Abd-B

Summary

Gene Symbol: Abd-B
Description: Abdominal B
Alias: ABD-B, ABDB, Abd B, Abd-b, Abd0B, AbdB, AbdB(CA)[[26]], AbdB-I, AbdB-II, AbdBm, Abdb, AdbB, BX-C, CG10291, CG11648, DROABDB, DmAbdB, Dmel\CG11648, Droabdb, FAB, Fab-6, Fab-7, Fab-8, Fab7, IAB 5, IAB5, IAB7, IAB8, Iab-7, MCP, Mcp, Sab, Tab, Uab-5[Sab], abd-B, abdB, bex, iab, iab-5, iab-6, iab-7, iab-8, iab5, iab6, iab7, iab8, iab8.9, iab9, l(3)89Ed, pH189, tuh-3, twig, CG11648 gene product from transcript CG11648-RE, Abd-B-PA, Abd-B-PB, Abd-B-PC, Abd-B-PD, Abd-B-PE, Abd-B-PF, Abd-B-PG, Abd-B-PH, Abd-B-PI, Abd-B-PJ, Abdominal-B, AbdominalB, CG11648-PA, CG11648-PB, CG11648-PC, CG11648-PD, CG11648-PE, CG11648-PF, CG11648-PG, CG11648-PH, CG11648-PI, CG11648-PJ, abdominal B, abdominal-A, corset, infra-abdominal 5, infra-abdominal 6, infra-abdominal 7, infra-abdominal 8, infra-abdominal 9, infraabdominal, infraabdominal-8.9, male chauvinist pigmentation, microcephalus, miscadastral pigmentation, superabdominal, transabdominal
Species: fruit fly

Top Publications

  1. doi Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila
    Katarzyna Oktaba
    EMBL, Gene Expression Programme, Heidelberg, Germany
    Dev Cell 15:877-89. 2008
  2. pmc MicroRNAs in the Drosophila bithorax complex
    Welcome Bender
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 22:14-9. 2008
  3. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  4. ncbi In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element
    J Mihaly
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Development 124:1809-20. 1997
  5. pmc The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex
    M Galloni
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    EMBO J 12:1087-97. 1993
  6. ncbi Hierarchical recruitment of polycomb group silencing complexes
    Liangjun Wang
    Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA
    Mol Cell 14:637-46. 2004
  7. pmc A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation
    H Gyurkovics
    Biological Research Center, Hungarian Academy of Sciences, Szeged
    EMBO J 9:2579-85. 1990
  8. pmc The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain
    S E Celniker
    Division of Biology, California Institute of Technology, Pasadena 91125
    EMBO J 9:4277-86. 1990
  9. pmc Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes
    Maxim Nekrasov
    Gene Expression Programme, EMBL, Heidelberg, Germany
    EMBO J 26:4078-88. 2007
  10. ncbi Dissecting the temporal requirements for homeotic gene function
    J Castelli-Gair
    Wellcome CRC Institute, Cambridge, UK
    Development 120:1983-95. 1994

Research Grants

Detail Information

Publications166 found, 100 shown here

  1. doi Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila
    Katarzyna Oktaba
    EMBL, Gene Expression Programme, Heidelberg, Germany
    Dev Cell 15:877-89. 2008
    ..Analysis of cell cycle regulators indicates that the PcG system also dynamically modulates the expression levels of certain genes, providing a possible explanation for the tumor phenotype of PcG mutants...
  2. pmc MicroRNAs in the Drosophila bithorax complex
    Welcome Bender
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 22:14-9. 2008
    The iab-4 noncoding RNA from the Drosophila bithorax complex is the substrate for a microRNA (miRNA). Gene conversion was used to delete the hairpin precursor of this miRNA; flies homozygous for this deletion are sterile...
  3. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  4. ncbi In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element
    J Mihaly
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Development 124:1809-20. 1997
    ..Fab-7 is a regulatory element that lies between iab-6 and iab-7 (the PS11- and PS12-specific cis-regulatory domains, respectively)...
  5. pmc The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex
    M Galloni
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    EMBO J 12:1087-97. 1993
    ..We describe a Ubx-lacZ transposon which is inserted into one of these domains, iab-7...
  6. ncbi Hierarchical recruitment of polycomb group silencing complexes
    Liangjun Wang
    Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA
    Mol Cell 14:637-46. 2004
    ....
  7. pmc A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation
    H Gyurkovics
    Biological Research Center, Hungarian Academy of Sciences, Szeged
    EMBO J 9:2579-85. 1990
    ..We report the molecular genetics of a new gain-of-function mutation, Fab-7, which transforms parasegment 11 into parasegment 12...
  8. pmc The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain
    S E Celniker
    Division of Biology, California Institute of Technology, Pasadena 91125
    EMBO J 9:4277-86. 1990
    ..i) loss-of-function mutants involving the iab-5, iab-6 and iab-7 regions, (ii) gain-of-function mutants Miscadastral pigmentation (Mcp) and Superabdominal (Sab), and (iii) a trans-regulator, Polycomb (Pc)...
