EGFR

Summary

Gene Symbol: EGFR
Description: epidermal growth factor receptor
Alias: c-erbB, CER, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Species: chicken

Top Publications

  1. pmc EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals
    Patricia M White
    Division of Cell Biology and Genetics, House Research Institute, 2100 W 3rd St, Los Angeles, CA 90057, USA
    Dev Biol 363:191-200. 2012
  2. ncbi DNA methylation down-regulates EGFR expression in chickens
    Juan Luo
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
    Avian Dis 57:366-71. 2013
  3. pmc An alternatively processed mRNA from the avian c-erbB gene encodes a soluble, truncated form of the receptor that can block ligand-dependent transformation
    T W Flickinger
    Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
    Mol Cell Biol 12:883-93. 1992
  4. ncbi c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor
    T W Nilsen
    Cell 41:719-26. 1985
  5. pmc c-erbB activation in avian leukosis virus-induced erythroblastosis: multiple epidermal growth factor receptor mRNAs are generated by alternative RNA processing
    R G Goodwin
    Mol Cell Biol 6:3128-33. 1986
  6. pmc Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha
    I Lax
    Rorer Central Research, King of Prussia, Pennsylvania 19406
    Mol Cell Biol 8:1970-8. 1988
  7. ncbi The viral envelope is a major determinant for the induction of lymphoid and myeloid tumours by avian leukosis virus subgroups A and J, respectively
    P M Chesters
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    J Gen Virol 83:2553-61. 2002
  8. ncbi Studies on epidermal growth factor receptor signaling in vertebrate limb patterning
    Minoru Omi
    Center for Limb and Skeletal Development, Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Dev Dyn 233:288-300. 2005
  9. doi Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes
    Han Na Suh
    Department of Veterinary Physiology, Biotherapy Human Resources Center BK21, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea
    J Cell Physiol 218:643-52. 2009

Detail Information

Publications9

  1. pmc EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals
    Patricia M White
    Division of Cell Biology and Genetics, House Research Institute, 2100 W 3rd St, Los Angeles, CA 90057, USA
    Dev Biol 363:191-200. 2012
    ..Here we show that in a subset of supporting cells marked by p75, EGFR signaling is required for proliferation, and this requirement is conserved between birds and mammals...
  2. ncbi DNA methylation down-regulates EGFR expression in chickens
    Juan Luo
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
    Avian Dis 57:366-71. 2013
    The epidermal growth factor receptor (EGFR), a growth-factor-receptor tyrosine kinase, is up-regulated in numerous tumors, which provides a good target for cancer therapy...
  3. pmc An alternatively processed mRNA from the avian c-erbB gene encodes a soluble, truncated form of the receptor that can block ligand-dependent transformation
    T W Flickinger
    Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
    Mol Cell Biol 12:883-93. 1992
    ..These data suggest that the secreted, truncated receptor encoded by the 2.6-kb c-erbB transcript can bind to TGF alpha and may play an important growth-regulatory function in vitro...
  4. ncbi c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor
    T W Nilsen
    Cell 41:719-26. 1985
    ..These results establish a novel pathway of promoter insertion oncogenesis that stands in contrast to the pathways used in the activation of c-myc in B lymphomas...
  5. pmc c-erbB activation in avian leukosis virus-induced erythroblastosis: multiple epidermal growth factor receptor mRNAs are generated by alternative RNA processing
    R G Goodwin
    Mol Cell Biol 6:3128-33. 1986
    ..Finally, blot hybridization evidence suggests that the two size classes of activated c-erbB mRNA in erythroblastic tissue represent truncated versions of the two c-erbB mRNAs present in normal tissue...
  6. pmc Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha
    I Lax
    Rorer Central Research, King of Prussia, Pennsylvania 19406
    Mol Cell Biol 8:1970-8. 1988
    ..The differential binding and potency of mammalian EGF and TGF-alpha by the avian EGF receptor contrasts with the similar affinities of the mammalian receptor for the two growth factors...
  7. ncbi The viral envelope is a major determinant for the induction of lymphoid and myeloid tumours by avian leukosis virus subgroups A and J, respectively
    P M Chesters
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    J Gen Virol 83:2553-61. 2002
    ..Induction of both LL and ML by the two chimeric viruses occurred through the activation of c-myc, while the EB tumours were induced by activation of the c-erbB oncogene...
  8. ncbi Studies on epidermal growth factor receptor signaling in vertebrate limb patterning
    Minoru Omi
    Center for Limb and Skeletal Development, Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Dev Dyn 233:288-300. 2005
    The epidermal growth factor receptor (EGFR) regulates multiple patterning events in Drosophila limb development, but its role in vertebrate limb morphogenesis has received little attention...
  9. doi Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes
    Han Na Suh
    Department of Veterinary Physiology, Biotherapy Human Resources Center BK21, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea
    J Cell Physiol 218:643-52. 2009
    ..In addition, IL-6 increased EGFR/src/FAK, PI3K/Akt phosphorylation and 2-DG uptake as well as GLUT-2 protein expression, which were blocked by AG ..