ap

Summary

Gene Symbol: ap
Description: apterous
Alias: Apt, CG8376, Dmel\CG8376, LIM, S-2a, blt, neuro, trw, CG8376 gene product from transcript CG8376-RA, APTEROUS, CG8376-PA, CG8376-PB, CG8376-PC, CG8376-PE, ap-PA, ap-PB, ap-PC, ap-PE, apteroys, neuromuscular, no-wings, tornwing, xasta
Species: fruit fly

Top Publications

  1. ncbi Apterous is a Drosophila LIM domain gene required for the development of a subset of embryonic muscles
    C Bourgouin
    Molecular Neurobiology Laboratory, Salk Institute, San Diego, California 92138
    Neuron 9:549-61. 1992
  2. ncbi The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe
    J F de Celis
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Development 127:1291-302. 2000
  3. ncbi fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development
    K D Irvine
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Cell 79:595-606. 1994
  4. ncbi Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila
    F J Diaz-Benjumea
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 75:741-52. 1993
  5. ncbi Dorsal-ventral signaling in limb development
    K D Irvine
    Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08854 8020, USA
    Curr Opin Cell Biol 9:867-76. 1997
  6. ncbi Different spatial and temporal interactions between Notch, wingless, and vestigial specify proximal and distal pattern elements of the wing in Drosophila
    T Klein
    Department of Zoology, University of Cambridge, United Kingdom
    Dev Biol 194:196-212. 1998
  7. ncbi Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor
    R J Benveniste
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO, USA
    Development 125:4757-65. 1998
  8. ncbi Dorsoventral lineage restriction in wing imaginal discs requires Notch
    C A Micchelli
    Neuroscience Training Program, Department of Zoology, University of Wisconsin, Madison 53706, USA
    Nature 401:473-6. 1999
  9. ncbi Control of growth and patterning of the Drosophila wing imaginal disc by EGFR-mediated signaling
    Myriam Zecca
    Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Development 129:1369-76. 2002
  10. ncbi Regulators acting in combinatorial codes also act independently in single differentiating neurons
    Douglas W Allan
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 45:689-700. 2005

Scientific Experts

Detail Information

Publications121 found, 100 shown here

  1. ncbi Apterous is a Drosophila LIM domain gene required for the development of a subset of embryonic muscles
    C Bourgouin
    Molecular Neurobiology Laboratory, Salk Institute, San Diego, California 92138
    Neuron 9:549-61. 1992
    ..We have identified a Drosophila member of this class, the product of the apterous (ap) gene...
  2. ncbi The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe
    J F de Celis
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Development 127:1291-302. 2000
    ..We suggest that Abruptex alleles identify a domain in the Notch protein that mediates the interactions between Notch, its ligands and Fringe that result in suppression of Notch activity...
  3. ncbi fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development
    K D Irvine
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Cell 79:595-606. 1994
    ..These observations suggest that fringe encodes a boundary-specific cell-signaling molecule that is responsible for dorsal-ventral cell interactions during wing development...
  4. ncbi Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila
    F J Diaz-Benjumea
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 75:741-52. 1993
    ..We report here that spatially localized expression of the homeobox gene apterous (ap) specifies the identity of dorsal cells in the wing...
  5. ncbi Dorsal-ventral signaling in limb development
    K D Irvine
    Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08854 8020, USA
    Curr Opin Cell Biol 9:867-76. 1997
    ....
  6. ncbi Different spatial and temporal interactions between Notch, wingless, and vestigial specify proximal and distal pattern elements of the wing in Drosophila
    T Klein
    Department of Zoology, University of Cambridge, United Kingdom
    Dev Biol 194:196-212. 1998
    ..Our results also indicate that the growth of the cells in the wing blade results from a synergistic effect of the three genes N, wg, and vg on the cells that have been specified as wing blade...
  7. ncbi Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor
    R J Benveniste
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO, USA
    Development 125:4757-65. 1998
    We describe the direct and cell-specific regulation of the Drosophila FMRFa neuropeptide gene by Apterous, a LIM homeodomain transcription factor...
  8. ncbi Dorsoventral lineage restriction in wing imaginal discs requires Notch
    C A Micchelli
    Neuroscience Training Program, Department of Zoology, University of Wisconsin, Madison 53706, USA
    Nature 401:473-6. 1999
    ..that arises late in the developing wing imaginal disc requires the dorsal expression of the transcription factor Apterous and it has been hypothesized that apterous (ap) maintains compartmentalization by directly regulating the ..
