:E818-25. 2013
    ..95 (0.21) vs. 0.51 (13); PCOS: 1.27 (0.23) vs. 0.84 (0.27); for GnRHant vs. T, P < 0.05]. These data demonstrate that androgen suppression improves microvascular dilation in PCOS via ET-A and ET-B receptors...
  42. pmc Simvastatin decreases invasiveness of human endometrial stromal cells
    Anna Sokalska
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California Davis, Sacramento, California 95817, USA
    Biol Reprod 87:2, 1-6. 2012
    ..Furthermore, the presently described effects of simvastatin are likely mediated, at least in part, by inhibition of geranylgeranylation...
  43. ncbi request reprint Regulation of insulin-like growth factor binding protein-1 promoter activity by FKHR and HOXA10 in primate endometrial cells
    J Julie Kim
    Department of Obstetrics and Gynecology, University of Illinois at Chicago College of Medicine and VA Chicago Healthcare System West Side, Chicago, Illinois 60612, USA
    Biol Reprod 68:24-30. 2003
    ..These studies show that FKHR and HOXA10 interact directly and can function cooperatively to stimulate IGFBP-1 promoter activity in endometrial cells and perhaps in other settings...
  44. ncbi request reprint Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx
    Gaurang S Daftary
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 87:367-72. 2007
    ..Increased endometrial HOXA10 expression may be one mechanism by which salpingectomy results in increased implantation rates in IVF...
  45. pmc GnRH antagonists may affect endometrial receptivity
    Beth W Rackow
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 89:1234-9. 2008
    ..HOXA10 is an essential regulator of endometrial receptivity. To determine the effect of GnRH antagonists on endometrial receptivity, we assessed endometrial HOXA10 expression in GnRH antagonist, GnRH agonist, and natural cycles...
  46. pmc Experimental murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium
    Banghyun Lee
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Reprod 80:79-85. 2009
    ..These data suggest the existence of a signal conduction pathway from endometriosis that alters endometrial gene expression through altered Pgr signaling and epigenetic programming...
  47. pmc Thrombin and interleukin-1beta decrease HOX gene expression in human first trimester decidual cells: implications for pregnancy loss
    Jennifer Sarno
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Hum Reprod 15:451-7. 2009
    ..Since HOXA10 and HOXA11 are known to be necessary for successful pregnancy, these findings suggest a molecular mechanism by which bleeding or inflammation may affect pregnancy outcome...
  48. pmc Maternal ghrelin deficiency compromises reproduction in female progeny through altered uterine developmental programming
    J Ryan Martin
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Endocrinology 152:2060-6. 2011
    ..In utero exposure to decreased levels of ghrelin led to defects in developmental programming of the uterus and subsequent subfertility in wild-type offspring...
  49. ncbi request reprint Implantation in the human: the role of HOX genes
    G S Daftary
    Division of Reproductive Endocrinology, Yale University School of Medicine, New Haven, Connecticut, 333 Cedar Street, PO Box 208063, New Haven, CT 06520, USA
    Semin Reprod Med 18:311-20. 2000
    ..The importance of Hox genes in this process has been well documented, and they remain one of the few well-characterized molecules necessary for implantation...
  50. pmc Resveratrol inhibits development of experimental endometriosis in vivo and reduces endometrial stromal cell invasiveness in vitro
    Kaylon L Bruner-Tran
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Biol Reprod 84:106-12. 2011
    ..0001). Resveratrol inhibits development of endometriosis in the nude mouse and reduces invasiveness of HES cells. These observations may aid in the development of novel treatments of endometriosis...
  51. pmc Migration of cells from experimental endometriosis to the uterine endometrium
    Xavier Santamaria
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Endocrinology 153:5566-74. 2012
    ..The ectopic expression of Wnt7A suggests a possible mechanism by which ectopic lesions affect the eutopic endometrium and interfere with embryo implantation and fertility...
