Meihua Yang

Summary

Publications

  1. doi request reprint A self-assembly aptasensor based on thick-shell quantum dots for sensing of ochratoxin A
    Xianfeng Chu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Nanoscale 8:4127-33. 2016
  2. doi request reprint Simultaneous targeted analysis of five active compounds in licorice by ultra-fast liquid chromatography coupled to hybrid linear-ion trap tandem mass spectrometry
    Weijun Kong
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Analyst 139:1883-94. 2014
  3. doi request reprint Simultaneous multi-mycotoxin determination in nutmeg by ultrasound-assisted solid-liquid extraction and immunoaffinity column clean-up coupled with liquid chromatography and on-line post-column photochemical derivatization-fluorescence detection
    Wei Jun Kong
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, China
    Analyst 138:2729-39. 2013
  4. ncbi request reprint A new lignan from the Jian-er syrup and its content determination by RP-HPLC
    Meihua Yang
    Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100094, PR China
    J Pharm Biomed Anal 41:662-6. 2006
  5. doi request reprint Occurrence of toxigenic fungi and determination of mycotoxins by HPLC-FLD in functional foods and spices in China markets
    Weijun Kong
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Food Chem 146:320-6. 2014
  6. doi request reprint Simultaneous determination of seven lignans in Justicia procumbens by high performance liquid chromatography-photodiode array detection using relative response factors
    Zuliang Luo
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    J Sep Sci 36:699-705. 2013
  7. doi request reprint Quantification and pharmacokinetics of Taiwanin E methyl ether in rats by liquid chromatography-tandem mass spectrometry
    Feng Qiu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Biomed Chromatogr 27:233-9. 2013
  8. doi request reprint Complete assignments of 1H and 13C NMR data for three new arylnaphthalene lignan from Justicia procumbens
    Guorui Liu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, P R China
    Magn Reson Chem 46:283-6. 2008
  9. doi request reprint LC-ESI-MS/MS analysis and pharmacokinetics of 6'-hydroxy justicidin A, a potential antitumor active component isolated from Justicia procumbens, in rats
    Feng Qiu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    J Pharm Biomed Anal 70:539-43. 2012
  10. doi request reprint UFLC-ESI-MS/MS analysis of multiple mycotoxins in medicinal and edible Areca catechu
    Hongmei Liu
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, China
    Chemosphere 150:176-83. 2016

Collaborators

  • Ming Zhao
  • Jun Wu
  • Riwei Wei
  • Wei Li
  • Qian Li
  • Hua Li
  • Juan Chen
  • Xiaoli Yang
  • Yan Li
  • Gang Zhao
  • Lei Zhang
  • Wei Liu
  • Jian Wang
  • Zhen Wang
  • Luqi Huang
  • Lan Xiang
  • Jun Xu
  • JunShan Yang
  • Weijun Kong
  • Jiaoyang Luo
  • Feng Qiu
  • Yichen Hu
  • Qiutao Liu
  • Xiangsheng Zhao
  • Hongmei Liu
  • Shihai Yang
  • Shujun Zhou
  • Jianhe Wei
  • Xiaowen Dou
  • Qing Miao
  • Yinhui Yang
  • Jing Wen
  • Jiliang Cao
  • Ying Kuang
  • Xiaohe Xiao
  • Antonio F Logrieco
  • Menghua Li
  • Jia an Qin
  • Xianfeng Chu
  • Weiying Guo
  • Lianhua Zhao
  • Bao Gong
  • Zhen Ou-Yang
  • Xiaofei Zhang
  • Linan Wang
  • Weilu Zhou
  • Shanshan Zhang
  • Qiang Xiao
  • Yun Qi
  • Li Wan
  • Wei Jun Kong
  • Zuliang Luo
  • Lizhi Wang
  • Shujun Fu
  • Shilin Chen
  • Yuchun Zhou
  • Yuguo Zheng
  • Qianzhen Liu
  • Shuyu Liu
  • Rong Xu
  • Jianyu Pan
  • Lei Yang
  • Guorui Liu
  • Jinming Zhang
  • Xiaoyan Shu
  • Xingguo Zhang
  • Hongli Luo
  • Deli Chen
  • Ruizheng Liang