  9. ncbi Control of growth and patterning of the Drosophila wing imaginal disc by EGFR-mediated signaling
    Myriam Zecca
    Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Development 129:1369-76. 2002
    ..wing-notum) primordia depends on Epidermal Growth Factor Receptor (EGFR) signaling, which heritably activates apterous (ap) in D compartment cells and maintains Iroquois Complex (Iro-C) gene expression in prospective notum cells...
  10. ncbi Regulators acting in combinatorial codes also act independently in single differentiating neurons
    Douglas W Allan
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 45:689-700. 2005
    In the Drosophila ventral nerve cord, a small number of neurons express the LIM-homeodomain gene apterous (ap). These ap neurons can be subdivided based upon axon pathfinding and their expression of neuropeptidergic markers...
  11. ncbi Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless
    Stefan Koelzer
    Institute for Genetics, University of Cologne, Germany
    Dev Biol 289:77-90. 2006
    ..Thus, de-repression of its target genes obscures the involvement of Su(H) in this process. Furthermore, we provide evidence that Dx does not signal in a Su(H)-independent manner as has been suggested previously...
  12. pmc The Drosophila basic helix-loop-helix protein DIMMED directly activates PHM, a gene encoding a neuropeptide-amidating enzyme
    Dongkook Park
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Mol Cell Biol 28:410-21. 2008
    ..This study supports the hypothesis that DIMM is a master regulator of a peptidergic cell fate in Drosophila and provides a detailed transcriptional mechanism of DIMM action on a defined target gene...
  13. doi Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila
    Katarzyna Oktaba
    EMBL, Gene Expression Programme, Heidelberg, Germany
    Dev Cell 15:877-89. 2008
    ..Analysis of cell cycle regulators indicates that the PcG system also dynamically modulates the expression levels of certain genes, providing a possible explanation for the tumor phenotype of PcG mutants...
  14. pmc Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues
    Daniel Karlsson
    Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    PLoS Biol 8:e1000368. 2010
    ..central nervous system, the segmentally repeated neuroblast 5-6 generates a unique group of neurons, the Apterous (Ap) cluster, only in thoracic segments...
  15. ncbi apterous, a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins
    B Cohen
    Department of Cell Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030
    Genes Dev 6:715-29. 1992
    The apterous (ap) gene is required for the normal development of the wing and haltere imaginal discs in Drosophila melanogaster. ap encodes a new member of the LIM family of developmental regulatory genes...
  16. pmc The developmental genetics of apterous mutants of Drosophila melanogaster
    F M Butterworth
    Genetics 52:1153-74. 1965
  17. ncbi Control of neuronal pathway selection by the Drosophila LIM homeodomain gene apterous
    S E Lundgren
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, San Diego, CA 92186, USA
    Development 121:1769-73. 1995
    The Drosophila apterous gene encodes a LIM homeodomain protein expressed embryonically in a small subset of differentiating neurons...
  18. ncbi Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing
    J Kim
    Howard Hughes Medical Institute, University of Wisconsin, Madison 53706, USA
    Cell 82:795-802. 1995
    ..of two dorsally expressed putative signaling molecules, fringe (fng) and Serrate (Ser), are regulated by the apterous selector gene...
  19. ncbi Compartments and appendage development in Drosophila
    S S Blair
    Department of Zoology, University of Wisconsin, Madison 53706, USA
    Bioessays 17:299-309. 1995
    ..states of gene expression; the compartment-specific expression of two such 'selector'-like genes, engrailed and apterous, are critical for anterior-posterior and dorso-ventral compartmentalization, respectively...
  20. ncbi Drosophila integrins and their ligands
    P J Gotwals
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Curr Opin Cell Biol 6:734-9. 1994
    ....
  21. ncbi The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila
    S S Blair
    Department of Zoology, University of Wisconsin, Madison 53706
    Development 120:1805-15. 1994
    ..Recent results suggest that the dorsally expressed transcription factor encoded by apterous may control dorsoventral identity in the wing...
  22. ncbi Organization of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundary
    J A Williams
    Howard Hughes Medical Institute, University of Wisconsin Madison 53706
    Nature 368:299-305. 1994
    ..The link between dorsal/ventral compartmentalization and wing formation distinguishes the development of this sheet-like appendage from that of legs and antennae...
