betaTub60D

Summary

Gene Symbol: betaTub60D
Description: beta-Tubulin at 60D
Alias: 143391_i_at, B3t, BETA 60D, CG3401, D.m.BETA-60D, DTB3, Dmbeta3, Dmel\CG3401, Tub, Tub2E, Tub60D, beta-Tub60D, beta-Tub6D, beta-tub, beta3, beta3 TU, beta3-Tub, beta3-tubulin, beta3TUB, beta3Tub, beta3t, beta3tub, beta60C, betaTub, betaTub3, betaTub60C, beta[[3]] tubulin, beta[[3]]-Tub, beta[[3]]-tubulin, betatub60D, p50, p50/tubulin, p53, p53/tubulin, CG3401 gene product from transcript CG3401-RA, 60C beta tubulin, B3-tubulin, CG3401-PA, CG3401-PB, b-3 tubulin, b3 tubulin, beta 3 tubulin, beta tubulin, beta-3 tubulin, beta-3-tubulin, beta-3tubulin, beta-Tubulin, beta-Tubulin at 60A, beta-tubulin 60D, beta-tubulin at 60D, beta-tubulin60D, beta3 tubulin, beta3-tubulin, beta3tubulin, betaTub60D-PA, betaTub60D-PB, tubulin, tubulin b-3
Species: fruit fly

Top Publications

  1. ncbi Genetic analysis of the Drosophila beta3-tubulin gene demonstrates that the microtubule cytoskeleton in the cells of the visceral mesoderm is required for morphogenesis of the midgut endoderm
    R W Dettman
    Department of Biology and Institute for Molecular and Cellular Biology, Indiana University, Bloomington, Indiana, 47405, USA
    Dev Biol 177:117-35. 1996
  2. ncbi Fusion from myoblasts to myotubes is dependent on the rolling stone gene (rost) of Drosophila
    A Paululat
    Philipps Universitat, Marburg, FRG
    Development 121:2611-20. 1995
  3. ncbi The beta 3 tubulin gene is a direct target of bagpipe and biniou in the visceral mesoderm of Drosophila
    Stephane Zaffran
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, Box 1020, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mech Dev 114:85-93. 2002
  4. ncbi Muscle development and attachment to the epidermis is accompanied by expression of beta 3 and beta 1 tubulin isotypes, respectively
    D Buttgereit
    FB Biologie, Marburg, Germany
    Int J Dev Biol 40:189-96. 1996
  5. pmc Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specification
    Christoph Schaub
    Friedrich Alexander University of Erlangen Nuremberg, Department of Biology, Division of Developmental Biology, Staudtstrasse 5, Erlangen, Germany
    Development 139:1001-12. 2012
  6. ncbi During Drosophila spermatogenesis beta 1, beta 2 and beta 3 tubulin isotypes are cell-type specifically expressed but have the potential to coassemble into the axoneme of transgenic flies
    B Kaltschmidt
    Gentechnologische Arbeitsgruppe am Max Planck Institut für Biochemie, Martinsried Bundesrepublik Deutschland
    Eur J Cell Biol 54:110-20. 1991
  7. pmc Two Drosophila beta tubulin isoforms are not functionally equivalent
    H D Hoyle
    Institute for Molecular and Cellular Biology, Indiana University, Bloomington 47405
    J Cell Biol 111:1009-26. 1990
  8. ncbi Drosophila MEF2, a transcription factor that is essential for myogenesis
    B A Bour
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA
    Genes Dev 9:730-41. 1995
  9. ncbi Microtubule architecture specified by a beta-tubulin isoform
    E C Raff
    Department of Biology and Indiana Molecular Biology Institute, Indiana University, Bloomington, IN 47405, USA
    Science 275:70-3. 1997
  10. pmc Structurally similar Drosophila alpha-tubulins are functionally distinct in vivo
    J A Hutchens
    Department of Biology, Indiana University, Bloomington 47405, USA
    Mol Biol Cell 8:481-500. 1997

Research Grants

Scientific Experts

  • Mark G Nielsen
  • H D Hoyle
  • Virginie Orgogozo
  • ELIZABETH RAFF
  • Frank Schnorrer
  • Dmitry Popichenko
  • Kimberly Mace
  • Joyce J Fernandes
  • Ellen M Popodi
  • S Gigliotti
  • D Buttgereit
  • G C Conant
  • M I Galindo
  • D F Eberl
  • Anja Rudolf
  • Renate Renkawitz-Pohl
  • Stephane Zaffran
  • R Renkawitz-Pohl
  • Manfred Frasch
  • Susanne Filiz Onel
  • Maria Giovanna Riparbelli
  • A Paululat
  • Anne Holz
  • Christine Dottermusch-Heidel
  • Christoph Schaub
  • Maria Grazia Giansanti
  • Stacie A Dilks
  • Julia Sellin
  • D J Sharp
  • Lothar Beck
  • T Kremser
  • Achim Paululat
  • R W Dettman
  • Gritt Schäfer
  • Janus S Jakobsen
  • David Liotta
  • Patrick C H Lo
  • Stefanie Albrecht
  • Begona De Velasco
  • Manika Pal Bhadra
  • Sven Bogdan
  • James Ashley
  • Zhigang Jin
  • Luis Alberto Baena-Lopez
  • Sarita Hebbar
  • Kirsten K Hanson
  • Gohta Goshima
  • F R Turner
  • Roxane H Schröter
  • Qiaofang Chen
  • Silvia Bonaccorsi
  • Maurizio Gatti
  • Giuliano Callaini
  • Martina Zikova
  • Fengwei Yu
  • Elisabetta Bucciarelli
  • Melanie Anderson
  • Monika Hassel
  • Katrin Hüsken
  • Nicole Rebscher
  • Christine Hübinger
  • Angelika Vogt
  • C Vied
  • Karl Heinz Rexer
  • D F Miller
  • S Zaffran
  • S Bulgheresi
  • Hong Jin
  • A Rau
  • Verena Groth
  • Hideyuki Nagaso
  • Stephen Dinardo
  • F Yu
  • N C Grieder
  • A Holz
  • J A Hutchens
  • J M Scholey
  • Hanh T Nguyen
  • Maik Drechsler
  • M H Lin
  • H M Brown
  • B M McCartney
  • G V Reddy
  • J T Robinson
  • U Irion
  • Martina Braun
  • Sabine Schumacher
  • Jun Han
  • Stuart Elgar
  • Thomas Sandmann

Detail Information

Publications108 found, 100 shown here

  1. ncbi Genetic analysis of the Drosophila beta3-tubulin gene demonstrates that the microtubule cytoskeleton in the cells of the visceral mesoderm is required for morphogenesis of the midgut endoderm
    R W Dettman
    Department of Biology and Institute for Molecular and Cellular Biology, Indiana University, Bloomington, Indiana, 47405, USA
    Dev Biol 177:117-35. 1996
    ..the cellular basis for lethality of mutant alleles of the Drosophila melanogaster beta3-tubulin gene, betaTub60D. Lethal beta3 mutations can be grouped into two classes: the most severe mutations (Class I alleles) cause death ..
