Elisabetta Ullu

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc RNA interference: advances and questions
    Elisabetta Ullu
    Department of Internal Medicine, and Department of Cell Biology, Yale Medical School, 333 Cedar Street, New Haven, CT 06520 8022, USA
    Philos Trans R Soc Lond B Biol Sci 357:65-70. 2002
  2. pmc Depletion of newly synthesized Argonaute1 impairs the RNAi response in Trypanosoma brucei
    Huafang Shi
    Department of Internal Medicine, Yale University Medical School, New Haven, CT 06536 0812, USA
    RNA 13:1132-9. 2007
  3. pmc Small sense and antisense RNAs derived from a telomeric retroposon family in Giardia intestinalis
    Elisabetta Ullu
    Department of Internal Medicine, Yale Medical School, BCMM 136D, 295 Congress Avenue, Box 9812, New Haven, CT 06536 8012, USA
    Eukaryot Cell 4:1155-7. 2005
  4. ncbi request reprint RNA interference in protozoan parasites
    Elisabetta Ullu
    Department of Internal Medicine, Yale Medical School, BCMM 136D, 295 Congress Avenue, Box 9812, New Haven, CT, 06536 8012, USA
    Cell Microbiol 6:509-19. 2004
  5. pmc RNA interference in Trypanosoma brucei: role of the n-terminal RGG domain and the polyribosome association of argonaute
    Huafang Shi
    Department of Internal Medicine, Yale University Medical School, New Haven, Connecticut 06536 8012, USA
    J Biol Chem 284:36511-20. 2009
  6. pmc Distinct and overlapping roles for two Dicer-like proteins in the RNA interference pathways of the ancient eukaryote Trypanosoma brucei
    Kristin L Patrick
    Department of Epidemiology and Public Health, Yale University Medical School, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Proc Natl Acad Sci U S A 106:17933-8. 2009
  7. pmc Genomic rearrangements and transcriptional analysis of the spliced leader-associated retrotransposon in RNA interference-deficient Trypanosoma brucei
    Kristin L Patrick
    Department of Epidemiology and Public Health, Yale University Medical School, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Mol Microbiol 67:435-47. 2008
  8. pmc Evidence for a capping enzyme with specificity for the trypanosome spliced leader RNA
    Jia Peng Ruan
    Department of Epidemiology and Public Health, Yale University Medical School, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Mol Biochem Parasitol 156:246-54. 2007
  9. pmc Selection and characterization of RNA interference-deficient trypanosomes impaired in target mRNA degradation
    Huafang Shi
    Department of Internal Medicine, Yale Medical School, BCMM 136D, 295 Congress Ave, Box 9812, New Haven, CT 06536 8012, USA
    Eukaryot Cell 3:1445-53. 2004
  10. pmc Role of a 300-kilodalton nuclear complex in the maturation of Trypanosoma brucei initiator methionyl-tRNA
    George K Arhin
    Department of Epidemiology and Public Health, Yale University Medical School, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Eukaryot Cell 3:893-9. 2004

Research Grants

Collaborators

  • Christian Tschudi
  • Appolinaire Djikeng
  • Matthias Mann
  • Hugo D Lujan
  • Henriette Irmer
  • Cynthia Y He
  • Derek Toomre
  • Mark C Field
  • A H Fairlamb
  • JOHN DONELSON
  • Frederic Bringaud
  • Neil Hall
  • Klaus Ersfeld
  • Huafang Shi
  • Nikolay G Kolev
  • George K Arhin
  • Vanessa D Atayde
  • Jia Peng Ruan
  • Kristin L Patrick
  • Kiantra Ramey-Butler
  • Rebecca L Barnes
  • Joseph B Franklin
  • Shuiyuan Shen
  • Megan Ericson
  • Nathalie Chamond
  • Nicholas Carriero
  • George A M Cross
  • Christian J Janzen
  • Matthew Berriman
  • David Wanless
  • Mark D Adams
  • Lihua Hou
  • Grace Pai