  23. ncbi The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation
    S A Speicher
    Institut fur Entwicklungsbiologie, Universitat zu Koln, FRG
    Development 120:535-44. 1994
    ....
  24. ncbi Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions
    J A Williams
    Howard Hughes Medical Institute, University of Wisconsin Madison 53706
    Development 117:571-84. 1993
    ..The wingless product is required to restrict the expression of the apterous gene to dorsal cells and to promote the expression of the vestigial and scalloped genes that demarcate the wing ..
  25. ncbi Morphogens, compartments, and pattern: lessons from drosophila?
    P A Lawrence
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 85:951-61. 1996
  26. ncbi Specification of the wing by localized expression of wingless protein
    M Ng
    European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 381:316-8. 1996
    ..DV subdivision of the wing disc occurs during the second larval instar through localized expression of the apterous protein (Apterous) in dorsal cells...
  27. ncbi Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene
    J Kim
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, 53706, USA
    Nature 382:133-8. 1996
    ..Signal integration must be a general feature of genes like vestigial, that regulate growth or patterning along more than one axis...
  28. ncbi Serrate and wingless cooperate to induce vestigial gene expression and wing formation in Drosophila
    J P Couso
    Department of Zoology, University of Cambridge, UK
    Curr Biol 5:1437-48. 1995
    ....
  29. ncbi Visualization of gene expression in living adult Drosophila
    M Calleja
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, Madrid 28049, Spain
    Science 274:252-5. 1996
    ..The boundary between two of these domains coincides with localized expression of the signaling molecule wingless...
  30. ncbi The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate
    C A Micchelli
    Department of Zoology, University of Wisconsin, Madison 53706, USA
    Development 124:1485-95. 1997
    ..We propose that the boundary of Notch ligand along the normal margin plays a similar role as part of a dynamic feedback loop that maintains the tripartite pattern of margin gene expression...
  31. pmc The engrailed story
    A Garcia-Bellido
    Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    Genetics 148:539-44. 1998
  32. ncbi Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development
    T Klein
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Development 125:2951-62. 1998
    ..In these processes, the activity of Notch is controlled by the activity of the dorsal specific nuclear protein Apterous, which regulates the expression of the Notch ligand, Serrate, and the Fringe signalling molecule...
  33. ncbi Positive and negative control of Serrate expression during early development of the Drosophila wing
    A Bachmann
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225, Dusseldorf, Germany
    Mech Dev 76:67-78. 1998
    ..of expression in the dorsal compartment of the wing discs of second and early third instar larvae depends on apterous, as revealed by reporter gene expression in discs either lacking or ectopically expressing apterous...
  34. ncbi Compartment boundaries: at the edge of development
    C Dahmann
    Institut fur Molekularbiologie, Universitat Zurich, Winterthurerstr 190, 8057 Zurich, Switzerland
    Trends Genet 15:320-6. 1999
    ..Here, we describe the exciting progress that has been made recently towards elucidating the mechanisms of boundary formation...
  35. ncbi Notch signaling is not sufficient to define the affinity boundary between dorsal and ventral compartments
    M Milan
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Cell 4:1073-8. 1999
    ..Here, we present evidence that the dorsal selector gene apterous plays a role in establishing the dorsoventral affinity boundary that is independent of Notch-mediated signaling ..
  36. ncbi Chip is an essential cofactor for apterous in the regulation of axon guidance in Drosophila
    D J van Meyel
    The Salk Institute for Biological Studies, PO Box 85800, San Diego, CA 92186, USA
    Development 127:1823-31. 2000
    ..The LIM-homeodomain family member Apterous requires the LIM-binding protein Chip to execute patterned outgrowth of the Drosophila wing...
  37. ncbi Two different activities of Suppressor of Hairless during wing development in Drosophila
    T Klein
    Institut fur Genetik, Universitat zu Koln, Weyertal 121, Germany
    Development 127:3553-66. 2000
    ..After its release Su(H) can activate gene expression in absence of Nintra...
  38. pmc Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development
    S H Wang
    Department of Molecular Genetics, Ohio State University, Columbus, Ohio 43210, USA
    Genes Dev 14:2271-6. 2000
    ..genes; (2) Vn/EGFR signaling directs cells to become part of the dorsal compartment by induction of apterous, the dorsal selector gene, and consequently also controls wing development, which depends on an interaction ..
