Dfd

Summary

Gene Symbol: Dfd
Description: Deformed
Alias: BG:DS00276.5, CG2189, DFD, DmDfd, Dmel\CG2189, EbR11, dfd, l(3)84Ae, CG2189 gene product from transcript CG2189-RA, CG2189-PA, Dfd-PA, deformed
Species: fruit fly

Top Publications

  1. ncbi Abdominal-B protein isoforms exhibit distinct cuticular transformations and regulatory activities when ectopically expressed in Drosophila embryos
    M A Kuziora
    Department of Biological Sciences, University of Pittsburgh, PA 15260
    Mech Dev 42:125-37. 1993
  2. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  3. ncbi Homeotic genes have specific functional roles in the establishment of the Drosophila embryonic peripheral nervous system
    J G Heuer
    Howard Hughes Medical Institute, Department of Biology, Indiana University, Bloomington 47405
    Development 115:35-47. 1992
  4. ncbi Expression and embryonic function of empty spiracles: a Drosophila homeo box gene with two patterning functions on the anterior-posterior axis of the embryo
    D Dalton
    Department of Human Genetics, Yale University, New Haven, Connecticut 06511
    Genes Dev 3:1940-56. 1989
  5. ncbi A genetic and developmental analysis of mutations in the Deformed locus in Drosophila melanogaster
    V K Merrill
    Dev Biol 122:379-95. 1987
  6. ncbi Specification of anteroposterior cell fates in Caenorhabditis elegans by Drosophila Hox proteins
    C P Hunter
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0554, USA
    Nature 377:229-32. 1995
  7. ncbi The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene
    J J Zhao
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029 6574
    Genes Dev 7:343-54. 1993
  8. ncbi Functional analysis of the mouse homeobox gene HoxB9 in Drosophila development
    J Malicki
    Department of Genetics, Yale University, New Haven, CT 06511
    Mech Dev 42:139-50. 1993
  9. ncbi Switching the in vivo specificity of a minimal Hox-responsive element
    S K Chan
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Development 124:2007-14. 1997
  10. ncbi A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development
    G Gellon
    Department of Biology, Yale University, New Haven, CT 06520 8114, USA
    Development 124:3321-31. 1997

Scientific Experts

Detail Information

Publications113 found, 100 shown here

  1. ncbi Abdominal-B protein isoforms exhibit distinct cuticular transformations and regulatory activities when ectopically expressed in Drosophila embryos
    M A Kuziora
    Department of Biological Sciences, University of Pittsburgh, PA 15260
    Mech Dev 42:125-37. 1993
    ..A structural and functional comparison of the ABD-B proteins and a chimeric DFD/ABD-B protein reaffirms that target specificity is largely determined by the homeodomain region and suggests ..
  2. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  3. ncbi Homeotic genes have specific functional roles in the establishment of the Drosophila embryonic peripheral nervous system
    J G Heuer
    Howard Hughes Medical Institute, Department of Biology, Indiana University, Bloomington 47405
    Development 115:35-47. 1992
    ..In addition, we also report the effects of ectopic expression of the homeotic genes labial (lab), Deformed (Dfd), Scr, Antp or Ubx on the normal development of sensory organs in the embryonic PNS...
  4. ncbi Expression and embryonic function of empty spiracles: a Drosophila homeo box gene with two patterning functions on the anterior-posterior axis of the embryo
    D Dalton
    Department of Human Genetics, Yale University, New Haven, Connecticut 06511
    Genes Dev 3:1940-56. 1989
    ..In contrast, the metameric ems pattern is initiated independently of bicoid protein, and ems becomes expressed at high levels in the primordia of the duplicated fïlzkörper that develop in the anterior half of bicoid mutant embryos...
  5. ncbi A genetic and developmental analysis of mutations in the Deformed locus in Drosophila melanogaster
    V K Merrill
    Dev Biol 122:379-95. 1987
    Individuals expressing recessive mutations in the Deformed (Dfd) locus of Drosophila melanogaster were examined for embryonic and adult defects...
  6. ncbi Specification of anteroposterior cell fates in Caenorhabditis elegans by Drosophila Hox proteins
    C P Hunter
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0554, USA
    Nature 377:229-32. 1995
    ..Together these findings suggest that factors important for target recognition by specific Hox proteins have been conserved throughout much of the animal kingdom...
  7. ncbi The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene
    J J Zhao
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029 6574
    Genes Dev 7:343-54. 1993
    ..3. The results suggest that mouse Hox-1.3 cannot only substitute functionally for Drosophila Scr in the determination of external structures but also can participate in the regulatory hierarchy of insect organogenesis...
  8. ncbi Functional analysis of the mouse homeobox gene HoxB9 in Drosophila development
    J Malicki
    Department of Genetics, Yale University, New Haven, CT 06511
    Mech Dev 42:139-50. 1993
    ..2), suggesting that HoxB9 specifies a positional identity that is intermediate between Antennapedia and Abdominal-B...