  2. ncbi Fusion from myoblasts to myotubes is dependent on the rolling stone gene (rost) of Drosophila
    A Paululat
    Philipps Universitat, Marburg, FRG
    Development 121:2611-20. 1995
    ..b>beta 3 tubulin, which is an early marker for the onset of mesoderm differentiation, is still expressed in these cells...
  3. ncbi The beta 3 tubulin gene is a direct target of bagpipe and biniou in the visceral mesoderm of Drosophila
    Stephane Zaffran
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, Box 1020, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mech Dev 114:85-93. 2002
    ..show that both genes are required for the activation of beta 3Tub60D in the visceral mesoderm, which encodes beta 3 tubulin. We demonstrate that a 254 bp derivative of a previously defined visceral mesoderm-specific enhancer element, ..
  4. ncbi Muscle development and attachment to the epidermis is accompanied by expression of beta 3 and beta 1 tubulin isotypes, respectively
    D Buttgereit
    FB Biologie, Marburg, Germany
    Int J Dev Biol 40:189-96. 1996
    ..Here we focus on the expression of the beta 3 tubulin isotype during mesoderm differentiation and beta 1 tubulin expression in the apodemes during embryonic ..
  5. pmc Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specification
    Christoph Schaub
    Friedrich Alexander University of Erlangen Nuremberg, Department of Biology, Division of Developmental Biology, Staudtstrasse 5, Erlangen, Germany
    Development 139:1001-12. 2012
    ..These findings provide new insights into the regulatory circuits that control the proper pattering of the larval somatic musculature in Drosophila...
  6. ncbi During Drosophila spermatogenesis beta 1, beta 2 and beta 3 tubulin isotypes are cell-type specifically expressed but have the potential to coassemble into the axoneme of transgenic flies
    B Kaltschmidt
    Gentechnologische Arbeitsgruppe am Max Planck Institut für Biochemie, Martinsried Bundesrepublik Deutschland
    Eur J Cell Biol 54:110-20. 1991
    ..b>beta 3 Tubulin is present exclusively in cytoplasmic microtubules of cells somatic in origin, while the beta 1 isotype is ..
  7. pmc Two Drosophila beta tubulin isoforms are not functionally equivalent
    H D Hoyle
    Institute for Molecular and Cellular Biology, Indiana University, Bloomington 47405
    J Cell Biol 111:1009-26. 1990
    ..These data show that beta 3 tubulin can support only a subset of the multiple functions normally performed by beta 2, and also suggest that the ..
  8. ncbi Drosophila MEF2, a transcription factor that is essential for myogenesis
    B A Bour
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA
    Genes Dev 9:730-41. 1995
    ..early differentiation of somatic muscle precursors are not affected because even-skipped-, nautilus-, and beta 3-tubulin-expressing myoblasts are present...
  9. ncbi Microtubule architecture specified by a beta-tubulin isoform
    E C Raff
    Department of Biology and Indiana Molecular Biology Institute, Indiana University, Bloomington, IN 47405, USA
    Science 275:70-3. 1997
    In Drosophila melanogaster, a testis-specific beta-tubulin (beta2) is required for spermatogenesis. A sequence motif was identified in carboxyl termini of axonemal beta-tubulins in diverse taxa...
  10. pmc Structurally similar Drosophila alpha-tubulins are functionally distinct in vivo
    J A Hutchens
    Department of Biology, Indiana University, Bloomington 47405, USA
    Mol Biol Cell 8:481-500. 1997
    We used transgenic analysis in Drosophila to compare the ability of two structurally similar alpha-tubulin isoforms to support microtubule assembly in vivo...
  11. ncbi Independent regulatory elements in the upstream region of the Drosophila beta 3 tubulin gene (beta Tub60D) guide expression in the dorsal vessel and the somatic muscles
    C Damm
    Philipps Universitat Marburg, Germany
    Dev Biol 199:138-49. 1998
    The beta 3 tubulin gene (beta Tub60D) is a structural gene expressed during mesoderm development from the extended germ band stage onward. Expression within the individual mesodermal derivatives is guided by different control elements...
  12. ncbi The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes
    E Logarinho
    Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, Portugal
    J Cell Sci 111:2897-909. 1998
    ....