  • Hongzheng Zhao
  • Huanhuan Feng
  • Dandan Kong
  • Yakui Zhou
  • Ruilin Wang
  • Zhen Ouyang
  • Xiaoyan Xing
  • Xinping Ma
  • Xiaojiao Sun
  • Yanling Zhao
  • Xiaochi Ma
  • Liwei Xie
  • Ping Sheng
  • Dan Yan
  • Weiwei Gao
  • Jieping Qin
  • Shu Yu Liu
  • Lihui Yin
  • Haiyan Cheng
  • Xiao He Xiao
  • Xiaoping Dong

Detail Information

Publications63

  1. doi request reprint A self-assembly aptasensor based on thick-shell quantum dots for sensing of ochratoxin A
    Xianfeng Chu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Nanoscale 8:4127-33. 2016
    ..Moreover, the high quality thick-shell QDs provide an ideal alternative for highly sensitive imaging and intensive illumination in the fields of biotechnology and bioengineering. ..
  2. doi request reprint Simultaneous targeted analysis of five active compounds in licorice by ultra-fast liquid chromatography coupled to hybrid linear-ion trap tandem mass spectrometry
    Weijun Kong
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Analyst 139:1883-94. 2014
    ..The results showed that the contents of the 5 compounds in licorice from different sources were widely varied...
  3. doi request reprint Simultaneous multi-mycotoxin determination in nutmeg by ultrasound-assisted solid-liquid extraction and immunoaffinity column clean-up coupled with liquid chromatography and on-line post-column photochemical derivatization-fluorescence detection
    Wei Jun Kong
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, China
    Analyst 138:2729-39. 2013
    ..8% of nutmeg samples at contamination levels of 0.73-16.31 μg kg(-1). At least two different mycotoxins were co-occurred in three samples, and three AFs were simultaneously detected in one sample...
  4. ncbi request reprint A new lignan from the Jian-er syrup and its content determination by RP-HPLC
    Meihua Yang
    Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100094, PR China
    J Pharm Biomed Anal 41:662-6. 2006
    ..0 ml/min. This method was validated in terms of selectivity, linearity, precision, accuracy, limit of detection, limit of quantitation and solution stability. It can be used to control the quality of this preparation effectively...
  5. doi request reprint Occurrence of toxigenic fungi and determination of mycotoxins by HPLC-FLD in functional foods and spices in China markets
    Weijun Kong
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Food Chem 146:320-6. 2014
    ..Four functional foods and three spices were found to be positive at low levels for mycotoxins including aflatoxin B1 (up to 0.26μg/kg) and ochratoxin A (OTA) (5.0μg/kg). The more frequently detected mycotoxin was AFB1 (16.7%). ..
  6. doi request reprint Simultaneous determination of seven lignans in Justicia procumbens by high performance liquid chromatography-photodiode array detection using relative response factors
    Zuliang Luo
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    J Sep Sci 36:699-705. 2013
    ..This method not only can determine multiple indexes in traditional Chinese medicines (TCMs) simultaneously, but also resolve the problem of lacking of chemical standards. It will be a good quality evaluation method and pattern for TCMs...
  7. doi request reprint Quantification and pharmacokinetics of Taiwanin E methyl ether in rats by liquid chromatography-tandem mass spectrometry
    Feng Qiu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Biomed Chromatogr 27:233-9. 2013
    ..45 mg/kg TEME. The oral absolute bioavailability of TEME was estimated to be 5.85 ± 1.41% with an elimination half-life value of 2.61 ± 0.55 h, suggesting its poor absorption and/or strong metabolism in vivo...