  9. ncbi Switching the in vivo specificity of a minimal Hox-responsive element
    S K Chan
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Development 124:2007-14. 1997
    ..change in a Hox-PBC binding site switches the Hox-dependent expression pattern generated in vivo, from labial to Deformed. The change in vivo correlates with an altered Hox binding specificity in vitro...
  10. ncbi A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development
    G Gellon
    Department of Biology, Yale University, New Haven, CT 06520 8114, USA
    Development 124:3321-31. 1997
    ..genes, we screened for mutations on loci on the Drosophila second chromosome that interact with the homeotic gene Deformed (Dfd)...
  11. pmc The tracheae defective gene encodes a bZIP protein that controls tracheal cell movement during Drosophila embryogenesis
    K G Eulenberg
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, Am Fassberg 11, 37070 Gottingen, Germany
    EMBO J 16:7156-65. 1997
    ..We propose that the bZIP protein TDF functions as a co-regulator of target genes that provide cells with the ability to migrate...
  12. ncbi Phenotypic suppression of empty spiracles is prevented by buttonhead
    F Schock
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, Gottingen, Germany
    Nature 405:351-4. 2000
    ..The data indicate that this interaction may allow ems to escape from the bottom of the HOX-cluster gene hierarchy and cause a dominant switch of homeotic prevalence in the anterior-posterior direction...
  13. ncbi Multiplex detection of RNA expression in Drosophila embryos
    Dave Kosman
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Science 305:846. 2004
    ....
  14. ncbi Tarsus determination in Drosophila melanogaster
    Anthony Percival-Smith
    Department of Biology, University of Western Ontario, London, Canada
    Genome 48:712-21. 2005
    ..iii) Ectopic overexpression of ANTP, Labial (LAB), Deformed (DFD), SCR, Ultrabithorax (UBX), Abdominal-A (ABD-A), or Abdominal-B (ABD-B), using the dppGAL4 driver, resulted ..
  15. ncbi The rise and fall of Hox gene clusters
    Denis Duboule
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Development 134:2549-60. 2007
    ..By integrating these parameters, general conclusions emerge that can help solve the aforementioned dilemma...
  16. doi Timing of Wingless signalling distinguishes maxillary and antennal identities in Drosophila melanogaster
    Gaelle Lebreton
    Centre de Biologie du Developpement, UMR 5547 and IFR 109, Université de Toulouse and CNRS, 118 route de Narbonne, Bâtiment 4R3, 31062 Toulouse Cedex, France
    Development 135:2301-9. 2008
    ..We found that a maxillary field, defined by expression of the Hox gene Deformed, is established at about the same time as the eye and antennal fields during the L2 larval stage...
  17. pmc Dissecting the functional specificities of two Hox proteins
    Rohit Joshi
    Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Genes Dev 24:1533-45. 2010
    ..Here we provide evidence that another Drosophila Hox protein, Deformed (Dfd), uses a very similar mechanism to achieve specificity in vivo, thus generalizing this mechanism...
  18. doi A statistical fat-tail test of predicting regulatory regions in the Drosophila genome
    Jian Jun Shu
    School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    Comput Biol Med 42:935-41. 2012
    ..These two fatness coefficients may serve as valuable filtering indexes to predict CRMs experimentally...
  19. ncbi Human Hox-4.2 and Drosophila deformed encode similar regulatory specificities in Drosophila embryos and larvae
    N McGinnis
    Department of Molecular Biophysics and Biochemistry Yale University, New Haven, Connecticut 06511
    Cell 63:969-76. 1990
    ..complexes, it is possible to define a subgroup that is structurally homologous to the Drosophila homeotic gene Deformed (Dfd)...
  20. pmc An autoregulatory enhancer element of the Drosophila homeotic gene Deformed
    C Bergson
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511
    EMBO J 9:4287-97. 1990
    ..One mechanism that has been proposed to explain the persistent expression of the homeotic gene Deformed is an autoactivation circuit that would be used once Deformed expression had been established by earlier acting ..
  21. ncbi Control of morphogenesis and differentiation by HOM/Hox genes
    J Botas
    Baylor College of Medicine, Houston
    Curr Opin Cell Biol 5:1015-22. 1993
    ..Some of the genes they regulate and that mediate specific identify functions have been identified. Research in Drosophila has shown that HOM genes are continuously required during development for correct axial identity...
  22. pmc Regulation by homeoproteins: a comparison of deformed-responsive elements
    J A Pederson
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    Genetics 156:677-86. 2000
    ..Here we present evidence that the gene 1.28 is likely to be a direct target of Deformed in the maxillary segment. We identified a 664-bp Deformed Response Element (1...
  23. pmc The Drosophila genes disconnected and disco-related are redundant with respect to larval head development and accumulation of mRNAs from deformed target genes
    J W Mahaffey
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    Genetics 157:225-36. 2001
    ..in an attempt to identify loci potentially encoding cofactors for the protein encoded by the HOM-C gene Deformed (Dfd)...
