interferon

Summary

Gene Symbol: interferon
Description: interferon
Alias: IFN-alpha, IFN-gamma, IFNA, IFNA1, IFNA2, IFNA6, interferon type A1/A2, IFN alpha, interferon alpha, interferon type A3
Species: chicken

Top Publications

  1. pmc Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes
    Fei Liu
    Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America
    PLoS Pathog 9:e1003613. 2013
  2. pmc Genetic screen of a library of chimeric poxviruses identifies an ankyrin repeat protein involved in resistance to the avian type I interferon response
    Karen Buttigieg
    Section of Virology, Faculty of Medicine, Imperial College London, St Mary s Campus, London, United Kingdom
    J Virol 87:5028-40. 2013
  3. ncbi Chicken interferon gene: cloning, expression, and analysis
    M J Sekellick
    Department of Molecular and Cell Biology, University of Connecticut, Storrs 06269 3044
    J Interferon Res 14:71-9. 1994
  4. ncbi A family of genes coding for two serologically distinct chicken interferons
    C Sick
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, University of Freiburg, Federal Republic of Germany
    J Biol Chem 271:7635-9. 1996
  5. ncbi The interferon-alpha genes from three chicken lines and its effects on H9N2 influenza viruses
    C Xia
    The 211 Key Laboratory of Veterinary Molecular Biology, College of Animal Medicine, China Agricultural University, Beijing, China
    Anim Biotechnol 15:77-88. 2004
  6. doi Abundance of IFN-α and IFN-γ gene transcripts and absence of IL-2 transcripts in the blood of chickens vaccinated with live or inactivated NDV
    Mirta Balenović
    Poultry Centre, Croatian Veterinary Institut, Zagreb, Croatia
    Acta Vet Hung 59:141-8. 2011
  7. pmc Mx is dispensable for interferon-mediated resistance of chicken cells against influenza A virus
    Benjamin Schusser
    Department of Veterinary Science, University Munich, Germany
    J Virol 85:8307-15. 2011

Scientific Experts

  • Chun Xia
  • Mirta Balenović
  • Fei Liu
  • Karen Buttigieg
  • Benjamin Schusser
  • Sichen Li
  • Ju Tao Guo
  • Stephen M Laidlaw
  • Chunxiao Xu
  • Michael A Skinner
  • Wenhui Li
  • Xuesen Zhao
  • Matthew Campagna
  • Stephen Goodbourn
  • Craig Ross
  • Yonghe Qi
  • Jinhong Chang
  • Marc Davies
  • Timothy M Block
  • Fang Guo
  • Nicola Penski
  • Steffen Weigend
  • Peter Staeheli
  • Alexander von der Malsburg
  • Sonja Härtle
  • Antje Reuter
  • Bernd Kaspers
  • C Sick
  • M J Sekellick
  • U Schultz
  • P Staeheli
  • A F Ferrandino
  • D A Hopkins
  • P I Marcus

Detail Information

Publications7

  1. pmc Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes
    Fei Liu
    Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America
    PLoS Pathog 9:e1003613. 2013
    ..Moreover, IFN-α treatment also induced a delayed response that appeared to accelerate the decay of cccDNA. Our studies have thus shed light on the molecular mechanism by which IFN-α noncytolytically controls hepadnavirus infection. ..
  2. pmc Genetic screen of a library of chimeric poxviruses identifies an ankyrin repeat protein involved in resistance to the avian type I interferon response
    Karen Buttigieg
    Section of Virology, Faculty of Medicine, Imperial College London, St Mary s Campus, London, United Kingdom
    J Virol 87:5028-40. 2013
    Viruses must be able to resist host innate responses, especially the type I interferon (IFN) response. They do so by preventing the induction or activity of IFN and/or by resisting the antiviral effectors that it induces...
  3. ncbi Chicken interferon gene: cloning, expression, and analysis
    M J Sekellick
    Department of Molecular and Cell Biology, University of Connecticut, Storrs 06269 3044
    J Interferon Res 14:71-9. 1994
    A gene encoding chicken interferon (ChIFN) was cloned from a cDNA library made from primary chick embryo cells that had been "aged" in vitro so as to produce copious amounts of IFN upon induction...
  4. ncbi A family of genes coding for two serologically distinct chicken interferons
    C Sick
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, University of Freiburg, Federal Republic of Germany
    J Biol Chem 271:7635-9. 1996
    Southern blot analysis and screening of a genomic lambda phage library with the previously cloned chicken interferon (IFN) cDNA indicated that the chicken genome contains at least 10 IFN genes...
  5. ncbi The interferon-alpha genes from three chicken lines and its effects on H9N2 influenza viruses
    C Xia
    The 211 Key Laboratory of Veterinary Molecular Biology, College of Animal Medicine, China Agricultural University, Beijing, China
    Anim Biotechnol 15:77-88. 2004
    The interferon-alpha genes from three chicken lines were cloned by a direct PCR technique, and the effects of recombinant protein expressed in a prokaryotic system on highly pathogenic H9N2 influenza viruses were investigated...
  6. doi Abundance of IFN-α and IFN-γ gene transcripts and absence of IL-2 transcripts in the blood of chickens vaccinated with live or inactivated NDV
    Mirta Balenović
    Poultry Centre, Croatian Veterinary Institut, Zagreb, Croatia
    Acta Vet Hung 59:141-8. 2011
    ..The results show that cells stimulated to produce IFN-α and IFN-γ enter the circulating blood but those stimulated to produce IL-2 do not, or in very low number, and the IFN responses to both vaccines are the same...
  7. pmc Mx is dispensable for interferon-mediated resistance of chicken cells against influenza A virus
    Benjamin Schusser
    Department of Veterinary Science, University Munich, Germany
    J Virol 85:8307-15. 2011
    The type I interferon (IFN) system plays an important role in antiviral defense against influenza A viruses (FLUAV), which are natural chicken pathogens...