  52. pmc MicroRNA 135 regulates HOXA10 expression in endometriosis
    Rafaella Petracco
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 96:E1925-33. 2011
    ..Although sex steroids regulate HOXA10, these hormones are unaltered in endometriosis. We hypothesized a role for microRNA in the regulation of HOXA10...
  53. pmc Derivation of insulin producing cells from human endometrial stromal stem cells and use in the treatment of murine diabetes
    Xavier Santamaria
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Mol Ther 19:2065-71. 2011
    ..Endometrium provides an easily accessible, renewable, and immunologically identical source of stem cells with potential therapeutic applications in diabetes...
  54. pmc Statins inhibit monocyte chemotactic protein 1 expression in endometriosis
    Hakan Cakmak
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Reprod Sci 19:572-9. 2012
    ..05). In conclusion, statins exert anti-inflammatory effect in endometriotic cells and could provide a potential treatment of endometriosis in the future...
  55. ncbi request reprint Menopause: developing a rational treatment plan
    Danielle Vitiello
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Gynecol Endocrinol 23:682-91. 2007
    ..Through the use of extensive patient history, quality-of-life questionnaires and powerful biological profiling, we may be able to develop a rational approach to menopausal HT that safely guides our patients through this transition...
  56. pmc A polymorphism in a let-7 microRNA binding site of KRAS in women with endometriosis
    Olga Grechukhina
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    EMBO Mol Med 4:206-17. 2012
    ..These findings suggest that an inherited polymorphism of a let-7 miRNA binding site in KRAS leads to abnormal endometrial growth and endometriosis. The LCS6 polymorphism is the first described genetic marker of endometriosis risk...
  57. ncbi request reprint HOXA10 expression in endometrial adenocarcinoma
    Danielle B Lane
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Tumour Biol 25:264-9. 2004
    ..HOXA10 expression is elevated in high nuclear grade stage I and II endometrial adenocarcinomas. Aberrant regulation of HOX gene expression is associated with abnormal differentiation of endometrial tissue...
  58. ncbi request reprint Methoxychlor disrupts uterine Hoxa10 gene expression
    Xiaolan Fei
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Endocrinology 146:3445-51. 2005
    ..One common mechanism by which endocrine disrupting chemicals produce lasting reproductive tract defects is through permanent alteration of developmental gene expression...
  59. ncbi request reprint Exogenous oestradiol and progesterone administration does not cause oedema in healthy young women
    Nina S Stachenfeld
    The John B Pierce Laboratory and Department of Epidemiology and Public Health and Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06519, USA
    Clin Endocrinol (Oxf) 66:410-8. 2007
    ..Thus we hypothesized that oestradiol decreases, while combined oestradiol + progesterone increases, protein and fluid movement out of the vasculature...
  60. pmc Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells
    Ivan Penna
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Mol Hum Reprod 14:613-8. 2008
    ..Decreased apoptosis in endometrial cells may promote the development of endometriosis through a pathway involving HOXA10, Calpain5 and caspase...
  61. pmc Decreased endometrial HOXA10 expression associated with use of the copper intrauterine device
    Amy M Tetrault
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Fertil Steril 92:1820-4. 2009
    ..To characterize human endometrial HOXA10 expression in patients using a copper intrauterine device (IUD)...
  62. doi request reprint Sex hormone effects on body fluid and sodium regulation in women with and without exercise-associated hyponatremia
    Nina S Stachenfeld
    The John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Appl Physiol (1985) 107:864-72. 2009
    ..11 (SD 0.11) liter] compared with no Hypo [0.01 (SD 0.15), 0.03 (SD 17), and -0.16 (SD 0.13) liter for GnRH, E2, and E2-P4, P < 0.05] indicates water retention was the primary contributor to the lower S([Na+]) in Hypo women...
  63. pmc Molecular mechanisms of treatment resistance in endometriosis: the role of progesterone-hox gene interactions
    Hakan Cakmak
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Semin Reprod Med 28:69-74. 2010
    ..The relatively permanent nature of methylation may explain the widespread failure of treatments for endometriosis-related infertility...