  24. ncbi The Drosophila Hox gene deformed sculpts head morphology via direct regulation of the apoptosis activator reaper
    Ingrid Lohmann
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093, USA
    Cell 110:457-66. 2002
    ..We show that during early Drosophila development, the Hox protein Deformed (Dfd) maintains the boundary between the maxillary and mandibular head lobes by activating localized apoptosis...
  25. ncbi Embryonic expression pattern of the Drosophila Kallmann syndrome gene kal-1
    Davide Andrenacci
    Institute of Genetics and Biophysics, A Buzzati Traverso, CNR Via P Castellino 111, 80131 Napoli, Italy
    Gene Expr Patterns 5:67-73. 2004
    ..By studying the expression in Dfd and cnc homeotic mutants, we found that these ectodermal cells derive from the anterior and posterior mandibular ..
  26. pmc Structural complexity and evolutionary conservation of the Drosophila homeotic gene proboscipedia
    D L Cribbs
    Howard Hughes Medical Institute, Indiana University, Bloomington 47401
    EMBO J 11:1437-49. 1992
    ..Finally, evolutionary considerations suggest that pb may be one of several ancient genes which preceded the process yielding the modern homeotic gene complexes...
  27. ncbi Altering the regulatory targets of the Deformed protein in Drosophila embryos by substituting the Abdominal-B homeodomain
    M A Kuziora
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511
    Mech Dev 33:83-93. 1990
    ..A heat-shock promoter/selector gene was constructed that encodes a Deformed/Abdominal-B chimera in which the Abdominal-B homeodomain is substituted for that of Deformed...
  28. ncbi Ectopic expression from the Deformed gene triggers a dominant defect in Drosophila adult head development
    R Chadwick
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Dev Biol 141:130-40. 1990
    Drosophila adults carrying a dominant allele of the Deformed locus (DfdD) have a mutant phenotype in which lower eye and orbital structures of the adult head are eliminated...
  29. ncbi The spatial and temporal deployment of Dfd and Scr transcripts throughout development of Drosophila
    A Martinez-Arias
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK
    Development 100:673-83. 1987
    In Drosophila, the Deformed (Dfd) and Sex combs reduced (Scr) genes determined the developmental pathways followed by the most anterior metameric units...
  30. pmc The homeotic gene Sex Combs Reduced of Drosophila: gene structure and embryonic expression
    P K LeMotte
    Biozentrum, University of Basel, Switzerland
    EMBO J 8:219-27. 1989
    ..Expression begins at gastrulation and is eventually apparent in three tissues, epidermis, nervous system and visceral mesoderm, though there are clear contrasts in the domains of expression in these three tissues...
  31. pmc Deformed expression in the Drosophila central nervous system is controlled by an autoactivated intronic enhancer
    L Lou
    Department of Pediatrics, Yale University, New Haven, CT 06520, USA
    Nucleic Acids Res 23:3481-7. 1995
    b>Deformed (Dfd) is a Drosophila homeotic selector gene required for normal development of maxillary segment morphology in the larval and adult head...
  32. ncbi If birds can fly, why can't we? Homeotic genes and evolution
    C Kenyon
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0554
    Cell 78:175-80. 1994
  33. ncbi Developmental consequences of unrestricted expression of the abd-A gene of Drosophila
    E Sánchez-Herrero
    Centro de Biología Molecular Severo Ochod, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Mech Dev 46:153-67. 1994
    ..This competition has been studied by looking at the expression on the visceral mesoderm of a gene downstream of abd-A, decapentaplegic, when two homeoproteins with opposing effects on its transcription are simultaneously induced...
  34. pmc The Antennapedia-type homeobox genes have evolved from three precursors separated early in metazoan evolution
    F R Schubert
    Abteilungun für Molekulare Zellbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Federal Republic of Germany
    Proc Natl Acad Sci U S A 90:143-7. 1993
    ..These genes later independently gave rise to the 13 groups of paralogous genes in vertebrates and to the 11 Antennapedia-type genes in the Drosophila complexes...
  35. ncbi Rough genes with Deformed homeobox substitutions exhibit rough regulatory specificity during Drosophila eye development
    T J Lockett
    Laboratory for Molecular Biology, CSIRO Division of Biomolecular Engineering, North Ryde, NSW, Australia
    Mech Dev 41:57-68. 1993
    ..regulatory specificity of such genes, rough homeobox sequences were changed in part or entirely to those of the Deformed gene, and the modified rough genes tested for their ability to rescue the rough mutant phenotype...
  36. pmc DEAF-1, a novel protein that binds an essential region in a Deformed response element
    C T Gross
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 8114, USA
    EMBO J 15:1961-70. 1996
    A 120 bp homeotic response element that is regulated specifically by Deformed in Drosophila embryos contains a single binding site for Deformed protein...