  13. pmc The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles
    D J Sharp
    Section of Molecular and Cellular Biology, University of California Davis, Davis, California 95616, USA
    J Cell Biol 144:125-38. 1999
    ..Thus we propose that bipolar kinesin motors and MTs interact by a "sliding filament mechanism" during the formation and function of the mitotic spindle...
  14. pmc Functional coordination of three mitotic motors in Drosophila embryos
    D J Sharp
    Section of Molecular and Cellular Biology, University of California Davis, Davis, California 95616, USA
    Mol Biol Cell 11:241-53. 2000
    ..During anaphase, however, Ncd appears to have no effect on spindle pole movements, suggesting that its activity is down-regulated at this time, allowing dynein and KLP61F to drive spindle elongation during anaphase B...
  15. pmc biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila
    S Zaffran
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genes Dev 15:2900-15. 2001
    ....
  16. ncbi Functional constraint underlies 60 million year stasis of Dipteran testis-specific beta-tubulin
    Mark G Nielsen
    Department of Biology, University of Dayton, 300 College Park, Dayton, OH 45469 2320, USA
    Evol Dev 8:23-9. 2006
    ..find a highly stringent structure/function relationship between the Drosophila melanogaster testis-specific tubulin beta2 and the spermtail axoneme, such that small changes in the beta2 protein render it unable to generate a ..
  17. ncbi The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster
    Stefanie Albrecht
    Universitat Osnabruck, Fachbereich Biologie chemie, Zoologie, Barbarastrasse 11, D 49069 Osnabruck, Germany
    Mech Dev 123:372-87. 2006
    ..Our data presented herein suggest that Kuzbanian acts during lateral inhibition within the cardiac primordium. Furthermore we discuss a second function of Kuzbanian in heart cell morphogenesis...
  18. ncbi The transmembrane protein Kon-tiki couples to Dgrip to mediate myotube targeting in Drosophila
    Frank Schnorrer
    Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Dev Cell 12:751-66. 2007
    ..Forced overexpression of Kon stimulates muscle motility. We propose that Kon promotes directed myotube migration and transduces a target-derived signal that initiates the formation of a stable connection...
  19. doi Axoneme-dependent tubulin modifications in singlet microtubules of the Drosophila sperm tail
    Henry D Hoyle
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Cell Motil Cytoskeleton 65:295-313. 2008
    ..We show here that axonemes are the substrate for these tubulin C-terminal modifications. Axoneme architecture is required, but full length, motile axonemes are not necessary...
  20. pmc Tubulin evolution in insects: gene duplication and subfunctionalization provide specialized isoforms in a functionally constrained gene family
    Mark G Nielsen
    Department of Biology, University of Dayton, OH 45467, USA
    BMC Evol Biol 10:113. 2010
    ..Previous in vivo studies in Drosophila find a stringent relationship between tubulin structure and function; small, biochemically similar changes in the major alpha 1 or testis-specific beta 2 ..
  21. pmc Intron and upstream sequences regulate expression of the Drosophila beta 3-tubulin gene in the visceral and somatic musculature, respectively
    A Gasch
    Gentechnologische Arbeitsgruppe am Max Planck Institute für Biochemie, Martinsried, Federal Republic of Germany
    Proc Natl Acad Sci U S A 86:3215-8. 1989
    ..beta 3-tubulin has proved to be a good marker for mesoderm development as this tubulin isotype is detectable soon after mesoderm ..
  22. ncbi Regulation of Drosophila alpha- and beta-tubulin genes during development
    J E Natzle
    Dev Biol 104:187-98. 1984
    Both the alpha and the beta subunit of tubulin in Drosophila melanogaster are encoded by small multigene families...
  23. ncbi A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila
    G Ranganayakulu
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 171:169-81. 1995
    ..These results demonstrate that the D-mef2 gene has multiple functions in myogenesis and tissue morphogenesis during Drosophila development...
  24. pmc Cytoplasmic dynein is required for the nuclear attachment and migration of centrosomes during mitosis in Drosophila
    J T Robinson
    University of Minnesota, Department of Genetics, Cell Biology and Development, St Paul, Minnesota 55108 1095, USA
    J Cell Biol 146:597-608. 1999
    ..The disruption of these centrosome attachments in mutant embryos reveals a critical role for dynein function and centrosome positioning in the spatial organization of the syncytial cytoplasm of the developing embryo...
  25. pmc Axoneme beta-tubulin sequence determines attachment of outer dynein arms
    Elizabeth C Raff
    Department of Biology, Indiana Molecular Biology Institute, Indiana University, Bloomington, IN 47405, USA
    Curr Biol 18:911-4. 2008
    ..We report here that attachment of ODAs requires glycine 56 in the beta-tubulin internal variable region (IVR)...
  26. ncbi During Drosophila embryogenesis the beta 1 tubulin gene is specifically expressed in the nervous system and the apodemes
    D Buttgereit
    Gentechnologische Arbeitsgruppe am MPI für Biochemie, Martinsried Munchen, F R G
    Mech Dev 33:107-18. 1991
    We determined the in vivo distribution of the beta 1 tubulin from D. melanogaster using isotype specific antibodies. Maternally expressed beta 1 tubulin is incorporated into mitotic spindles...
  27. ncbi The development of adult abdominal muscles in Drosophila: myoblasts express twist and are associated with nerves
    D A Currie
    Department of Zoology, Cambridge, UK
    Development 113:91-102. 1991
    ..across the developing abdominal epidermis, and as twist expression declines, the myoblasts begin to synthesize beta 3 tubulin. There follows a process involving cell fusion and segregation into cell groups to form multinucleate muscle ..
