abd-A

Summary

Gene Symbol: abd-A
Description: abdominal A
Alias: ABD-A, Abd-A, AbdA, Abda, BX-C, CG10325, Cbxd, DmabdA, Dmabda, Dmel\CG10325, Fab-3, Fab-4, Hab, abd A, abd-a, abdA, abd_a, abda, iab, iab-2, iab-3, iab-4, iab-5, iab2, iab3, iab4, l(3)89Ec, CG10325 gene product from transcript CG10325-RD, Abdominal-A, CG10325-PA, CG10325-PB, CG10325-PC, CG10325-PD, abd-A-PA, abd-A-PB, abd-A-PC, abd-A-PD, abdominalA, contrabithoraxoid, hyperabdominal, infra-abdominal 2, infra-abdominal 3, infra-abdominal 4, infraabdominal, ultraabdominal
Species: fruit fly

Top Publications

  1. pmc MicroRNAs in the Drosophila bithorax complex
    Welcome Bender
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 22:14-9. 2008
  2. ncbi A gene complex controlling segmentation in Drosophila
    E B Lewis
    Nature 276:565-70. 1978
  3. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  4. ncbi A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis
    Bruno C Bello
    Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Neuron 37:209-19. 2003
  5. ncbi Direct integration of Hox and segmentation gene inputs during Drosophila development
    Brian Gebelein
    Department of Biochemistry and Molecular Biophysics and Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, HHSC 1104, New York, New York 10032, USA
    Nature 431:653-9. 2004
  6. pmc The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain
    S E Celniker
    Division of Biology, California Institute of Technology, Pasadena 91125
    EMBO J 9:4277-86. 1990
  7. ncbi Multiplex detection of RNA expression in Drosophila embryos
    Dave Kosman
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Science 305:846. 2004
  8. pmc Functional and regulatory interactions between Hox and extradenticle genes
    N Azpiazu
    Centro de Biologia Molecular Centro Superior de Investigaciones Cientificas Universidad Autońoma de Madrid, Madrid, Spain
    Genes Dev 12:261-73. 1998
  9. ncbi Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity
    M Peifer
    Department of Biology, Princeton University, New Jersey 08544 1003
    Genes Dev 4:1209-23. 1990
  10. ncbi Specification, migration and assembly of the somatic cells of the Drosophila gonad
    M Boyle
    Rockefeller University, NYC, NY 10021 6399, USA
    Development 121:1815-25. 1995

Scientific Experts

Detail Information

Publications155 found, 100 shown here

  1. pmc MicroRNAs in the Drosophila bithorax complex
    Welcome Bender
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 22:14-9. 2008
    The iab-4 noncoding RNA from the Drosophila bithorax complex is the substrate for a microRNA (miRNA). Gene conversion was used to delete the hairpin precursor of this miRNA; flies homozygous for this deletion are sterile...
  2. ncbi A gene complex controlling segmentation in Drosophila
    E B Lewis
    Nature 276:565-70. 1978
    ....
  3. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  4. ncbi A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis
    Bruno C Bello
    Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Neuron 37:209-19. 2003
    ..A burst of expression of the Hox protein Abdominal-A (AbdA) specifies the time at which apoptosis occurs, thereby determining the final number of progeny that each neuroblast ..
  5. ncbi Direct integration of Hox and segmentation gene inputs during Drosophila development
    Brian Gebelein
    Department of Biochemistry and Molecular Biophysics and Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, HHSC 1104, New York, New York 10032, USA
    Nature 431:653-9. 2004
    ..Our results suggest that these two classes of proteins may collaborate to directly control gene expression at many downstream target genes...
  6. pmc The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain
    S E Celniker
    Division of Biology, California Institute of Technology, Pasadena 91125
    EMBO J 9:4277-86. 1990
    ..for two proteins, ABD-BI (54 kd) and ABD-BII (36 kd) and cis-regulatory regions extending from infra-abdominal-5 (iab-5) to iab-9, inclusive...
  7. ncbi Multiplex detection of RNA expression in Drosophila embryos
    Dave Kosman
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Science 305:846. 2004
    ....
  8. pmc Functional and regulatory interactions between Hox and extradenticle genes
    N Azpiazu
    Centro de Biologia Molecular Centro Superior de Investigaciones Cientificas Universidad Autońoma de Madrid, Madrid, Spain
    Genes Dev 12:261-73. 1998
    ..As the Hoxd10 gene has the same properties as Drosophila BX-C genes, we suggest that the control mechanism of subcellular distribution of Exd found in Drosophila probably operates in other organisms as well...
