ct

Summary

Gene Symbol: ct
Description: cut
Alias: BcDNA:GH10590, CG11387, CUT, Cut, Dmel\CG11387, l(1)7Ba, l(1)7Bb, l(1)VE614, CG11387 gene product from transcript CG11387-RE, CG11387-PA, CG11387-PC, CG11387-PD, CG11387-PE, Cut, ct-PA, ct-PC, ct-PD, ct-PE, kinked-femur
Species: fruit fly

Top Publications

  1. ncbi Transformation of sensory organ identity by ectopic expression of Cut in Drosophila
    K Blochlinger
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Genes Dev 5:1124-35. 1991
  2. ncbi Functional analysis of Drosophila and mammalian cut proteins in files
    C Ludlow
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Dev Biol 178:149-59. 1996
  3. pmc Insulation of enhancer-promoter communication by a gypsy transposon insert in the Drosophila cut gene: cooperation between suppressor of hairy-wing and modifier of mdg4 proteins
    M Gause
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Mol Cell Biol 21:4807-17. 2001
  4. ncbi Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:3241-51. 1997
  5. ncbi RNA interference machinery influences the nuclear organization of a chromatin insulator
    Elissa P Lei
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Nat Genet 38:936-41. 2006
  6. ncbi The ubiquitin ligase dTopors directs the nuclear organization of a chromatin insulator
    Maya Capelson
    Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Mol Cell 20:105-16. 2005
  7. ncbi Knot/Collier and cut control different aspects of dendrite cytoskeleton and synergize to define final arbor shape
    Shiho Jinushi-Nakao
    RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Neuron 56:963-78. 2007
  8. ncbi Antagonistic regulation of the Drosophila PCNA gene promoter by DREF and Cut
    Hirokazu Seto
    Department of Applied Biology, Kyoto Institute of Technology, Sakyo ku, Kyoto 606 8585, Japan
    Genes Cells 11:499-512. 2006
  9. ncbi Selective expression of Knot/Collier, a transcriptional regulator of the EBF/Olf-1 family, endows the Drosophila sensory system with neuronal class-specific elaborated dendritic patterns
    Yukako Hattori
    Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    Genes Cells 12:1011-22. 2007
  10. ncbi Study of the posterior spiracles of Drosophila as a model to understand the genetic and cellular mechanisms controlling morphogenesis
    N Hu
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, United Kingdom
    Dev Biol 214:197-210. 1999

Research Grants

Detail Information

Publications167 found, 100 shown here

  1. ncbi Transformation of sensory organ identity by ectopic expression of Cut in Drosophila
    K Blochlinger
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Genes Dev 5:1124-35. 1991
    The loss of cut activity results in a change in neural identity in the peripheral nervous system so that the neurons and support cells of external sensory (es) organs are transformed into those of internal chordotonal (ch) organs, cut ..
  2. ncbi Functional analysis of Drosophila and mammalian cut proteins in files
    C Ludlow
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Dev Biol 178:149-59. 1996
    The cut locus acts as a bimodal switch controlling cell fate in the peripheral nervous system of Drosophila and is also required for the development of the wing margin...
  3. pmc Insulation of enhancer-promoter communication by a gypsy transposon insert in the Drosophila cut gene: cooperation between suppressor of hairy-wing and modifier of mdg4 proteins
    M Gause
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Mol Cell Biol 21:4807-17. 2001
    ..by showing that some loss-of-function mod(mdg4) mutations decrease enhancer blocking by a gypsy insert in the cut gene. We find that the C terminus of Mod(mdg4)-67...
  4. ncbi Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:3241-51. 1997
    ..non-autonomous effects on proliferation, and activating expression of the target genes E(spl), wingless and cut. The analysis of these clones reveals several mechanisms important for maintaining and delimiting Notch function at ..
  5. ncbi RNA interference machinery influences the nuclear organization of a chromatin insulator
    Elissa P Lei
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Nat Genet 38:936-41. 2006
    ..These results suggest that the RNAi machinery acts as a modulator of nuclear architecture capable of effecting global changes in gene expression...
  6. ncbi The ubiquitin ligase dTopors directs the nuclear organization of a chromatin insulator
    Maya Capelson
    Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Mol Cell 20:105-16. 2005
    ..Thus, dTopors appears to be involved in the establishment of chromatin organization through its ability to mediate the association of insulator complexes with a fixed nuclear substrate...
  7. ncbi Knot/Collier and cut control different aspects of dendrite cytoskeleton and synergize to define final arbor shape
    Shiho Jinushi-Nakao
    RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Neuron 56:963-78. 2007
    ..We show that the combination of the transcription factors Knot and Cut is particular to Drosophila class IV dendritic arborization (da) neurons...