  28. ncbi Functions of tubulin isoforms
    D B Murphy
    Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Curr Opin Cell Biol 3:43-51. 1991
    The biological significance of tubulin isotypes lies in their ability to function in different chemical and physical environments...
  29. pmc Three Drosophila beta-tubulin sequences: a developmentally regulated isoform (beta 3), the testis-specific isoform (beta 2), and an assembly-defective mutation of the testis-specific isoform (B2t8) reveal both an ancient divergence in metazoan isotypes an
    J E Rudolph
    Mol Cell Biol 7:2231-42. 1987
    ..are presented for three Drosophila melanogaster beta-tubulins: a developmentally regulated isoform beta 3-tubulin, the wild-type testis-specific isoform beta 2-tubulin, and an ethyl methanesulfonate-induced assembly-defective ..
  30. ncbi Normal expression and the effects of ectopic expression of the Drosophila muscle segment homeobox (msh) gene suggest a role in differentiation and patterning of embryonic muscles
    P C Lord
    Department of Biochemistry M C 536, University of Illinois, College of Medicine, Chicago 60612, USA
    Dev Biol 171:627-40. 1995
    ....
  31. ncbi Effect of hydrogen peroxide on cytoskeletal proteins of Drosophila cells: comparison with heat shock and other stresses
    A M Courgeon
    Groupe de Génétique Cellulaire et Moléculaire, UA CNRS 1135, Universite Pierre et Marie Curie, Paris, France
    Exp Cell Res 204:30-7. 1993
    ..The synthesis of two cytoskeletal proteins, tubulin and a 46-kDa insoluble protein of the intermediate filament fraction, was also slightly increased by H2O2 in ..
  32. pmc Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila
    S Eaton
    Programme in Cell Biology, European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Biol 135:1277-89. 1996
    ..During hair formation, the apical microtubules that point distally elongate and fill the emerging wing hair. As the hair elongates, junctional proteins are reorganized on the proximal and distal edges of each cell...
  33. ncbi Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 function
    J M Crawford
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, 27710 7599, USA
    Dev Biol 204:151-64. 1998
    ..These embryos halt in cellularization and do not proceed to gastrulation. We conclude that Rho activity and Cdc42 regulation are required for cytoskeletal function in actomyosin-driven furrow canal formation and nuclear positioning...
  34. ncbi Essential genes for myoblast fusion in Drosophila embryogenesis
    A Paululat
    Department of Biology, Philipps University, Marburg, D 35032, Marburg, Germany
    Mech Dev 83:17-26. 1999
    ..The molecular characterization of further genes relevant for fusion such as singles bar and sticks and stones will help to elucidate the mechanism of myoblast fusion in Drosophila...
  35. ncbi Tinman regulates the transcription of the beta3 tubulin gene (betaTub60D) in the dorsal vessel of Drosophila
    T Kremser
    Fachbereich Biologie, Entwicklungsbiologie, Philipps Universitat Marburg, Marburg, 35032, Germany
    Dev Biol 216:327-39. 1999
    During Drosophila embryogenesis, the beta3 tubulin gene is expressed in the visceral and somatic mesoderm as well as in the dorsal vessel. Transcription of the gene is limited to four pairs of cardioblasts per segment...
  36. ncbi Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization
    F Yu
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Cell 100:399-409. 2000
    ....
  37. pmc Tubulin sorting during dimerization in vivo
    H D Hoyle
    Department of Biology and Indiana Molecular Biology Institute, Indiana University, Bloomington, Indiana 47405, USA
    Mol Biol Cell 12:2185-94. 2001
    We demonstrate sorting of beta-tubulins during dimerization in the Drosophila male germ line. Different beta-tubulin isoforms exhibit distinct affinities for alpha-tubulin during dimerization...
  38. ncbi A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells
    Melanie Anderson
    Cancer Center, Department of Medicine, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    Dev Genes Evol 212:107-13. 2002
    ..Over expression of Dcyp33 in DrosophilaSL1 cells results in down-regulation of AbdominalB Hoxgene expression, mirroring the effect of human Cyp33 on the expression of human HOXgenes...
  39. pmc Patterning of the cardiac outflow region in Drosophila
    Martina Zikova
    Institut National de la Sante et de la Recherche Medicale, Unité 384, Faculte de Medecine, 28 Place Henri Dunant, 63001 Clermont Ferrand, France
    Proc Natl Acad Sci U S A 100:12189-94. 2003
    ....
  40. pmc Genetic dissection of meiotic cytokinesis in Drosophila males
    Maria Grazia Giansanti
    Istituto Pasteur Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, 00185 Rome, Italy
    Mol Biol Cell 15:2509-22. 2004
    ..Examination of preparations stained for tubulin, anillin, KLP3A, and F-actin revealed discrete defects in the components of the cytokinetic apparatus, suggesting ..
  41. ncbi Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis
    Zhigang Jin
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada
    Development 132:4075-85. 2005
    ..Based on these observations, we propose that Myt1 serves unique Cdk1 regulatory functions required for efficient coupling of cell differentiation with cell cycle progression...
  42. ncbi Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development
    Kirsten K Hanson
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Development 132:4777-87. 2005
    ..Unexpectedly, during late larval development, cells survive loss of borr and develop giant bristles that may reflect their high degree of ploidy...
  43. ncbi Variation in fiber number of a male-specific muscle between Drosophila species: a genetic and developmental analysis
    Virginie Orgogozo
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Evol Dev 9:368-77. 2007
    ..simulans to two genomic regions on chromosome 2. Our data eliminate the possibility of evolving mutations in the fruitless gene and suggest that a change in the twist might be partly responsible for this evolutionary change...
  44. pmc Non-cell-autonomous control of denticle diversity in the Drosophila embryo
    Stacie A Dilks
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 137:1395-404. 2010
    ..We propose that stripe mediates its effect on hook orientation, in part, via upregulation of shot...