  9. ncbi Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity
    M Peifer
    Department of Biology, Princeton University, New Jersey 08544 1003
    Genes Dev 4:1209-23. 1990
    ..Complete removal of extradenticle, maternally and zygotically, leads to specific alterations in segmentation, many of which result from failure to maintain the expression of the homeo domain protein engrailed...
  10. ncbi Specification, migration and assembly of the somatic cells of the Drosophila gonad
    M Boyle
    Rockefeller University, NYC, NY 10021 6399, USA
    Development 121:1815-25. 1995
    ..The functions of the homeotic genes abdominal A and Abdominal B are required for the development of gonadal precursors, however, here we provide evidence that ..
  11. ncbi Elements of the Drosophila bithorax complex that mediate repression by Polycomb group products
    J Simon
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Dev Biol 158:131-44. 1993
    ..We describe germ-line transformation constructs, containing portions of the bxd, iab-2, or iab-3 regulatory regions of the bithorax complex (BX-C), that are controlled by Pc group products in embryos...
  12. ncbi The hexapeptide and linker regions of the AbdA Hox protein regulate its activating and repressive functions
    Samir Merabet
    Laboratoire de Genetique et Physiologie du Developpement, IBDM, CNRS, Universite de la Mediterranee, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Dev Cell 4:761-8. 2003
    ..Here we report that mutation of the AbdA HX motif does not alter its binding site selection but does modify its transregulatory properties in a gene-..
  13. ncbi A simple and efficient method to identify replacements of P-lacZ by P-Gal4 lines allows obtaining Gal4 insertions in the bithorax complex of Drosophila
    Luis de Navas
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Mech Dev 123:860-7. 2006
    ..Our experiments confirm that the abdominal-A gene can replace Ultrabithorax in haltere development but that it cannot substitute for Abdominal-B in the formation of the genitalia...
  14. ncbi The 412 retrotransposon and the development of gonadal mesoderm in Drosophila
    J J Brookman
    Department of Anatomy, University of Cambridge, UK
    Development 116:1185-92. 1992
    ..We show that the maintenance of high levels of 412 expression in gonadal mesoderm is not induced by contact with germ cells, but rather depends on genetic control by the homeotic genes abdominal-A and Abdominal-B...
  15. ncbi Functional dominance among Hox genes: repression dominates activation in the regulation of Dpp
    M Capovilla
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Development 125:4949-57. 1998
    ..Thus, these results suggest that other cases of Hox competition and functional dominance may also be understood in terms of competition for target gene regulation in which repression dominates over activation...
  16. pmc The bithorax complex of Drosophila melanogaster: Underreplication and morphology in polytene chromosomes
    Y M Moshkin
    Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk 630090, Russia
    Proc Natl Acad Sci U S A 98:570-4. 2001
    ..We speculate that the wild-type Su(UR)ES protein hampers DNA replication of silenced domains and leads to their underreplication in salivary gland polytene chromosomes...
  17. ncbi The rise and fall of Hox gene clusters
    Denis Duboule
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Development 134:2549-60. 2007
    ..By integrating these parameters, general conclusions emerge that can help solve the aforementioned dilemma...
  18. pmc A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands
    Alexander Stark
    Broad Institute of Massachussetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02141, USA
    Genes Dev 22:8-13. 2008
    ..Here, we report that the miRNA iab-4 locus in the Drosophila Hox cluster is transcribed convergently from both DNA strands, giving rise to two ..
  19. ncbi The abdominal region of the bithorax complex
    F Karch
    Cell 43:81-96. 1985
    ..Complementation tests suggest interactions between widely spaced DNA regions; indeed, the right half cannot be split anywhere without some loss of function...
  20. ncbi The ABC of the BX-C: the bithorax complex explained
    Robert K Maeda
    Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, 30 quai E Ansermet, 1211 Geneva 4, Switzerland
    Development 133:1413-22. 2006
    ..This primer attempts to distill and explain our current knowledge about this classic, complex locus...
  21. pmc Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci
    David M Tyler
    Department of Developmental Biology, Sloan Kettering Institute, New York, New York 10021, USA
    Genes Dev 22:26-36. 2008
    ..We report here that antisense transcription of the Hox miRNA locus mir-iab-4 generates the novel pre-miRNA hairpin mir-iab-8, which is then processed into endogenous mature miRNAs...
  22. ncbi Multiple roles for Hox genes in segment-specific shaping of CNS lineages
    Ana Rogulja-Ortmann
    Institute of Genetics, University of Mainz, Mainz, Germany
    Fly (Austin) 2:316-9. 2008
    ....
  23. ncbi Genetic organization of Drosophila bithorax complex
    E Sánchez-Herrero
    Nature 313:108-13. 1985
    ..Each of these genes plays its principal part in a particular anatomical domain of the body, where it is specifically required to determine the correct segmental pattern...