  • Anjana J Simpson
  • Linda Hannick
  • Elisabet Caler
  • Claire M Fraser
  • Andrew Tait
  • Susan Van Aken
  • Vanessa Leech
  • Tamara Feldblyum
  • Owen White
  • Christopher Larkin
  • Gaelle Blandin
  • Brian Haas
  • Annette MacLeod
  • C Michael R Turner
  • Jeremy Peterson
  • Elodie Ghedin
  • Najib M A El-Sayed
  • Falk Butter
  • Michael A Janes
  • Li Liu
  • Lon Fye Lye
  • Katherine Owens
  • Stephen M Beverley
  • Timothy Notton
  • Paula M Luz
  • Frederick van Deursen
  • Hongjie Li
  • Keith R Matthews
  • J David Barry
  • Doug Ormond
  • Lucio Marcello
  • Jessica Hostetler
  • Hean Koo
  • Keith Gull
  • Hubert Renauld
  • Zahra Hance
  • Nicola J Lennard
  • Kay Jagels
  • Danielle Walker
  • Martin A Aslett
  • Scott Landfear
  • Natasha Larke
  • Inna Cherevach
  • Mark Carrington
  • Bill Wickstead
  • Ann Cronin
  • Sally Whitehead
  • Ian Goodhead
  • Louise N Clark
  • Adrian R Tivey
  • Justin Johnson
  • Audrey Fraser
  • Craig H Corton
  • Huân Ngo
  • Jennifer Wortman
  • Al Ivens
  • Nancy E Hamlin

Detail Information

Publications45

  1. pmc RNA interference: advances and questions
    Elisabetta Ullu
    Department of Internal Medicine, and Department of Cell Biology, Yale Medical School, 333 Cedar Street, New Haven, CT 06520 8022, USA
    Philos Trans R Soc Lond B Biol Sci 357:65-70. 2002
    ..We provide a synopsis of what is currently known about RNAi in T. brucei and outline the recent advances that make RNAi the method of choice to disrupt gene function in these organisms...
  2. pmc Depletion of newly synthesized Argonaute1 impairs the RNAi response in Trypanosoma brucei
    Huafang Shi
    Department of Internal Medicine, Yale University Medical School, New Haven, CT 06536 0812, USA
    RNA 13:1132-9. 2007
    ..We speculate that newly processed siRNAs may be preferentially loaded onto newly synthesized TbAGO1, and this mechanism may contribute to the homeostasis of the RNAi pathway...
  3. pmc Small sense and antisense RNAs derived from a telomeric retroposon family in Giardia intestinalis
    Elisabetta Ullu
    Department of Internal Medicine, Yale Medical School, BCMM 136D, 295 Congress Avenue, Box 9812, New Haven, CT 06536 8012, USA
    Eukaryot Cell 4:1155-7. 2005
    ..These small RNAs may contribute to silencing GilT expression via the RNA interference pathway...
  4. ncbi request reprint RNA interference in protozoan parasites
    Elisabetta Ullu
    Department of Internal Medicine, Yale Medical School, BCMM 136D, 295 Congress Avenue, Box 9812, New Haven, CT, 06536 8012, USA
    Cell Microbiol 6:509-19. 2004
    ....
  5. pmc RNA interference in Trypanosoma brucei: role of the n-terminal RGG domain and the polyribosome association of argonaute
    Huafang Shi
    Department of Internal Medicine, Yale University Medical School, New Haven, Connecticut 06536 8012, USA
    J Biol Chem 284:36511-20. 2009
    ..This mechanism may represent an ancient adaptation to ensure that retroposon transcripts are efficiently destroyed, if they become associated with the translational apparatus...
  6. pmc Distinct and overlapping roles for two Dicer-like proteins in the RNA interference pathways of the ancient eukaryote Trypanosoma brucei
    Kristin L Patrick
    Department of Epidemiology and Public Health, Yale University Medical School, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Proc Natl Acad Sci U S A 106:17933-8. 2009
    ..Our finding that dcl2KO cells are more sensitive to RNAi triggers than wild-type cells has significant implications for reverse genetic analyses in this important human pathogen...
