c myc

Summary

Gene Symbol: c myc
Description: v-myc avian myelocytomatosis viral oncogene homolog
Alias: c-myc, myc proto-oncogene protein, v-myc myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene-like protein
Species: chicken

Top Publications

  1. ncbi The relationship between cell proliferation and the transcription of the nuclear oncogenes c-myc, c-myb and c-ets-1 during feather morphogenesis in the chick embryo
    X Desbiens
    Laboratoire de Biologie du Developpement, Université des Sciences et Techniques de Lille Flandres Artois, Villeneuve, d Ascq, France
    Development 111:699-713. 1991
  2. pmc Viral mutations enhance the Max binding properties of the vMyc b-HLH-LZ domain
    D H Crouch
    Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Nucleic Acids Res 33:5235-42. 2005
  3. pmc The MYC, TERT, and ZIC1 genes are common targets of viral integration and transcriptional deregulation in avian leukosis virus subgroup J-induced myeloid leukosis
    Yuhao Li
    National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, People s Republic of China
    J Virol 88:3182-91. 2014
  4. pmc MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division
    Nikolay Zinin
    Department of Microbiology, Tumor and Cell Biology MTC Karolinska Institutet, Stockholm, Sweden
    EMBO Rep 15:383-91. 2014
  5. doi Marek's disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway
    Jia Qi Chi
    College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, People s Republic of China Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, People s Republic of China College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People s Republic of China
    Virology 476:72-84. 2015
  6. pmc Myc oncoproteins are phosphorylated by casein kinase II
    B Luscher
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    EMBO J 8:1111-9. 1989
  7. doi Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation
    P Singh
    Institute for Biochemistry, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Oncogene 30:4864-73. 2011
  8. ncbi Contrasting patterns of c-myc and N-myc expression in proliferating, quiescent, and differentiating cells of the embryonic chicken lens
    L L Harris
    Howard Hughes Medical Institute, N I H Research Scholars Program, Bethesda, Maryland 20814
    Development 115:813-20. 1992
  9. pmc Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas
    M Hahn
    Graduate Program in Molecular Biology, Sloan Kettering Institute for Cancer Research, New York, New York
    Mol Cell Biol 8:2659-63. 1988
  10. pmc Transcription of three c-myc exons is enhanced in chicken bursal lymphoma cell lines
    M Linial
    Proc Natl Acad Sci U S A 82:53-7. 1985

Scientific Experts

  • D H Crouch
  • Jia Qi Chi
  • Nikolay Zinin
  • Yuhao Li
  • P Singh
  • Marina Shkreli
  • Zu Hua Yu
  • Rui Guang Deng
  • Guang Xu Xing
  • Pu Zhao
  • Jun Luo
  • Liang Hu Qu
  • Jing wei Su
  • Man Teng
  • Hui Xu
  • Gai Ping Zhang
  • Hong De Liang
  • Marie Arsenian Henriksson
  • Ming Liao
  • Manman Dai
  • Margareta Wilhelm
  • Xuemei Liu
  • Jianru Qin
  • Liqiang Tan
  • P M Chesters
  • Igor Adameyko
  • Nicolas Fritz
  • Per Uhlen
  • Min Feng
  • Weisheng Cao
  • Jianyong Hao
  • Patrik Ernfors
  • Xiaorong Huang
  • Di Liu
  • Zhen Yang
  • Chenggang Xu
  • M D Carr
  • L C Waters
  • K H Klempnauer
  • L Wedeken
  • Denis Rasschaert
  • Denis Soubieux
  • Emmanuel Kut
  • Ginette Dambrine
  • L N Payne
  • K Howes
  • L Petherbridge
  • K Venugopal
  • S Evans
  • L L Harris
  • M Linial
  • C K Shih
  • W S Hayward
  • X Desbiens
  • D K Watson
  • B Luscher
  • M Hahn
  • P S Zelenka
  • J C Talian
  • M Groudine
  • T S Papas
  • T Jaffredo
  • E A Kuenzel
  • E P Reddy
  • C Queva
  • P H Duesberg
  • E G Krebs
  • B Vandenbunder
  • M M Goodenow
  • R N Eisenman
  • D Stehelin