  37. ncbi The role of HOM-C genes in segmental transformations: reexamination of the Drosophila Sex combs reduced embryonic phenotype
    J D Pederson
    Department of Genetics, North Carolina State University, Raleigh 27695 7614, USA
    Dev Biol 180:131-42. 1996
    ..of the posterior head segments; the labial segment requires Sex combs reduced (Scr) for proper development, Deformed (Dfd) specifies maxillary and mandibular identity, and labial is necessary for intercalary segment identity...
  38. pmc Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster
    A D Long
    Center for Population Biology, University of California, Davis 95616, USA
    Genetics 144:1497-510. 1996
    ....
  39. pmc Prospero is a panneural transcription factor that modulates homeodomain protein activity
    B Hassan
    Molecular, Cellular and Developmental Biology Program, The Ohio State University, Columbus, OH 43210 1002, USA
    Proc Natl Acad Sci U S A 94:10991-6. 1997
    ..and homeodomain proteins is supported by the observation that Prospero, together with the homeodomain protein Deformed, is required for proper regulation of a Deformed-dependent neural-specific transcriptional enhancer...
  40. ncbi Interaction between spineless-aristapedia gene and genes from Antennapedia and bithorax complexes of Drosophila melanogaster
    B Kuzin
    N K Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Int J Dev Biol 41:867-75. 1997
    ....
  41. pmc Amalgam is a ligand for the transmembrane receptor neurotactin and is required for neurotactin-mediated cell adhesion and axon fasciculation in Drosophila
    F Frémion
    Laboratoire de Genetique et de Physiologie du Developpement, IBDM, CNRS INSERM Université de la Méditerranée A P de Marseille, Parc Scientifique de Luminy Case 907, 13288 Marseille, Cedex 9, France
    EMBO J 19:4463-72. 2000
    ..Using an ama-deficient stock, we find that ama function is not essential for viability. Pupae deficient for ama do exhibit defasciculation defects of the ocellar nerves similar to those found in nrt mutants...
  42. ncbi Interchange of DNA-binding modes in the deformed and ultrabithorax homeodomains: a structural role for the N-terminal arm
    Richard W Frazee
    Department of Chemistry, University of Michigan Flint, Flint, MI 48502, USA
    J Mol Biol 323:665-83. 2002
    The deformed (Dfd) and ultrabithorax (Ubx) homeoproteins regulate developmental gene expression in Drosophila melanogaster by binding to specific DNA sequences within its genome...
  43. ncbi Common functions of central and posterior Hox genes for the repression of head in the trunk of Drosophila
    Delphine Coiffier
    Institut de Biologie du Developpement de Marseille Luminy, UMR6216 CNRS Université de la Méditerranée, Case 907 Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Development 135:291-300. 2008
    ..We propose that an evolutionary early function of Hox genes was to modify primitive head morphology with novel functions specialising the trunk appearing later on...
  44. pmc Improving Hox protein classification across the major model organisms
    Stefanie D Hueber
    Genomic Interactions Group, Research School of Biology, College of Medicine, Biology and Environment, The Australian National University, Canberra, Australian Capital Territory, Australia
    PLoS ONE 5:e10820. 2010
    ....
  45. pmc Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins
    Matthew Slattery
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168 th Street, HHSC 1104, New York, NY 10032, USA
    Cell 147:1270-82. 2011
    ..Together, these data suggest that emergent DNA recognition properties revealed by interactions with cofactors contribute to transcription factor specificities in vivo...
  46. pmc The cis-regulatory code of Hox function in Drosophila
    Sebastian Sorge
    CellNetworks Cluster of Excellence and Centre for Organismal Studies COS Heidelberg, Heidelberg University, Heidelberg, Germany
    EMBO J 31:3323-33. 2012
    ..downstream gene activity with high cellular specificity, we have identified binding regions for the Hox TF Deformed (Dfd) in the Drosophila genome...
  47. pmc Hox proteins coordinate peripodial decapentaplegic expression to direct adult head morphogenesis in Drosophila
    Brian G Stultz
    Division of Cell and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Dev Biol 369:362-76. 2012
    ..of labial and homothorax are required for dpp expression in the peripodial epithelium, while the Hox gene Deformed represses labial in this location, thus limiting its expression and indirectly that of dpp to the lateral side of ..
  48. doi Neuroblast lineage identification and lineage-specific Hox gene action during postembryonic development of the subesophageal ganglion in the Drosophila central brain
    Philipp A Kuert
    Biozentrum, University of Basel, Basel, Switzerland Electronic address
    Dev Biol 390:102-15. 2014
    ..The Hox genes Dfd, Scr, and Antp are expressed in a lineage-specific manner in these lineages during postembryonic development...
  49. pmc Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila
    Henrike Becker
    Institute of Genetics, University of Mainz, Mainz, Germany
    PLoS Genet 12:e1005961. 2016
    ..We show that NB6-4 is primarily determined by the cell-autonomous function of the Hox gene Deformed (Dfd)...
