IL2

Summary

Gene Symbol: IL2
Description: interleukin 2
Alias: IL-2, interleukin-2
Species: chicken

Top Publications

  1. pmc Effects of zearalenone on IL-2, IL-6, and IFN-γ mRNA levels in the splenic lymphocytes of chickens
    Y C Wang
    College of Veterinary Medicine, Sichuan Agricultural University, Yaan, Sichuan 625014, China
    ScientificWorldJournal 2012:567327. 2012
  2. ncbi A cloned chicken lymphokine homologous to both mammalian IL-2 and IL-15
    R S Sundick
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 159:720-5. 1997
  3. ncbi Promoter sequence, exon:intron structure, and synteny of genetic location show that a chicken cytokine with T-cell proliferative activity is IL2 and not IL15
    P Kaiser
    Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    Immunogenetics 49:26-35. 1999
  4. ncbi Molecular and functional characterization of chicken IL-15
    K D Choi
    Immunology and Disease Resistance Laboratory, Livestock and Poultry Sciences Institute, USDA, Beltsville, MD 20705, USA
    Dev Comp Immunol 23:165-77. 1999
  5. ncbi Genetic variation among chicken lines and mammalian species in specific genes
    H Zhou
    Department of Animal Science, Iowa State University, Ames 50011 3150, USA
    Poult Sci 80:284-8. 2001
  6. doi Identification of the functional interleukin-2 binding domain of the chicken common cytokine receptor gamma chain
    Jianyou Gu
    Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China
    Dev Comp Immunol 34:258-63. 2010
  7. doi Identification of functional domains of chicken interleukin 2
    Jianyou Gu
    Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou, PR China
    Vet Immunol Immunopathol 134:230-8. 2010
  8. doi Abundance of IFN-α and IFN-γ gene transcripts and absence of IL-2 transcripts in the blood of chickens vaccinated with live or inactivated NDV
    Mirta Balenović
    Poultry Centre, Croatian Veterinary Institut, Zagreb, Croatia
    Acta Vet Hung 59:141-8. 2011

Scientific Experts

  • R S Sundick
  • Mirta Balenović
  • Jianyou Gu
  • Y C Wang
  • Xizhen Ruan
  • Zhenyu Huang
  • Jiyong Zhou
  • S W Xu
  • H Zhou
  • Y Wang
  • Z H Ren
  • X Peng
  • H M Cui
  • Z C Zuo
  • J L Deng
  • Qiaoyang Teng
  • Jigang Chen
  • P Kaiser
  • K D Choi
  • W Liu
  • S J Lamont
  • J Y Han
  • K D Song
  • H S Lillehoj
  • P Mariani

Detail Information

Publications8

  1. pmc Effects of zearalenone on IL-2, IL-6, and IFN-γ mRNA levels in the splenic lymphocytes of chickens
    Y C Wang
    College of Veterinary Medicine, Sichuan Agricultural University, Yaan, Sichuan 625014, China
    ScientificWorldJournal 2012:567327. 2012
    ..05). These data suggest that ZEN has potent effects on the expression of chicken splenic lymphocytes cytokines at the mRNA level...
  2. ncbi A cloned chicken lymphokine homologous to both mammalian IL-2 and IL-15
    R S Sundick
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 159:720-5. 1997
    ..It has one characteristic that is unique to IL-15: four conserved cysteines allowing for two intrachain disulfide bonds...
  3. ncbi Promoter sequence, exon:intron structure, and synteny of genetic location show that a chicken cytokine with T-cell proliferative activity is IL2 and not IL15
    P Kaiser
    Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    Immunogenetics 49:26-35. 1999
    ..The results show that this cytokine is chicken IL2 and not IL15...
  4. ncbi Molecular and functional characterization of chicken IL-15
    K D Choi
    Immunology and Disease Resistance Laboratory, Livestock and Poultry Sciences Institute, USDA, Beltsville, MD 20705, USA
    Dev Comp Immunol 23:165-77. 1999
    ..Continuous culture of spleen Con A lymphoblasts with chicken IL-15 over two months resulted in an enriched T lymphocyte population expressing the gammadeltaTCR, CD8alpha, and CD3 cell surface antigens...
  5. ncbi Genetic variation among chicken lines and mammalian species in specific genes
    H Zhou
    Department of Animal Science, Iowa State University, Ames 50011 3150, USA
    Poult Sci 80:284-8. 2001
    ..The following genes were selected as candidates for immune response or transcription activation: B2M, DAD1, IAP1, IL2, IREB1, LAP18, MAFL, POU1F1, RREB1, TAD, TBP1, TCRG, and ZOV3...
  6. doi Identification of the functional interleukin-2 binding domain of the chicken common cytokine receptor gamma chain
    Jianyou Gu
    Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China
    Dev Comp Immunol 34:258-63. 2010
    ..The functional domain of chCD132 that binds to chicken interleukin 2, Q(84)E(94)L(95)Q(96)N(97)L(98), was found through phage display and peptide-competitive ELISA, and its ..
  7. doi Identification of functional domains of chicken interleukin 2
    Jianyou Gu
    Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou, PR China
    Vet Immunol Immunopathol 134:230-8. 2010
    b>Interleukin 2 (IL-2) is an essential cytokine that plays a pivotal role in the replication, maturation and differentiation of lymphocytes...
  8. doi Abundance of IFN-α and IFN-γ gene transcripts and absence of IL-2 transcripts in the blood of chickens vaccinated with live or inactivated NDV
    Mirta Balenović
    Poultry Centre, Croatian Veterinary Institut, Zagreb, Croatia
    Acta Vet Hung 59:141-8. 2011
    ..The results show that cells stimulated to produce IFN-α and IFN-γ enter the circulating blood but those stimulated to produce IL-2 do not, or in very low number, and the IFN responses to both vaccines are the same...