  7. pmc Genomic rearrangements and transcriptional analysis of the spliced leader-associated retrotransposon in RNA interference-deficient Trypanosoma brucei
    Kristin L Patrick
    Department of Epidemiology and Public Health, Yale University Medical School, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Mol Microbiol 67:435-47. 2008
    ..We speculate that the small SLACS transcripts serve as substrates for the production of siRNAs to regulate SLACS expression...
  8. pmc Evidence for a capping enzyme with specificity for the trypanosome spliced leader RNA
    Jia Peng Ruan
    Department of Epidemiology and Public Health, Yale University Medical School, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Mol Biochem Parasitol 156:246-54. 2007
    ..Furthermore, consistent with co-transcriptional addition of the m(7)G cap, chromatin immunoprecipitation revealed recruitment of TbCgm1 to the SL RNA genes...
  9. pmc Selection and characterization of RNA interference-deficient trypanosomes impaired in target mRNA degradation
    Huafang Shi
    Department of Internal Medicine, Yale Medical School, BCMM 136D, 295 Congress Ave, Box 9812, New Haven, CT 06536 8012, USA
    Eukaryot Cell 3:1445-53. 2004
    ..Since in RiD cells the AGO1 gene was not mutated and was expressed at wild-type levels, we propose that in trypanosomes the cleavage of mRNA by AGO1 is regulated by the interaction with another factor(s)...
  10. pmc Role of a 300-kilodalton nuclear complex in the maturation of Trypanosoma brucei initiator methionyl-tRNA
    George K Arhin
    Department of Epidemiology and Public Health, Yale University Medical School, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Eukaryot Cell 3:893-9. 2004
    ..Taken together, our data provide a glance at the maturation of tRNAs in parasitic protozoa and suggest that at least for initiator tRNA(Met), 3' trimming precedes 5' processing...
  11. pmc An unusual Dicer-like1 protein fuels the RNA interference pathway in Trypanosoma brucei
    Huafang Shi
    Department of Internal Medicine, Yale University Medical School, New Haven, Connecticut 06536 0812, USA
    RNA 12:2063-72. 2006
    ..This domain organization is specific to trypanosomatids and further illustrates the variable structures of protozoan Dicer-like proteins as compared to fungal and metazoan Dicer...
  12. pmc Characterization of the Trypanosoma brucei cap hypermethylase Tgs1
    Jia Peng Ruan
    Department of Epidemiology and Public Health, Yale University Medical School, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Mol Biochem Parasitol 155:66-9. 2007
    ....
  13. pmc Role of the Trypanosoma brucei HEN1 family methyltransferase in small interfering RNA modification
    Huafang Shi
    Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA
    Eukaryot Cell 13:77-86. 2014
    ..Moreover, expression of TbHEN1 in Leishmania (Viannia) panamensis did not result in siRNA 3' end methylation, further emphasizing mechanistic differences in the trypanosome and Leishmania RNAi mechanisms. ..
  14. pmc Small interfering RNA-producing loci in the ancient parasitic eukaryote Trypanosoma brucei
    Christian Tschudi
    Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06536, USA
    BMC Genomics 13:427. 2012
    ..Recent evidence from higher eukaryotes suggests that a variety of genomic sequences with the potential to produce double-stranded RNA are sources for small interfering RNAs (siRNAs)...
  15. pmc Argonaute protein in the early divergent eukaryote Trypanosoma brucei: control of small interfering RNA accumulation and retroposon transcript abundance
    Huafang Shi
    Department of Internal Medicine, Yale University Medical School, New Haven, Connecticut 06536 0812, USA
    Mol Cell Biol 24:420-7. 2004
    ..Our results suggest that AGO1 function is required for production and/or stabilization of siRNAs and provide the first evidence for an Argonaute protein being involved in the regulation of retroposon transcript levels...