  50. doi Gene and epigene networks: two levels in organizing the hereditary system
    R N Tchuraev
    Institute of Biology, Ufa Research Center, Russian Academy of Sciences, 69 Prospect Oktyabrya, Ufa 450054, Russia
    J Theor Biol 259:659-69. 2009
    ..In addition, the experimental results are given on construction an artificial epigene...
  51. doi Lack of the Drosophila BEAF insulator proteins alters regulation of genes in the Antennapedia complex
    Swarnava Roy
    NIDDK Metabolic Diseases Branch, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Genet Genomics 285:113-23. 2011
    ..In contrast, the embryonic expression levels and patterns of four examined ANT-C genes were altered (bcd, Dfd, ftz, pb). A control gene, Dref, was not affected...
  52. pmc Spontaneous unequal exchange in the rosy region of Drosophila melanogaster
    W M Gelbart
    Genetics 92:849-59. 1979
    ....
  53. ncbi Homeodomain-independent activity of the fushi tarazu polypeptide in Drosophila embryos
    V D Fitzpatrick
    Banting and Best Department of Medical Research, Charles H Best Institute, University of Toronto, Ontario, Canada
    Nature 356:610-2. 1992
    ..Here we show that the same phenotype is induced by ectopic expression of a ftz polypeptide containing a deletion in the homeodomain. Thus, ftz can alter gene expression without binding directly to DNA...
  54. ncbi Organogenesis in Drosophila melanogaster: embryonic salivary gland determination is controlled by homeotic and dorsoventral patterning genes
    S Panzer
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Development 114:49-57. 1992
    ....
  55. pmc Differential DNA sequence recognition is a determinant of specificity in homeotic gene action
    S C Ekker
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    EMBO J 11:4059-72. 1992
    ..We show here that the homeodomains encoded by the Ultrabithorax and Deformed homeotic genes bind optimally to distinct DNA sequences and have mapped the determinants responsible for ..
  56. ncbi The role of the teashirt gene in trunk segmental identity in Drosophila
    L Röder
    Laboratoire de Génétique et Biologie Cellulaires, CNRS Case 907, Centre Universitaire Marseille Luminy, France
    Development 115:1017-33. 1992
    ..Our results are consistent with the idea that tsh is defining the ground state of the Drosophila trunk region seen in the absence of the Antp and BX-C genes...
  57. pmc Properties of promoter regions of mdg1 Drosophila retrotransposon indicate that it belongs to a specific class of promoters
    I R Arkhipova
    V A Engelhardt Institute of Molecular Biology, Academy of Sciences of the USSR, Moscow
    EMBO J 10:1169-77. 1991
    ..The identified sequence-specific downstream initiation factor may be responsible for transcription initiation on promoters of some genes which belong to this class...
  58. pmc A functional and structural analysis of the Sex combs reduced locus of Drosophila melanogaster
    A M Pattatucci
    Howard Hughes Medical Institute, Indiana University, Bloomington 47405
    Genetics 129:423-41. 1991
    ....
  59. ncbi The developmental effect of overexpressing a Ubx product in Drosophila embryos is dependent on its interactions with other homeotic products
    A González-Reyes
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Canto Blanco, Madrid, Spain
    Cell 61:515-22. 1990
    ..In segment A9 the highly expressed Ubx product is phenotypically suppressed by the r product of Abdominal-B. The presence of high levels of Ubx protein is also irrelevant in the telson...
  60. ncbi Effects of ectopic expression of caudal during Drosophila development
    M Mlodzik
    Department of Cell Biology, Biozentrum der Universitat, Basel, Switzerland
    Development 109:271-7. 1990
    ..of segmentation genes such as fushi tarazu and engrailed, as well as repression of head-determining genes such as Deformed. These results support the conclusion that, while CAD is probably required to activate transcription of fushi ..
  61. ncbi What determines the specificity of action of Drosophila homeodomain proteins?
    S Hayashi
    National Institute of Genetics, Shizuoka ken, Japan
    Cell 63:883-94. 1990
  62. ncbi Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene
    A Graham
    Laboratory of Molecular Embryology, National Institute for Medical Research, London, UK
    Genes Dev 2:1424-38. 1988
    ..The Drosophila Deformed (Dfd) gene also shares these same regions of similarity, and based on this sequence conservation, we suggest that ..
  63. ncbi A homeodomain substitution changes the regulatory specificity of the deformed protein in Drosophila embryos
    M A Kuziora
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 59:563-71. 1989
    ..To test the role of the homeodomain in determining target specificity, we replaced the homeobox of Deformed with the homeobox of Ultrabithorax...
  64. ncbi Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network
    G Frigerio
    Cell 47:735-46. 1986
    ..The observed linking of gene sets through combinations of homologies coding for protein domains is consistent with a general network concept of gene action...