  24. ncbi Muscle pattern diversification in Drosophila is determined by the autonomous function of homeotic genes in the embryonic mesoderm
    A M Michelson
    Department of Medicine, Brigham and Women s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Development 120:755-68. 1994
    ..Finally, these experiments reveal that homeotic cues specific to both the mesoderm and the ectoderm cooperate to specify the pattern of muscle attachment sites...
  25. pmc Complete sequence of the bithorax complex of Drosophila
    C H Martin
    Human Genome Center, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 92:8398-402. 1995
    ..previously known ABD-A protein and a putative glucose transporter-like gene (1521 bp) located at or near the bithoraxoid (bxd), infra-abdominal-2 (iab-2) boundary on the opposite strand relative to that of the homeobox-containing genes.
  26. ncbi Hox protein mutation and macroevolution of the insect body plan
    Matthew Ronshaugen
    Section of Cell and Developmental Biology, Universith of California San Diego, Jolla, CA 92093, USA
    Nature 415:914-7. 2002
    ..In Drosophila melanogaster and other insects, the Ultrabithorax (Ubx) and abdominal A (AbdA, also abd-A) Hox proteins are expressed largely in the abdominal segments, where they can suppress ..
  27. ncbi Segment-specific prevention of pioneer neuron apoptosis by cell-autonomous, postmitotic Hox gene activity
    Irene Miguel-Aliaga
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Development 131:6093-105. 2004
    ..In addition, they provide a novel mechanism linking Hox positional information to differences in neuronal architecture along the anteroposterior axis by the selective elimination of mature neurons...
  28. ncbi Genome-wide analysis of Polycomb targets in Drosophila melanogaster
    Yuri B Schwartz
    Rutgers University, Department of Molecular Biology and Biochemistry, 604 Allison Road, Piscataway, New Jersey 08854, USA
    Nat Genet 38:700-5. 2006
    ..PcG targets are highly enriched in genes encoding transcription factors, but they also include genes coding for receptors, signaling proteins, morphogens and regulators representing all major developmental pathways...
  29. ncbi Regulation of a decapentaplegic midgut enhancer by homeotic proteins
    J R Manak
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305 5427
    Development 120:3605-19. 1994
    ..In the Drosophila midgut, the Ultrabithorax (Ubx) protein activates and the abdominalA (abd-A) protein represses transcription of the decapentaplegic (dpp) gene, which encodes a secreted signalling ..
  30. ncbi Imaginal disc silencers from Ultrabithorax: evidence for Polycomb response elements
    B Christen
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Mech Dev 48:255-66. 1994
    ..Since silencing by BXD also requires Pc function, this suggests that BXD contains target sites for Pc or for Pc-like proteins. We propose that stable silencing of Ubx is achieved through cooperation between hb and Pc target sites...
  31. ncbi Regulation of segmentation and segmental identity by Drosophila homeoproteins: the role of DNA binding in functional activity and specificity
    M D Biggin
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 208114, USA
    Development 124:4425-33. 1997
    ..In this 'widespread binding' model, cofactors act mainly by helping to distinguish the way in which homeoproteins regulate targets to which they are already bound...
  32. ncbi Homeotic regulation of segment-specific differences in neuroblast numbers and proliferation in the Drosophila central nervous system
    A Prokop
    Institut für Genetik Zellbiologie, Becherweg 32, D 55128 Mainz, Germany
    Mech Dev 74:99-110. 1998
    ....
  33. ncbi Dissecting the regulatory landscape of the Abd-B gene of the bithorax complex
    Jozsef Mihaly
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, 6723 Szeged, Hungary
    Development 133:2983-93. 2006
    ..Our results highlight four key features of the iab-5, iab-6 and iab-7 cis-regulatory region of Abd-B...
  34. pmc Evolutionary plasticity of polycomb/trithorax response elements in Drosophila species
    Arne Hauenschild
    Universitat Bielefeld, Center for Biotechnology CeBiTec, Bielefeld, Germany
    PLoS Biol 6:e261. 2008
    ..By demonstrating that PRE evolution is not limited to the adaptation of preexisting elements, these findings document a novel dimension of cis-regulatory evolution...
  35. pmc Molecular dissection of cis-regulatory modules at the Drosophila bithorax complex reveals critical transcription factor signature motifs
    Michael O Starr
    Biology Department, Harvey Mudd College, Claremont, CA 91711, USA
    Dev Biol 359:290-302. 2011
    ....
  36. ncbi Specification of anteroposterior cell fates in Caenorhabditis elegans by Drosophila Hox proteins
    C P Hunter
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0554, USA
    Nature 377:229-32. 1995
    ..Together these findings suggest that factors important for target recognition by specific Hox proteins have been conserved throughout much of the animal kingdom...
