MX1

Summary

Gene Symbol: MX1
Description: myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
Alias: interferon-induced GTP-binding protein Mx, dynamin family GTP-binding, interferon-inducible Mx protein, myxocirus-resistance protein, myxovirus resistance protein 1, myxovirus resistence, myxovirus-resistance protein
Species: chicken

Top Publications

  1. ncbi The interferon-induced Mx protein of chickens lacks antiviral activity
    D Bernasconi
    Institut für Mikrobiologie und Hygiene, Abteilung Virologie, University of Freiburg, Germany
    J Interferon Cytokine Res 15:47-53. 1995
  2. pmc Asparagine 631 variants of the chicken Mx protein do not inhibit influenza virus replication in primary chicken embryo fibroblasts or in vitro surrogate assays
    Camilla T O Benfield
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, United Kingdom
    J Virol 82:7533-9. 2008
  3. ncbi [Ectopic expression of duck albumin down-regulates the expressions of IFN-β and myxovirus resistance 1 mRNA in DF-1 cells]
    Yiyu Tong
    Animal Science and Technology College, Yangzhou University, Yangzhou 225009, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30:917-20. 2014
  4. pmc Pathogenicity of Genetically Similar, H5N1 Highly Pathogenic Avian Influenza Virus Strains in Chicken and the Differences in Sensitivity among Different Chicken Breeds
    Aya Matsuu
    Thailand Japan Zoonotic Diseases Collaborating Center ZDCC, Kasetlang, Chatuchak, Bangkok, Thailand
    PLoS ONE 11:e0153649. 2016
  5. doi Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers
    Y Wang
    Department of Animal Science, University of California, Davis 951616, USA
    Poult Sci 91:3019-24. 2012
  6. doi Both antiviral activity and intracellular localization of chicken Mx protein depend on a polymorphism at amino acid position 631
    Keisuke Sasaki
    Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Biochem Biophys Res Commun 430:161-6. 2013
  7. ncbi The chicken Mx promoter contains an ISRE motif and confers interferon inducibility to a reporter gene in chick and monkey cells
    B Schumacher
    Institut für Mikrobiologie und Hygiene, University of Freiburg, Germany
    Virology 203:144-8. 1994
  8. ncbi Skewed allele frequencies of an Mx gene mutation with potential resistance to avian influenza virus in different chicken populations
    X Y Li
    Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing
    Poult Sci 85:1327-9. 2006
  9. ncbi Interferon alpha-induced inhibition of infectious bursal disease virus in chicken embryo fibroblast cultures differing in Mx genotype
    Ann Marie O'Neill
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Avian Dis 54:802-6. 2010
  10. pmc The cytoplasmic location of chicken mx is not the determining factor for its lack of antiviral activity
    Camilla T O Benfield
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e12151. 2010

Scientific Experts

  • S J Ewald
  • Ann Marie O'Neill
  • Camilla T O Benfield
  • Aya Matsuu
  • Yiyu Tong
  • Keisuke Sasaki
  • Y Wang
  • Benjamin Schusser
  • X Y Li
  • Shingo Suzuki
  • Kridsada Chaichoune
  • Tomoko Kobayashi
  • Takehiko Saito
  • Haruka Abe
  • Parntep Ratanakorn
  • Takashi Shiina
  • Yasuaki Hiromoto
  • Sujira Parchariyanon
  • Tuangthong Patchimasiri
  • Qinming Yu
  • Zhen Zhu
  • Yang Chen
  • Guohong Chen
  • Zhengyang Huang
  • Yang Zhang
  • Qi Xu
  • Akinori Ninomiya
  • Manabu Kawahara
  • Tomomasa Watanabe
  • Akihiro Yoneda
  • X Li
  • S Reddy
  • H Chiang
  • B Lupiani
  • H Zhou
  • R Okimoto
  • V Brahmakshatriya
  • Peter Staeheli
  • Nicola Penski
  • Antje Reuter
  • Steffen Weigend
  • Sonja Härtle
  • Alexander von der Malsburg
  • Bernd Kaspers
  • J F Yao
  • N Yang
  • L J Qu
  • D Bernasconi
  • P Staeheli
  • U Schultz
  • B Schumacher