  8. doi request reprint Complete assignments of 1H and 13C NMR data for three new arylnaphthalene lignan from Justicia procumbens
    Guorui Liu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, P R China
    Magn Reson Chem 46:283-6. 2008
    ..The complete assignments of 1H and 13C NMR data for three new lignans were first obtained by means of 2D NMR techniques, including HSQC and HMBC...
  9. doi request reprint LC-ESI-MS/MS analysis and pharmacokinetics of 6'-hydroxy justicidin A, a potential antitumor active component isolated from Justicia procumbens, in rats
    Feng Qiu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    J Pharm Biomed Anal 70:539-43. 2012
    ..25 mg/kg HJA. The oral bioavailability (F) of HJA was estimated to be 36.0±13.4% with an elimination half-life (t(1/2)) value of 1.04±0.20 h...
  10. doi request reprint UFLC-ESI-MS/MS analysis of multiple mycotoxins in medicinal and edible Areca catechu
    Hongmei Liu
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, China
    Chemosphere 150:176-83. 2016
    ..catechu. The developed method with many advantages of simple pretreatment, rapid determination and high sensitivity is a proposed candidate for large-scale detection and quantification of multiple mycotoxins in other complex matrixes...
  11. doi request reprint Simultaneous determination of five bioactive components in radix glycyrrhizae by pressurised liquid extraction combined with UPLC-PDA and UPLC/ESI-QTOF-MS confirmation
    Shujun Zhou
    Jilin Agricultural University, 130118, Changchun, China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, 100193, Beijing, China
    Phytochem Anal 24:527-33. 2013
    ..The contents of these bioactive compounds may vary in different batches and affect the therapeutic effects. Thus comprehensive quality control and monitoring of their herbal formulation are of paramount concern...
  12. doi request reprint Dynamic variation of bioactive compounds and aflatoxins in contaminated Radix Astragali during extraction process
    Yichen Hu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, China
    J Sci Food Agric 96:1571-9. 2016
    ..There have been no studies on mycotoxin transfer into pharmaceutical preparations or derivative products...
  13. doi request reprint High-throughput determination of multi-mycotoxins in Chinese yam and related products by ultra fast liquid chromatography coupled with tandem mass spectrometry after one-step extraction
    Menghua Li
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China School of Pharmacy, Jiangsu University, Zhenjiang 212013, China
    J Chromatogr B Analyt Technol Biomed Life Sci 1022:118-25. 2016
    ..The detected concentrations of AFB1 in 2 moldy samples exceeded the regulatory maximum residue levels. The proposed method was capable for simultaneous determination of mycotoxins in this and other types of complex matrices. ..
  14. doi request reprint Ultra-fast liquid chromatography with tandem mass spectrometry determination of ochratoxin A in traditional Chinese medicines based on vortex-assisted solid-liquid microextraction and aptamer-affinity column clean-up
    XiHui Yang
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China School of Pharmacy, Jiangsu University, Jiangsu, China
    J Sep Sci 37:3052-9. 2014
    ..0 μg/kg) set by the European Union. This study provided a preferred choice for the rapid and accurate monitoring of ochratoxin A in complex matrices. ..
  15. doi request reprint Multi-residue analysis of 26 organochlorine pesticides in Alpinia oxyphylla by GC-ECD after solid phase extraction and acid cleanup
    Xiangsheng Zhao
    Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Wanning 571533, China
    J Chromatogr B Analyt Technol Biomed Life Sci 1017:211-20. 2016
    ..3 samples were found to be positive with four pesticides (α-BHC, quintozene, trans-chlordane and op'-DDD), which were confirmed by gas chromatography-mass spectrometry (GC-MS) in selective ion monitoring (SIM) mode. ..