  37. ncbi Dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS
    E Kurant
    Unit of Genetics, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Development 125:1037-48. 1998
    ..Based on our observations we propose that the genetic interactions between hth and exd serve as a novel mechanism for regulating homeotic protein activity in embryonic PNS development...
  38. ncbi Homeotic gene action in embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, University of Basel, Basel, Switzerland
    Development 125:1579-89. 1998
    ..Our findings demonstrate that the action of the homeotic genes labial and Deformed are required for neuronal differentiation in the developing brain of Drosophila...
  39. pmc Binding of trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis
    V Orlando
    ZMBH, University of Heidelberg, INF 282, 69120 Heidelberg, Germany
    EMBO J 17:5141-50. 1998
    ..Later, at germ band extension, the time of derepression in Polycomb mutants, PC binding is also detected outside core PREs and additionally binds to the fragments containing promoters...
  40. pmc Distinct hox protein sequences determine specificity in different tissues
    S Chauvet
    Laboratoire de Génétique et Biologie du Développement, Institut de Biologie du Developpement de Marseille, Centre National de la Recherche Scientifique Université de la Méditerranée, Parc Scientifique de Luminy, Case 907, 13288 Marseille, France
    Proc Natl Acad Sci U S A 97:4064-9. 2000
    ..Available genetic markers allow the regulatory effects of two Hox proteins, Abdominal-A (AbdA) and Ultrabithorax (Ubx), to be distinguished in the Drosophila embryonic epidermis and visceral mesoderm (VM)...
  41. ncbi Functional equivalence of Hox gene products in the specification of the tritocerebrum during embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 128:4781-8. 2001
    ..This suggests that in embryonic brain development, differences in Hox gene action rely mainly on cis-acting regulatory elements and not on Hox protein specificity...
  42. ncbi A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster
    Christian Berger
    Institute for Genetics, University of Mainz, D 55099 Mainz, Germany
    Nat Cell Biol 7:56-62. 2005
    ..However, other components of the cell cycle seem to have a minor role in this process, suggesting a critical role for CycE in regulating cell fate in segment-specific neural lineages...
  43. pmc Conservation of regulatory sequences and gene expression patterns in the disintegrating Drosophila Hox gene complex
    Barbara Negre
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Genome Res 15:692-700. 2005
    ..Firstly, we sequenced two regions of the D. buzzatii genome, one containing the genes labial and abdominal A, and another one including proboscipedia, and compared their organization with that of D. melanogaster and D...
  44. ncbi Tarsus determination in Drosophila melanogaster
    Anthony Percival-Smith
    Department of Biology, University of Western Ontario, London, Canada
    Genome 48:712-21. 2005
    ..Therefore, the possibility exists that normal tarsus determination is HOX independent...
  45. doi Temporal transcription factors and their targets schedule the end of neural proliferation in Drosophila
    Cédric Maurange
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Cell 133:891-902. 2008
    ..These studies identify the timing mechanism ending CNS proliferation and reveal how aging progenitors transduce bursts of transcription factors into long-lasting changes in cell proliferation and cell identity...
  46. pmc Multi-step control of muscle diversity by Hox proteins in the Drosophila embryo
    Jonathan Enriquez
    Centre de Biologie du Developpement, UMR 5547 CNRS UPS, IFR 109 Institut d Exploration Fonctionnelle des Génomes, 31062 Toulouse Cedex 9, France
    Development 137:457-66. 2010
    ..We conclude that Hox proteins both regulate and contribute to the combinatorial code of transcription factors that specify muscle identity and act at several steps during the muscle-specification process to generate muscle diversity...
  47. ncbi Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products
    J Simon
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115
    Development 114:493-505. 1992
    ..Here the requirements for Pc group genes in controlling the abdA and AbdB products of the bithorax complex are described...
  48. ncbi Homeotic genes have specific functional roles in the establishment of the Drosophila embryonic peripheral nervous system
    J G Heuer
    Howard Hughes Medical Institute, Department of Biology, Indiana University, Bloomington 47405
    Development 115:35-47. 1992
    ..Our results are suggestive of a role for the homeotic gene products in regulating genes which are necessary for generating sensory progenitor cells in the developing PNS...
  49. ncbi Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less
    G Vachon
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030
    Cell 71:437-50. 1992
    ..Repression of limb development in the abdomen appears to be controlled at the DII enhancer. Thus DII may serve as a downstream target gene through which the homeotic genes control abdominal segment identity in the Drosophila embryo...