  64. pmc Greater exercise sweating in obese women with polycystic ovary syndrome compared with obese controls
    Nina S Stachenfeld
    The John B Pierce Laboratory, 290 Congress Ave, New Haven, CT 06519, USA
    Med Sci Sports Exerc 42:1660-8. 2010
    ..We hypothesized that core temperature (Tc) threshold for sweating during exercise is delayed in women with PCOS and that testosterone delays the Tc set point for sweating during exercise...
  65. pmc Cigarette smoke inhibits recruitment of bone-marrow-derived stem cells to the uterus
    Yuping Zhou
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Reprod Toxicol 31:123-7. 2011
    ..Inhibition of stem cells recruitment may be a general mechanism by which smoking leads to long term organ damage through inability to repair or regenerate multiple tissues...
  66. pmc Cigarette smoke increases progesterone receptor and homeobox A10 expression in human endometrium and endometrial cells: a potential role in the decreased prevalence of endometrial pathology in smokers
    Yuping Zhou
    Department of Obstetrics, Gynecology and Reproductive Sciences, Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA
    Biol Reprod 84:1242-7. 2011
    ..This mechanism contrasts with the accepted paradigm that the effects of smoking on the uterus are secondary to ovarian alterations rather than direct effects on endometrium as demonstrated here...
  67. ncbi request reprint HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract
    D Cermik
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 86:3387-92. 2001
    ..Decreased myometrial expression of developmental regulatory genes such as HOXA10 in the nonpregnant uterus may dedifferentiate the myometrium and allow growth in preparation for pregnancy...
  68. pmc Tissue selective estrogen complexes (TSECs) differentially modulate markers of proliferation and differentiation in endometrial cells
    Jaime Kulak
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Reprod Sci 20:129-37. 2013
    ..The differential effect of TSECs on endometrial gene expression suggests a mechanism by which they manifest differential effects on endometrial safety against the risk of estrogen-induced endometrial hyperplasia...
  69. pmc Endometrial stem cell transplantation restores dopamine production in a Parkinson's disease model
    Erin F Wolff
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    J Cell Mol Med 15:747-55. 2011
    ..HEDSC are a highly inducible source of allogenic stem cells that rescue dopamine concentrations in an immunocompetent PD mouse model...
  70. doi request reprint Stem cells and the reproductive system: historical perspective and future directions
    Cindy M P Duke
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Maturitas 76:284-9. 2013
    ..While we still have much to understand about stem cells, their potential applications in reproductive biology and medicine are countless. ..
  71. pmc Global gene expression profiling of proliferative phase endometrium reveals distinct functional subdivisions
    Rafaella G Petracco
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Reprod Sci 19:1138-45. 2012
    ....
  72. doi request reprint FKBP4 is regulated by HOXA10 during decidualization and in endometriosis
    Huan Yang
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Reproduction 143:531-8. 2012
    ..The P(4) resistance seen in endometriosis may be mediated through HOXA10-regulated FKBP4 expression...
  73. ncbi request reprint Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells
    Gaurang S Daftary
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Mol Endocrinol 16:571-9. 2002
    ..beta3-Integrin expression was directly up-regulated by HOXA10 through a 41-bp 5'-regulatory element. Sex steroids regulate the expression of endometrial beta3-integrin through a pathway involving HOXA10...
  74. ncbi request reprint HOXC and HOXD gene expression in human endometrium: lack of redundancy with HOXA paralogs
    G Eda Akbas
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Reprod 70:39-45. 2004
    ..A network of HOX genes may be involved in regulating multiple aspects of endometrial development, including both proliferation and differentiation...
  75. ncbi request reprint HOXA10 regulates p53 expression and matrigel invasion in human breast cancer cells
    Micheline C Chu
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Cancer Biol Ther 3:568-72. 2004
    ....