  9. pmc Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes
    Maxim Nekrasov
    Gene Expression Programme, EMBL, Heidelberg, Germany
    EMBO J 26:4078-88. 2007
    ..Pcl-PRC2 is thus the HMTase that generates the high levels of H3-K27 trimethylation in Polycomb target genes that are needed to maintain a Polycomb-repressed chromatin state...
  10. ncbi Dissecting the temporal requirements for homeotic gene function
    J Castelli-Gair
    Wellcome CRC Institute, Cambridge, UK
    Development 120:1983-95. 1994
    ..We also provide evidence that supports the hypothesis of in vivo competition between the bithorax complex proteins for the regulation of their down-stream targets...
  11. pmc The regulation and evolution of a genetic switch controlling sexually dimorphic traits in Drosophila
    Thomas M Williams
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Cell 134:610-23. 2008
    ..These findings reveal how new dimorphic characters can emerge from genetic networks regulating pre-existing dimorphic traits...
  12. ncbi P element homing to the Drosophila bithorax complex
    W Bender
    BCMP Department, Harvard Medical School, Boston, MA 02115, USA
    Development 127:3981-92. 2000
    ..The mapping of segmental domains has now been revised, with enlargement of the abx/bx, bxd/pbx, and the iab-3 domains...
  13. ncbi Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less
    G Vachon
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030
    Cell 71:437-50. 1992
    ..Repression of limb development in the abdomen appears to be controlled at the DII enhancer. Thus DII may serve as a downstream target gene through which the homeotic genes control abdominal segment identity in the Drosophila embryo...
  14. ncbi The morphogenetic and regulatory functions of the Drosophila Abdominal-B gene are encoded in overlapping RNAs transcribed from separate promoters
    M Zavortink
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84132
    Genes Dev 3:1969-81. 1989
    ..4-kb RNA encodes a 30-kD protein (the r protein). The m and r proteins share a carboxy-terminal sequence that includes the homeo domain, but the r protein lacks a glutamine-rich amino-terminal domain found in the m protein...
  15. pmc Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function
    Ian F G King
    Massachusetts General Hospital, Dept of Molecular Biology, Welman 10, 50 Blossom St, Boston, MA 02114, USA
    Mol Cell Biol 25:6578-91. 2005
    ....
  16. pmc Initiator elements function to determine the activity state of BX-C enhancers
    Carole Iampietro
    National Centre of Competence in Research NCCR Frontiers in Genetics and Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland
    PLoS Genet 6:e1001260. 2010
    ..to better understand the process of domain activation, we have undertaken a systematic in situ dissection of the iab-6 cis-regulatory domain using a new method, called InSIRT...
  17. pmc The homeodomain protein defective proventriculus is essential for male accessory gland development to enhance fecundity in Drosophila
    Ryunosuke Minami
    Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    PLoS ONE 7:e32302. 2012
    ..We provide the first evidence that secondary cells are crucial for male fecundity, and also that Dve activity is required for survival of the secondary cells. These findings provide new insights into a mechanism of fertility/fecundity...
  18. doi Hox-mediated regulation of doublesex sculpts sex-specific abdomen morphology in Drosophila
    Wei Wang
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama 35487, USA
    Dev Dyn 241:1076-90. 2012
    ..Together these transcription factors regulate numerous sex-specific characters, including pigmentation, cuticle morphology, and abdominal segment number...
  19. pmc Transvection in the iab-5,6,7 region of the bithorax complex of Drosophila: homology independent interactions in trans
    R Hopmann
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Genetics 139:815-33. 1995
    ..Here we focus on iab-5, iab-6 and iab-7, regulatory regions of Abd-B that control expression in the fifth, sixth and seventh abdominal ..
  20. ncbi Chromatin. Ga-ga over GAGA factor
    H Granok
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Curr Biol 5:238-41. 1995
    ..Recent results suggest that the Drosophila transcriptional activator known as GAGA factor functions by influencing chromatin structure...
  21. ncbi A simple and efficient method to identify replacements of P-lacZ by P-Gal4 lines allows obtaining Gal4 insertions in the bithorax complex of Drosophila
    Luis de Navas
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Mech Dev 123:860-7. 2006
    ..Our experiments confirm that the abdominal-A gene can replace Ultrabithorax in haltere development but that it cannot substitute for Abdominal-B in the formation of the genitalia...
  22. pmc The abdominal-B promoter tethering element mediates promoter-enhancer specificity at the Drosophila bithorax complex
    Omar S Akbari
    Biology Department University of Nevada at Reno, USA
    Fly (Austin) 1:337-9. 2007
    ....