Detail Information

Publications12

  1. ncbi The interferon-induced Mx protein of chickens lacks antiviral activity
    D Bernasconi
    Institut für Mikrobiologie und Hygiene, Abteilung Virologie, University of Freiburg, Germany
    J Interferon Cytokine Res 15:47-53. 1995
    ..Thus, chick Mx joins the list of Mx proteins without recognized antiviral activity, supporting the concept that Mx proteins serve unrelated functions...
  2. pmc Asparagine 631 variants of the chicken Mx protein do not inhibit influenza virus replication in primary chicken embryo fibroblasts or in vitro surrogate assays
    Camilla T O Benfield
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, United Kingdom
    J Virol 82:7533-9. 2008
    ..systems (A/PR/8/34 and A/Turkey/England/50-92/91 [H5N1]), which were highly sensitive to inhibition by the murine Mx1 and human MxA proteins, respectively, Shamo chicken Mx also proved ineffective in the context of avian as well as ..
  3. ncbi [Ectopic expression of duck albumin down-regulates the expressions of IFN-β and myxovirus resistance 1 mRNA in DF-1 cells]
    Yiyu Tong
    Animal Science and Technology College, Yangzhou University, Yangzhou 225009, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30:917-20. 2014
    To investigate the impact of duck albumin (ALB) gene on the mRNA expression levels of interferon β (IFN-β) and myxovirus resistance-1 (Mx1).
  4. pmc Pathogenicity of Genetically Similar, H5N1 Highly Pathogenic Avian Influenza Virus Strains in Chicken and the Differences in Sensitivity among Different Chicken Breeds
    Aya Matsuu
    Thailand Japan Zoonotic Diseases Collaborating Center ZDCC, Kasetlang, Chatuchak, Bangkok, Thailand
    PLoS ONE 11:e0153649. 2016
    ..Although polymorphisms were observed in the Mx and MHC class I genes, there was no significant association between the polymorphisms in these loci and resistance to HPAIV. ..
  5. doi Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers
    Y Wang
    Department of Animal Science, University of California, Davis 951616, USA
    Poult Sci 91:3019-24. 2012
    ..In this study, the embryos and young chicks were generated from the cross of Mx1 heterozygous (S631N) parents with an expected segregating ratio of 1:2:1 in the progeny...
  6. doi Both antiviral activity and intracellular localization of chicken Mx protein depend on a polymorphism at amino acid position 631
    Keisuke Sasaki
    Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Biochem Biophys Res Commun 430:161-6. 2013
    ..These results demonstrated that a single amino acid polymorphism at 631 aa of the chicken Mx protein altered both the antiviral activity and intracellular localization...
  7. ncbi The chicken Mx promoter contains an ISRE motif and confers interferon inducibility to a reporter gene in chick and monkey cells
    B Schumacher
    Institut für Mikrobiologie und Hygiene, University of Freiburg, Germany
    Virology 203:144-8. 1994
    ..The exon/intron structure of the chicken Mx gene resembles that of the mouse Mx1 gene: exon 1 is very small, the first intron contains a noncoding exon 1' that is alternatively spliced in ..
  8. ncbi Skewed allele frequencies of an Mx gene mutation with potential resistance to avian influenza virus in different chicken populations
    X Y Li
    Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing
    Poult Sci 85:1327-9. 2006
    ..The results suggested that further studies are needed with regard to the genetic resistance to avian influenza in different populations with various domestication background and selection history...
  9. ncbi Interferon alpha-induced inhibition of infectious bursal disease virus in chicken embryo fibroblast cultures differing in Mx genotype
    Ann Marie O'Neill
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Avian Dis 54:802-6. 2010
    ..Furthermore, the reduction in viral yield did not differ significantly among Mx genotypes, indicating that Mx Asn631 is not a pivotal determinant of resistance to this strain of IBDV in CEF...
  10. pmc The cytoplasmic location of chicken mx is not the determining factor for its lack of antiviral activity
    Camilla T O Benfield
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e12151. 2010
    ..We also report the consequences of re-locating chicken Mx to the nucleus...
  11. doi Association of Mx1 Asn631 variant alleles with reductions in morbidity, early mortality, viral shedding, and cytokine responses in chickens infected with a highly pathogenic avian influenza virus
    Sandra J Ewald
    Department of Pathobiology, Auburn University, 166 Greene Hall, Auburn, AL 36849 5519, USA
    Immunogenetics 63:363-75. 2011
    ..According to an early report, chicken Mx1 variants encoding Asn at position 631 have antiviral activity, whereas variants with Ser at 631 lack activity in ..
  12. pmc Mx is dispensable for interferon-mediated resistance of chicken cells against influenza A virus
    Benjamin Schusser
    Department of Veterinary Science, University Munich, Germany
    J Virol 85:8307-15. 2011
    ..Studies of mice identified the Mx1 protein as a key effector molecule of the IFN-induced antiviral state against FLUAV...