  16. ncbi request reprint Analysis of gene function in Trypanosoma brucei using RNA interference
    Appolinaire Djikeng
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Biol 265:73-83. 2004
    ..brucei with particular emphasis on transfection and cloning of procyclic cells, induction of dsRNA expression, isolation of RNA and analysis of dsRNA, and target mRNA...
  17. ncbi request reprint 2'-O-methylation of position 2 of the trypanosome spliced leader cap 4 is mediated by a 48 kDa protein related to vaccinia virus VP39
    George K Arhin
    Department of Internal Medicine, Yale University Medical School, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Mol Biochem Parasitol 147:137-9. 2006
  18. pmc The structure and repertoire of small interfering RNAs in Leishmania (Viannia) braziliensis reveal diversification in the trypanosomatid RNAi pathway
    Vanessa D Atayde
    Departments of Internal Medicine, Yale University, New Haven, CT 06536, USA
    Mol Microbiol 87:580-93. 2013
    ..Thus, our results indicate that organism-specific diversification has occurred in the RNAi pathway during evolution of the trypanosomatid lineage...
  19. pmc A single-cloning-step procedure for the generation of RNAi plasmids producing long stem-loop RNA
    Vanessa D Atayde
    Department of Internal Medicine, Yale School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Mol Biochem Parasitol 184:55-8. 2012
    ..The protocol is suitable for any plasmid (for constitutive or inducible expression) and for any organism in which long stem-loops can be used to elicit RNAi...
  20. pmc A protein related to the vaccinia virus cap-specific methyltransferase VP39 is involved in cap 4 modification in Trypanosoma brucei
    George K Arhin
    Department of Epidemiology and Public Health, Yale University Medical School, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    RNA 12:53-62. 2006
    ..Interestingly, MT57 homologs are only found in trypanosomatid protozoa that have a cap 4 structure and in poxviruses, of which vaccinia virus is a prototype...
  21. ncbi request reprint Repression of gene expression by the coliphage MS2 coat protein in Trypanosoma brucei
    Huafang Shi
    Department of Internal Medicine, Yale Medical School, BCMM 136D, 295 Congress Avenue, Box 9812, New Haven, CT 06536 8012, USA
    Mol Biochem Parasitol 144:119-22. 2005
  22. ncbi request reprint Downregulation of the essential Trypanosoma brucei La protein affects accumulation of elongator methionyl-tRNA
    George K Arhin
    Department of Internal Medicine, Yale University Medical School, BCMM 136D, 295 Congress Avenue, Box 9812, New Haven, CT 06536 8012, USA
    Mol Biochem Parasitol 144:104-8. 2005
  23. pmc An siRNA ribonucleoprotein is found associated with polyribosomes in Trypanosoma brucei
    Appolinaire Djikeng
    Department of Internal Medicine, Yale University Medical School, New Haven, Connecticut 06520 8022, USA
    RNA 9:802-8. 2003
    ..We further provide evidence that siRNAs are associated with translating ribosomes and that this association is mediated by a 70-kD ribonucleoprotein complex...
  24. pmc Functional characterization of a Trypanosoma brucei TATA-binding protein-related factor points to a universal regulator of transcription in trypanosomes
    Jia Peng Ruan
    Department of Epidemiology and Public Health, Yale University Medical School, 295 Congress Ave, New Haven, CT 06536 0812, USA
    Mol Cell Biol 24:9610-8. 2004
    ..Finally, a search for TRF4 binding sites in the T. brucei genome led to the identification of such sites in the 3' portion of certain protein-coding genes, indicating a unique aspect of Pol II transcription in these organisms...
  25. pmc RNA interference in protozoan parasites: achievements and challenges
    Nikolay G Kolev
    Department of Internal Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Eukaryot Cell 10:1156-63. 2011
    ..Here we review the current status of RNAi in studies of parasitic protozoa, with special emphasis on its use as a postgenomic tool...