  23. ncbi abdA expression in Drosophila embryos
    F Karch
    Department of Animal Biology, University of Geneva, Switzerland
    Genes Dev 4:1573-87. 1990
    ..in the Bithorax Complex of Drosophila encoding a homeo box protein; it is flanked by Ultrabithorax (Ubx) and Abdominal B (AbdB). The abdA gene is required for segmental identity of the second through eighth abdominal segments...
  24. ncbi The Fab-8 boundary defines the distal limit of the bithorax complex iab-7 domain and insulates iab-7 from initiation elements and a PRE in the adjacent iab-8 domain
    S Barges
    Department of Zoology and Animal Biology, University of Geneva, CH 1211 Geneva 4, Switzerland
    Development 127:779-90. 2000
    ..its identity and, in PS10-13, Abd-B expression is controlled by four parasegment-specific cis-regulatory domains, iab-5 to iab-8, respectively...
  25. pmc The bithorax complex of Drosophila melanogaster: Underreplication and morphology in polytene chromosomes
    Y M Moshkin
    Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk 630090, Russia
    Proc Natl Acad Sci U S A 98:570-4. 2001
    ..We speculate that the wild-type Su(UR)ES protein hampers DNA replication of silenced domains and leads to their underreplication in salivary gland polytene chromosomes...
  26. pmc Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins
    Bernadett Papp
    European Molecular Biology Laboratory, Gene Expression Programme, Heidelberg, Germany
    Genes Dev 20:2041-54. 2006
    ....
  27. ncbi The rise and fall of Hox gene clusters
    Denis Duboule
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Development 134:2549-60. 2007
    ..By integrating these parameters, general conclusions emerge that can help solve the aforementioned dilemma...
  28. pmc Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila
    Tatiana I Gerasimova
    Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Mol Cell 28:761-72. 2007
    CTCF plays a central role in vertebrate insulators and forms part of the Fab-8 insulator in Drosophila...
  29. pmc A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands
    Alexander Stark
    Broad Institute of Massachussetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02141, USA
    Genes Dev 22:8-13. 2008
    ..Here, we report that the miRNA iab-4 locus in the Drosophila Hox cluster is transcribed convergently from both DNA strands, giving rise to two ..
  30. pmc Molecular basis of transabdominal--a sexually dimorphic mutant of the bithorax complex of Drosophila
    S E Celniker
    Biology Division, California Institute of Technology, Pasadena 91125
    Proc Natl Acad Sci U S A 90:1566-70. 1993
    b>Transabdominal (Tab) is a dominant gain-of-function mutation that results in islands of sexually dimorphic abdominal cuticle in the dorsal thorax of the adult fly...
  31. ncbi Evolution in black and white: genetic control of pigment patterns in Drosophila
    Patricia J Wittkopp
    Molecular Biology and Genetics, 227 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Trends Genet 19:495-504. 2003
  32. ncbi The ABC of the BX-C: the bithorax complex explained
    Robert K Maeda
    Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, 30 quai E Ansermet, 1211 Geneva 4, Switzerland
    Development 133:1413-22. 2006
    ..This primer attempts to distill and explain our current knowledge about this classic, complex locus...
  33. ncbi Multiple roles for Hox genes in segment-specific shaping of CNS lineages
    Ana Rogulja-Ortmann
    Institute of Genetics, University of Mainz, Mainz, Germany
    Fly (Austin) 2:316-9. 2008
    ....
  34. doi Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system
    Ramakrishnan Kannan
    Center for Cellular and Molecular Biology, Hyderabad, India
    Mech Dev 127:137-45. 2010
    ..Furthermore, our data suggest a complex network to regulate CycE expression where AbdA functions as a key regulator...
  35. ncbi Identification and characterization of a parasegment specific regulatory element of the abdominal-B gene of Drosophila
    J Casanova
    Cell 47:627-36. 1986
    ..The regulatory element also suppresses those BX-C genes and other homeotics that, in the absence of Polycomb or extra sex combs function, can become active in parasegment 14...
  36. pmc Polycomblike: a gene that appears to be required for the normal expression of the bithorax and antennapedia gene complexes of Drosophila melanogaster
    I M Duncan
    Genetics 102:49-70. 1982
    ....
  37. ncbi Muscle pattern diversification in Drosophila is determined by the autonomous function of homeotic genes in the embryonic mesoderm
    A M Michelson
    Department of Medicine, Brigham and Women s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Development 120:755-68. 1994
    ..Finally, these experiments reveal that homeotic cues specific to both the mesoderm and the ectoderm cooperate to specify the pattern of muscle attachment sites...
  38. pmc Complete sequence of the bithorax complex of Drosophila
    C H Martin
    Human Genome Center, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 92:8398-402. 1995
    ..previously known ABD-A protein and a putative glucose transporter-like gene (1521 bp) located at or near the bithoraxoid (bxd), infra-abdominal-2 (iab-2) boundary on the opposite strand relative to that of the homeobox-containing genes.
