Yajun Zhou

Summary

Publications

  1. ncbi request reprint Egr-1 is involved in the inhibitory effect of leptin on PPARgamma expression in hepatic stellate cell in vitro
    Yajun Zhou
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Qixiu Road 19, Nantong, 226001, Jiangsu, China
    Life Sci 84:544-51. 2009
  2. doi request reprint PI-3 K/AKT and ERK signaling pathways mediate leptin-induced inhibition of PPARgamma gene expression in primary rat hepatic stellate cells
    Yajun Zhou
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Nantong, 226001, Jiangsu, China
    Mol Cell Biochem 325:131-9. 2009
  3. doi request reprint Leptin inhibits PPARgamma gene expression in hepatic stellate cells in the mouse model of liver damage
    Yajun Zhou
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Qi Xiou Road 19, Nantong, 226001 Jiangsu, China
    Mol Cell Endocrinol 323:193-200. 2010
  4. doi request reprint Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol regulatory element binding protein-1c expression of rat hepatic stellate cells
    Wei Zhang
    Department of Pharmacology, Medical College, Nantong University, Qi Xiou Road 19, Nantong 226001, Jiangsu, China
    Int J Biochem Cell Biol 45:736-44. 2013
  5. doi request reprint Sex-determining region Y-box 9 acts downstream of NADPH oxidase to influence the effect of leptin on PPARγ1 expression in hepatic stellate cells
    Haowen Qiao
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Qi Xiou Road 19, Nantong 226001, Jiangsu, China
    Biochim Biophys Acta 1862:2186-2196. 2016
  6. doi request reprint Curcumin regulates peroxisome proliferator-activated receptor-γ coactivator-1α expression by AMPK pathway in hepatic stellate cells in vitro
    Xuguang Zhai
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Nantong 226001, Jiangsu, China
    Eur J Pharmacol 746:56-62. 2015
  7. pmc The β-catenin pathway contributes to the effects of leptin on SREBP-1c expression in rat hepatic stellate cells and liver fibrosis
    Xuguang Zhai
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Nantong, China
    Br J Pharmacol 169:197-212. 2013
  8. doi request reprint Curcumin affects β-catenin pathway in hepatic stellate cell in vitro and in vivo
    Lei Cui
    Department of Radiology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
    J Pharm Pharmacol 66:1615-22. 2014
  9. pmc p38 mitogen-activated protein kinase and liver X receptor-α mediate the leptin effect on sterol regulatory element binding protein-1c expression in hepatic stellate cells
    Kunfeng Yan
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Jiangsu, China
    Mol Med 18:10-8. 2012
  10. doi request reprint GATA binding protein 2 mediates leptin inhibition of PPARγ1 expression in hepatic stellate cells and contributes to hepatic stellate cell activation
    Qian Zhou
    Department of Pharmacology, School of Pharmacy, Nantong University, Qi Xiou Road 19, Nantong 226001, Jiangsu, China
    Biochim Biophys Acta 1842:2367-77. 2014