  39. ncbi Apterous mediates development of direct flight muscles autonomously and indirect flight muscles through epidermal cues
    A Ghazi
    National Centre for Biological Sciences, TIFR, Bangalore 560065, India
    Development 127:5309-18. 2000
    ..We show that the direct flight muscles are specified by the expression of Apterous, a Lim homeodomain protein, in groups of myoblasts...
  40. ncbi Direct regulation of the muscle-identity gene apterous by a Hox protein in the somatic mesoderm
    M Capovilla
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 67084 Strasbourg, France
    Development 128:1221-30. 2001
    ..We show that apterous expression in the somatic mesoderm is under direct Hox control...
  41. ncbi Regulation of Apterous activity in Drosophila wing development
    U Weihe
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Development 128:4615-22. 2001
    b>Apterous is a LIM-homeodomain protein that confers dorsal compartment identity in Drosophila wing development. Apterous activity requires formation of a complex with a co-factor, Chip/dLDB...
  42. pmc Expression profiling of Drosophila imaginal discs
    Ansgar Klebes
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Genome Biol 3:RESEARCH0038. 2002
    ..To identify genes that establish and express the different states of determination in discs and larval tissues, we used DNA microarrays to analyze mRNAs isolated from single imaginal discs...
  43. ncbi A re-evaluation of the contributions of Apterous and Notch to the dorsoventral lineage restriction boundary in the Drosophila wing
    Marco Milan
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Development 130:553-62. 2003
    ..The wing is subdivided into dorsal (D) and ventral (V) compartments by the activity of the selector gene apterous in D cells. Apterous causes segregation of D and V cell populations by at least two distinct mechanisms...
  44. ncbi Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code
    Douglas W Allan
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Cell 113:73-86. 2003
    ..Each Tv neuron resides within a neuronal cell group specified by the LIM-homeodomain gene apterous. We find that the zinc-finger gene squeeze acts in Tv cells to promote their unique axon pathfinding to a ..
  45. ncbi Lineage compartments in Drosophila
    Seth S Blair
    Department of Zoology, University of Wisconsin, Madison, WI 53706, USA
    Curr Biol 13:R548-51. 2003
  46. ncbi Control of apterous by vestigial drives indirect flight muscle development in Drosophila
    F Bernard
    Institut Jacques Monod, UMR 7592 CNRS, Universite Paris 7, Tour 43, 2, place Jussieu, 75251 Paris Cedex 05, France
    Dev Biol 260:391-403. 2003
    ..DFM development requires key regulatory genes such as cut (ct) and apterous (ap), whereas IFM development requires vestigial (vg)...
  47. ncbi Retrograde Gbb signaling through the Bmp type 2 receptor wishful thinking regulates systemic FMRFa expression in Drosophila
    Guillermo Marques
    Department of Genetics, Cell Biology and Development, Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN55455, USA
    Development 130:5457-70. 2003
    ..of the FMRFamide class regulate numerous physiological processes including synaptic efficacy at the Drosophila neuromuscular junction (NMJ)...
  48. ncbi Ap-let neurons--a peptidergic circuit potentially controlling ecdysial behavior in Drosophila
    Dongkook Park
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Dev Biol 269:95-108. 2004
    ..We show that a small complement of 28 apterous-expressing cells (Ap-let neurons) in the ventral nerve cord (VNC) of Drosophila larvae co-express numerous gene ..
  49. ncbi Independent roles of the dachshund and eyes absent genes in BMP signaling, axon pathfinding and neuronal specification
    Irene Miguel-Aliaga
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Development 131:5837-48. 2004
    ..dac is required for high-level Fmrf expression, and acts potently together with apterous and BMP signaling to trigger Fmrf expression ectopically, even in motoneurons...
  50. ncbi Boundary formation in the Drosophila wing: functional dissection of Capricious and Tartan
    Marco Milan
    Icrea and Parc Cientific de Barcelona, Barcelona, Spain
    Dev Dyn 233:804-10. 2005
    ..is subdivided into dorsal (D) and ventral (V) compartments by the activity of the LIM-homeodomain protein Apterous in D cells...