  16. doi request reprint Mechanisms of antifungal and anti-aflatoxigenic properties of essential oil derived from turmeric (Curcuma longa L.) on Aspergillus flavus
    Yichen Hu
    School of Pharmacy and Bioengineering, Chengdu University, Chengdu 610106, PR China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, PR China
    Food Chem 220:1-8. 2017
    ..Finally, the suppression effect of fungal contamination in maize indicated that turmeric EO has potential as an eco-friendly antifungal agent...
  17. doi request reprint Quantitative and fingerprinting analysis of Pogostemon cablin based on GC-FID combined with chemometrics
    Yinhui Yang
    Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    J Pharm Biomed Anal 121:84-90. 2016
    ..cablin oil samples. The results demonstrate that chromatographic fingerprinting and quantitative analysis can be achieved simultaneously when evaluating quality and authenticating samples of P. cablin. ..
  18. doi request reprint Rapid analysis of multi-pesticides in Morinda officinalis by GC-ECD with accelerated solvent extraction assisted matrix solid phase dispersion and positive confirmation by GC-MS
    Hongmei Liu
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    J Chromatogr B Analyt Technol Biomed Life Sci 974:65-74. 2015
    ..The combination of ASE/MSPD and GC-ECD could be especially useful for trace analysis of pesticide residues in complex matrices...
  19. doi request reprint Simultaneous determination of aflatoxins B₁, B₂, G₁, G₂ in Fructus Bruceae by high-performance liquid chromatography with online postcolumn photochemical derivatization
    Jiliang Cao
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China School of Pharmacy, Chengdu University of TCM, Chengdu, China
    J Sep Sci 37:2771-8. 2014
    ..26 to 27.52 μg/kg and the occurrence of aflatoxin B1 , the most toxic one, was as high as 91% in all the samples, highlighting the severe contamination and the necessity to set legal limits for aflatoxins in F. Bruceae. ..
  20. doi request reprint Simultaneous quantification of mycotoxins and pesticide residues in ginseng with one-step extraction using ultra-high performance liquid chromatography-electrospray ionization tandem mass spectrometry
    Ying Kuang
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    J Chromatogr B Analyt Technol Biomed Life Sci 939:98-107. 2013
    ..63 to 158.60μg/kg. Ion ratios, retention times and experimental Q/q ratios were also compared with those of the corresponding reference standard in order to avoid false-positive results. ..
  21. doi request reprint Simultaneous determination of aflatoxin B(1) and ochratoxin A in licorice roots and fritillary bulbs by solid-phase extraction coupled with high-performance liquid chromatography-tandem mass spectrometry
    Lizhi Wang
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Food Chem 138:1048-54. 2013
    ..024 μg/kg and 0.095 μg/kg, respectively. The validated method was successfully applied to the rapid screening for AFB(1) and OTA in licorice roots and fritillary bulbs...
  22. doi request reprint Molecularly imprinted polymer-based solid phase clean-up for analysis of ochratoxin A in beer, red wine, and grape juice
    Jiliang Cao
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, P R China
    J Sep Sci 36:1291-7. 2013
    ..The developed method was applied to the detection of 30 beer, red wine, and grape juice samples and only four samples were contaminated by OTA with levels below the legal limits...
  23. doi request reprint Chromatographic fingerprint analysis and simultaneous determination of eight lignans in Justicia procumbens and its compound preparation by HPLC-DAD
    Linan Wang
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, P R China
    J Sep Sci 34:667-74. 2011
    ..All the results indicated that HPLC fingerprint assay in combination with multi-marker determination afforded a useful method for the quality control of J. procumbens and its compound preparation, Jian-er syrup...
  24. doi request reprint Determination of ochratoxin A in traditional Chinese medicinal plants by HPLC-FLD
    Lei Yang
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27:989-97. 2010
    ..2-158.7 and 2.5-5.6 microg kg(-1), respectively. This is the first report of the natural occurrence of OTA in TCMPs...