  39. pmc Drosophila Polycomb-group regulated chromatin inhibits the accessibility of a trans-activator to its target DNA
    D Zink
    ZMBH, Center for Molecular Biology, University of Heidelberg, Germany
    EMBO J 14:5660-71. 1995
    ..We have tested the functional role of the FAB fragment, a PRE of the bithorax complex...
  40. pmc Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression
    H Strutt
    ZMBH, University of Heidelberg, Germany
    EMBO J 16:3621-32. 1997
    ..We propose that GAGA factor binds constitutively to regulatory elements in the bithorax complex, which function both as PREs and as trithorax group response elements...
  41. ncbi Genetic control and evolution of sexually dimorphic characters in Drosophila
    A Kopp
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin Madison, 53706 1596, USA
    Nature 408:553-9. 2000
    ..Pigmentation patterns specified by bab affect mating preferences, suggesting that sexual selection has contributed to the evolution of bab regulation...
  42. ncbi Segment-specific prevention of pioneer neuron apoptosis by cell-autonomous, postmitotic Hox gene activity
    Irene Miguel-Aliaga
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Development 131:6093-105. 2004
    ..This segmental specificity is achieved by differential expression of the Hox gene Abdominal B, which in posterior segments prevents pioneer neuron death postmitotically and cell-autonomously by repressing ..
  43. ncbi Genome-wide analysis of Polycomb targets in Drosophila melanogaster
    Yuri B Schwartz
    Rutgers University, Department of Molecular Biology and Biochemistry, 604 Allison Road, Piscataway, New Jersey 08854, USA
    Nat Genet 38:700-5. 2006
    ..PcG targets are highly enriched in genes encoding transcription factors, but they also include genes coding for receptors, signaling proteins, morphogens and regulators representing all major developmental pathways...
  44. ncbi Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification
    Fabienne Cléard
    Department of Zoology and Animal Biology and National Research Center Frontiers in Genetics, University of Geneva, 30 quai E Ansermet, 1211 Geneva 4, Switzerland
    Nat Genet 38:931-5. 2006
    ..In order to test this hypothesis, we used Dam identification to probe for interactions between the Fab-7 boundary and other regions in the BX-C...
  45. pmc Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins
    Christian Beisel
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 104:16615-20. 2007
    ..Besides its presumptive function in recruiting PcG complexes to their site of action, our results now uncover that Pho plays an additional role in the repression of already induced genes...
  46. ncbi The Trithorax-like gene encodes the Drosophila GAGA factor
    G Farkas
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Nature 371:806-8. 1994
    ..Our genetic analysis suggests that the chromatin modelling function of the GAGA factor is not restricted to promoter regions...
  47. ncbi Polycomb group proteins and heritable silencing of Drosophila Hox genes
    D Beuchle
    Max Planck Institut fur Entwicklungsbiologie, Spemannstr 35 III, 72076 Tubingen, Germany
    Development 128:993-1004. 2001
    ..Some PcG proteins may be required to define and propagate this mark; others may function to repress the transcription of Hox genes that bear the mark...
  48. ncbi Dissecting the regulatory landscape of the Abd-B gene of the bithorax complex
    Jozsef Mihaly
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, 6723 Szeged, Hungary
    Development 133:2983-93. 2006
    ..Our results highlight four key features of the iab-5, iab-6 and iab-7 cis-regulatory region of Abd-B...
  49. ncbi extradenticle raises the DNA binding specificity of homeotic selector gene products
    M A van Dijk
    Department of Biology, University of California, San Diego, La Jolla 92093
    Cell 78:617-24. 1994
    ....
  50. pmc Inheritance of Polycomb-dependent chromosomal interactions in Drosophila
    Frédéric Bantignies
    Institute of Human Genetics, Centre National de la Recherche Scientifique, 34396 Montpellier 5, France
    Genes Dev 17:2406-20. 2003
    ..b>Fab-7 is a well-defined cellular memory module involved in regulation of the homeotic gene Abdominal-B (Abd-B)...
  51. pmc Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila
    D Moazed
    UCSF School of Medicine, Department of Biochemistry and Biophysics 94143
    Development 116:805-10. 1992
    ....
  52. ncbi Expression and regulation of the abd-A gene of Drosophila
    A Macias
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Madrid, Spain
    Development 110:1197-207. 1990
    ..Finally, we show that the abd-A gene is down-regulated in part of the Abdominal-B (Abd-B) domain, precisely in those regions where the Abd-B gene is expressed at high levels...
  53. ncbi Specification of anteroposterior cell fates in Caenorhabditis elegans by Drosophila Hox proteins
    C P Hunter
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0554, USA
    Nature 377:229-32. 1995
    ..Together these findings suggest that factors important for target recognition by specific Hox proteins have been conserved throughout much of the animal kingdom...
  54. ncbi Functional analysis of the mouse homeobox gene HoxB9 in Drosophila development
    J Malicki
    Department of Genetics, Yale University, New Haven, CT 06511
    Mech Dev 42:139-50. 1993
    ..2), suggesting that HoxB9 specifies a positional identity that is intermediate between Antennapedia and Abdominal-B...
