Zhongjian Xie

Summary

Publications

  1. Xie Z, Chen Y, Liao E, Jiang Y, Liu F, Pennypacker S. Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis. Biochem Biophys Res Commun. 2010;397:296-300 pubmed publisher
    ..These data suggest that PLC-gamma1 is required for EGFR-induced SCC cell mitogenesis and the mitogenic function of PLC-gamma1 is independent of its lipase activity. ..
  2. Xie Z, Chen Y, Pennypacker S, Zhou Z, Peng D. The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis. Biochem Biophys Res Commun. 2010;398:719-22 pubmed publisher
    ..These data suggest that the SH3 domain, but not the catalytic domain, is required for PLC-gamma1 to mediate EGF-induced SCC4 cell mitogenesis. ..
  3. Xie Z, Peng J, Pennypacker S, Chen Y. Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration. Biochem Biophys Res Commun. 2010;399:425-8 pubmed publisher
    ..These data indicate that EGF-induced cell migration is mediated by the lipase domain of PLC-gamma1 and the subsequent IP(3) generation and intracellular calcium mobilization. ..
  4. Xie Z, Jiang Y, Liao E, Chen Y, Pennypacker S, Peng J, et al. PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells. Oncogene. 2012;31:5090-8 pubmed publisher
    ..However, inhibition of the catalytic activity of PLC-γ1 had little effect. These data suggest that PIKE has a critical role in EGF-induced SCC cell proliferation and may function as a proto-oncogene in SCC. ..

Detail Information

Publications4

  1. Xie Z, Chen Y, Liao E, Jiang Y, Liu F, Pennypacker S. Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis. Biochem Biophys Res Commun. 2010;397:296-300 pubmed publisher
    ..These data suggest that PLC-gamma1 is required for EGFR-induced SCC cell mitogenesis and the mitogenic function of PLC-gamma1 is independent of its lipase activity. ..
  2. Xie Z, Chen Y, Pennypacker S, Zhou Z, Peng D. The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis. Biochem Biophys Res Commun. 2010;398:719-22 pubmed publisher
    ..These data suggest that the SH3 domain, but not the catalytic domain, is required for PLC-gamma1 to mediate EGF-induced SCC4 cell mitogenesis. ..
  3. Xie Z, Peng J, Pennypacker S, Chen Y. Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration. Biochem Biophys Res Commun. 2010;399:425-8 pubmed publisher
    ..These data indicate that EGF-induced cell migration is mediated by the lipase domain of PLC-gamma1 and the subsequent IP(3) generation and intracellular calcium mobilization. ..
  4. Xie Z, Jiang Y, Liao E, Chen Y, Pennypacker S, Peng J, et al. PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells. Oncogene. 2012;31:5090-8 pubmed publisher
    ..However, inhibition of the catalytic activity of PLC-γ1 had little effect. These data suggest that PIKE has a critical role in EGF-induced SCC cell proliferation and may function as a proto-oncogene in SCC. ..