  51. pmc Specification of neuronal identities by feedforward combinatorial coding
    Magnus Baumgardt
    Division of Molecular Genetics, Department of Physics, Chemistry and Biology, Linkoping University, Linkoping, Sweden
    PLoS Biol 5:e37. 2007
    ..These results indicate that a limited number of regulators may constitute a potent combinatorial code that dictates unique neuronal cell fate, and that such codes show a surprising disregard for many global instructive cues...
  52. ncbi Recruitment of cells into the Drosophila wing primordium by a feed-forward circuit of vestigial autoregulation
    Myriam Zecca
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
    Development 134:3001-10. 2007
    ..We propose that Wg promotes the expansion of the wing primordium following the D-V segregation by fueling this non-autonomous autoregulatory mechanism...
  53. doi Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT
    Tetsuo Yasugi
    Laboratory of Pattern Formation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Development 135:1471-80. 2008
    ....
  54. pmc The color-vision circuit in the medulla of Drosophila
    Javier Morante
    Center for Developmental Genetics, Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA
    Curr Biol 18:553-65. 2008
    ..This paper analyzes the neural network underlying color vision into the medulla...
  55. doi Neuronal subtype specification within a lineage by opposing temporal feed-forward loops
    Magnus Baumgardt
    Department of Clinical and Experimental Medicine, Linkoping University, Linkoping SE 581 85, Sweden
    Cell 139:969-82. 2009
    ..This mechanism of temporal and "subtemporal" genes acting in opposing feed-forward loops may be used by many stem cell lineages to generate diversity...
  56. pmc Refined LexA transactivators and their use in combination with the Drosophila Gal4 system
    Ryohei Yagi
    Institute of Molecular Life Sciences, University of Zurich, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 107:16166-71. 2010
    ..The optimized LexA system facilitates precise analyses of complex biological phenomena and signaling pathways in Drosophila...
  57. pmc Regulation and functions of the lms homeobox gene during development of embryonic lateral transverse muscles and direct flight muscles in Drosophila
    Dominik Muller
    Division of Developmental Biology, Department of Biology, University of Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 5:e14323. 2010
    ..Herein, we report on the expression and function of a new Drosophila homeobox gene during both embryonic and adult muscle development...
  58. pmc Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6
    Javier Morante
    Center for Developmental Genetics, Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Development 138:687-93. 2011
    In the developing Drosophila optic lobe, eyeless, apterous and distal-less, three genes that encode transcription factors with important functions during development, are expressed in broad subsets of medulla neurons...
  59. ncbi Function and specificity of LIM domains in Drosophila nervous system and wing development
    D D O'Keefe
    Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Development 125:3915-23. 1998
    ..Here we use Drosophila to test the roles of the LIM domains of the LIM-HD family member Apterous (Ap) in wing and nervous system development...
  60. ncbi Short-range cell interactions and cell survival in the Drosophila wing
    Marco Milan
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Dev Cell 2:797-805. 2002
    ..We also present evidence showing that activation of the Notch signal transduction pathway is involved in triggering apoptosis of cells misspecified for their dorsal-ventral position...
  61. pmc Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repression
    Aidan J Peterson
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genetics 167:1225-39. 2004
    ..These results suggest that SCM, although not a core component of PRC1, interacts and functions with PRC1 in gene silencing...
  62. doi Enhancer loops appear stable during development and are associated with paused polymerase
    Yad Ghavi-Helm
    European Molecular Biology Laboratory, Genome Biology Unit, D 69117 Heidelberg, Germany
    Nature 512:96-100. 2014
    ..Our results indicate that the general topology governing enhancer contacts is conserved from flies to humans and suggest that transcription initiates from preformed enhancer-promoter loops through release of paused polymerase. ..
  63. pmc Cholinergic circuits integrate neighboring visual signals in a Drosophila motion detection pathway
    Shin Ya Takemura
    Department of Psychology and Neuroscience, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2
    Curr Biol 21:2077-84. 2011
    ..We propose that Tm2 integrates sign-conserving inputs from neighboring columns to mediate the detection of front-to-back motion generated during forward motion...
  64. ncbi Male sexual signaling is defective in mutants of the apterous gene of Drosophila melanogaster
    J Ringo
    Scheinfeld Center for Human Genetics in the Social Sciences, Department of Psychology, Hebrew University, Jerusalem, Israel
    Behav Genet 22:469-87. 1992
    The apterous (ap) gene of Drosophila melanogaster exhibits extreme pleiotrophy: its functioning is essential for life, normal wing structure, juvenile hormone production, female fertility, and normal development of female sexual ..