  55. ncbi Cis-regulatory sequences leading to female-specific expression of yolk protein genes 1 and 2 in the fat body of Drosophila melanogaster
    N Abrahamsen
    Developmental Biology Center, University of Edinburgh, Scotland
    Mol Gen Genet 237:41-8. 1993
    ..g. Adh, Actin 5C). We suggest that DSX acts in concert with other proteins to mediate sex- and tissue-specific expression of the yp genes...
  56. ncbi Development of the indirect flight muscle attachment sites in Drosophila: role of the PS integrins and the stripe gene
    J J Fernandes
    Molecular Biology Unit, TIFR, Bombay, India
    Dev Biol 176:166-84. 1996
    ..The PS integrins are detected at later stages, suggesting a role in the stabilization and maturation of the muscle-epidermal contacts into myotendon junctions...
  57. ncbi Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex
    K Hagstrom
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Genes Dev 10:3202-15. 1996
    b>Fab-7 deletions in the bithorax complex have a novel gain-of-function phenotype, typically transforming parasegment 11 (PS11) into PS12 identity...
  58. ncbi Chromatin domain boundaries in the Bithorax complex
    J Mihaly
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Cell Mol Life Sci 54:60-70. 1998
    ..On the other hand, domain boundaries of the Bithorax complex (BX-C) like Fab-7 and Mcp have been identified through mutational analysis...
  59. ncbi Homeotic gene action in embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, University of Basel, Basel, Switzerland
    Development 125:1579-89. 1998
    ..Our findings demonstrate that the action of the homeotic genes labial and Deformed are required for neuronal differentiation in the developing brain of Drosophila...
  60. pmc Mutations in Drosophila heat shock cognate 4 are enhancers of Polycomb
    R Mollaaghababa
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:3958-63. 2001
    ..HSC4 might be needed for the proper folding of a component of the Polycomb repression complex, or it may be a functional member of that complex...
  61. ncbi General transcription factors bind promoters repressed by Polycomb group proteins
    A Breiling
    DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Nature 412:651-5. 2001
    ..We further show that PcG proteins interact in vitro with GTFs. We suggest that PcG complexes maintain silencing by inhibiting GTF-mediated activation of transcription...
  62. pmc Intergenic transcription through a polycomb group response element counteracts silencing
    Sabine Schmitt
    Zentrum für Molekular Biologie Heidelberg ZMBH, University of Heidelberg, D 69120 Heidelberg, Germany
    Genes Dev 19:697-708. 2005
    ....
  63. pmc The Mcp element from the bithorax complex contains an insulator that is capable of pairwise interactions and can facilitate enhancer-promoter communication
    Natalia Gruzdeva
    Institute of Gene Biology, Russian Academy of Sciences, 34 5 Vavilov St, 119334 Moscow, Russia
    Mol Cell Biol 25:3682-9. 2005
    ..Boundary elements such as Mcp, Fab-7, and Fab-8 and adjacent silencers flank the iab domains and restrict the activity of the iab enhancers...
  64. ncbi Tarsus determination in Drosophila melanogaster
    Anthony Percival-Smith
    Department of Biology, University of Western Ontario, London, Canada
    Genome 48:712-21. 2005
    ..Therefore, the possibility exists that normal tarsus determination is HOX independent...
  65. pmc Efficient and specific targeting of Polycomb group proteins requires cooperative interaction between Grainyhead and Pleiohomeotic
    Andras Blastyak
    Hungarian Academy of Sciences, Biological Research Center, Institute of Genetics, Temesvari krt 62, P O B 521, H 6701 Szeged, Hungary
    Mol Cell Biol 26:1434-44. 2006
    ....
  66. pmc The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning
    Man Mohan
    Institute for Genetics, Justus Liebig University Giessen, Heinrich Buff Ring, Giessen, Germany
    EMBO J 26:4203-14. 2007
    ..A short pulse of dCTCF expression during larval development rescues the dCTCF loss of function phenotype. Overall, we demonstrate the importance of dCTCF in fly development and in the regulation of abdominal segmentation...
  67. ncbi A gene complex controlling segmentation in Drosophila
    E B Lewis
    Nature 276:565-70. 1978
    ....
  68. ncbi Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products
    J Simon
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115
    Development 114:493-505. 1992
    ..Here the requirements for Pc group genes in controlling the abdA and AbdB products of the bithorax complex are described...
  69. ncbi The developmental effect of overexpressing a Ubx product in Drosophila embryos is dependent on its interactions with other homeotic products
    A González-Reyes
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Canto Blanco, Madrid, Spain
    Cell 61:515-22. 1990
    ..In segment A9 the highly expressed Ubx product is phenotypically suppressed by the r product of Abdominal-B. The presence of high levels of Ubx protein is also irrelevant in the telson...