  8. ncbi Antagonistic regulation of the Drosophila PCNA gene promoter by DREF and Cut
    Hirokazu Seto
    Department of Applied Biology, Kyoto Institute of Technology, Sakyo ku, Kyoto 606 8585, Japan
    Genes Cells 11:499-512. 2006
    ..screen using three tandem repeats of DRE in dPCNA promoter as the bait allowed isolation of a cDNA encoding Cut, a Drosophila homolog of mammalian CCAAT-displacement protein (CDP)/Cux...
  9. ncbi Selective expression of Knot/Collier, a transcriptional regulator of the EBF/Olf-1 family, endows the Drosophila sensory system with neuronal class-specific elaborated dendritic patterns
    Yukako Hattori
    Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    Genes Cells 12:1011-22. 2007
    ..with dramatic alterations in the expression patterns of two other transcriptional regulators, Abrupt (Ab) and Cut (Ct), which play important roles in shaping dendritic trees with distinct class specificity from Kn...
  10. ncbi Study of the posterior spiracles of Drosophila as a model to understand the genetic and cellular mechanisms controlling morphogenesis
    N Hu
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, United Kingdom
    Dev Biol 214:197-210. 1999
    ..This results in a spiracle without a lumen and with the tracheal opening located outside it...
  11. ncbi Cellular mechanisms of dendrite pruning in Drosophila: insights from in vivo time-lapse of remodeling dendritic arborizing sensory neurons
    Darren W Williams
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    Development 132:3631-42. 2005
    ..Finally, we find that phagocytic blood cells not only engulf neuronal debris but also attack and sever intact branches that show signs of destabilization...
  12. pmc The Hippo pathway regulates apical-domain size independently of its growth-control function
    Alice Genevet
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 122:2360-70. 2009
    ..Therefore, Hippo signalling controls growth and apical domain size by distinct mechanisms...
  13. ncbi Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila
    Sudip Mandal
    Department of Molecular, Cell, and Developmental Biology, Department of Biological Chemistry and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    Dev Cell 9:843-54. 2005
    ..We demonstrate that in multiple tissues the mitochondrion has a direct and specific role in enforcing a G1-S cell cycle checkpoint during periods of energy deprivation...
  14. ncbi Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for notch activity in wing margin establishment in Drosophila
    P Ligoxygakis
    Institute of Molecular Biology, Foundation for Research and Technology Department of Biology, University of Crete, Vasilika Vouton, GR 71110, Heraklion, Greece
    Development 126:2205-14. 1999
    ..of the vg quadrant enhancer, whereas later they appear to relay the Notch signal that triggers activation of cut expression. Of the seven proteins, E(spl)mgamma is most active in both of these processes...
  15. ncbi The centrosomal protein CP190 is a component of the gypsy chromatin insulator
    Chi Yun Pai
    Department of Biology, Johns Hopkins University, 3400 N Charles Street, Baltimore, Maryland 21218, USA
    Mol Cell 16:737-48. 2004
    ..The results suggest that endogenous gypsy insulators contain binding sites for CP190, which is essential for insulator function, and may or may not contain binding sites for Su(Hw) and Mod(mdg4)2.2...
  16. pmc Genetic regulation of patterned tubular branching in Drosophila
    E Hatton-Ellis
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Proc Natl Acad Sci U S A 104:169-74. 2007
    ..the tubular gut and results in the spatially restricted coexpression of two transcription factors, Krüppel and Cut, in the hindgut, whose activity drives cells toward renal tubule fate...
  17. ncbi Dendrite self-avoidance is controlled by Dscam
    Benjamin J Matthews
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Cell 129:593-604. 2007
    ..The selectivity of Dscam-mediated cell interactions is likely to be widely important in the developing fly nervous system, where processes of cells must distinguish between self and nonself during the construction of neural circuits...
  18. ncbi UDP-sugar transporter implicated in glycosylation and processing of Notch
    S Goto
    Genetic Strain Research Center, National Institute of Genetics, Mishima, Shizuoka ken 411 8540, Japan
    Nat Cell Biol 3:816-22. 2001
    ..The results suggest that changes in nucleotide-sugar levels can differently affect Wingless and two distinct aspects of Notch signalling...
  19. ncbi Molecular organization of the cut locus of Drosophila melanogaster
    J W Jack
    Cell 42:869-76. 1985
    Mutations of the cut locus (ct) of Drosophila can be divided into four groups based on their phenotypes and complementation patterns. Each group alters the phenotype of a different set of tissues...
  20. pmc Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase
    Keisuke Kamimura
    Dept of Genetics, Cell Biology, and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    J Cell Biol 166:1069-79. 2004
    ..These findings suggest that Hs3st-B is involved in Notch signaling by affecting stability or intracellular trafficking of Notch protein...
