Genomes and Genes
Gene Symbol: dlg1
Description: discs large 1
Alias: CG1725, CG1730, CPD, DLG, DLG-A, DLG1, Discs-large, Dlg, Dlg-A, Dlg1, DlgA, DlgS97, Dmel\CG1725, Drodlg, PSD-95, PSD95, SAP97, anon-EST:Posey93, anon-WO03040301.258, anon-WO03040301.260, anon-WO03040301.268, d. lg.-1, dlg, dlg-1, dlg-A, dlgA, dlgS97, l(1)10Bf, l(1)G0276, l(1)G0342, l(1)G0456, l(1)G19, l(1)L11, l(1)bwn, l(1)d.lg-1, l(1)d.lg.-1, l(1)discs large, l(1)dlg, l(1)dlg-1, l(1)dlg1, l(1)l.pr.-2, l(1)lpr-2, misb, CG1725 gene product from transcript CG1725-RL, CG1725-PA, CG1725-PB, CG1725-PC, CG1725-PD, CG1725-PE, CG1725-PF, CG1725-PG, CG1725-PH, CG1725-PI, CG1725-PJ, CG1725-PK, CG1725-PL, CG1725-PM, CG1725-PN, CG1725-PO, CG1725-PP, CG1725-PQ, CG1725-PR, CG1725-PS, CG1725-PT, CG1725-PU, Disc-Large, Discs-large, disc large, disclarge, discs large, discslarge, disk large, dlg1-PA, dlg1-PB, dlg1-PC, dlg1-PD, dlg1-PE, dlg1-PF, dlg1-PG, dlg1-PH, dlg1-PI, dlg1-PJ, dlg1-PK, dlg1-PL, dlg1-PM, dlg1-PN, dlg1-PO, dlg1-PP, dlg1-PQ, dlg1-PR, dlg1-PS, dlg1-PT, dlg1-PU, lethal(1)benign wing imaginal disc neoplasm, lethal(1)discs large, lethal(1)discs-large, lethal(2)discs large
Species: fruit fly
Publications194 found, 100 shown here
- A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junctionJan Pielage
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 175:491-503. 2006..We propose a model in which a postsynaptic Spectrin-actin lattice acts as an organizing scaffold upon which pre- and postsynaptic development are arranged...
- Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent mannerGiuseppa Pennetta
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
Neuron 35:291-306. 2002..We propose that a DVAP-33A-mediated interaction between microtubules and presynaptic membrane plays a pivotal role during bouton budding...
- Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functionsPeri T Kurshan
F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts, USA
Nat Neurosci 12:1415-23. 2009..Our results indicate that alpha(2)delta proteins have functions that are independent of their roles in the biophysics and localization of Ca(2+) channels and that synaptic architecture depends on these functions...
- The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eyeAlexandre Djiane
Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
Cell 121:621-31. 2005..We propose a model whereby the dPatj/aPKC complex regulates PCP by inhibiting Fz1 in cells where it should not be active...
- Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblastsSarah E Siegrist
Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
Cell 123:1323-35. 2005..We show that astral microtubules, kinesin Khc-73, and Discs large (Dlg) induce cortical polarization of Pins/Galphai in Drosophila neuroblasts; this cortical domain is ..
- Cooperative regulation of cell polarity and growth by Drosophila tumor suppressorsD Bilder
Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Science 289:113-6. 2000..We show that the tumor suppressors lethal giant larvae (lgl) and discs-large (dlg) have identical effects on all three epithelia, and that scrib also acts as a tumor suppressor...
- A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epitheliaSeonok Lee
Department of Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical School, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
Mol Cell Biol 22:1778-91. 2002..We also report the identification of a novel isoform of Discs Large, a Drosophila melanogaster orthologue of SAP97, which contains a region highly related to the SAP97 N terminus ..
- The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiationMary Packard
Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
Cell 111:319-30. 2002..We suggest that Wg signals the coordinated development of pre- and postsynaptic compartments...
- Shar-pei mediates cell proliferation arrest during imaginal disc growth in DrosophilaMadhuri Kango-Singh
Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center, Houston, TX 77030, USA
Development 129:5719-30. 2002..shar-pei encodes a WW-domain-containing protein that has homologs in worms, mice and humans, suggesting that mechanisms of organ growth control are evolutionarily conserved...