  70. ncbi Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity
    M Peifer
    Department of Biology, Princeton University, New Jersey 08544 1003
    Genes Dev 4:1209-23. 1990
    ..Complete removal of extradenticle, maternally and zygotically, leads to specific alterations in segmentation, many of which result from failure to maintain the expression of the homeo domain protein engrailed...
  71. ncbi The molecular genetics of the bithorax complex of Drosophila: characterization of the products of the Abdominal-B domain
    S E Celniker
    Division of Biology, California Institute of Technology, Pasadena 91125
    Genes Dev 3:1424-36. 1989
    ..segments, comprises homeo-protein-coding regions and cis-regulatory regions, and extends from infra-abdominal-5 (iab-5) to iab-8, inclusive...
  72. pmc Different transcripts of the Drosophila Abd-B gene correlate with distinct genetic sub-functions
    M A Kuziora
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511
    EMBO J 7:3233-44. 1988
    ....
  73. ncbi Drosophila homoeotic genes encode transcriptional activators similar to mammalian OTF-2
    M Thali
    Arbeitsgruppe Walter Schaffner, Institut fur Molekularbiologie II, Universitat Zurich, Switzerland
    Nature 336:598-601. 1988
    ..Their activity, as well as their target specificity, is similar to that of a mammalian lymphoid-specific octamer transcription factor, OTF-2, which was recently found to contain a homoeodomain...
  74. ncbi Ectopic expression of homeotic genes caused by the elimination of the Polycomb gene in Drosophila imaginal epidermis
    A Busturia
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    Development 104:713-20. 1988
    ..We have established a hierarchical order among these genes: Antp less than Scr less than Ubx less than abd-A less than Abd-B. In addition, we show that the engrailed gene is ectopically active in Pc- imaginal cells...
  75. ncbi The bithorax complex
    I Duncan
    Department of Biology, Washington University, St Louis, Missouri 63130
    Annu Rev Genet 21:285-319. 1987
  76. ncbi Regulation of the genes of the bithorax complex in Drosophila
    E B Lewis
    Cold Spring Harb Symp Quant Biol 50:155-64. 1985
    ..Three rules governing cis-regulation of BX-C are applicable over a region extending from Ubx to at least iab-7, a distance of nearly 300 kb on the DNA map: The colinearity (COL) rule: genes are colinear with respect to map ..
  77. ncbi Genetic organization of Drosophila bithorax complex
    E Sánchez-Herrero
    Nature 313:108-13. 1985
    ..Each of these genes plays its principal part in a particular anatomical domain of the body, where it is specifically required to determine the correct segmental pattern...
  78. ncbi Recessive lethal mutations within the bithorax-complex in Drosophila
    S Tiong
    Mol Gen Genet 200:335-42. 1985
    ..Homozygotes for each of only three groups of lethals, Ubx, abdA and AbdB, produce homoeotic segmental transformations in embryos...
  79. ncbi The abdominal region of the bithorax complex
    F Karch
    Cell 43:81-96. 1985
    ..Complementation tests suggest interactions between widely spaced DNA regions; indeed, the right half cannot be split anywhere without some loss of function...
  80. ncbi Regulation of the Ultrabithorax gene of Drosophila by other bithorax complex genes
    G Struhl
    Cell 43:507-19. 1985
    ..Using mutations in the abd-A, Abd-B, and esc (extra sex combs) genes we show that these distinct patterns result in large part from regulation of Ubx gene expression by the abd-A and Abd-B gene functions...
  81. pmc Setting limits on homeotic gene function: restraint of Sex combs reduced activity by teashirt and other homeotic genes
    D J Andrew
    Department of Developmental Biology, Stanford University School of Medicine, CA 94305 5427
    EMBO J 13:1132-44. 1994
    ..trunk by the homeotic gene teashirt (tsh) and in the last abdominal segment by the third BX-C gene, Abdominal-B (AbdB)...
  82. pmc The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins
    S C Ekker
    Johns Hopkins School of Medicine, Howard Hughes Medical Institute, Baltimore, MD
    EMBO J 13:3551-60. 1994
    ..This and other patterns of residue conservation suggest that differential DNA sequence recognition may play a role in HOM protein function in a wide range of organisms...
  83. pmc Mcp and Fab-7: molecular analysis of putative boundaries of cis-regulatory domains in the bithorax complex of Drosophila melanogaster
    F Karch
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Nucleic Acids Res 22:3138-46. 1994
    ..Mcp is located between iab-4 and iab-5, the parasegment-specific regulatory subunits which direct Abd-B in parasegments 9 and 10...
  84. ncbi The Fab-7 element of the bithorax complex attenuates enhancer-promoter interactions in the Drosophila embryo
    J Zhou
    Department of Molecular and Cellular Biology, Division of Genetics, University of California, Berkeley 94720 3201, USA
    Genes Dev 10:3195-201. 1996
    ..A specialized DNA element, Fab-7, has been proposed to function as a boundary element that separates the iab-6 and iab-7 cis regulatory regions ..