  21. ncbi Chromatin insulators and boundaries: effects on transcription and nuclear organization
    T I Gerasimova
    Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, UDA
    Annu Rev Genet 35:193-208. 2001
    ..Insulators might modulate transcription by organizing the chromatin fiber within the nucleus through the establishment of higher-order domains of chromatin structure...
  22. ncbi An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling
    Leo Tsuda
    Department of Biological Chemistry and Department of Human Genetics, Molecular Biology Institute, Los Angeles, CA 90095, USA
    Cell 110:625-37. 2002
    ..EGFR-activated transcriptional derepression requires ebi and sno, is proteasome-dependent, and correlates with the translocation of SMRTER to the cytoplasm...
  23. ncbi Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development
    Antonio J Giraldez
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 130:6533-43. 2003
    ..However, only part of this effect was attributable to Notch-dependent induction of Wg, suggesting that other Notch-inducible signaling molecules contribute to the control of cell proliferation in the wing...
  24. ncbi The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
    Eric C Lai
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, 545 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Development 132:2319-32. 2005
    ..We conclude that ubiquitination of Delta and Serrate by Neuralized and D-mib is an obligate feature of DSL ligand activation throughout Drosophila development...
  25. pmc 'Insulator bodies' are aggregates of proteins but not of insulators
    Anton Golovnin
    Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34 5 Vavilov Street, Moscow 119334, Russia
    EMBO Rep 9:440-5. 2008
    ..Hence, it is not the functional genomic insulators but rather aggregated proteins that make the so-called 'insulator bodies'...
  26. ncbi numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos
    T Uemura
    Howard Hughes Medical Institute, University of California, San Francisco, 94143 0724
    Cell 58:349-60. 1989
    ..Thus the numb gene controls the fate of progeny derived from sensory organ precursors. The numb gene has been isolated by the plasmid rescue method. The structure of its predicted product is discussed...
  27. pmc Dominant effects of suppressor of Hairy-wing mutations on gypsy-induced alleles of forked and cut in Drosophila melanogaster
    K K Hoover
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218
    Genetics 132:691-7. 1992
    Mutations induced by the gypsy retrotransposon in the forked (f) and cut (ct) loci render their expression under the control of the suppressor of Hairy-wing [su(Hw)] gene...
  28. ncbi Patterning of the Drosophila nervous system: the achaete-scute gene complex
    S Campuzano
    Centro de Biologia Molecular, CSIC, Madrid, Spain
    Trends Genet 8:202-8. 1992
    ..Neuroblasts or sensory organ mother cells are born within these clusters. Thus, the patterns of expression of the AS-C genes help to define the topology of the nervous system...
  29. pmc Patterning muscles using organizers: larval muscle templates and adult myoblasts actively interact to pattern the dorsal longitudinal flight muscles of Drosophila
    S Roy
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560012, India
    J Cell Biol 141:1135-45. 1998
    ..Since the use of such organizers is a common theme in myogenesis in several organisms, it is likely that many of the processes that we describe are conserved...
  30. ncbi Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila
    T L Jacobsen
    Program in Genetics, Cell and Developmental Biology, Department of Biology, Indiana University, Bloomington, Indiana, USA
    Development 125:4531-40. 1998
    ....
  31. ncbi Combinatorial signaling in the specification of primary pigment cells in the Drosophila eye
    Raghavendra Nagaraj
    Department of Molecular, Cell and Developmental Biology, Department of Biological Chemistry, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Development 134:825-31. 2007
    ..Combined with previous work, these data show that unique combinations of only two pathways--Notch and EGFR--can specify at least five different cell types within the Drosophila eye...
  32. doi Control of multidendritic neuron differentiation in Drosophila: the role of Collier
    Michele Crozatier
    Centre de Biologie du Developpement, UMR 5547 and IFR 109, CNRS and Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 09, France
    Dev Biol 315:232-42. 2008
    ..Col control on dendrite branching is distinct from that exerted by Cut, another transcription factor expressed in class IV neurons and necessary for proper dendrite morphogenesis...
  33. doi Determination of cell fates in the R7 equivalence group of the Drosophila eye by the concerted regulation of D-Pax2 and TTK88
    Yandong Shi
    Institute for Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dev Biol 331:68-77. 2009
    ..Thus, the fates of R1/R6/R7 and cone cells are determined by a dual mechanism that coordinately activates one fate while inhibiting the other...
  34. ncbi Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase
    B J Dickson
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 80:453-62. 1995
    ..phyl thus represents a possible target gene of the Raf pathway during eye development, controlling the fates of a novel subset of photoreceptors...
  35. ncbi The wingless signalling pathway and the patterning of the wing margin in Drosophila
    J P Couso
    Department of Zoology, University of Cambridge, UK
    Development 120:621-36. 1994
    ..The expression of the genes cut and achaete in a small domain in the prospective wing margin region reflects the activity of wg and probably ..