  50. ncbi The role of the teashirt gene in trunk segmental identity in Drosophila
    L Röder
    Laboratoire de Génétique et Biologie Cellulaires, CNRS Case 907, Centre Universitaire Marseille Luminy, France
    Development 115:1017-33. 1992
    ..Our results are consistent with the idea that tsh is defining the ground state of the Drosophila trunk region seen in the absence of the Antp and BX-C genes...
  51. ncbi Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patterns
    A Lloyd
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
    Mech Dev 36:87-102. 1991
    ....
  52. ncbi Are cross-regulatory interactions between homoeotic genes functionally significant?
    A González-Reyes
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Madrid, Spain
    Nature 344:78-80. 1990
    ..Hence our results challenge the view that these, and possibly other cross-regulatory interactions have a role in determining segmental identity...
  53. ncbi abdA expression in Drosophila embryos
    F Karch
    Department of Animal Biology, University of Geneva, Switzerland
    Genes Dev 4:1573-87. 1990
    The abdominal A (abdA) gene is one of three transcription units in the Bithorax Complex of Drosophila encoding a homeo box protein; it is flanked by Ultrabithorax (Ubx) and Abdominal B (AbdB)...
  54. ncbi Expression and regulation of the abd-A gene of Drosophila
    A Macias
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Madrid, Spain
    Development 110:1197-207. 1990
    ..Finally, we show that the abd-A gene is down-regulated in part of the Abdominal-B (Abd-B) domain, precisely in those regions where the Abd-B gene is expressed at high levels...
  55. ncbi Mutations affecting the stability of the fushi tarazu protein of Drosophila
    K A Kellerman
    Department of Biology, Washington University, St Louis, Missouri 63130
    Genes Dev 4:1936-50. 1990
    ..Both ftz transcript and protein stripes are persistent in Rpl embryos, suggesting that the Rpl RNA is stabilized relative to wild type...
  56. ncbi Spatially ordered transcription of regulatory DNA in the bithorax complex of Drosophila
    E Sánchez-Herrero
    Department of Genetics, University of Cambridge, UK
    Development 107:321-9. 1989
    ..The correct deployment of these two genes requires an extensive region (the iab region) located between the two protein-coding transcription units...
  57. ncbi Regulation of the genes of the bithorax complex in Drosophila
    E B Lewis
    Cold Spring Harb Symp Quant Biol 50:155-64. 1985
    ..Three rules governing cis-regulation of BX-C are applicable over a region extending from Ubx to at least iab-7, a distance of nearly 300 kb on the DNA map: The colinearity (COL) rule: genes are colinear with respect to map ..
  58. ncbi Recessive lethal mutations within the bithorax-complex in Drosophila
    S Tiong
    Mol Gen Genet 200:335-42. 1985
    ..Homozygotes for each of only three groups of lethals, Ubx, abdA and AbdB, produce homoeotic segmental transformations in embryos...
  59. ncbi Regulation of the Ultrabithorax gene of Drosophila by other bithorax complex genes
    G Struhl
    Cell 43:507-19. 1985
    ..Using mutations in the abd-A, Abd-B, and esc (extra sex combs) genes we show that these distinct patterns result in large part from regulation of Ubx gene expression by the abd-A and Abd-B gene functions...
  60. ncbi Homeotic response elements are tightly linked to tissue-specific elements in a transcriptional enhancer of the teashirt gene
    A McCormick
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305 5427, USA
    Development 121:2799-812. 1995
    ..We propose that local interactions between homeotic proteins and other factors effect activation of targets in proper cell types...
  61. ncbi Control of Drosophila adult pattern by extradenticle
    S González-Crespo
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    Development 121:2117-25. 1995
    ..Our findings indicate that exd is critically involved in adult morphogenesis, not only in the homeotic function but also in several other developmental processes...
  62. pmc Transvection in the iab-5,6,7 region of the bithorax complex of Drosophila: homology independent interactions in trans
    R Hopmann
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Genetics 139:815-33. 1995
    ..Here we focus on iab-5, iab-6 and iab-7, regulatory regions of Abd-B that control expression in the fifth, sixth and seventh abdominal ..
  63. ncbi Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis
    M Affolter
    Biozentrum, Universitat Basel, Switzerland
    Development 120:3105-17. 1994
    ..The requirements for tkv in dorsal closure, visceral mesoderm and trachea development assign novel functions to dpp or a closely related member of the TGF beta superfamily...
  64. ncbi Homeotic genes and the regulation and evolution of insect wing number
    S B Carroll
    Howard Hughes Medical Institute, Madison, Wisconsin, USA
    Nature 375:58-61. 1995
    ....
  65. pmc Conservation of a functional hierarchy between mammalian and insect Hox/HOM genes
    D Bachiller
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 13:1930-41. 1994
    ..Our results strongly suggest a general conservation of the functional hierarchy of homeotic genes that correlates with genetic order and expression patterns...