  85. ncbi Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein
    G E Rieckhof
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 91:171-83. 1997
    ..These data suggest a novel and evolutionarily conserved mechanism for regulating HOX activity in which a direct protein-protein interaction between EXD and HTH results in EXD's nuclear translocation...
  86. pmc The polycomb group protein complex of Drosophila melanogaster has different compositions at different target genes
    H Strutt
    ZMBH, University of Heidelberg, Germany
    Mol Cell Biol 17:6773-83. 1997
    ..Polyhomeotic and Posterior Sex Combs may participate in a more general transcriptional mechanism that causes modulated gene repression, whereas the inclusion of Polycomb protein in the complex at PREs leads to stable silencing...
  87. ncbi Polycomb and trithorax group proteins mediate the function of a chromatin insulator
    T I Gerasimova
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Cell 92:511-21. 1998
    ..The results suggest a model in which PcG and TrxG proteins regulate insulator function by establishing higher order domains of chromatin organization required for the assembly of functional insulators at the nuclear matrix...
  88. ncbi Implications of the spatial and temporal regulation of Hox genes on development and evolution
    J Castelli-Gair
    Department of Zoology, University of Cambridge, United Kingdom
    Int J Dev Biol 42:437-44. 1998
    ..Finally, I discuss the implications of dynamic Hox gene expression on the evolution of segment morphology...
  89. pmc Needs and targets for the multi sex combs gene product in Drosophila melanogaster
    O Saget
    Centre de Genetique Moleculaire du Centre National de la Recherche Scientifique, 91198 Gif sur Yvette Cedex, France
    Genetics 149:1823-38. 1998
    ..We discuss these data in view of the numerous functions of PcG genes during development...
  90. pmc Binding of trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis
    V Orlando
    ZMBH, University of Heidelberg, INF 282, 69120 Heidelberg, Germany
    EMBO J 17:5141-50. 1998
    ..Later, at germ band extension, the time of derepression in Polycomb mutants, PC binding is also detected outside core PREs and additionally binds to the fragments containing promoters...
  91. ncbi Caudal is the Hox gene that specifies the most posterior Drosophile segment
    E Moreno
    Centro de Biologia Molecular CSIC UAM, Madrid, Spain
    Nature 400:873-7. 1999
    ..In the absence of the Hh pathway, cad induces internal analia development, probably by activating the brachyenteron and even-skipped genes...
  92. ncbi A novel cis-regulatory element, the PTS, mediates an anti-insulator activity in the Drosophila embryo
    J Zhou
    Department of Molecular Cell Biology, University of California, Berkeley 94720, USA
    Cell 99:567-75. 1999
    ..The lab-7 domain activates Abd-B in parasegment 12 (ps12), whereas lab-8 controls expression in ps13. iab-7 is flanked by two insulators, Fab-7 and Fab-8, which are thought to prevent regulatory factors, such as Polycomb ..
  93. ncbi Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing
    R Lupo
    DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy
    Mol Cell 7:127-36. 2001
    ..find that the PcG protein Polyhomeotic (PH) interacts physically with TOPOII and BARR and that BARR is required for Fab-7-regulated homeotic gene expression...
  94. ncbi Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants
    A Birve
    Department of Genetics, Umea University, S 90187 Umea, Sweden
    Development 128:3371-9. 2001
    ..Notably, EMF2 is a repressor of floral homeotic genes. These results suggest that at least some of the regulatory machinery that controls homeotic gene expression is conserved between animals and plants...
  95. ncbi Functional equivalence of Hox gene products in the specification of the tritocerebrum during embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 128:4781-8. 2001
    ..This suggests that in embryonic brain development, differences in Hox gene action rely mainly on cis-acting regulatory elements and not on Hox protein specificity...
  96. ncbi Replacement of Fab-7 by the gypsy or scs insulator disrupts long-distance regulatory interactions in the Abd-B gene of the bithorax complex
    I Hogga
    Department of Zoology and Animal Biology, University of Geneva, 1211 4, Geneva, Switzerland
    Mol Cell 8:1145-51. 2001
    ..Boundary elements in the bithorax complex (BX-C), such as Fab-7 and Fab-8, have been identified genetically and been shown to have insulator activity in transgene assays...
  97. ncbi Transcription through the iab-7 cis-regulatory domain of the bithorax complex interferes with maintenance of Polycomb-mediated silencing
    Ilham Hogga
    Department of Zoology and Animal Biology, University of Geneva, 30 quai E Ansermet, Switzerland
    Development 129:4915-22. 2002
    The Fab-7 chromatin domain boundary insures functional autonomy of the iab-6 and iab-7 cis-regulatory domains in the bithorax complex (BX-C)...
  98. ncbi Transcription activates repressed domains in the Drosophila bithorax complex
    Welcome Bender
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Development 129:4923-30. 2002
    ..Blocking transcription from the P element promoter reverts the mutant phenotype. Previously identified Ultraabdominal alleles, not associated with P elements, also show abnormal transcription of the same region...