  36. ncbi Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc
    R J Fleming
    Department of Biology, The University of Rochester, NY 14627, USA
    Development 124:2973-81. 1997
    ..Furthermore, replacement of the N-terminal region of Serrate with the corresponding region of Delta abolishes the ability of fringe to regulate Serrate without altering Serrate-specific signaling...
  37. ncbi cut interacts with Notch and protein kinase A to regulate egg chamber formation and to maintain germline cyst integrity during Drosophila oogenesis
    S M Jackson
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Development 124:3663-72. 1997
    ..In this report, we demonstrate that the function of a somatically expressed gene, cut, is critical for maintaining the structural integrity of germline-derived cells and their arrangement within an egg ..
  38. ncbi Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila
    M Gho
    Laboratoire de Génétique du Développement de la Drosophile, URA 1857, Ecole Normale Superieure, Paris, France
    Nature 393:178-81. 1998
    ..This difference in cell-division orientation is largely independent of the identity of the secondary precursor cells, and is regulated by Frizzled-independent mechanisms...
  39. ncbi Multiple functions of the EGF receptor in Drosophila eye development
    M Dominguez
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Biol 8:1039-48. 1998
    ..Its importance in the recruitment of photoreceptors in the developing fly eye, a useful model for neural development, has already been reported. Other EGFR functions in the eye have not been characterised...
  40. ncbi Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function
    W Helms
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Dev Biol 215:358-74. 1999
    ..are modified by mutations in Notch and Wg pathway genes and are correlated with depressed expression of wg, cut, and vg...
  41. pmc Covalent modification of the transcriptional repressor tramtrack by the ubiquitin-related protein Smt3 in Drosophila flies
    F Lehembre
    Unite de Recombinaison et Expression Genetique, INSERM U 163, Institut Pasteur, 75724 Paris Cedex 15, France
    Mol Cell Biol 20:1072-82. 2000
    ..Altogether, these data indicate a high conservation of the Smt3 conjugation pathway and further suggest that this mechanism may play a role in the transcriptional regulation of cell differentiation in Drosophila flies...
  42. ncbi The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe
    J F de Celis
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Development 127:1291-302. 2000
    ..ligands Delta and Serrate is required to make the dorsoventral boundary, where several genes, such as wingless and cut, are expressed in a 2- to 4-cell-wide domain...
  43. pmc Notch signaling directly controls cell proliferation in the Drosophila wing disc
    A Baonza
    Centro de Biologia Molecular Severo Ochoa Consejo Superior de Investigaciones Cientificas, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Proc Natl Acad Sci U S A 97:2609-14. 2000
    ..We propose that the nonautonomous effects (induction of extraproliferation and vein differentiation in the surrounding wild-type cells) result from pattern accommodation to positional values caused by the ectopic expression of Notch...
  44. ncbi R7 photoreceptor specification requires Notch activity
    M T Cooper
    Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY, Cambridge, UK
    Curr Biol 10:1507-10. 2000
    ....
  45. ncbi Control of a genetic regulatory network by a selector gene
    K A Guss
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
    Science 292:1164-7. 2001
    ..The obligate integration of selector and signaling protein inputs on cis-regulatory DNA may be a general mechanism by which selector proteins control extensive genetic regulatory networks during development...
  46. ncbi Translational repression determines a neuronal potential in Drosophila asymmetric cell division
    M Okabe
    Division of Developmental Genetics, National Institute of Genetics, and Department of Genetics, Graduate University for Advanced Studies, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Nature 411:94-8. 2001
    ..Thus, Notch signalling is likely to regulate MSI activity rather than its expression. Our results define cell-type-specific translational control of ttk69 by MSI as a downstream event of Notch signalling in asymmetric cell division...
  47. ncbi hamlet, a binary genetic switch between single- and multiple- dendrite neuron morphology
    Adrian W Moore
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, CA 94143, USA
    Science 297:1355-8. 2002
    ..Moreover, hamlet expression induced in MD neurons undergoing dendrite outgrowth drastically reduces arbor branching...
  48. ncbi Binary cell death decision regulated by unequal partitioning of Numb at mitosis
    Virginie Orgogozo
    Ecole Normale Superieure, CNRS UMR 8542, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Development 129:4677-84. 2002
    ..Our study also indicates that regulation of programmed cell death modulates the final pattern of sensory organs in a segment-specific manner...
  49. ncbi Different levels of the homeodomain protein cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons
    Wesley B Grueber
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, 533 Parnassus Avenue, Room U226, San Francisco, CA 94143, USA
    Cell 112:805-18. 2003
    ..Here, we show in embryonic and larval development that the level of Cut immunoreactivity in individual dendritic arborization (da) sensory neurons correlates with distinct patterns of ..