  26. ncbi request reprint Analysis of gene function in Trypanosoma brucei using RNA interference
    Appolinaire Djikeng
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Biol 270:287-98. 2004
    ..brucei with particular emphasis on transfection and cloning of procyclic cells, induction of dsRNA expression, isolation of RNA, and analysis of dsRNA and target mRNA...
  27. pmc Functional replacement of Trypanosoma brucei Argonaute by the human slicer Argonaute2
    Huafang Shi
    Department of Internal Medicine, Yale University Medical School, New Haven, Connecticut 06536, USA
    RNA 12:943-7. 2006
    ..This finding indicates that the basic features of the RNAi mechanism are conserved from T. brucei to man...
  28. pmc Developmental progression to infectivity in Trypanosoma brucei triggered by an RNA-binding protein
    Nikolay G Kolev
    Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06536, USA
    Science 338:1352-3. 2012
    ..Thus, events leading to acquisition of infectivity in the insect vector are now accessible to laboratory investigation, providing an opening for new intervention strategies...
  29. pmc Comparative genomics reveals two novel RNAi factors in Trypanosoma brucei and provides insight into the core machinery
    Rebecca L Barnes
    Department of Internal Medicine, Yale University, New Haven, Connecticut, USA
    PLoS Pathog 8:e1002678. 2012
    ..The availability of the core RNAi machinery in T. brucei provides a platform to gain mechanistic insights in this ancient eukaryote and to identify the minimal set of components required to reconstitute RNAi in RNAi-deficient parasites...
  30. ncbi request reprint Function of the Trypanosome Argonaute 1 protein in RNA interference requires the N-terminal RGG domain and arginine 735 in the Piwi domain
    Huafang Shi
    Department of Internal Medicine, Yale University Medical School, New Haven, Connecticut 06536 0812, USA
    J Biol Chem 279:49889-93. 2004
    ..Although the R735A mutant bound siRNAs and associated with polyribosomes, it displayed a severe defect in the cleavage of target mRNA...
  31. ncbi request reprint In vivo analysis of the RNA interference mechanism in Trypanosoma brucei
    Christian Tschudi
    Department of Internal Medicine, Yale University Medical School, 333 Cedar Street, New Haven, Connecticut 06520 8022, USA
    Methods 30:304-12. 2003
    ..In this article, we describe some of the methods we employ for the analysis of the RNAi mechanism in T. brucei with particular emphasis on detection, cloning, and fractionation of siRNAs and siRNA complexes...
  32. pmc Biochemical analysis of PIFTC3, the Trypanosoma brucei orthologue of nematode DYF-13, reveals interactions with established and putative intraflagellar transport components
    Joseph B Franklin
    Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06536, USA
    Mol Microbiol 78:173-86. 2010
    ..Thus, our biochemical analysis supports the model, proposed by genetic analysis in C. elegans, that the trypanosome orthologue of DYF-13 plays a central role in the IFT mechanism...
  33. ncbi request reprint Efficient transposition of preformed synaptic Tn5 complexes in Trypanosoma brucei
    Huafang Shi
    Department of Internal Medicine, Yale Medical School, 333 Cedar Street, New Haven, CT 06529 8022, USA
    Mol Biochem Parasitol 121:141-4. 2002
  34. doi request reprint snoRNAs in Giardia lamblia: a novel role in RNA silencing?
    Nikolay G Kolev
    Yale School of Public Health, New Haven, CT 06536 0812, USA
    Trends Parasitol 25:348-50. 2009
    ..Interestingly, these RNAs occur not only in this parasite but also in humans...
  35. ncbi request reprint A PCR-based method for gene deletion and protein tagging in Trypanosoma brucei
    George K Arhin
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Biol 270:277-86. 2004
    ..The PCR product is then transfected directly into procyclic T. brucei cells, and homologous recombinants that carry the deleted or tagged target gene are identified...
  36. pmc Synchronous expression of individual metacyclic variant surface glycoprotein genes in Trypanosoma brucei
    Kiantra Ramey-Butler
    Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06536, USA
    Mol Biochem Parasitol 200:1-4. 2015
    ..We observed that activation of these two mVSGs was simultaneous both at the transcript and protein level, and manifested by the appearance of only one of the mVSGs in individual cells. ..