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Egr-1 is involved in the inhibitory effect of leptin on PPARgamma expression in hepatic stellate cell in vitro
    Yajun Zhou
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Qixiu Road 19, Nantong, 226001, Jiangsu, China
    Life Sci 84:544-51. 2009
    ..The aim of this study is to explore the molecular mechanisms underlying the inhibitory effect of leptin on PPARgamma expression in rat HSCs in vitro...
  2. doi request reprint PI-3 K/AKT and ERK signaling pathways mediate leptin-induced inhibition of PPARgamma gene expression in primary rat hepatic stellate cells
    Yajun Zhou
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Nantong, 226001, Jiangsu, China
    Mol Cell Biochem 325:131-9. 2009
    ..Our results might provide novel insights into the mechanisms for the pro-fibrogenic action of leptin in liver...
  3. doi request reprint Leptin inhibits PPARgamma gene expression in hepatic stellate cells in the mouse model of liver damage
    Yajun Zhou
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Qi Xiou Road 19, Nantong, 226001 Jiangsu, China
    Mol Cell Endocrinol 323:193-200. 2010
    ..The in vivo findings from this report might provide additional insights into the mechanisms underlying the profibrogenic action of leptin in liver...
  4. doi request reprint Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol regulatory element binding protein-1c expression of rat hepatic stellate cells
    Wei Zhang
    Department of Pharmacology, Medical College, Nantong University, Qi Xiou Road 19, Nantong 226001, Jiangsu, China
    Int J Biochem Cell Biol 45:736-44. 2013
    ....
  5. doi request reprint Sex-determining region Y-box 9 acts downstream of NADPH oxidase to influence the effect of leptin on PPARγ1 expression in hepatic stellate cells
    Haowen Qiao
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Qi Xiou Road 19, Nantong 226001, Jiangsu, China
    Biochim Biophys Acta 1862:2186-2196. 2016
    ..These results might deepen understanding of the molecular mechanisms for leptin inhibition of PPARγ1 expression in HSCs and for the liver fibrosis associated with leptin...
  6. doi request reprint Curcumin regulates peroxisome proliferator-activated receptor-γ coactivator-1α expression by AMPK pathway in hepatic stellate cells in vitro
    Xuguang Zhai
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Nantong 226001, Jiangsu, China
    Eur J Pharmacol 746:56-62. 2015
    ..These data might suggest a possible new explanation for the inhibitory effect of curcumin on HSC activation and on liver fibrogenesis. ..
  7. pmc The β-catenin pathway contributes to the effects of leptin on SREBP-1c expression in rat hepatic stellate cells and liver fibrosis
    Xuguang Zhai
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Nantong, China
    Br J Pharmacol 169:197-212. 2013
    ..Hence, we aimed to clarify whether the β-catenin pathway, the crucial negative regulator of adipocyte differentiation, mediates the effects of leptin on SREBP-1c expression in HSCs and in mouse liver fibrosis...
  8. doi request reprint Curcumin affects β-catenin pathway in hepatic stellate cell in vitro and in vivo
    Lei Cui
    Department of Radiology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
    J Pharm Pharmacol 66:1615-22. 2014
    ..This study is aimed to examine whether curcumin affects β-catenin expression/activity in HSCs and explores the underlying mechanisms...
  9. pmc p38 mitogen-activated protein kinase and liver X receptor-α mediate the leptin effect on sterol regulatory element binding protein-1c expression in hepatic stellate cells
    Kunfeng Yan
    Department of Biochemistry and Molecular Biology, Medical College, Nantong University, Jiangsu, China
    Mol Med 18:10-8. 2012
    ....
  10. doi request reprint GATA binding protein 2 mediates leptin inhibition of PPARγ1 expression in hepatic stellate cells and contributes to hepatic stellate cell activation
    Qian Zhou
    Department of Pharmacology, School of Pharmacy, Nantong University, Qi Xiou Road 19, Nantong 226001, Jiangsu, China
    Biochim Biophys Acta 1842:2367-77. 2014
    ..Our data might suggest a possible new explanation for the promotion effect of leptin on liver fibrogenesis. ..
  11. doi request reprint Curcumin regulates delta-like homolog 1 expression in activated hepatic stellate cell
    Jianwei Qiu
    Department of Gastroenterology, The Second Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China
    Eur J Pharmacol 728:9-15. 2014
    ..Our results in this study may reveal a new mechanisms through which curcumin exerts its inhibitory effect on HSC activation and liver fibrosis. ..
  12. doi request reprint β-Catenin pathway is required for TGF-β1 inhibition of PPARγ expression in cultured hepatic stellate cells
    Jingjing Qian
    Affiliated Hospital of Nantong University, Qi Xiou Road 19, Nantong 226001, Jiangsu, China
    Pharmacol Res 66:219-25. 2012
    ..These results indicated for the first time that TGF-β1 could down-regulate PPARγ expression through β-catenin pathway and subsequently contributed to the increase in alpha1(1) collagen level in cultured HSCs...
  13. ncbi request reprint The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro
    Yajun Zhou
    Department of Biochemistry, Nantong University, Nantong, China
    Lab Invest 87:488-98. 2007
    ..These results provide novel insights into the mechanisms of curcumin in the induction of PPARgamma gene expression in activated HSC...
  14. doi request reprint GATA binding protein 3 is correlated with leptin regulation of PPARγ1 in hepatic stellate cells
    Wei Guan
    Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China
    J Cell Mol Med . 2016
    ....
  15. doi request reprint Akt and cAMP response element binding protein mediate 17β-estradiol regulation of glucose transporter 3 expression in human SH-SY5Y neuroblastoma cell line
    Yaohui Ni
    Department of Neurology, Affiliated Hospital of Nantong University, Nantong, 226002 Jiangsu, China
    Neurosci Lett 604:58-63. 2015
    ..These results suggested the mechanisms underlying E2-induced increase in Glut3 expression in human SH-SY5Y cell line and might provide the new data for elucidating the neuroprotective role of E2 against AD. ..