  50. pmc In vivo analysis of a developmental circuit for direct transcriptional activation and repression in the same cell by a Runx protein
    Jude Canon
    Department of Biological Chemistry and Department of Molecular, Cell, and Developmental Biology, Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Genes Dev 17:838-43. 2003
    ..We describe a regulatory circuit in which Lz causes transcriptional activation of the homeodomain protein Cut, which can then stabilize a Lz repressor complex in the same cell...
  51. ncbi Unequal segregation of Neuralized biases Notch activation during asymmetric cell division
    Roland Le Borgne
    Departement de Biologie, Ecole Normale Superieure, CNRS UMR 8542, 46, rue d Ulm 75230, Cedex, Paris, France
    Dev Cell 5:139-48. 2003
    ..We propose that coordinated upregulation of ligand activity by Neuralized and inhibition of receptor activity by Numb results in a robust bias in Notch signaling...
  52. ncbi Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development
    Yi A Zeng
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada
    Development 131:2911-20. 2004
    ..These observations suggest that the patterning mechanism governed by Wg involves a negative feedback circuit in which Wg induces expression of its own antagonist Nemo...
  53. ncbi Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch
    Weidong Wang
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
    Development 131:5367-80. 2004
    ..Alternatively Epsin may be required to target mono-ubiquitinated DSL proteins to a particular subclass of coated pits that have special properties essential for Notch activation...
  54. pmc Notch-dependent downregulation of the homeodomain gene cut is required for the mitotic cycle/endocycle switch and cell differentiation in Drosophila follicle cells
    Jianjun Sun
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4370, USA
    Development 132:4299-308. 2005
    ..We show that the homeodomain gene cut functions as a linker between Notch and genes that are involved in cell-cycle progression...
  55. pmc Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-secretase activity
    Héctor Herranz
    ICREA and Institut de Recerca Biomedica, Parc Cientific de Barcelona, Josep Samitier, 1 5, 08028 Barcelona, Spain
    EMBO Rep 7:297-302. 2006
    ..These results indicate a novel molecular mechanism of the regulation of Notch signal, and also that defects in Crumbs might be involved in similar abnormal gamma-Secretase complex activity observed in Alzheimer's disease...
  56. pmc Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells
    Katherine C Jordan
    Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195, USA
    BMC Dev Biol 6:16. 2006
    ..Previously, we showed that Notch signaling is required for the mitotic-to-endocycle transition, through downregulating String/Cdc25, and Dacapo/p21 and upregulating Fizzy-related/Cdh1...
  57. pmc Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte
    John S Poulton
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4370, USA
    Proc Natl Acad Sci U S A 103:12775-80. 2006
    ..Our data indicate that Dystroglycan links EGFR-induced repression of the anterior follicle cell fate and anterior-posterior polarity formation in the oocyte...
  58. pmc Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis
    Marcus Glittenberg
    Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, UK
    EMBO J 25:4697-706. 2006
    ..The balance of ubiquitinated/unubiquitinated ligand will thus affect the signalling capacity of the cell at several levels...
  59. ncbi The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila
    Ciara M Gallagher
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 11:641-53. 2006
    ..Our experiments suggest that Lgd is a critical regulator of endocytosis that is not present in yeast and acts in the degradative pathway after Hrs...
  60. pmc Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis
    Jennifer L Childress
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 16:2228-33. 2006
    ..Taken together, our data identify Lgd as a novel tumor-suppressor protein that regulates Notch signaling by targeting Notch for degradation or recycling...
  61. pmc Hindsight mediates the role of notch in suppressing hedgehog signaling and cell proliferation
    Jianjun Sun
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    Dev Cell 12:431-42. 2007
    ..To do so, it represses string, Cut, and Hedgehog signaling, which promote proliferation during early oogenesis...
  62. pmc Endosomal entry regulates Notch receptor activation in Drosophila melanogaster
    Thomas Vaccari
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Cell Biol 180:755-62. 2008
    ....
  63. pmc The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity
    Jianzhong Yu
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS ONE 3:e1761. 2008
    ....
  64. doi Dendrite branching and self-avoidance are controlled by Turtle, a conserved IgSF protein in Drosophila
    Hong Long
    Centre for Research in Neuroscience and Department of Neurology and Neurosurgery, McGill University, and the McGill University Health Centre Research Institute, QC, Canada
    Development 136:3475-84. 2009
    ....
  65. ncbi Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut
    E J Neufeld
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nat Genet 1:50-5. 1992
    ..The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and "cut repeats"...