  66. ncbi Enhancer point mutation results in a homeotic transformation in Drosophila
    M J Shimell
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717
    Science 264:968-71. 1994
    ..In the dominant Hyperabdominal mutations (Hab), portions of the third thoracic segment (T3) are transformed toward A2 as the result of ..
  67. pmc Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins
    C Rauskolb
    Department of Molecular Biology, Princeton University, NJ 08544
    EMBO J 13:3561-9. 1994
    ..Thus, exd is an indispensable component in target gene regulation by the homeotic selector proteins...
  68. ncbi extradenticle raises the DNA binding specificity of homeotic selector gene products
    M A van Dijk
    Department of Biology, University of California, San Diego, La Jolla 92093
    Cell 78:617-24. 1994
    ....
  69. ncbi Dissecting the temporal requirements for homeotic gene function
    J Castelli-Gair
    Wellcome CRC Institute, Cambridge, UK
    Development 120:1983-95. 1994
    ..We also provide evidence that supports the hypothesis of in vivo competition between the bithorax complex proteins for the regulation of their down-stream targets...
  70. ncbi Early tagma-specific commitment of Drosophila CNS progenitor NB1-1
    A Prokop
    Institut für Genetik Zellbiologie, Mainz, Germany
    Development 120:2567-78. 1994
    ..At that stage antibody stainings reveal both proteins to be present in NB1-1 during normal development. Possible mechanisms conferring the early tagma-specific determination are discussed...
  71. ncbi Colinearity and functional hierarchy among genes of the homeotic complexes
    D Duboule
    Département de Zoologie et Biologie Animale, Universite de Geneve, Switzerland
    Trends Genet 10:358-64. 1994
    ....
  72. pmc The Antennapedia-type homeobox genes have evolved from three precursors separated early in metazoan evolution
    F R Schubert
    Abteilungun für Molekulare Zellbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Federal Republic of Germany
    Proc Natl Acad Sci U S A 90:143-7. 1993
    ..These genes later independently gave rise to the 13 groups of paralogous genes in vertebrates and to the 11 Antennapedia-type genes in the Drosophila complexes...
  73. pmc Cell-type-specific mechanisms of transcriptional repression by the homeotic gene products UBX and ABD-A in Drosophila embryos
    B Appel
    Department of Human Genetics, Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112
    EMBO J 12:1099-109. 1993
    ..The latter mechanism of repression requires only that multiple homeodomain binding sequences be present and is not dependent on any particular binding site...
  74. ncbi Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins
    R S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University, NY 10032, USA
    Trends Genet 12:258-62. 1996
    ....
  75. ncbi Expression patterns of developmental genes reveal segment and parasegment organization of D. melanogaster genital discs
    D E Freeland
    Department of Biology, University of Central Florida, Orlando 32816, USA
    Mech Dev 56:61-72. 1996
    ..Models are presented to show how the segments and parasegments may fuse together during embryogenesis to form the mature male and female genital discs...
  76. pmc Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression
    H Strutt
    ZMBH, University of Heidelberg, Germany
    EMBO J 16:3621-32. 1997
    ..We propose that GAGA factor binds constitutively to regulatory elements in the bithorax complex, which function both as PREs and as trithorax group response elements...
  77. ncbi Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein
    G E Rieckhof
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 91:171-83. 1997
    ..These data suggest a novel and evolutionarily conserved mechanism for regulating HOX activity in which a direct protein-protein interaction between EXD and HTH results in EXD's nuclear translocation...
  78. pmc Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling
    N C Grieder
    Abteilung Zellbiologie, Biozentrum, Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    EMBO J 16:7402-10. 1997
    ..Our results illustrate how a tissue-specific response to DPP can be generated through synergistic effects on an enhancer carrying both DPP- and HOX-responsive sequences...
  79. ncbi zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila
    H T Broihier
    Skirball Institute, New York University Medical Center, NY, NY 10016, USA
    Development 125:655-66. 1998
    ..Finally, through analysis of a tinman zfh-1 double mutant, we show that zfh-1 acts in conjunction with tinman, another homeodomain protein, in the specification of lateral mesodermal derivatives, including the gonadal mesoderm...
  80. ncbi Gonadal mesoderm and fat body initially follow a common developmental path in Drosophila
    L A Moore
    Skirball Institute, New York University Medical Center, NY, NY 10016, USA
    Development 125:837-44. 1998
    ..dorsolateral mesoderm along the anteroposterior axis is determined by the combined actions of genes including abdA, AbdB and srp; while srp promotes fat body development, abdA allows gonadal mesoderm to develop by repressing srp ..