  76. ncbi request reprint HOXA10 gene expression in human fallopian tube and ectopic pregnancy
    Sana M Salih
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Am J Obstet Gynecol 190:1404-6. 2004
    ..The molecular mechanisms underlying ectopic implantation have not been well characterized. Here we investigate HOXA10 gene expression at the site of ectopic implantation as compared with the endometrium and with the normal fallopian tube...
  77. ncbi request reprint A HOXA10 estrogen response element (ERE) is differentially regulated by 17 beta-estradiol and diethylstilbestrol (DES)
    G Eda Akbas
    Yale University School of Medicine, Division of Reproductive Endocrinology, P O Box 208063, 333 Cedar Street, New Haven, CT 06520 8063, USA
    J Mol Biol 340:1013-23. 2004
    ....
  78. ncbi request reprint Xenoestrogen exposure imprints expression of genes (Hoxa10) required for normal uterine development
    Caroline C Smith
    Department of Epidemiology and Public Health, Yale University, New Haven, CT, USA
    FASEB J 21:239-46. 2007
    ..In utero exposure to a xenoestrogen produces reproductive tract alterations by imprinting essential developmental regulatory genes...
  79. ncbi request reprint HOX genes in implantation
    Danielle Vitiello
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Semin Reprod Med 25:431-6. 2007
    ..The role of HOX genes and their products continues to be explored as animal models that demonstrate implantation-specific infertile phenotypes continue to be investigated...
  80. pmc Stem cells and the pathogenesis of endometriosis
    Isaac E Sasson
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, P O Box 208063, New Haven, CT 06520 8063, USA
    Ann N Y Acad Sci 1127:106-15. 2008
    ....
  81. pmc Hypermethylation of homeobox A10 by in utero diethylstilbestrol exposure: an epigenetic mechanism for altered developmental programming
    Jason G Bromer
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Endocrinology 150:3376-82. 2009
    ..We identify hypermethylation as a novel mechanism of DES-induced altered developmental programming...
  82. pmc Diminished vaginal HOXA13 expression in women with pelvic organ prolapse
    Kathleen A Connell
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Menopause 16:529-33. 2009
    ..We hypothesized that vaginal expression of HOXA13 may be decreased in women with pelvic organ prolapse (POP) and sought to determine if hypoestrogenism affects its expression...
  83. pmc Endometrial polyps affect uterine receptivity
    Beth W Rackow
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 95:2690-2. 2011
    ..These findings suggest a molecular mechanism to support the clinical findings of diminished pregnancy rates in women with endometrial polyps...
  84. pmc Effect of estradiol on oocyte development
    Katherine Bianco
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143, USA
    Int J Gynaecol Obstet 104:230-2. 2009
    ..To determine whether elevated serum estradiol (E(2)) concentrations in oocyte donors affect assisted reproduction outcome...
  85. ncbi request reprint HOXA10, Pbx2, and Meis1 protein expression in the human endometrium: formation of multimeric complexes on HOXA10 target genes
    Jennifer L Sarno
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 90:522-8. 2005
    ..Enhanced target gene specificity imparted by multimer binding is likely necessary for HOXA10-mediated endometrial receptivity...
  86. ncbi request reprint Hydrosalpinx fluid diminishes endometrial cell HOXA10 expression
    Gaurang S Daftary
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Fertil Steril 78:577-80. 2002
    ..To determine the effect of hydrosalpinx fluid on the expression of HOXA10, an essential regulator of endometrial receptivity...
  87. ncbi request reprint The role of HOX genes in human implantation
    Hye Eun Kwon
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Yale University School of Medicine, 333 Cedar Street, P O Box 2008063, New Haven, CT 06520, USA
    Ann N Y Acad Sci 1034:1-18. 2004
    ..HOX genes are markers of endometrial receptivity. The possibility of augmenting HOX gene expression with gene therapy to improve implantation has promise for the future...
  88. pmc HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse
    Kathleen A Connell
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 118:1050-5. 2008
    ....
