Zhongjian Xie

Summary

Publications

  1. doi request reprint PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells
    Z Xie
    Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Oncogene 31:5090-8. 2012
  2. pmc Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 397:296-300. 2010
  3. pmc The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 398:719-22. 2010
  4. pmc Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 399:425-8. 2010
  5. pmc Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California at San Francisco, San Francisco, CA 94121, USA
    Mol Biol Cell 20:1695-704. 2009
  6. ncbi request reprint Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Biol Chem 283:3519-28. 2008
  7. pmc Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California San Francisco, San Francisco, CA 94121, USA
    Mol Biol Cell 16:3236-46. 2005
  8. ncbi request reprint The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiation
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California, San Francisco, California 94121, USA
    J Biol Chem 282:8695-703. 2007
  9. pmc Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-γ1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma
    Yi Jiang
    Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China
    Int J Clin Exp Pathol 8:9042-51. 2015
  10. ncbi request reprint Development and progression of alopecia in the vitamin D receptor null mouse
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Cell Physiol 207:340-53. 2006

Detail Information

Publications15

  1. doi request reprint PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells
    Z Xie
    Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Oncogene 31:5090-8. 2012
    ..However, inhibition of the catalytic activity of PLC-γ1 had little effect. These data suggest that PIKE has a critical role in EGF-induced SCC cell proliferation and may function as a proto-oncogene in SCC...
  2. pmc Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 397:296-300. 2010
    ..These data suggest that PLC-gamma1 is required for EGFR-induced SCC cell mitogenesis and the mitogenic function of PLC-gamma1 is independent of its lipase activity...
  3. pmc The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 398:719-22. 2010
    ..These data suggest that the SH3 domain, but not the catalytic domain, is required for PLC-gamma1 to mediate EGF-induced SCC4 cell mitogenesis...
  4. pmc Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 399:425-8. 2010
    ..These data indicate that EGF-induced cell migration is mediated by the lipase domain of PLC-gamma1 and the subsequent IP(3) generation and intracellular calcium mobilization...
  5. pmc Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California at San Francisco, San Francisco, CA 94121, USA
    Mol Biol Cell 20:1695-704. 2009
    ..This signaling pathway is critical for Cao-induced generation of the second messengers IP3 and Cai and keratinocyte differentiation...
  6. ncbi request reprint Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Biol Chem 283:3519-28. 2008
    ..Our results indicate that the CaR regulates cell survival and Ca(2+)(o)-induced differentiation in keratinocytes at least in part by activating the E-cadherin/PI3K pathway through a Src family tyrosine kinase-mediated signaling...
  7. pmc Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California San Francisco, San Francisco, CA 94121, USA
    Mol Biol Cell 16:3236-46. 2005
    ..These data indicate that calcium activates PLC-gamma1 via increased PIP3 formation mediated by c-src- and fyn-activated PI3K. This activation is required for calcium-induced human keratinocyte differentiation...
  8. ncbi request reprint The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiation
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California, San Francisco, California 94121, USA
    J Biol Chem 282:8695-703. 2007
    ....
  9. pmc Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-γ1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma
    Yi Jiang
    Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China
    Int J Clin Exp Pathol 8:9042-51. 2015
    ..These data indicate that increased expression of PLC-γ1 and PIKE and decreased expression of E-cadherin and p120 are associated with the aggressiveness of OSCC...
  10. ncbi request reprint Development and progression of alopecia in the vitamin D receptor null mouse
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Cell Physiol 207:340-53. 2006
    ..These changes are associated with increased expression of Hr, suggesting a role for VDR in regulating Hr expression. Both Hr and VDR are required for normal hair follicle cycling...
  11. ncbi request reprint Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why?
    Daniel D Bikle
    Veterans Affairs Medical Center 111 N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Recent Results Cancer Res 164:111-22. 2003
    ....
  12. ncbi request reprint Hairless suppresses vitamin D receptor transactivation in human keratinocytes
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Endocrinology 147:314-23. 2006
    ..These data indicate that Hr functions as a corepressor of VDR to block 1,25(OH)2D3 action on keratinocytes...
  13. pmc Inhibition of 4-nitroquinoline-1-oxide-induced oral carcinogenesis by dietary calcium
    Yi Jiang
    Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China
    Int J Clin Exp Pathol 8:3529-42. 2015
    ..Increased E-cadherin, β-catenin, p120 and EGFR and decreased PLC-γ1 may participate in the inhibitory effect of dietary calcium in oral carcinogenesis. ..
  14. ncbi request reprint The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, USA
    J Invest Dermatol 119:1109-13. 2002
    ....
  15. ncbi request reprint The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Biol Chem 277:36987-90. 2002
    ..We believe this to be a unique mechanism for autoregulation of steroid hormone synthesis...