  81. ncbi Wnt and TGFbeta signals subdivide the AbdA Hox domain during Drosophila mesoderm patterning
    D Bilder
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5427, USA
    Development 125:1781-90. 1998
    ..We have examined the mechanism underlying subdivision of the abdominal-A (abdA) Hox domain in the visceral mesoderm...
  82. pmc The control of trunk Hox specificity and activity by Extradenticle
    H D Ryoo
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Genes Dev 13:1704-16. 1999
    ..These results suggest that Exd is a specificity cofactor for the trunk Hox genes, and that the control of Exd subcellular localization is a mechanism to regulate Hox activity during development...
  83. ncbi P element homing to the Drosophila bithorax complex
    W Bender
    BCMP Department, Harvard Medical School, Boston, MA 02115, USA
    Development 127:3981-92. 2000
    ..The mapping of segmental domains has now been revised, with enlargement of the abx/bx, bxd/pbx, and the iab-3 domains...
  84. ncbi Cross-regulation of Hox genes in the Drosophila melanogaster embryo
    D F Miller
    Department of Biology, Howard Hughes Medical Institute, Indiana University, Bloomington, IN 47405, USA
    Mech Dev 102:3-16. 2001
    ..A summary of Hox gene cross-regulation by ectopically driven Hox proteins is tabulated for embryogenesis...
  85. ncbi General transcription factors bind promoters repressed by Polycomb group proteins
    A Breiling
    DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Nature 412:651-5. 2001
    ..We further show that PcG proteins interact in vitro with GTFs. We suggest that PcG complexes maintain silencing by inhibiting GTF-mediated activation of transcription...
  86. ncbi abdominal A specifies one cell type in Drosophila by regulating one principal target gene
    Véronique Brodu
    Medical Research Council, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Development 129:2957-63. 2002
    ..to the abdomen and induced in response to a non-cell autonomous, transient and highly selective input from abdominal A (abdA)...
  87. ncbi Transcription activates repressed domains in the Drosophila bithorax complex
    Welcome Bender
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Development 129:4923-30. 2002
    ..These dominant Ultraabdominal alleles are all associated with P element insertions which are transcribed in the first abdominal segment...
  88. ncbi Drosophila cardiac tube organogenesis requires multiple phases of Hox activity
    Laurent Perrin
    Laboratoire de Genetique et Physiologie du Developpement, UMR 6545 CNRS Université, IBDM CNRS Université de la Méditerranée, Marseille Cedex 09, 13288 France
    Dev Biol 272:419-31. 2004
    ..This analysis illustrates the mechanisms by which Hox genes can orchestrate organogenesis and, in particular, allows a clear uncoupling of the different phases of Hox activity in this process...
  89. ncbi Getting a molecular grasp on Hox contextual activity
    Samir Merabet
    Laboratoire de Genetique et Physiologie du Developpement, IBDM, CNRS, Universite de la Mediterranee, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Trends Genet 21:477-80. 2005
    ..A recent study identified novel Hox molecular partners, whose properties set a conceptual framework to understand how Hox proteins use and integrate contextual information...
  90. ncbi Pleiotropic functions of a conserved insect-specific Hox peptide motif
    Chris Todd Hittinger
    Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 132:5261-70. 2005
    ....
  91. ncbi Requirement of Abdominal-A and Abdominal-B in the developing genitalia of Drosophila breaks the posterior downregulation rule
    David Foronda
    Centro de Biología Molecular Severo Ochoa C S I C U A M Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Development 133:117-27. 2006
    ..The relationship between Abd-B and abd-A in the female genital disc is opposite to that of the embryonic epidermis, and contravenes the rule that posteriorly expressed Hox genes downregulate more anterior ones...
  92. ncbi Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification
    Fabienne Cléard
    Department of Zoology and Animal Biology and National Research Center Frontiers in Genetics, University of Geneva, 30 quai E Ansermet, 1211 Geneva 4, Switzerland
    Nat Genet 38:931-5. 2006
    ..Overall, our work provides the first documented example of a dynamic, long-distance physical interaction between distal regulatory elements within a living, multicellular organism...
  93. pmc The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning
    Man Mohan
    Institute for Genetics, Justus Liebig University Giessen, Heinrich Buff Ring, Giessen, Germany
    EMBO J 26:4203-14. 2007
    ..A short pulse of dCTCF expression during larval development rescues the dCTCF loss of function phenotype. Overall, we demonstrate the importance of dCTCF in fly development and in the regulation of abdominal segmentation...
  94. ncbi Polycomb response elements mediate the formation of chromosome higher-order structures in the bithorax complex
    Chiara Lanzuolo
    Dulbecco Telethon Institute at IGB CNR, Epigenetics and Genome Reprogramming, Via Pietro Castellino 111, 80131 Naples, Italy
    Nat Cell Biol 9:1167-74. 2007
    ....