  65. ncbi Localized cell death in Drosophila imaginal wing disc epithelium caused by the mutation apterous-blot
    B J Sedlak
    Dev Biol 104:489-96. 1984
    Drosophila melanogaster carrying the mutation apterous-blot have blistered wings...
  66. ncbi Expression of phenotypes in a temperature-sensitive allele of the apterous mutation in Drosophila melanogaster
    T G Wilson
    Dev Biol 85:425-33. 1981
  67. ncbi Genetic and molecular studies of apterous: a gene implicated in the juvenile hormone system of Drosophila
    A Shtorch
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Israel
    Arch Insect Biochem Physiol 30:195-209. 1995
    The apterous (ap) gene in Drosophila melanogaster encodes a homeodomain transcription factor. It is required for the development of the wings and of a subset of embryonic muscles...
  68. ncbi Axon guidance molecules
    R Keynes
    Department of Anatomy, University of Cambridge, England
    Cell 83:161-9. 1995
  69. ncbi Distinguishable functions for engrailed and invected in anterior-posterior patterning in the Drosophila wing
    A J Simmonds
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    Nature 376:424-7. 1995
    ..gene engrailed has been implicated in specification of posterior cell fate, whereas the LIM/homeobox gene, apterous, specifies dorsal fate...
  70. ncbi Mechanisms of compartment formation: evidence that non-proliferating cells do not play a critical role in defining the D/V lineage restriction in the developing wing of Drosophila
    S S Blair
    Department of Zoology, University of Wisconsin, Madison 53706
    Development 119:339-51. 1993
    ..This cut-expressing region is split into dorsal and ventral regions by the expression of the dorsal-specific gene apterous. (3) The D/V lineage restriction defined by marked dorsal and ventral clones lies in the middle of the cut-..
  71. ncbi Chromosomal binding sites of Ultrabithorax homeotic proteins
    J Botas
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mech Dev 56:129-38. 1996
    ..Some of these sites correspond to the locations of known genes that are good candidates, or are known to be, under direct Ubx control...
  72. ncbi Controlling growth of the wing: vestigial integrates signals from the compartment boundaries
    S M Cohen
    European Molecular, Biology Laboratory, Heidelberg, Germany
    Bioessays 18:855-8. 1996
    ..Recent work suggests that the vestigial gene may function as a nodal point through which the growth-controlling activity of these two patterning systems is integrated...
  73. pmc Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila
    P Morcillo
    Molecular Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10021 USA
    Genes Dev 11:2729-40. 1997
    ..Chip protein interacts with the LIM domains in the Apterous homeodomain protein, and Chip interacts genetically with apterous, showing that these interactions are important ..
  74. ncbi Nucleotide compositional constraints on genomes generate alanine-, glycine-, and proline-rich structures in transcription factors
    Y Nakachi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Mol Biol Evol 14:1042-9. 1997
    ..Furthermore, reptile class III POU sequences revealed no evolutionary directionality increasing the GC contents from cold- to warm-blooded vertebrates...
  75. ncbi Growth and patterning from the engrailed interface
    A Hidalgo
    Department of Genetics, University of Cambridge, United Kingdom
    Int J Dev Biol 42:317-24. 1998
    ..Finally, regulatory interactions between en/En-1 and hh/Shh may be significant in the context of morphogenetic regulation during normal development...
  76. ncbi Genetic lesions in Drosophila behavioural mutants
    G O Pflugfelder
    Theodor Boveri Institut Biozentrum, Lehrstuhl fur Genetik, Universität Würzburg Am Hubland, Germany
    Behav Brain Res 95:3-15. 1998
    ..Various mutagens are reviewed as to their suitability in inducing selective regulatory mutations...
  77. ncbi Hox genes: from master genes to micromanagers
    M Akam
    University Museum of Zoology, Department of Zoology, Cambridge, UK
    Curr Biol 8:R676-8. 1998
    ....
  78. ncbi Notch signalling mediates segmentation of the Drosophila leg
    J F de Celis
    Department of Genetics and Department of Anatomy, University of Cambridge, Downing Street, Cambridge, UK
    Development 125:4617-26. 1998
    ....