Detail Information

Publications14

  1. ncbi The relationship between cell proliferation and the transcription of the nuclear oncogenes c-myc, c-myb and c-ets-1 during feather morphogenesis in the chick embryo
    X Desbiens
    Laboratoire de Biologie du Developpement, Université des Sciences et Techniques de Lille Flandres Artois, Villeneuve, d Ascq, France
    Development 111:699-713. 1991
    ..We suggest that the differential expression of these nuclear oncogenes reflects the activation of different mitotic controlling pathways during the development of the skin...
  2. pmc Viral mutations enhance the Max binding properties of the vMyc b-HLH-LZ domain
    D H Crouch
    Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Nucleic Acids Res 33:5235-42. 2005
    ..We therefore propose that this virally derived mutation is functional by significantly contributing to establishing a more hydrophobic interface between the LZs of Myc and Max...
  3. pmc The MYC, TERT, and ZIC1 genes are common targets of viral integration and transcriptional deregulation in avian leukosis virus subgroup J-induced myeloid leukosis
    Yuhao Li
    National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, People s Republic of China
    J Virol 88:3182-91. 2014
    ..Our findings contribute to the understanding of the relationship between multipathotypes associated with ALV-J infection and the molecular background of tumorigenesis...
  4. pmc MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division
    Nikolay Zinin
    Department of Microbiology, Tumor and Cell Biology MTC Karolinska Institutet, Stockholm, Sweden
    EMBO Rep 15:383-91. 2014
    ..These results reveal an unexpected role of MYC in the control of stemness versus differentiation of neural stem cells in vivo. ..
  5. doi Marek's disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway
    Jia Qi Chi
    College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, People s Republic of China Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, People s Republic of China College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People s Republic of China
    Virology 476:72-84. 2015
    ..Our findings reveal a novel and important mechanism of how mdv1-miR-M4-5p potentially contributes to MDV-induced tumorigenesis...
  6. pmc Myc oncoproteins are phosphorylated by casein kinase II
    B Luscher
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    EMBO J 8:1111-9. 1989
    ..Since CK-II can be rapidly activated after mitogen treatment we postulate that CK-II mediated phosphorylation of Myc plays a role in signal transduction to the nucleus...
  7. doi Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation
    P Singh
    Institute for Biochemistry, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Oncogene 30:4864-73. 2011
    ....
  8. ncbi Contrasting patterns of c-myc and N-myc expression in proliferating, quiescent, and differentiating cells of the embryonic chicken lens
    L L Harris
    Howard Hughes Medical Institute, N I H Research Scholars Program, Bethesda, Maryland 20814
    Development 115:813-20. 1992
    ....
  9. pmc Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas
    M Hahn
    Graduate Program in Molecular Biology, Sloan Kettering Institute for Cancer Research, New York, New York
    Mol Cell Biol 8:2659-63. 1988
    ....
  10. pmc Transcription of three c-myc exons is enhanced in chicken bursal lymphoma cell lines
    M Linial
    Proc Natl Acad Sci U S A 82:53-7. 1985
    ..The pattern of c-myc transcription observed by others in a vast majority of avian leukosis virus-induced neoplasms is not observed in any of the five cell lines examined...
  11. pmc Nucleotide sequence 5' of the chicken c-myc coding region: localization of a noncoding exon that is absent from myc transcripts in most avian leukosis virus-induced lymphomas
    C K Shih
    Proc Natl Acad Sci U S A 81:4697-701. 1984
    ..Sequences from the upstream noncoding exon were absent from the myc transcripts in these lymphomas; RNA transcripts from the normal c-myc allele were not expressed at detectable levels...
  12. pmc Nucleotide sequence analysis of the chicken c-myc gene reveals homologous and unique coding regions by comparison with the transforming gene of avian myelocytomatosis virus MC29, delta gag-myc
    D K Watson
    Proc Natl Acad Sci U S A 80:2146-50. 1983
    ..The hybrid onc gene of MC29 must have been generated from the c-myc gene by deletion of the 5' cellular coding sequence, followed by substitution with the 5' region of the viral gag gene...
  13. ncbi The viral envelope is a major determinant for the induction of lymphoid and myeloid tumours by avian leukosis virus subgroups A and J, respectively
    P M Chesters
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    J Gen Virol 83:2553-61. 2002
    ..Induction of both LL and ML by the two chimeric viruses occurred through the activation of c-myc, while the EB tumours were induced by activation of the c-erbB oncogene...
  14. pmc Involvement of the oncoprotein c-Myc in viral telomerase RNA gene regulation during Marek's disease virus-induced lymphomagenesis
    Marina Shkreli
    Equipe Télomérase et Lymphome Viro Induit, Centre INRA de Tours, Unité IASP 213, 37380 Nouzilly, France
    J Virol 81:4848-57. 2007
    ..Finally, an Ets binding site was specifically implicated in the transcriptional regulation of vTR in the MDV-transformed lymphoblastoid cell line MSB-1...