  65. pmc The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo
    T Berleth
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, FRG
    EMBO J 7:1749-56. 1988
    ..The localization of the transcript requires the function of the maternal effect genes exuperantia and swallow while transcript stability is reduced by functions depending on posterior group genes...
  66. ncbi Drosophila homoeotic genes encode transcriptional activators similar to mammalian OTF-2
    M Thali
    Arbeitsgruppe Walter Schaffner, Institut fur Molekularbiologie II, Universitat Zurich, Switzerland
    Nature 336:598-601. 1988
    ..Their activity, as well as their target specificity, is similar to that of a mammalian lymphoid-specific octamer transcription factor, OTF-2, which was recently found to contain a homoeodomain...
  67. ncbi The interaction of proteins encoded by Drosophila homeotic and segmentation genes with specific DNA sequences
    A Laughon
    Laboratory of Genetics, University of Wisconsin, Madison 53706
    Development 104:75-83. 1988
    ..The DNA sequence specificities of the Dfd and ftz homeodomains appear to overlap completely in vitro, indicating that differences in regulatory specificity ..
  68. pmc Genetic and developmental analysis of a temperature-sensitive minute mutation of Drosophila melanogaster
    D A Sinclair
    Genetics 97:581-606. 1981
    ....
  69. pmc Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue
    P G Feinstein
    Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Genetics 140:573-86. 1995
    ..These results illustrate potentially general rules about the homeotic control of target gene expression and suggest that subtractive hybridization can be used to isolate interesting homeotic target genes...
  70. ncbi The Sex combs reduced gene of Drosophila melanogaster has multiple transcripts
    D J Andrew
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305 5247
    Gene 152:149-55. 1995
    ..As with most of the D. melanogaster homeotic genes, Scr has alternative exons...
  71. pmc Discovery and genetic definition of the Drosophila Antennapedia complex
    R Denell
    Division of Biology, Kansas State University, Manhattan 66506 4901
    Genetics 138:549-52. 1994
  72. ncbi Identification and characterization of a gene activated by the deformed homeoprotein
    J W Mahaffey
    Department of Genetics, North Carolina State University, Raleigh 27695
    Development 118:203-14. 1993
    ..Here we identify and characterize one such target gene, a gene activated by the product of the homeotic gene Deformed. DNA binding assays and expression of reporter gene constructs indicate that activation of this gene requires a ..
  73. ncbi A sequence conserved in vertebrate Hox gene introns functions as an enhancer regulated by posterior homeotic genes in Drosophila imaginal discs
    L P Keegan
    Department of Cell Biology, Basel University Biozentrum, Switzerland
    Mech Dev 63:145-57. 1997
    ..Testing a reporter gene construct with mutated binding sites in mouse embryos shows that HB1 is also active in the expression domains of posterior Hox genes in the mouse neural tube...
  74. ncbi Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development
    Z Yin
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 124:4971-82. 1997
    ....
  75. ncbi No premature gene expression in germ cells of embryos deriving from nos females
    A Heller
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Mech Dev 72:169-73. 1998
    ..Germ cells of such embryos, however, often show artefactual lacZ staining even in the absence of a lacZ gene...
  76. pmc Needs and targets for the multi sex combs gene product in Drosophila melanogaster
    O Saget
    Centre de Genetique Moleculaire du Centre National de la Recherche Scientifique, 91198 Gif sur Yvette Cedex, France
    Genetics 149:1823-38. 1998
    ..demonstrate that the mxc product is needed for imaginal head specification, through regulation of the ANT-C gene Deformed. Our analysis reveals that mxc is involved in the maternal control of early zygotic gap gene expression ..
  77. ncbi Hox genes differentially regulate Serrate to generate segment-specific structures
    E L Wiellette
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
    Development 126:1985-95. 1999
    ..In the head, Deformed is required to activate Serrate transcription in the maxillary segment, where Serrate is required for normal ..
  78. ncbi Characterization of the Tribolium Deformed ortholog and its ability to directly regulate Deformed target genes in the rescue of a Drosophila Deformed null mutant
    S Brown
    Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    Dev Genes Evol 209:389-98. 1999
    We have analyzed the Tribolium castaneum ortholog of the Drosophila homeotic gene Deformed (Dfd) and determined its expression pattern during embryogenesis in this beetle...
  79. ncbi A common mechanism for antenna-to-Leg transformation in Drosophila: suppression of homothorax transcription by four HOM-C genes
    L C Yao
    Institute of Genetics, Department of Life Science, National Yang Ming University, Shipai, Taipei, 112, Taiwan, Republic of China
    Dev Biol 211:268-76. 1999
    ..We also show that ectopic hth expression can cause duplication of the proximodistal axis of the antenna, suggesting that it is involved in proximodistal development of the antenna...
  80. ncbi A comparison of homologous developmental genes from Drosophila and Tribolium reveals major differences in length and trinucleotide repeat content
    K J Schmid
    Institut fur Genetik, Universitat zu Koln, Weyertal 121, 50931 Koln, Germany
    J Mol Evol 49:558-66. 1999
    ....