  45. doi The Hydra FGFR, Kringelchen, partially replaces the Drosophila Heartless FGFR
    Anja Rudolf
    Faculty of Biology, Morphology and Evolution of Invertebrates, Philipps Universitat Marburg, Karl von Frisch Str 8, 35032, Marburg, Germany
    Dev Genes Evol 223:159-69. 2013
    ..Our data provide evidence for functional conservation of this early-diverged FGFR across these distantly related phyla, but also selectivity for the Htl FGFR in the Drosophila system...
  46. pmc Further sequence requirements for male germ cell-specific expression under the control of the 14 bp promoter element (beta 2UE1) of the Drosophila beta 2 tubulin gene
    F Michiels
    Genzentrum am MPI für Biochemie, Martinsried, FRG
    Nucleic Acids Res 19:4515-21. 1991
    ..beta 2 tubulin gene promoter was exchanged for a related sequence from the promoter region of the Drosophila beta 3 tubulin gene led to a dramatic reduction in the expression of the lacZ gene in the testis...
  47. pmc Characterization and developmental expression of beta tubulin genes in Drosophila melanogaster
    S Bialojan
    EMBO J 3:2543-8. 1984
    Genomic clones containing beta tubulin sequences were isolated from a lambda library of Drosophila melanogaster. In situ hybridization localized three genes to 56D and 60B on chromosome 2 as well as to 85D on chromosome 3...
  48. ncbi Control of morphogenesis and differentiation by HOM/Hox genes
    J Botas
    Baylor College of Medicine, Houston
    Curr Opin Cell Biol 5:1015-22. 1993
    ..Some of the genes they regulate and that mediate specific identify functions have been identified. Research in Drosophila has shown that HOM genes are continuously required during development for correct axial identity...
  49. ncbi In Drosophila Kc cells 20-OHE induction of the 60C beta3 tubulin gene expression is a primary transcriptional event
    S Chapel
    Laboratoire de Biochemie Médicale, Faculte de Medecine, Clermont Ferrand, France
    Insect Mol Biol 2:39-48. 1993
    In Drosophila Kc cells, the 60C beta3 tubulin transcription unit, whose expression is induced by 20-hydroxyecdysone (20-OHE), has the same structure as in Drosophila...
  50. ncbi Homeotic Complex (Hox) gene regulation and homeosis in the mesoderm of the Drosophila melanogaster embryo: the roles of signal transduction and cell autonomous regulation
    D F Miller
    Department of Biology, Howard Hughes Medical Institute, Indiana University, Bloomington, IN 47405, USA
    Mech Dev 102:17-32. 2001
    ..We find that extrinsic specification of cell fate by signaling can be overridden by Hox protein expression in mesodermal cells and propose the term autonomic dominance for this phenomenon...
  51. pmc The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis
    Patrick C H Lo
    Brookdale Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 311:287-96. 2007
    ....
  52. doi The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts
    Christine Dottermusch-Heidel
    Fachbereich Biologie, Entwicklungsbiologie, Philipps Universitat Marburg, Karl von Frisch Str 8, D 35043 Marburg, Germany
    Dev Biol 368:18-27. 2012
    ..Based on our findings, we propose a model where N-cadherin must be removed from the myoblast membrane to induce a protein-free zone at the cell-cell contact point to permit fusion...
  53. doi The syncytial visceral and somatic musculature develops independently of β3-Tubulin during Drosophila embryogenesis, while maternally supplied β1-Tubulin is stable until the early steps of myoblast fusion
    Anja Rudolf
    Philipps Universitat Marburg, Fachbereich Biologie, Entwicklungsbiologie, Karl von Frisch Str 8, 35043 Marburg, Germany
    Eur J Cell Biol 91:192-203. 2012
    ..In Drosophila, several isoforms of β-Tubulin, the functional subunit of microtubules, are expressed in different tissues of the developing embryo, while ..
  54. ncbi Ultrabithorax is a regulator of beta 3 tubulin expression in the Drosophila visceral mesoderm
    U Hinz
    Gentechnologische Arbeitsgruppen am MPI für Biochemie, Martinsried, FRG
    Development 116:543-54. 1992
    b>beta 3 tubulin expression accompanies the specification and differentiation of the Drosophila mesoderm. The genetic programs involved in these processes are largely unknown...
  55. ncbi Neither enhanced removal of cyclobutane pyrimidine dimers nor strand-specific repair is found after transcription induction of the beta 3-tubulin gene in a Drosophila embryonic cell line Kc
    J G de Cock
    MGC Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Netherlands
    Mutat Res 293:11-20. 1992
    ..In this cell line the hormone induces transcription of the beta 3-tubulin gene which is not expressed under standard culture conditions...
  56. ncbi From genes to tensile forces: genetic dissection of contractile protein assembly and function in Drosophila melanogaster
    E Fyrberg
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218
    J Cell Sci Suppl 14:27-9. 1991
    ..Here we review some recent progress...
  57. pmc Regulatory elements in the first intron contribute to transcriptional regulation of the beta 3 tubulin gene by 20-hydroxyecdysone in Drosophila Kc cells
    A Bruhat
    Laboratoire de Biochimie Medicale, CJF INSERM 88 06, Clermont Ferrand, France
    Nucleic Acids Res 18:2861-7. 1990
    We have studied the transcriptional regulation of the beta 3 tubulin gene by the steroid hormone 20-hydroxyecdysone (20-OH-E) in Drosophila Kc cells...