  89. pmc Gene expression profiling reveals putative HOXA10 downstream targets in the periimplantation mouse uterus
    Danielle Vitiello
    Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Reprod Sci 15:529-35. 2008
    ..Elucidation of these pathways will allow further characterization of the molecular mechanisms governing endometrial development, which also may function to enhance uterine receptivity...
  90. pmc HOXA10 regulates endometrial GABAA {pi} receptor expression and membrane translocation
    Homayoun Sadeghi
    Dept of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Endocrinol Metab 298:E889-93. 2010
    ....
  91. pmc Stem cells and reproduction
    Hongling DU
    Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Curr Opin Obstet Gynecol 22:235-41. 2010
    ..To review the latest developments in reproductive tract stem cell biology...
  92. ncbi request reprint In vivo gene transfer of lefty leads to implantation failure in mice
    Meiyi Tang
    Department of Obstetrics and Gynecology, Stony Brook University, Stony Brook, NY, USA
    Hum Reprod 20:1772-8. 2005
    ..Endometrium is a unique tissue that is prepared for implantation of blastocyst during each menstrual cycle. In humans, if implantation does not occur or fails, endometrium is shed...
  93. ncbi request reprint Thrombin and interleukin-1beta regulate HOXA10 expression in human term decidual cells: implications for preterm labor
    Jennifer L Sarno
    Division of Reproductive Endocrinology and Fertility, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 91:2366-72. 2006
    ..The uteri of Hoxa10(-/-) mice demonstrate progesterone resistance; several genes, including prostaglandin receptors, are inappropriately regulated in response to progesterone...
  94. pmc Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling
    Leo F Doherty
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Endocrinol Metab 300:E86-93. 2011
    ..In endometrial glands, HOXA10 decreases TDO mRNA leading to increased serotonin that in turn acts to promote normal embryo development...
  95. pmc Leiomyoma simultaneously impair endometrial BMP-2-mediated decidualization and anticoagulant expression through secretion of TGF-β3
    Donna C Sinclair
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 96:412-21. 2011
    ..Leiomyoma reduce implantation, increase miscarriage risk, and increase menstrual bleeding. We hypothesized that endometrial defects induced by leiomyoma result in menorrhagia and reproductive dysfunction...
  96. pmc Treatment with bazedoxifene, a selective estrogen receptor modulator, causes regression of endometriosis in a mouse model
    Jaime Kulak
    Division of Reproductive Endocrinology and Infertility, Yale University, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Endocrinology 152:3226-32. 2011
    ..BZA may be an effective novel agent for the treatment of endometriosis due to greater endometrial-specific estrogen antagonism compared with other SERM...
  97. ncbi request reprint Altered expression of HOXA10 in endometriosis: potential role in decidualization
    J Julie Kim
    Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, USA
    Mol Hum Reprod 13:323-32. 2007
    ..These data demonstrate that HOXA10 negatively influences IGFBP1 expression in decidualizing cells. Thus, the decrease in HOXA10 levels may in part be involved with the altered uterine environment associated with endometriosis...
  98. ncbi request reprint Homeobox gene expression in ovarian cancer
    Susan M Pando
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, USA
    Cancer Treat Res 107:231-45. 2002
  99. ncbi request reprint The Women's Health Initiative could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition
    Frederick Naftolin
    Yale University, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 81:1498-501. 2004
    ..Randomized controlled trials are urgently needed to test cardioprotection in women starting treatment during the menopausal transition...
  100. pmc Training of residents in laparoscopic tubal sterilization: long-term failure rates
    Beth W Rackow
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Eur J Contracept Reprod Health Care 13:148-52. 2008
    ..This study investigated the long-term failure rate of this procedure when performed by Obstetrics and Gynaecology residents on women treated in their teaching clinics...
  101. pmc The immunoconjugate "icon" targets aberrantly expressed endothelial tissue factor causing regression of endometriosis
    Graciela Krikun
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06520 8063, USA
    Am J Pathol 176:1050-6. 2010
    ..Thus, Icon could serve as a novel, nontoxic, fertility-preserving, and effective treatment for endometriosis...