  37. doi request reprint Construction of Trypanosoma brucei Illumina RNA-Seq libraries enriched for transcript ends
    Nikolay G Kolev
    Department of Epidemiology of Microbial Diseases, School of Public Health, Yale University, New Haven, CT, USA
    Methods Mol Biol 1201:165-75. 2015
    ....
  38. pmc The emerging role of RNA-binding proteins in the life cycle of Trypanosoma brucei
    Nikolay G Kolev
    Department of Epidemiology of Microbial Diseases, School of Public Health, Yale University, New Haven, CT, USA
    Cell Microbiol 16:482-9. 2014
    ..Here, we discuss recent progress in the identification of RBPs with crucial roles in different stages of the T. brucei life cycle, and in elucidating targets of RBPs. ..
  39. pmc Golgi duplication in Trypanosoma brucei
    Cynthia Y He
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar St, P O Box 208002, New Haven, CT 06520 8002, USA
    J Cell Biol 165:313-21. 2004
    ..Rather, it is supplied, at least in part, by material directly from the old Golgi. Pharmacological experiments show that the site of the new Golgi and ER export is determined by the location of the new basal body...
  40. pmc The emerging world of small silencing RNAs in protozoan parasites
    Vanessa D Atayde
    Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06536, USA
    Trends Parasitol 27:321-7. 2011
    ..In this article, we focus on the striking diversity of small silencing RNAs that have been identified in several protozoan parasites and their potential biological role...
  41. pmc On the extent and role of the small proteome in the parasitic eukaryote Trypanosoma brucei
    Megan Ericson
    Department of Epidemiology of Microbial Diseases, School of Public Health, Yale University, New Haven, CT, USA
    BMC Biol 12:14. 2014
    ..Such information can be particularly relevant to human pathogens, such as Trypanosoma brucei, the causative agent of African trypanosomiasis, since it will provide further insight into the parasite biology and life cycle...
  42. ncbi request reprint RNA interference of signal peptide-binding protein SRP54 elicits deleterious effects and protein sorting defects in trypanosomes
    Li Liu
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Biol Chem 277:47348-57. 2002
    ..The translocation of these proteins to the endoplasmic reticulum under SRP54 depletion suggests that an alternative pathway for protein translocation exists in trypanosomes...
  43. pmc Expression site silencing and life-cycle progression appear normal in Argonaute1-deficient Trypanosoma brucei
    Christian J Janzen
    Laboratory of Molecular Parasitology, The Rockefeller University, Box 185, 1230 York Avenue, New York, NY 10021 6399, USA
    Mol Biochem Parasitol 149:102-7. 2006
  44. ncbi request reprint The genome of the African trypanosome Trypanosoma brucei
    Matthew Berriman
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Science 309:416-22. 2005
    ..brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified...
  45. pmc The sequence and analysis of Trypanosoma brucei chromosome II
    Najib M A El-Sayed
    The Institute for Genomic Research, Rockville, MD 20850, USA
    Nucleic Acids Res 31:4856-63. 2003
    ....

Research Grants3

  1. 2006 Biology of Host-Parasite Interactions Gordon Research Conference
    Elisabetta Ullu; Fiscal Year: 2006
    ..Host-Cell Invasion (Discussion Leader: Barbara Burleigh: Harvard) Trichomonads and Amoebae (Discussion Leader: Patricia Johnson, UCLA) Parasite Membrane Biology (Discussion Leader: Scott Landfear: University of Oregon) ..
  2. Biology of Host-Parasite Interactions 2008 Gordon Research Conference
    Elisabetta Ullu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  3. RNA METABOLISM IN TRYPANOSOMES
    Elisabetta Ullu; Fiscal Year: 2009
    ..3. Further characterize the RNAi pathway in terms of its components and how the interaction of TbAGO1 with translating ribosomes is brought about. ..