  25. doi request reprint An aptamer based lateral flow strip for on-site rapid detection of ochratoxin A in Astragalus membranaceus
    Weilu Zhou
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China
    J Chromatogr B Analyt Technol Biomed Life Sci 1022:102-8. 2016
    ....
  26. doi request reprint Quantitative and fingerprinting analysis of Atractylodes rhizome based on gas chromatography with flame ionization detection combined with chemometrics
    Qiutao Liu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Sep Sci 39:2517-26. 2016
    ..The method is simple, stable, accurate, and reproducible. Our results provide a foundation for quality control analysis of A. lancea and A. koreana. ..
  27. doi request reprint Differentiation of essential oils in Atractylodes lancea and Atractylodes koreana by gas chromatography with mass spectrometry
    Qiutao Liu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Sep Sci 39:4773-4780. 2016
    ..lancea and A. koreana samples. These results suggest that different species of Atractylodes rhizome may yield essential oils that differ significantly in content and composition...
  28. doi request reprint Aptamer-affinity column clean-up coupled with ultra high performance liquid chromatography and fluorescence detection for the rapid determination of ochratoxin A in ginger powder
    XiHui Yang
    School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    J Sep Sci 37:853-60. 2014
    ..In conclusion, the method of clean-up based on the AAC coupled to ultra-HPLC with fluorescence detection was rapid, specific, and sensitive for the quantitative analysis of OTA in a complex matrix. ..
  29. doi request reprint A gold-based nanobeacon probe for fluorescence sensing of organophosphorus pesticides
    Xiaowen Dou
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Anal Chim Acta 891:291-7. 2015
    ..The probe is stable, easy to operate and does not need sophisticated instruments. These features makes the probe feasible for screening trace organophosphorus pesticides in real samples. ..
  30. doi request reprint GC-FID coupled with chemometrics for quantitative and chemical fingerprinting analysis of Alpinia oxyphylla oil
    Qing Miao
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China Jilin Agricultural University, Changchun 130118, China
    J Pharm Biomed Anal 102:436-42. 2015
    ..The profiles of almost all the samples were consistent and stable. The harvesting time and source were major factors that affected the profile, while the volatile oil yield and the nootkatone content had minor secondary effects...
  31. doi request reprint A multiresidue method for simultaneous determination of 44 organophosphorous pesticides in Pogostemon cablin and related products using modified QuEChERS sample preparation procedure and GC-FPD
    Yinhui Yang
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China
    J Chromatogr B Analyt Technol Biomed Life Sci 974:118-25. 2015
    ..cablin and its related products. Moreover, it also attaches great importance to pesticide monitoring programs in food, soil and air in the future...
  32. doi request reprint Rapid analysis of multi-pesticide residues in lotus seeds by a modified QuEChERS-based extraction and GC-ECD
    Qing Miao
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Chemosphere 91:955-62. 2013
    ..The method described here was found to be practicable in the routine residue analysis of pesticides in lotus seeds...
  33. doi request reprint Fragmentation investigation of seven arylnaphthalide lignans using liquid chromatography/tandem quadrupole time-of-flight mass spectrometry
    Wei Li
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, PR China
    Rapid Commun Mass Spectrom 26:950-6. 2012
    ..The combination of fragmentation patterns in positive and negative ion modes could be helpful in understanding the structural features of these arylnaphthalide lignans...
  34. doi request reprint Application of a sensitive and specific LC-MS/MS method for determination of chinensinaphthol methyl ether in rat plasma for a bioavailability study
    Shujun Zhou
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    J Chromatogr B Analyt Technol Biomed Life Sci 903:75-80. 2012
    ..80 mg/kg CME in rats. The oral absolute bioavailability (F) of CME was estimated to be 3.2±0.2% with an elimination half-life (t½) value of 2.4±0.8h, suggesting its poor absorption and/or strong metabolism in vivo...