  81. ncbi A sequence motif distinct from Hox binding sites controls the specificity of a Hox response element
    X Li
    Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Development 126:5581-9. 1999
    ..A 21 bp cofactor binding sequence from an embryonic Deformed Hox response element, containing no Hox or Hox-PBC binding sites, was combined with single or multimeric sites ..
  82. ncbi Functional equivalence of Hox gene products in the specification of the tritocerebrum during embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 128:4781-8. 2001
    ..This suggests that in embryonic brain development, differences in Hox gene action rely mainly on cis-acting regulatory elements and not on Hox protein specificity...
  83. ncbi Temperature compensation and temporal expression mediated by an enhancer element in Drosophila
    Barry Hoopengardner
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mech Dev 110:27-37. 2002
    A comparison of the activity of genetic elements from the regulatory region of the Drosophila melanogaster Deformed gene during embryogenesis and adult life reveals important similarities and differences. The 2...
  84. ncbi The evolution of HOM-C homeoboxes in the Dipteran family Drosophilidae
    R DeSalle
    Division of Invertebrates, American Museum of Natural History, 79th Street at Central Park West, New York, NY 10024, USA
    Insect Mol Biol 12:345-51. 2003
    ..These new homeoboxes are from the labial, proboscipedia, Deformed, Sex combs reduced, fushi tarazu, Antennapedia, Ultrabithorax, abdominal-A and Abdominal-B genes...
  85. ncbi An interactive network of zinc-finger proteins contributes to regionalization of the Drosophila embryo and establishes the domains of HOM-C protein function
    Lisa K Robertson
    Department of Genetics, Campus Box 7614, North Carolina State University, Raleigh, NC 27695 7614, USA
    Development 131:2781-9. 2004
    ..We conclude that a combination of regionalizing factors, in concert with the HOM-C proteins, promotes the specification of individual segment identity...
  86. ncbi Hox gene cross-regulatory interactions in the embryonic brain of Drosophila
    Simon G Sprecher
    Institute of Zoology, Biocenter Pharmacenter University of Basel, Klingelbergstr 50, CH 4056 Basel, Switzerland
    Mech Dev 121:527-36. 2004
    ....
  87. ncbi Recognition of distinct target sites by a unique Labial/Extradenticle/Homothorax complex
    Andreas Ebner
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 132:1591-600. 2005
    ..Thus Lab, and most probably other Hox proteins, selects different DNA sequences in regulating downstream target genes. These observations have implications with regard to the current model of Hox-binding selectivity...
  88. pmc 3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion
    Karen Beckett
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Dev Biol 309:113-25. 2007
    ..5 h. Altogether, our data have led us to propose a new model of myoblast fusion where the frequency of myoblast fusion events may be influenced by the spatial arrangements of FCs and FCMs...
  89. pmc Multifactorial regulation of a hox target gene
    Petra Stöbe
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 5:e1000412. 2009
    ..Here, we analyze the regulation of the cell death gene reaper (rpr) by the Hox protein Deformed (Dfd) and suggest that local activation of rpr expression in the anterior part of the maxillary segment is ..
  90. pmc Visualization of individual Scr mRNAs during Drosophila embryogenesis yields evidence for transcriptional bursting
    Adam Pare
    Section of Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Curr Biol 19:2037-42. 2009
    ..Our data provide evidence for transcriptional bursting, as well for divergent "accumulation" and "maintenance" phases of gene activity at the Scr locus...
  91. pmc Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
    Johanna C Scheuermann
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 465:243-7. 2010
    ..Polycomb gene silencing may thus entail a dynamic balance between H2A ubiquitination by PRC1 and dRAF, and H2A deubiquitination by PR-DUB...
  92. ncbi Deformed autoregulatory element from Drosophila functions in a conserved manner in transgenic mice
    A Awgulewitsch
    Medical University of South Carolina, Department of Biochemistry and Molecular Biology, Charleston 29425
    Nature 358:341-4. 1992
    ..5). One of the few elements characterized in detail is the autoregulatory enhancer of the homeotic gene Deformed (Dfd), which supports expression in subregions of posterior head segments of Drosophila embryos...
  93. ncbi (HX)n repeats: a pH-controlled protein-protein interaction motif of eukaryotic transcription factors?
    R Janknecht
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Germany
    FEBS Lett 295:1-2. 1991
    ..g. HPHAHPHP in paired protein. Detailed molecular modelling and database searches lead to the suggestion that (HX)n repeats can mediate interaction between transcription factors in a pH-controlled fashion...
  94. ncbi The structure of the homeodomain and its functional implications
    W J Gehring
    University of Basel, Switzerland
    Trends Genet 6:323-9. 1990
    ..Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution...