  79. pmc The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing
    P Fernandez-Funez
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    EMBO J 17:6846-53. 1998
    Dorso-ventral axis formation in the Drosophila wing requires the localized accumulation of the Apterous LIM/homeodomain protein (Ap) in dorsal cells. Here we report that dLdb/Chip encodes a LIM-binding cofactor that controls Ap activity...
  80. pmc Nipped-B, a Drosophila homologue of chromosomal adherins, participates in activation by remote enhancers in the cut and Ultrabithorax genes
    R A Rollins
    Molecular Biology Program, Sloan Kettering Institute Cornell University Medical College, Weill Graduate School of Medical Sciences, New York, NY 10021, USA
    Genetics 152:577-93. 1999
    ..Compatible with this idea, Nipped-B protein is homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair...
  81. ncbi The LIM homeodomain protein dLim1 defines a subclass of neurons within the embryonic ventral nerve cord of Drosophila
    B Lilly
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, P O Box 85800, San Diego, CA 92186, USA
    Mech Dev 88:195-205. 1999
    ..In Drosophila three LIM homeobox genes, apterous, lim3 and isl, have been shown to control axon pathfinding of subsets of neurons within the embryo...
  82. pmc Chip interacts with diverse homeodomain proteins and potentiates bicoid activity in vivo
    E Torigoi
    Molecular Biology Program, Sloan Kettering Division of the Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:2686-91. 2000
    ..Chip and its mammalian homologs interact with and promote dimerization of nuclear LIM proteins...
  83. ncbi Cell behaviour of Drosophila fat cadherin mutations in wing development
    F Garoia
    Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Italy
    Mech Dev 94:95-109. 2000
    ..Mutant ft cells show, in addition, smaller cell sizes during proliferation and abnormal cuticular differentiation, which reflect cell membrane and cytoskeleton anomalies, which are not modulated by the DER pathway...
  84. ncbi Interactions between chip and the achaete/scute-daughterless heterodimers are required for pannier-driven proneural patterning
    P Ramain
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, Strasbourg, France
    Mol Cell 6:781-90. 2000
    ..Chip was previously identified as a cofactor of the dorsal selector Apterous, and we show here that both Apterous and Chip also regulate ASC expression...
  85. ncbi Drosophila wing development in the absence of dorsal identity
    D D O'Keefe
    The Salk Institute for Biological Studies, PO Box 85800, San Diego, CA 92186, USA
    Development 128:703-10. 2001
    ..The selector gene apterous (ap) is expressed in dorsal cells of the wing disc and is essential for D/V compartmentalization, wing margin ..
  86. ncbi The Iroquois family of genes: from body building to neural patterning
    F Cavodeassi
    Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, 28049 Madrid, Spain
    Development 128:2847-55. 2001
    ..Later in development in both Drosophila and vertebrates, the Iro genes function again to subdivide those territories into smaller domains...
  87. ncbi The LRR proteins capricious and Tartan mediate cell interactions during DV boundary formation in the Drosophila wing
    M Milan
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Cell 106:785-94. 2001
    ....
  88. ncbi A screen for genes expressed in Drosophila imaginal discs
    Offer Gerlitz
    Institut fur Molekularbiologie, Universitat Zurich, Switzerland
    Int J Dev Biol 46:173-6. 2002
    ..The procedure has been optimized for high-throughput. 2'000 P-element insertions have been established which exhibit expression in imaginal discs...
  89. ncbi Neurosecretory identity conferred by the apterous gene: lateral horn leucokinin neurons in Drosophila
    Pilar Herrero
    Departamento de Biologia, Fisiologia Animal, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Comp Neurol 457:123-32. 2003
    The LIM-HD protein Apterous has been shown to regulate expression of the FMRFamide neuropeptide in Drosophila neurons (Benveniste et al. [1998] Development 125:4757-4765)...
  90. ncbi Wnts as morphogens? The view from the wing of Drosophila
    Alfonso Martinez Arias
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Nat Rev Mol Cell Biol 4:321-5. 2003
    ..However, a close analysis of their activity indicates that they do not fulfil all of the critera that are associated with the classical definition...
  91. ncbi Ecdysteroids regulate yolk protein uptake by Drosophila melanogaster oocytes
    L I Gilbert
    Department of Biology, University of North Carolina at Chapel Hill, Coker Hall CB 3280, Chapel Hill, USA
    J Insect Physiol 44:637-644. 1998
    ..However, the level of JH production in a mutant stock (ap(56f)) is depressed yet the flies are normally vitellogenic...