  35. doi request reprint Analysis of fumonisins B1 and B2 in spices and aromatic and medicinal herbs by HPLC-FLD with on-line post-column derivatization and positive confirmation by LC-MS/MS
    Weijun Kong
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Analyst 137:3166-74. 2012
    ..Positive confirmation of detected samples was performed by liquid chromatography tandem electrospray ionization mass spectrometry (LC-ESI-MS/MS), using a triple quadrupole analyzer and operated in the multiple reaction monitoring mode...
  36. doi request reprint Determination and pharmacokinetics of chinensinaphthol methyl ether in rat urine by a sensitive and specific UFLC-ESI-MS/MS method
    Jia an Qin
    School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    J Chromatogr B Analyt Technol Biomed Life Sci 1033:311-6. 2016
    ..0mg/kg), the accumulated amount of CME excreted in urine was 162.3±54.1ng, and the terminal elimination half-life was 53.4±5.3h, indicating low CME excretion in urine and significant CME metabolism in vivo. ..
  37. doi request reprint Multi-elements determination in medical and edible Alpinia oxyphylla and Morinda officinalis and their decoctions by ICP-MS
    Xiangsheng Zhao
    Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Wanning, 571533, China
    Chemosphere 164:430-435. 2016
    ..Especially for the heavy metals, the transfer ratios were below 30% except As (79.73%) in Morinda officinalis. The results showed that decoction of the samples may reduce the intake of heavy metals...
  38. doi request reprint Validation of a gas chromatography-electron capture detection of T-2 and HT-2 toxins in Chinese herbal medicines and related products after immunoaffinity column clean-up and pre-column derivatization
    Weijun Kong
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Food Chem 132:574-81. 2012
    ..These results were reliable by confirmation using GC-MS. Some unknown peaks were interfering peaks not the target toxins...
  39. pmc Evaluation and structure-activity relationship analysis of a new series of arylnaphthalene lignans as potential anti-tumor agents
    Jiaoyang Luo
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P R China
    PLoS ONE 9:e93516. 2014
    ....
  40. doi request reprint GC-MS combined with chemometric techniques for the quality control and original discrimination of Curcumae longae rhizome: analysis of essential oils
    Yichen Hu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    J Sep Sci 37:404-11. 2014
    ..This finding revealed that fingerprinting analysis based on GC-MS coupled with chemometric techniques could provide a reliable platform to discriminate herbs from different origins, which is a benefit for quality control. ..
  41. doi request reprint Natural occurrence of ochratoxin A in wolfberry fruit wine marketed in China
    Ying Kuang
    a Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Food Addit Contam Part B Surveill 5:70-4. 2012
    ..3% to 94.7% and relative standard deviations from 1.1% to 4.3% within the spiking range of 0.2-20 ng mL⁻¹. OTA was detected in one sample, below the maximum allowable limit as established by the European community...
  42. doi request reprint Streamlined pretreatment and GC-FPD analysis of multi-pesticide residues in perennial Morinda roots: a tropical or subtropical plant
    Hongmei Liu
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Chemosphere 95:33-40. 2014
    ..Meanwhile, it also draws attention to the need of pesticide monitoring programs in local soils...
  43. doi request reprint One-step extraction for gas chromatography with flame photometric detection of 18 organophosphorus pesticides in Chinese medicine health wines
    Qianzhen Liu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    J Chromatogr B Analyt Technol Biomed Life Sci 885:90-6. 2012
    ..2-37.9ngmL(-1). These pesticides were successfully confirmed by GC-MS. This is the first report of determining OPPs in CM health wines, providing references for monitoring the quality of CM health wine in routine analysis...
  44. ncbi request reprint Complete assignments of 1H and 13C NMR data for seven arylnaphthalide lignans from Justicia procumbens
    Meihua Yang
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100094, P R China
    Magn Reson Chem 44:727-30. 2006
    ..The complete assignments of 1H and 13C NMR chemical shifts for the new lignans and the 13C NMR chemical shifts for the known lignans were obtained for the first time by means of 2D NMR techniques, including HSQC and HMBC...