  99. ncbi The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel
    TyAnna L Lovato
    Department of Biology, University of New Mexico, Albuquerque 87131 1091, USA
    Development 129:5019-27. 2002
    ..These findings for the first time demonstrate a specific involvement for Hox genes in patterning the muscular circulatory system, and suggest a mechanism of broad relevance for animal heart patterning...
  100. ncbi Histone methyltransferase activity of a Drosophila Polycomb group repressor complex
    Jurg Muller
    EMBL, Gene Expression Programme, Meyerhofstr 1, 69117 Heidelberg, Germany
    Cell 111:197-208. 2002
    ..These results identify E(Z) as a PcG protein with enzymatic activity and implicate histone methylation in PcG-mediated silencing...
  101. pmc The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins
    Tetyana Klymenko
    EMBL, Gene Expression Programme, Meyerhofstrasse 1, Heidelberg 69117, Germany
    EMBO Rep 5:373-7. 2004
    ..We propose that histone methylation by Ash1 and Trx is required continuously throughout development to prevent inappropriate PcG silencing of HOX genes in cells in which they must stay transcriptionally active...

Research Grants17

  1. NORMAL AND MUTANT CHORION GENES OF DROSOPHILA
    Allan Spradling; Fiscal Year: 2003
    ..Therefore, these studies will elucidate the structure and function of eukaryotic chromosomes, a subject of widespread importance to the genetics of all organisms, including humans. ..
  2. OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATION
    Blanche Capel; Fiscal Year: 2010
    ....
  3. HOX GENE EXPRESSION IN HUMAN ENDOMETRIUM
    Hugh Taylor; Fiscal Year: 2007
    ..These studies will further characterize the molecular mechanisms by which HOX expression is related to normal and pathologic endometrial development. ..
  4. Evolution of insect gastrulation
    Matthew Ronshaugen; Fiscal Year: 2006
    ..It is our hope that this will lead to a specific understanding of the evolution of transcriptional regulation and to events that underlie transition of cells toward a migratory state. ..
  5. RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMS
    Richard Goodman; Fiscal Year: 2006
    ..Core laboratories for cell culture, protein chemistry, and administration are designed to allow the proposed studies to be performed in an efficient and cost-effective manner. ..
  6. Genetic Transfer in the Evolution of Infectious Disease
    Rob DeSalle; Fiscal Year: 2005
    ....
  7. "Model organisms to human biology: strategies for the future of genetic research"
    Allan Spradling; Fiscal Year: 2008
    ..The meeting is expected to attract 300-5000 people. It will be held at the Town and Country Resort, about 10 miles outside of San Diego, All meeting attendees will be housed on- ..
  8. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005
    ....
  9. Organ-specific Mechanisms of Vascular Development
    Blanche Capel; Fiscal Year: 2007
    ..In addition, the molecular signals that control or repress the growth of vasculature into a tissue are of critical concern for the design of therapies in the fields of wound healing and tumor biology. [unreadable] [unreadable]..
  10. TRANSCRIPTIONAL COACTIVATORS IN ENDOCRINE REGULATION
    Richard Goodman; Fiscal Year: 2003
    ..Finally, we will characterize the ability of the "CREB binding domain" of CBP to interact with other transcription factors activated or inhibited by Ser/Thr phosphorylation. ..
  11. Integrated Approcahes to Find Hox-regulated DNA Elements
    Richard Mann; Fiscal Year: 2008
    ..Once these methods are worked out, they will be applicable to a wide variety of problems in biology. [unreadable] [unreadable]..
  12. Regulation of Cell Migration by the APC-Microtubule Complex
    William Nelson; Fiscal Year: 2009
    ..abstract_text> ..
  13. SYNAPSE STRUCTURE AND DEVELOPMENT
    W Nelson; Fiscal Year: 2001
    ..This research will aid in the prevention of psychiatric illness and the development of therapies for afflicted individuals. ..
  14. DISSECTION OF ONCOGENIC PATHWAYS USING DROSOPHILA
    Richard Mann; Fiscal Year: 2004
    ..The use of Drosophila genetics is proposed to help make connections between genetic functions that cannot be easily identified in mammalian experimental systems. ..
  15. Fourth Symposium Biology Vertebrate Sex Determination
    Blanche Capel; Fiscal Year: 2006
    ..Understanding how critical genes in sex determining pathways evolved and how they function in lower vertebrates is expected to improve diagnosis and treatment of human disorders. [unreadable] [unreadable] [unreadable]..
  16. Identification of gene targets for morphine and other drugs of abuse
    Richard Goodman; Fiscal Year: 2009
    ..The concept that CREB signaling induces mediators of translational arrest has profound implications for the understanding of drug action. ..
  17. Regulation of MeCP2 by CREB-induced microRNAs
    Richard H Goodman; Fiscal Year: 2010
    ..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..