  95. ncbi Homeotic genes and positional signalling in the Drosophila viscera
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Trends Genet 10:22-6. 1994
    ..The homeotic genes that are expressed in the viscera control morphogenesis and differentiation of the larval midgut...
  96. pmc The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins
    S C Ekker
    Johns Hopkins School of Medicine, Howard Hughes Medical Institute, Baltimore, MD
    EMBO J 13:3551-60. 1994
    ..the Ultrabithorax and Antennapedia homeodomains display indistinguishable preferences outside the core while Deformed differs...
  97. pmc A model for extradenticle function as a switch that changes HOX proteins from repressors to activators
    J Pinsonneault
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 8114, USA
    EMBO J 16:2032-42. 1997
    ..Here we show that exd function is required for the autoactivation phase of Dfd expression in the posterior head...
  98. ncbi Involvement of the Bombyx Scr gene in development of the embryonic silk gland
    H Kokubo
    National Institute for Basic Biology, Myodaiji cho, Okazaki, Japan
    Dev Biol 186:46-57. 1997
    ..two genes that encode the homeodomain and its flanking regions identical to the corresponding regions of Deformed and Sex combs reduced...
  99. ncbi Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression
    V Pirrotta
    Department of Zoology, University of Geneva, Switzerland
    Trends Genet 13:314-8. 1997
    ..In vivo, complexes formed at one genomic site can interact with those at other sites, suggesting that they, like heterochromatin complexes, affect the folding of chromatin and the organization of chromosomes in the nucleus...

Research Grants14

  1. REGULATION OF INSECT JUVENILE HORMONE BIOSYNTHESIS
    LINDA RESTIFO; Fiscal Year: 2001
    ..The study of CYP4C7 is a first and unique opportunity to study the processes by which the corpora allata are turned off. These processes have until now been addressed mostly at the morphological level. ..
  2. DISSECTION OF ONCOGENIC PATHWAYS USING DROSOPHILA
    Richard Mann; Fiscal Year: 2004
    ..The use of Drosophila genetics is proposed to help make connections between genetic functions that cannot be easily identified in mammalian experimental systems. ..
  3. CONTROL OF CNS DEVELOPMENT BY BRC TRANSCRIPTION FACTORS
    LINDA RESTIFO; Fiscal Year: 2005
    ..Defining molecular pathways between hormonal signals and specific events in brain development should lead to better therapeutic strategies for treating CNS dysfunction due to congenital and acquired disorders. ..
  4. CADDMR: a Cell-based Assay for Drug Discovery for Mental Retardation Disorders
    LINDA RESTIFO; Fiscal Year: 2007
    ..The proposed experiments are an important step toward that goal. [unreadable] [unreadable] [unreadable]..
  5. Integrated Approcahes to Find Hox-regulated DNA Elements
    Richard Mann; Fiscal Year: 2008
    ..Once these methods are worked out, they will be applicable to a wide variety of problems in biology. [unreadable] [unreadable]..
  6. MOLECULAR AND GENETIC CONTROL OF PROGRAMMED CELL DEATH
    John Abrams; Fiscal Year: 2003
    ..This information, in turn, may provide novel rationales for the treatment of some human diseases and could offer valuable new targets for drugs that specifically activate or block the apoptosis pathway. ..
  7. TRANSCRIPTIONAL COACTIVATORS IN ENDOCRINE REGULATION
    Richard Goodman; Fiscal Year: 2003
    ..Finally, we will characterize the ability of the "CREB binding domain" of CBP to interact with other transcription factors activated or inhibited by Ser/Thr phosphorylation. ..
  8. Genetic Transfer in the Evolution of Infectious Disease
    Rob DeSalle; Fiscal Year: 2005
    ....
  9. RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMS
    Richard Goodman; Fiscal Year: 2006
    ..Core laboratories for cell culture, protein chemistry, and administration are designed to allow the proposed studies to be performed in an efficient and cost-effective manner. ..
  10. Molecular and Genetic Determinants of Alcohol-Induced Apoptosis
    John Abrams; Fiscal Year: 2007
    ..This information, in turn, could lead to improved therapies for pathologies associated with excessive alcohol consumption. [unreadable] [unreadable] [unreadable] [unreadable]..
  11. Identification of gene targets for morphine and other drugs of abuse
    Richard Goodman; Fiscal Year: 2009
    ..The concept that CREB signaling induces mediators of translational arrest has profound implications for the understanding of drug action. ..
  12. MOLECULAR AND GENETIC CONTROL OF PROGRAMMED CELL DEATH
    John Abrams; Fiscal Year: 2008
    ..abstract_text> ..
  13. Regulation of MeCP2 by CREB-induced microRNAs
    Richard H Goodman; Fiscal Year: 2010
    ..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..
  14. Universal Determinants of Alcohol - Induced Toxicity
    JOHN MICHAEL ABRAMS; Fiscal Year: 2010
    ..In turn, these insights will expose new opportunities for improved management of disease caused by alcohol and related stressors in humans ..