  45. doi request reprint A new benzofuran derivative from Flemingia philippinensis Merr. et Rolfe
    Hua Li
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Molecules 17:7637-44. 2012
    ....
  46. ncbi request reprint [Simultaneous determination of aflatoxin B1, B2, G1, G2 and ochratoxin A in Glycyrrhiza uralensis by HPLC-fLD after immunoaffinity column with online post-column photochemical derivatization]
    Riwei Wei
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Zhongguo Zhong Yao Za Zhi 36:2342-6. 2011
    ..To develop a method for the simultaneous determination of aflatoxin B1, B2, G1, G2 and ochratoxin A in Glycyrrhiza uralensis by HPLC-FLD after immunoaffinity column with online post-column photochemical derivatization...
  47. ncbi request reprint [Investigation of fungal populations in seven ochratoxin A contaminated root herbs]
    Juan Chen
    Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100193, China
    Zhongguo Zhong Yao Za Zhi 35:2647-51. 2010
    ..To determine the fungal populations in seven ochratoxin A contaminated root herbs in Jiangxi province, and investigate the mycoflora associated with mycotoxin contamination in the root herbs...
  48. doi request reprint Prenylated isoflavones from Flemingia philippinensis
    Hua Li
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    Magn Reson Chem 46:1203-7. 2008
    ....
  49. doi request reprint Ultra high performance liquid chromatography-electrospray ionization-tandem mass spectrometry and pharmacokinetic analysis of justicidin B and 6'-hydroxy justicidin C in rats
    Jiaoyang Luo
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P R China
    J Sep Sci . 2016
    ..07 ± 0.70 h and 11.84 ± 1.06 L/h/kg. This newly developed and validated method was successfully applied to the quantification and pharmacokinetic study of justicidin B and 6'-hydroxy justicidin C in rats...
  50. doi request reprint Assessment of critical points and development of a practical strategy to extend the applicable scope of immunoaffinity column cleanup for aflatoxin detection in medicinal herbs
    Lei Zhang
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    J Chromatogr A . 2016
    ..After validation, we successfully used this method to determine the aflatoxin concentration of real samples. The approach described here could potentially be used to extract aflatoxin from other complex matrices with varying acidity...
  51. doi request reprint Antibacterial evaluation of flavonoid compounds against E. coli by microcalorimetry and chemometrics
    Weijun Kong
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China
    Appl Microbiol Biotechnol 99:6049-58. 2015
    ..Liquiritin might be a promising candidate against E. coli. This study provides a valuable method for searching for novel antibacterial agents using microcalorimetry with chemometrics...
  52. pmc Multicomponent therapeutics of berberine alkaloids
    Jiaoyang Luo
    China Military Institute of Chinese Medicine, Integrative Medical Center of 302 Military Hospital, Beijing 100039, China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Evid Based Complement Alternat Med 2013:545898. 2013
    ..702 : 0.863 : 1 : 0.491 : 0.526, and the potency of the optimal combination on cyclophosphamide-immunocompromised mouse model was better than the natural combinations of herbs containing BAs...
  53. ncbi request reprint HJC, a new arylnaphthalene lignan isolated from Justicia procumbens, causes apoptosis and caspase activation in K562 leukemia cells
    Jiaoyang Luo
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, China
    J Pharmacol Sci 125:355-63. 2014
    ..This study suggests that HJC is a high-potency anti-tumor agent, and it induces apoptosis through a caspase-dependent pathway in human leukemia K562 cells. It also presents a potential alternative to leukemia therapy. ..
  54. doi request reprint Gas chromatography with flame photometric detection of 31 organophosphorus pesticide residues in Alpinia oxyphylla dried fruits
    Xiangsheng Zhao
    Institute of Medicinal Plant Development, Chinese Academy of Medicinal Science and Peking Union Medical College, Beijing 100193, China Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences and Peking Union Medical College, Wanning 571533, China
    Food Chem 162:270-6. 2014
    ..Five pesticide residues were detected in four (7.27%) samples. The positive samples were confirmed by gas chromatography with tandem mass spectrometry (GC-MS/MS)...