  58. ncbi A variant beta-tubulin isoform of Drosophila melanogaster (beta 3) is expressed primarily in tissues of mesodermal origin in embryos and pupae, and is utilized in populations of transient microtubules
    M Kimble
    Department of Biology, Indiana University, Bloomington 47405
    Dev Biol 131:415-29. 1989
    ..The expression of beta 3 tubulin ceases by the end of pupal development in all of these tissues except the ovaries and testes where expression ..
  59. pmc In situ hybridization analysis of chromosomal homologies in Drosophila melanogaster and Drosophila virilis
    J H Whiting
    Department of Zoology, Brigham Young University, Provo, Utah 84602
    Genetics 122:99-109. 1989
    ..Probes representing two multigene families (beta-tubulin and yolk-protein) hybridized as would be expected if all sites had been conserved in the two species on the same ..
  60. ncbi 20-OH-ecdysone regulates 60 C beta tubulin gene expression in Kc cells and during Drosophila development
    M L Sobrier
    Laboratoire de Biochimie Medicale, UFR de Medecine, Clermont Ferrand, France
    Exp Cell Res 184:241-9. 1989
    ..The 60 C beta tubulin gene which is expressed only in 20-OH-E-treated cells encodes a 2...
  61. ncbi Beta 3 tubulin expression characterizes the differentiating mesodermal germ layer during Drosophila embryogenesis
    D Leiss
    Gentechnologische Arbeitsgruppe, Max Planck Institut fur Biochemie, Martinsried, FRG
    Development 104:525-31. 1988
    During embryogenesis, the beta 3 tubulin gene of Drosophila is transcribed predominantly in the mesoderm...
  62. pmc Genetics of microtubule systems
    E C Raff
    J Cell Biol 99:1-10. 1984
    In most eucaryotes the tubulin genes comprise small multigene families with approximately equal numbers of genes for alpha- and beta-tubulin, the structural proteins of microtubules...
  63. ncbi The mutant not enough muscles (nem) reveals reduction of the Drosophila embryonic muscle pattern
    S Burchard
    Philipps Universitat, Marburg, FRG
    J Cell Sci 108:1443-54. 1995
    ..are characterized by partial absence of muscles, monitored by immunostainings with mesoderm-specific anti-beta 3 tubulin and anti-myosin heavy chain antibodies...
  64. pmc Structural analysis of mutations in the Drosophila beta 2-tubulin isoform reveals regions in the beta-tubulin molecular required for general and for tissue-specific microtubule functions
    J D Fackenthal
    Department of Biology, Indiana University, Bloomington 47405
    Genetics 139:267-86. 1995
    ..the lesions in a number of mutant alleles of beta Tub85D, the gene that encodes the testis-specific beta 2-tubulin isoform in Drosophila melanogaster...
  65. ncbi Ectoderm induces muscle-specific gene expression in Drosophila embryos
    R Baker
    Department of Genetics, University of Washington, Seattle 98195, USA
    Development 121:1387-98. 1995
    ..Our findings suggest that muscle determination in Drosophila is regulated by induction between germ layers during gastrulation...
  66. ncbi The beta-tubulin genes of Drosophila auraria are arranged in a cluster
    Z G Scouras
    Department of Genetics, School of Biology, Faculty of Science, Aristotelian University of Thessaloniki, Greece
    Curr Genet 25:84-7. 1994
    When the beta 1-, beta 2- and beta 3-tubulin-specific DNAs from Drosophila melanogaster were used as probes to recognize tubulin-specific sequences in the chromosomes of Drosophila auraria, they were found to hybridize to the same ..
  67. ncbi Ectopic expression of MEF2 in the epidermis induces epidermal expression of muscle genes and abnormal muscle development in Drosophila
    M H Lin
    Department of Biochemistry M C536, University of Illinois College of Medicine, Chicago 60612, USA
    Dev Biol 182:240-55. 1997
    ..We also find that the level of MEF2 in the mesoderm and/or muscles in embryos is critical to body-wall muscle formation; however, no effect is observed on the development of the visceral muscle or dorsal vessel...
  68. pmc A new enhancer of position-effect variegation in Drosophila melanogaster encodes a putative RNA helicase that binds chromosomes and is regulated by the cell cycle
    D F Eberl
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 146:951-63. 1997
    ....
  69. ncbi beta3-tubulin is directly repressed by the engrailed protein in Drosophila
    N Serrano
    Departement de Biologie du Developpement, Institut Jacques Monod, CNRS et Université Paris 7, France
    Development 124:2527-36. 1997
    ..We report here the identification of an effector gene, the beta3-tubulin gene, as a direct target of Engrailed...
  70. ncbi Somatic mesoderm differentiation and the development of a subset of pericardial cells depend on the not enough muscles (nem) locus, which contains the inscuteable gene and the intron located gene, skittles
    S Knirr
    Fachbereich Biologie, Zoologie Entwicklungsbiologie, Philipps University Marburg, Germany
    Mech Dev 67:69-81. 1997
    ..Our data suggest a role for insc in the specification process of a subset of muscle progenitors/founders. Furthermore, in insc mutants the eve expressing pericardial cells of the developing heart are significantly reduced in numbers...
  71. ncbi ladybird determines cell fate decisions during diversification of Drosophila somatic muscles
    T Jagla
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
    Development 125:3699-708. 1998
    ..Altogether our results provide new insights into the genetic control of diversification of muscle precursors and indicate a further similarity between the myogenic and neurogenic pathways...
  72. pmc Nup154, a new Drosophila gene essential for male and female gametogenesis is related to the nup155 vertebrate nucleoporin gene
    S Gigliotti
    Istituto Internazionale di Genetica e Biofisica, 80125 Napoli, Italia
    J Cell Biol 142:1195-207. 1998
    ..Finally, the multiplicity of phenotypes observed in Nup154 mutant alleles suggests that this gene plays a crucial role in cell physiology...