  66. ncbi Regulatory interactions and role in cell type specification of the Malpighian tubules by the cut, Krüppel, and caudal genes of Drosophila
    S Liu
    Program in Molecular Biology, Sloan Kettering Institute, New York, New York
    Dev Biol 150:133-43. 1992
    ..and caudal genes are both required for normal segmentation of the embryo, and the developmental regulatory gene cut is necessary for the normal specification of external sensory organs...
  67. ncbi prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Cell 67:941-53. 1991
    ..prospero encodes a large nuclear protein with multiple homopolymeric amino acid stretches and is expressed in neuronal precursors early during their formation. It is probably generally required for proper neuronal differentiation...
  68. ncbi Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila
    K Blochlinger
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Nature 333:629-35. 1988
    In the absence of cut gene activity in Drosophila, external sensory organs are transformed into chordotonal organs...
  69. ncbi Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes
    N H Patel
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
    Methods Cell Biol 44:445-87. 1994
  70. ncbi tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS
    M Guo
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco 94143, USA
    Neuron 14:913-25. 1995
    ..Epistatic studies suggest that ttk acts downstream of numb. We propose that ttk executes the command dictated by asymmetrically localized numb to specify distinct daughter cell fates during multiple asymmetric divisions...
  71. pmc Structure and regulation of a complex locus: the cut gene of Drosophila
    J Jack
    Department of Anatomy, University of Connecticut Health Center, Framington 06030, USA
    Genetics 139:1689-700. 1995
    The cut locus encodes a homeobox protein that is localized in the nuclei of a variety of tissues and is required for proper morphogenesis of those tissues...
  72. ncbi A new bipartite DNA-binding domain: cooperative interaction between the cut repeat and homeo domain of the cut homeo proteins
    V Andres
    Department of Cardiology, Children s Hospital, Boston, Massachusetts 02115
    Genes Dev 8:245-57. 1994
    The recently cloned Clox (Cut-like homeo box) and CDP (CCAAT displacement protein), two mammalian counterparts of the Drosophila Cut homeo protein, correspond to alternatively spliced products of the same gene (mClox, for mammalian Cut-..
  73. ncbi shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia
    U Tepass
    Department of Molecular Cellular Developmental Biology, University of California at Los Angeles, 90024 1606, USA
    Genes Dev 10:672-85. 1996
    ..We find that in zygotic shg nulls the level of Dalpha-catenin and Armadillo at adherens junctions is dramatically reduced, surprisingly also in epithelia that differentiate normally and possess a zonula adherens...
  74. ncbi Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation
    D Doherty
    Howard Hughes Medical Institute, University of California, San Francisco, 94143 0724, USA
    Genes Dev 10:421-34. 1996
    ..Moreover, ectopic Delta expression induces wingless, vestigial, and cut and causes adult wing tissue outgrowth in the dorsal compartment...
  75. pmc The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein
    J Kim
    Molecular Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 16:3381-92. 1996
    ..deletion mutants to support female fertility and to alter expression of gypsy insertion alleles of the yellow, cut, forked, and Ultrabithorax genes...
  76. ncbi Control of daughter cell fates during asymmetric division: interaction of Numb and Notch
    M Guo
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Neuron 17:27-41. 1996
    ..This leads to Ttk expression in the daughter cell that does not inherit Numb. Thus, the inherited determinant Numb bestows a bias in the machinery for cell-cell communication to allow the specification of distinct daughter cell fates...
  77. ncbi wingless signaling in the Drosophila eye and embryonic epidermis
    K M Cadigan
    Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA
    Development 122:2801-12. 1996
    ..However, we present evidence that wingless signaling still occurs normally in the complete absence of Notch protein in the embryonic epidermis. Thus, in the simplest model for wingless signalling, a direct role for Notch is unlikely...
  78. ncbi A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing
    C J Neumann
    European Molecular Biology Laboratory, Heidelberg, Germany
    Development 122:3477-85. 1996
    ..In addition, the Notch and Wingless pathways act synergistically to regulate expression of cut in cells at the dorsal/ventral boundary...
  79. ncbi The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate
    C A Micchelli
    Department of Zoology, University of Wisconsin, Madison 53706, USA
    Development 124:1485-95. 1997
    ..role of the Notch and Wingless signaling pathways in the maintenance of wing margin identity through the study of cut, a homeobox-containing transcription factor and a late-arising margin-specific marker...
  80. ncbi Transcription factors in eye development: a gorgeous mosaic?
    J Kumar
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    Genes Dev 11:2023-8. 1997
  81. ncbi Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless
    S Wang
    Howard Hughes Medical Institute, and Department of Physiology, University of California, San Francisco 94143 0724, USA
    Development 124:4435-46. 1997
    ..These studies reveal that Suppressor of Hairless is required for only a subset of the asymmetric divisions that depend on the function of numb and Notch...