  95. pmc Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins
    Christian Beisel
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 104:16615-20. 2007
    ..Besides its presumptive function in recruiting PcG complexes to their site of action, our results now uncover that Pho plays an additional role in the repression of already induced genes...
  96. pmc A unique Extradenticle recruitment mode in the Drosophila Hox protein Ultrabithorax
    Samir Merabet
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique, Universite de la Mediterranee, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 104:16946-51. 2007
    ....
  97. pmc Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS
    David Li-Kroeger
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Cell 15:298-308. 2008
    ..As the vertebrate senseless homolog is essential for neural development as well as hematopoiesis, we propose Hox-Senseless antagonism will broadly control cell fate decisions...
  98. pmc Regulation of Hox gene activity by transcriptional elongation in Drosophila
    Vivek S Chopra
    Division of Genetics, Center for Integrative Genomics, University of California, Berkeley, Berkeley, CA 94720 3200, USA
    Curr Biol 19:688-93. 2009
    ..Stalled Pol II persists in tissues where Ubx and Abd-B are silenced by the PcG complex. We propose that stalling fosters both the rapid induction and precise silencing of Hox gene expression during development...
  99. doi Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system
    Ramakrishnan Kannan
    Center for Cellular and Molecular Biology, Hyderabad, India
    Mech Dev 127:137-45. 2010
    ..During embryonic CNS development of Drosophila, the Hox protein Abdominal-A (AbdA) is required for the specification of the abdominal NB6-4 lineage...
  100. pmc Alternative epigenetic chromatin states of polycomb target genes
    Yuri B Schwartz
    Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Laboratories, Piscataway, New Jersey, United States of America
    PLoS Genet 6:e1000805. 2010
    ..These results have important implications for Polycomb gene regulation, the "bivalent" chromatin state of embryonic stem cells, and gene expression in development...
  101. pmc Comparing anterior and posterior Hox complex formation reveals guidelines for predicting cis-regulatory elements
    Juli D Uhl
    Division of Developmental Biology, Cincinnati Children s Hospital, 3333 Burnet Ave, MLC 7007, Cincinnati, OH 45229, USA
    Dev Biol 343:154-66. 2010
    ..Based upon these findings, we suggest a general set of guidelines to serve as a basis for designing bioinformatics algorithms aimed at identifying Hox regulatory elements using the wealth of recently sequenced genomes...

Research Grants10

  1. TRANSCRIPTIONAL COACTIVATORS IN ENDOCRINE REGULATION
    Richard Goodman; Fiscal Year: 2003
    ..Finally, we will characterize the ability of the "CREB binding domain" of CBP to interact with other transcription factors activated or inhibited by Ser/Thr phosphorylation. ..
  2. OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATION
    Blanche Capel; Fiscal Year: 2010
    ....
  3. DISSECTION OF ONCOGENIC PATHWAYS USING DROSOPHILA
    Richard Mann; Fiscal Year: 2004
    ..The use of Drosophila genetics is proposed to help make connections between genetic functions that cannot be easily identified in mammalian experimental systems. ..
  4. Genetic Transfer in the Evolution of Infectious Disease
    Rob DeSalle; Fiscal Year: 2005
    ....
  5. RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMS
    Richard Goodman; Fiscal Year: 2006
    ..Core laboratories for cell culture, protein chemistry, and administration are designed to allow the proposed studies to be performed in an efficient and cost-effective manner. ..
  6. Fourth Symposium Biology Vertebrate Sex Determination
    Blanche Capel; Fiscal Year: 2006
    ..Understanding how critical genes in sex determining pathways evolved and how they function in lower vertebrates is expected to improve diagnosis and treatment of human disorders. [unreadable] [unreadable] [unreadable]..
  7. Organ-specific Mechanisms of Vascular Development
    Blanche Capel; Fiscal Year: 2007
    ..In addition, the molecular signals that control or repress the growth of vasculature into a tissue are of critical concern for the design of therapies in the fields of wound healing and tumor biology. [unreadable] [unreadable]..
  8. Integrated Approcahes to Find Hox-regulated DNA Elements
    Richard Mann; Fiscal Year: 2008
    ..Once these methods are worked out, they will be applicable to a wide variety of problems in biology. [unreadable] [unreadable]..
  9. Identification of gene targets for morphine and other drugs of abuse
    Richard Goodman; Fiscal Year: 2009
    ..The concept that CREB signaling induces mediators of translational arrest has profound implications for the understanding of drug action. ..
  10. Regulation of MeCP2 by CREB-induced microRNAs
    Richard H Goodman; Fiscal Year: 2010
    ..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..