  73. pmc Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    J Cell Biol 146:1303-18. 1999
    ..We discuss the implications of our results for Wg signaling, and suggest a role for dAPC2 as a mediator of Wg effects on the cytoskeleton. We also speculate on more general roles that APCs may play in cytoskeletal dynamics...
  74. ncbi The fusome organizes the microtubule network during oocyte differentiation in Drosophila
    N C Grieder
    Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 127:4253-64. 2000
    ..We have investigated how the microtubule network polarizes using a GFP-tubulin construct that allows germ-cell microtubules to be visualized with greater sensitivity than in previous studies...
  75. pmc Embryonic expression of the divergent Drosophila beta3-tubulin isoform is required for larval behavior
    R W Dettman
    Department of Biology and Institute for Molecular Biology, Indiana University, 1001 E 3rd St, Bloomington, IN 47405, USA
    Genetics 158:253-63. 2001
    ..Drosophila beta3-tubulin (beta3) is a structurally divergent isoform transiently expressed during midembryogenesis...
  76. ncbi The sex determination master switch, Sex-lethal, responds to Hedgehog signaling in the Drosophila germline
    C Vied
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, Alabama 35294, USA
    Development 128:2649-60. 2001
    ..This is the first demonstration that downstream components of the Hedgehog signaling pathway regulate a target other than Cubitus interruptus...
  77. ncbi Inscuteable-dependent apical localization of the microtubule-binding protein Cornetto suggests a role in asymmetric cell division
    S Bulgheresi
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 114:3655-62. 2001
    ....
  78. ncbi rolling pebbles (rols) is required in Drosophila muscle precursors for recruitment of myoblasts for fusion
    A Rau
    Developmental Biology, Philipps Universitat Marburg, 35032 Marburg, Germany
    Development 128:5061-73. 2001
    ..Transplantation assays of rols mutant mesodermal cells into wild-type embryos show that Rols is required in muscle precursor cells and is essential to recruit fusion-competent myoblasts for myotube formation...
  79. pmc Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis
    Elisabetta Bucciarelli
    Istituto Pasteur Fondazione Cenci Bolognetti, 00185 Rome, Italy
    J Cell Biol 160:993-9. 2003
    ..This suggests that the association of Aurora B with chromosomes is not a prerequisite for its accumulation at the central spindle, or for its function during cytokinesis...
  80. ncbi Assembly of yolk spindles in the early Drosophila embryo
    Maria Giovanna Riparbelli
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 4, I 53100 Siena, Italy
    Mech Dev 120:441-54. 2003
    ..The presence of normal and abnormal centrosomes in the same cytoplasm provides an useful model for investigating the common regulators of the nucleus and centrosome cycle which ensure precise spindle pole duplication...
  81. pmc Asymmetric sequence divergence of duplicate genes
    Gavin C Conant
    Department of Biology, The University of New Mexico, Albuquerque, New Mexico 87131, USA
    Genome Res 13:2052-8. 2003
    ..The method is also more sensitive in detecting positive selection (Ka/Ks > 1) than models relying only on pairwise gene comparisons...
  82. ncbi The abnormal spindle protein is required for germ cell mitosis and oocyte differentiation during Drosophila oogenesis
    Maria Giovanna Riparbelli
    Department of Evolutionary Biology, University of Siena, I 53100, Italy
    Exp Cell Res 298:96-106. 2004
    ..spindles of the mutant cystocytes are composed by wavy microtubules and have abnormal poles that often lack gamma-tubulin. The fusome structure is also compromised...
  83. ncbi Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals
    Qiaofang Chen
    Department of Pediatrics and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
    J Exp Biol 207:3125-9. 2004
    ..The mechanism of this protection is probably related to a decrease in protein denaturation through protein-trehalose interactions...
  84. ncbi kette and blown fuse interact genetically during the second fusion step of myogenesis in Drosophila
    Roxane H Schröter
    Philipps Universitat Marburg, Fachbereich Biologie, Entwicklungsbiologie, Karl von Frisch Strasse 8, 35043 Marburg, Germany
    Development 131:4501-9. 2004
    ..We propose a model in which Dumbfounded/Sticks and stones-dependent cell adhesion is mediated over Rolling Pebbles, Myoblast city, Crk, Blown fuse and Kette, and thus induces membrane fusion...
  85. pmc The product of the split ends gene is required for the maintenance of positional information during Drosophila development
    Kimberly Mace
    Surgical Research Lab, University of California, San Francisco, Box 1302, San Francisco, CA 94143 1302, USA
    BMC Dev Biol 4:15. 2004
    ..Although spen mutants affect only a small subset of morphological structures in embryos, it has been difficult to find a common theme in spen mutant structural alterations, or in the interactions of spen with known signaling pathways...
  86. ncbi Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint
    James Ashley
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Neurosci 25:5943-55. 2005
    ..These results provide a novel mechanism by which cell adhesion molecules are regulated and provide fresh insights into the normal operation of APP during synapse development...
  87. ncbi A role for Fas II in the stabilization of motor neuron branches during pruning in Drosophila
    Sarita Hebbar
    Department of Zoology, 250 Pearson Hall, Miami University, Oxford, OH 45056, USA
    Dev Biol 285:185-99. 2005
    ..However, since not all Fas II positive branches are retained, we propose that it primes branches for stabilization. Our data suggest that Fas II functions to restrict branch length and arbor expanse...
  88. ncbi A dominant negative form of Rac1 affects myogenesis of adult thoracic muscles in Drosophila
    Joyce J Fernandes
    Center for Neuroscience, 250 Pearson Hall, Miami University, Oxford, OH 45056, USA
    Dev Biol 285:11-27. 2005
    ..We also show that the recently described DVM founder cells can be labeled with 22C10 and beta-3 tubulin, and that they are present under conditions of dominant negative Rac1(N17) expression...