  82. ncbi Dorsal-ventral signaling in limb development
    K D Irvine
    Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08854 8020, USA
    Curr Opin Cell Biol 9:867-76. 1997
    ....
  83. ncbi Dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS
    E Kurant
    Unit of Genetics, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Development 125:1037-48. 1998
    ..Based on our observations we propose that the genetic interactions between hth and exd serve as a novel mechanism for regulating homeotic protein activity in embryonic PNS development...
  84. ncbi Polycomb and trithorax group proteins mediate the function of a chromatin insulator
    T I Gerasimova
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Cell 92:511-21. 1998
    ..The results suggest a model in which PcG and TrxG proteins regulate insulator function by establishing higher order domains of chromatin organization required for the assembly of functional insulators at the nuclear matrix...
  85. ncbi Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing
    K M Cadigan
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University Medical Center, California 94305, USA
    Cell 93:767-77. 1998
    ..In contrast to other ligand-receptor relationships where the receptor limits diffusion of the ligand, Dfz2 broadens the range of Wg action by protecting it from degradation...
  86. ncbi Specification of primary pigment cell and outer photoreceptor fates by BarH1 homeobox gene in the developing Drosophila eye
    T Hayashi
    Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Dev Biol 200:131-45. 1998
    ..In primary pigment cells generated by cone cell transformation, the expression of cut, a homeobox gene specific to cone cells, was completely replaced with that of Bar homeobox genes...
  87. pmc The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development
    C Zeng
    Howard Hughes Medical Institute, Department of Physiology and Department of Biochemistry, University of California at San Francisco, San Francisco, CA 94143 0725, USA
    Proc Natl Acad Sci U S A 95:10637-42. 1998
    ..A mammalian homolog of dLMO is expressed in the developing limb bud of the mouse. This indicates that LMO proteins might function in an evolutionarily conserved mechanism involved in patterning the appendages...
  88. ncbi A dual role for homothorax in inhibiting wing blade development and specifying proximal wing identities in Drosophila
    F Casares
    Department of Biochemistry and Molecular Biophysics, Columbia University, HHSC 1108, New York, NY 10032 USA
    Development 127:1499-508. 2000
    ..Our results suggest that tsh and hth block wing blade development by repressing some of the activities of the Notch pathway at the D/V compartment boundary...
  89. ncbi Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila
    R Nolo
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 102:349-62. 2000
    ..Sens is then in turn required to further activate and maintain proneural gene expression. This feedback mechanism is essential for selective enhancement and maintenance of proneural gene expression in the SOPs...
  90. pmc The N-terminal BTB/POZ domain and C-terminal sequences are essential for Tramtrack69 to specify cell fate in the developing Drosophila eye
    Y Wen
    Department of Biology and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 156:195-203. 2000
    ..A dCtBP consensus binding motif in the C terminus appears to contribute to Ttk69 activity, but it cannot be fully responsible for the function of the C terminus...
  91. ncbi Expression of fringe is down regulated by Gurken/Epidermal Growth Factor Receptor signalling and is required for the morphogenesis of ovarian follicle cells
    D Zhao
    The University of Edinburgh, Institute of Cell and Molecular Biology, Darwin Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    J Cell Sci 113:3781-94. 2000
    ..This has been confirmed by re-examination of fng mutants and analysis of fng mutant clones in oogenesis...
  92. ncbi A chromatin insulator determines the nuclear localization of DNA
    T I Gerasimova
    Department of Biology The Johns Hopkins University, Baltimore, MD 21218, USA
    Mol Cell 6:1025-35. 2000
    ..The results suggest that the nuclear organization imposed by the gypsy insulator on the chromatin fiber is important for gene expression...
  93. pmc Naked cuticle targets dishevelled to antagonize Wnt signal transduction
    R Rousset
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 15:658-71. 2001
    ..Our results suggest that Nkd acts directly through Dsh to limit Wg activity and thus determines how efficiently Wnt signals stabilize Armadillo (Arm)/beta-catenin and activate downstream genes...
  94. ncbi The selector gene cut represses a neural cell fate that is specified independently of the Achaete-Scute-Complex and atonal
    R Brewster
    Department of Biology, The University of Michigan, 830 North University, 48109 1048, Ann Arbor, MI, USA
    Mech Dev 105:57-68. 2001
    ..ASC normally acts via the neural selector gene cut to specify appropriate sensory organ identities...
  95. ncbi A dual function of phyllopod in Drosophila external sensory organ development: cell fate specification of sensory organ precursor and its progeny
    H Pi
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan 11529
    Development 128:2699-710. 2001
    ..Thus, these analyses demonstrate that phyl acts downstream of N signaling in controlling cell fates in es organ development...
  96. ncbi The LRR proteins capricious and Tartan mediate cell interactions during DV boundary formation in the Drosophila wing
    M Milan
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Cell 106:785-94. 2001
    ....