  92. ncbi Osa modulates the expression of Apterous target genes in the Drosophila wing
    Marco Milan
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Mech Dev 121:491-7. 2004
    ..of the dorsal-ventral axis of the Drosophila wing depends on the activity of the LIM-homeodomain protein Apterous. Apterous activity depends on the formation of a higher order complex with its cofactor Chip to induce the ..
  93. ncbi Molecular evolution of sex-biased genes in Drosophila
    Zhi Zhang
    Department of Biology II, Section of Evolutionary Biology, University of Munich LMU, Munich, Germany
    Mol Biol Evol 21:2130-9. 2004
    ..melanogaster, and comparisons of polymorphism/divergence ratios suggest that the rapid evolution of male-biased genes is caused by positive selection...
  94. ncbi tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification
    Joaquín de Navascués
    Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, Madrid, Spain
    Development 134:1779-88. 2007
    The LIM-HD gene tailup (tup; also known as islet) has been categorised as a prepattern gene that antagonises the formation of sensory bristles on the notum of Drosophila by downregulating the expression of the proneural achaete-scute ..
  95. ncbi Squeeze involvement in the specification of Drosophila leucokinergic neurons: Different regulatory mechanisms endow the same neuropeptide selection
    Pilar Herrero
    Departamento de Biologia, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Mech Dev 124:427-40. 2007
    ..In the brain LHLK cells, both Sqz and Apterous (Ap) are required for LK expression, but surprisingly, high levels of either Sqz or Ap alone are sufficient to ..
  96. ncbi Drosophila T-box transcription factor Optomotor-blind prevents pathological folding and local overgrowth in wing epithelium through confining Hh signal
    Makoto Umemori
    Graduate School of Science, Kobe University, Kobe 657 8501, Japan
    Dev Biol 308:68-81. 2007
    ..These are the mechanisms for generating secondary phenotypes when a single signaling factor Omb fails to function...
  97. pmc A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth
    Myriam Zecca
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York, USA
    PLoS Biol 8:e1000386. 2010
    ..We posit that Wg propels wing growth at least in part by fueling a wave front of Ft-Ds signaling that propagates vg expression from one cell to the next...
  98. ncbi Replacement of posterior by anterior structures in the Drosophila wing caused by the mutation apterous-blot
    J R Whittle
    J Embryol Exp Morphol 53:291-303. 1979
    The recessive mutation apterous-blot in Drosophila melanogaster causes replacement of posterior wing structures by anterior ones, with variable penetrance and expressivity...
  99. ncbi Endocrine control of larval fat body histolysis in normal and mutant Drosophila melanogaster
    J H Postlethwait
    J Exp Zool 203:207-14. 1978

Research Grants9

  1. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ....
  2. Genome-wide expression profiling of miRNAs with single cell resolution
    Oliver Hobert; Fiscal Year: 2006
    ..Moreover, it will (4) validate the "sensor strategy" to determine miRNA expression profiles in C. elegans, and (5) build a toolkit of potentially useful gfp cell fate markers. [unreadable] [unreadable]..
  3. Regulation and function of cGMP in the nervous system
    David B Morton; Fiscal Year: 2011
    ..Viagra and other pharmacological treatments for erectile disfunction are probably just the tip of the iceberg for compounds that target cGMP mediated processes. ..
  4. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
    ..Consequently, the present research should have direct relevance to our understanding of how defects in TGF-B signaling can lead to disease. ..
  5. Left/right asymmetric neuronal cell fate specification
    Oliver Hobert; Fiscal Year: 2006
    ..These studies may reveal fundamental principles of neuronal development and may shed light onto the elusive mechanisms of generating L/R asymmetry in the nervous system...
  6. Novel Molecular Tools for Transsynaptic Circuit Analysis
    Haig Keshishian; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILA
    Mary Baylies; Fiscal Year: 2008
    ..and preliminary data, we propose that the combined activities of 5 transcriptional regulators, Kruppel, Twist, Apterous, Caupolican, and Muscle Segment Homeobox, control the morphogenesis of the lateral muscles...
  8. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010
    ..Consequently, the proposed studies should provide insights into diseases such as these, potentially leading to improved diagnosis and treatment. ..
  9. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary K Baylies; Fiscal Year: 2010
    ....