  89. pmc Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins
    Gohta Goshima
    The Howard Hughes Medical Institute and the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94107, USA
    J Cell Biol 171:229-40. 2005
    ..From these results and simulations, we propose a model on how two minus end-directed motors cooperate to ensure spindle pole coalescence during mitosis...
  90. ncbi Subdivision and developmental fate of the head mesoderm in Drosophila melanogaster
    Begona De Velasco
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Dev Genes Evol 216:39-51. 2006
    ..The lSHM contributes hemocytes, as well as the nephrocytes forming the subesophageal body, also called garland cells...
  91. pmc Misregulation of sex-lethal and disruption of male-specific lethal complex localization in Drosophila species hybrids
    Manika Pal Bhadra
    Division of Biological Sciences, University of Missouri, Columbia 65211 7400, USA
    Genetics 174:1151-9. 2006
    ..Lethal hybrid rescue (Lhr), which allows hybrid males from this cross to survive, corrects the SXL and MSL defects. The reciprocal cross of D. simulans mothers by D. melanogaster males exhibits underexpression of Sxl in embryos...
  92. ncbi Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila
    Stephane Zaffran
    Brookdale Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Development 133:4073-83. 2006
    ....
  93. ncbi The Wiskott-Aldrich syndrome protein (WASP) is essential for myoblast fusion in Drosophila
    Gritt Schäfer
    Fachbereich Biologie, Entwicklungsbiologie, Philipps Universitat Marburg, Karl von Frisch Str 8, D 35043 Marburg, Germany
    Dev Biol 304:664-74. 2007
    ..Furthermore, we show that the myoblast fusion phenotype of kette mutant embryos can be suppressed by reducing the gene dose of wasp3D3-035. Thus, Kette antagonizes WASP function during myoblast fusion...
  94. pmc The Him gene reveals a balance of inputs controlling muscle differentiation in Drosophila
    David Liotta
    Cardiff School of Biosciences, Cardiff University Main Building, Cardiff CF10 3TL, United Kingdom
    Curr Biol 17:1409-13. 2007
    ....
  95. pmc Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network
    Janus S Jakobsen
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Genes Dev 21:2448-60. 2007
    ..The regulatory connection of a number of Biniou target genes is conserved in mice, suggesting an ancient wiring of this developmental program...
  96. ncbi Axoneme specialization embedded in a "generalist" beta-tubulin
    Ellen M Popodi
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Cell Motil Cytoskeleton 65:216-37. 2008
    The relationship between the primary structure of the beta-tubulin C-terminal tail (CTT) and axoneme structure and function is explored using the spermatogenesis-specific beta2-tubulin of Drosophila...
  97. doi Antagonistic function of Lmd and Zfh1 fine tunes cell fate decisions in the Twi and Tin positive mesoderm of Drosophila melanogaster
    Julia Sellin
    Universitat Osnabruck, Fachbereich Biologie Chemie Zoologie Entwicklungsbiologie, Osnabruck, Germany
    Dev Biol 326:444-55. 2009
    ..We show further that Tin repression and pericardial restriction in the dorsal mesoderm facilitated by Lmd is instructed by a late Decapentaplegic (Dpp) signal that is abolished in embryos carrying the disk region mutation dpp(d6)...
  98. ncbi Probing spermatogenesis in Drosophila with P-element enhancer detectors
    P GONCZY
    Rockefeller University, New York City, NY 10021
    Development 114:89-98. 1992
    ..Finally, this collection of marker lines will allow the characterization of genes expressed either in the germ line or in the soma during spermatogenesis...
  99. ncbi A dispersed multigene family encoding tubulin in Drosophila melanogaster
    F Sanchez
    Cell 22:845-54. 1980
    We have used cloned chicken cDNA sequences for alpha- and beta-tubulin to investigate tubulin gene organization in Drosophila melanogaster...
  100. ncbi Intronic and 5' flanking sequences of the Drosophila beta 3 tubulin gene are essential to confer ecdysone responsiveness
    A Bruhat
    Laboratoire de Biochimie Medicale, C J F INSERM 88 06, U F R de Médecine, Clermont Ferrand, France
    Mol Cell Endocrinol 94:61-71. 1993
    The expression of the beta 3 tubulin gene is regulated, at the transcriptional level, by the steroid hormone ecdysone, in Drosophila Kc cells...
  101. ncbi Enhancer and silencer elements within the first intron mediate the transcriptional regulation of the beta 3 tubulin gene by 20-hydroxyecdysone in Drosophila Kc cells
    S Tourmente
    Laboratoire de Biochemie Médicale, CJF INSERM 88 06, UFR de Medecine, Clermont Ferrand, France
    Insect Biochem Mol Biol 23:137-43. 1993
    We have studied the transcriptional regulation of the beta 3 tubulin gene by the steroid hormone 20-hydroxyecdysone (20-E) in Drosophila Kc cells...

Research Grants4

  1. Genetic Control of Tubulin Function in Development
    ELIZABETH RAFF; Fiscal Year: 2005
    ..The basic subunit of microtubules is the alpha, Beta-tubulin heterodimer...
  2. Pruning of Motor Neuronal Arbors
    Joyce Fernandes; Fiscal Year: 2003
    ..These studies will have implications for better understanding the neurodevelopmental basis of diseases such as epilepsy, schizophrenia and Rett's syndrome, where pruning is thought to be defective. ..
  3. Axon stabilization: A role for glia in patterning adult innervation in Drosophila
    Joyce Fernandes; Fiscal Year: 2006
    ..unreadable] [unreadable]..