  97. ncbi neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis
    E Pavlopoulos
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Crete, Greece
    Dev Cell 1:807-16. 2001
    ..The potent modulatory effect of Neur on Dl activity makes Neur a candidate for establishing signaling asymmetries within cellular equivalence groups...
  98. ncbi A genetic hierarchy establishes mitogenic signalling and mitotic competence in the renal tubules of Drosophila
    Vikram Sudarsan
    Centre for Developmental Genetics, BMS, University of Sheffield, UK, S10 2TN
    Development 129:935-44. 2002
    ....
  99. pmc Trans-splicing as a novel mechanism to explain interallelic complementation in Drosophila
    Fabien Mongelard
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 160:1481-7. 2002
    ..A conclusion from this observation is that the trans-splicing reaction that takes place between transcripts produced on two different mutant chromosomes ensures wild-type levels of functional protein...
  100. ncbi Distinction between color photoreceptor cell fates is controlled by Prospero in Drosophila
    Tiffany Cook
    Department of Biology, New York University, 1009 Main Building, 100 Washington Square East, New York, NY 10003, USA
    Dev Cell 4:853-64. 2003
    ..Furthermore, this study provides transcriptional targets for pros that may lend insight into its role in regulating neuronal development in flies and vertebrates...
  101. ncbi The control of dendrite development
    Yuh Nung Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuron 40:229-42. 2003
    ..In contrast, the control of dendrite development is still much less well understood. However, recent progress has begun to shed light on the molecular mechanisms that orchestrate dendrite growth, arborization, and guidance...

Research Grants16

  1. MOLECULAR SEQUENCE DATA
    Samuel Karlin; Fiscal Year: 2001
    ..by spacings between repeats, and by properties of repeat families (intergenic, coding, direct, inverted, mixed). ..
  2. A Drosophilia Model of Amyotrophic Lateral Schlerosis
    Stephen Jackson; Fiscal Year: 2004
    ..Results from this work should clarify the normal cellular role of the ALS2 gene and may reveal strategies for treatment of ALS disease. ..
  3. Gene Expression Levels Across Diverse Genomes
    Samuel Karlin; Fiscal Year: 2006
    ..A third major objective of our research will be to extend our codon usage methods for predicting gene expression levels to eukaryotic genomes, including yeast, D. melanogaster, C. elegans, and human. [unreadable] [unreadable]..
  4. Genetic Modifiers of Epstein-Barr Virus/Host Interactns
    AMY ADAMSON; Fiscal Year: 2003
    ..The results from this genetic screen will shed light onto the mechanisms by which EBV alters normal cellular functions, as well as how genetic predisposition may play a role in EBV-related diseases. ..
  5. Gene Activation by Remote Transcriptional Enhancers
    Dale Dorsett; Fiscal Year: 2004
    ..Drosophila Nipped-B protein in a genetic screen for factors that support activation by a distant enhancer in the cut gene...
  6. High-Volume Confocal Imaging System
    Stephen Crews; Fiscal Year: 2005
    ..The Pascal will allow the labs to expeditiously and comprehensively study the cellular basis of embryonic development in combination with existing bright-field and spinning disk microscopes. ..
  7. A new site-specific recombination system in Drosophila
    Georg Halder; Fiscal Year: 2005
    ..These tools will have broad applications and will lead to the discovery of novel genetic interactions in Drosophila that could not have been detected using currently available methods. ..
  8. Genetic Analysis of Heavy Metals Neurotoxicity
    Fen Biao Gao; Fiscal Year: 2005
    ....
  9. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2006
    ....
  10. Identification of Genetic Modifiers of an Epstein-Barr Virus Protein.
    AMY ADAMSON; Fiscal Year: 2007
    ..Our studies aim to find human genes whose protein products enhance or suppress Epstein-Barr virus protein activity. [unreadable] [unreadable] [unreadable]..
  11. Animal Models For Studying Angelman Syndrome, A Developmental Brain Disorder
    Fen Biao Gao; Fiscal Year: 2008
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page J Description, [unreadable] [unreadable]..
  12. Drosophila deafness genes: analysis of chordotonal organ functions
    Daniel F Eberl; Fiscal Year: 2010
    ..We plan to use cut mutants initially as a paradigm...
  13. Receptor Tyrosine Kinase Regulation of Nuclear Import
    Lizabeth Perkins; Fiscal Year: 2004
    ..g. Csw) directly participate in the process of nuclear import will contribute to a greater understanding of how signaling pathways control cellular growth and differentiation. ..
  14. ELECTRONIC ATLAS OF FETAL BRAIN GENE EXPRESSION
    Tom Strachan; Fiscal Year: 2004
    ..abstract_text> ..
  15. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010
    ..abstract_text> ..