  55. doi request reprint Simultaneous determination of four aflatoxins and ochratoxin A in ginger and related products by HPLC with fluorescence detection after immunoaffinity column clean-up and postcolumn photochemical derivatization
    Jing Wen
    School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    J Sep Sci 36:3709-16. 2013
    ..05-1.19 μg/kg and ginger black tea bags were mainly contaminated by AFs at 3.37-5.76 μg/kg. All the contamination levels were below the legally allowable limits. ..
  56. ncbi request reprint [Determination of aflatoxins in nelumbinis semen by immunoaffinity column clean-up and HPLC-FLD with on-line post-column photochemical derivatization and LC-MS/MS confirmation]
    Shuyu Liu
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 37:305-9. 2012
    ..To determine the contents of aflatoxin B1, B2, G1 and G2 in Nelumbinis Semen using on-line post-column photochemical derivatization-HPLC-FLD method and verify the method by LC-MS method...
  57. doi request reprint A new solid-phase extraction and HPLC method for determination of patulin in apple products and hawthorn juice in China
    Yuchun Zhou
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, PR China
    J Sep Sci 35:641-9. 2012
    ..0%) and 1 of 13 hawthorn juice samples (7.7%) at concentrations ranging from 12.26 to 36.81 μg/kg. The positive results were further confirmed by liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS)...
  58. doi request reprint Multi-class mycotoxins analysis in Angelica sinensis by ultra fast liquid chromatography coupled with tandem mass spectrometry
    Qiutao Liu
    Pharmacy College, Liaoning Medical University, Jinzhou, Liaoning 121001, China Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences and Peking Union Medical College, Beijing 100193, China
    J Chromatogr B Analyt Technol Biomed Life Sci 988:175-81. 2015
    ....
  59. ncbi request reprint [Simultaneous determination of four tanshinones in Salvia miltiorrhiza by QAMS]
    Qian Li
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine of Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, Beijing 100193, China
    Zhongguo Zhong Yao Za Zhi 37:824-8. 2012
    ..To establish a new method and validate its feasibilities for quality evaluation of Salvia miltiorrhiza...
  60. doi request reprint Determination of zearalenone in traditional Chinese medicinal plants and related products by HPLC-FLD
    Xiaofei Zhang
    a Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 28:885-93. 2011
    ..7 to 211.4 µg kg(-1). Positive results were confirmed by UV spectrum and LC-ESI-MS/MS. This is the first report of ZON contamination of a Chinese medicinal herb...
  61. doi request reprint Evaluation of antibacterial effect and mode of Coptidis rhizoma by microcalorimetry coupled with chemometric techniques
    Weijun Kong
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, China
    Analyst 137:216-22. 2012
    ..Our results revealed that the developed microcalorimetry with chemometric techniques had the potential perspective for evaluating the effect and mode of Coptidis rhizoma and other Chinese materia medicas...
  62. doi request reprint Analysis of pesticide residues using the Quick Easy Cheap Effective Rugged and Safe (QuEChERS) pesticide multiresidue method in traditional Chinese medicine by gas chromatography with electron capture detection
    Rong Xu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, 100193 Beijing, China
    Chemosphere 84:908-12. 2011
    ..This study indicates that the proposed method is useful for analyzing OCPs in TCM...
  63. ncbi request reprint [Quantitative determination of pinoresinol diglucoside in Eucommiae unloads by NIRS]
    Wei Li
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Zhongguo Zhong Yao Za Zhi 35:3318-21. 2010
    ..To establish a rapid determination method of pinoresinol diglucoside in Eucommiae unloads by near-infrared reflectance spectroscopy (NIRS)...