- Planar polarity and actin dynamics in the epidermis of DrosophilaJulia A Kaltschmidt
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
Nat Cell Biol 4:937-44. 2002..We show that Wingless (Wg) signalling and Jun amino-terminal kinase (JNK) signalling have overlapping but different roles in these events...
- A Drosophila resource of transgenic RNAi lines for neurogeneticsJian Quan Ni
Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia 20147, USA
Genetics 182:1089-100. 2009....
- The Hippo pathway regulates apical-domain size independently of its growth-control functionAlice Genevet
Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
J Cell Sci 122:2360-70. 2009..Therefore, Hippo signalling controls growth and apical domain size by distinct mechanisms...
- Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesisNicole A Kaplan
Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 423, New York, NY 10021, USA
J Cell Sci 123:3157-65. 2010..We conclude that apical-basal proteins, used to establish polarity within a cell, can be independently co-opted to function in epithelial morphogenesis...
- Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in DrosophilaKatarína Tiklová
Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
Nat Cell Biol 12:1071-7. 2010..Mouse MTf complements the defects of Drosophila MTf mutants. Drosophila provides the first genetic model for the functional dissection of MTf in epithelial junction assembly and morphogenesis...
- Dynactin is necessary for synapse stabilizationBenjamin A Eaton
Department of Biochemistry and Biophysics, San Francisco, California 94143, USA
Neuron 34:729-41. 2002..Our data suggests that dynactin functions locally within the presynaptic arbor to promote synapse stability...
- The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue sizeMaria Willecke
Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Curr Biol 16:2090-100. 2006..However, components acting upstream of Expanded and Merlin, such as transmembrane receptors, have not yet been identified...
- Dynamic control of cell cycle and growth coupling by ecdysone, EGFR, and PI3K signaling in Drosophila histoblastsNikolay Ninov
Instituto de Biologia Molecular de Barcelona, Consejo Superior de Investigaciones Cientificas, Barcelona, Spain
PLoS Biol 7:e1000079. 2009..It sets the stage for the comprehensive understanding of the coordination of cell growth and cell-cycle progression in complex multicellular eukaryotes...
- Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinasesE Kim
Howard Hughes Medical Institute, Massachusetts General Hospital, Department of Neurobiology, Harvard Medical School, Boston 02114, USA
Nature 378:85-8. 1995..3) and syntrophin), suggest that PDZ-domain-containing polypeptides may be widely involved in the organization of proteins at sites of membrane specialization...
- Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wingDavid D O'Keefe
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Dev Biol 311:25-39. 2007..Ras, therefore, regulates both the transcriptional responses necessary for vein cell identity, and the cell adhesive changes that determine vein and intervein cell morphology...
- Synergy between bacterial infection and genetic predisposition in intestinal dysplasiaYiorgos Apidianakis
Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 106:20883-8. 2009..Assessment of progenitor cell responses to pathogenic intestinal bacteria could provide a measure of predisposition for apoptotic enterocyte-assisted intestinal dysplasias in humans...
- Echinoid regulates Flamingo endocytosis to control ommatidial rotation in the Drosophila eyeYu Huei Ho
Institute of Molecular Medicine, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 30034, Republic of China
Development 137:745-54. 2010..Thus, co-endocytosis of Ed and Fmi provides a link between apicobasal polarity and PCP...
- Malignant neoplasms of genetic origin in Drosophila melanogasterE Gateff
Science 200:1448-59. 1978..Thus Drosophila and vertebrate neoplasms show striking similarities...
- Regulation of DLG localization at synapses by CaMKII-dependent phosphorylationY H Koh
Department of Biology, University of Massachusetts, Amherst 01003, USA
Cell 98:353-63. 1999b>Discs large (DLG) mediates the clustering of synaptic molecules. Here we demonstrate that synaptic localization of DLG itself is regulated by CaMKII...
- Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and functionY Q Zhang
Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
Cell 107:591-603. 2001..dfxr futsch double mutants restore normal synaptic structure and function. We propose that dFXR acts as a translational repressor of Futsch to regulate microtubule-dependent synaptic growth and function...
- Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in DrosophilaIan P Coyle
Laboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA
Neuron 41:521-34. 2004..We propose that Nwk controls synapse morphology by regulating actin dynamics downstream of growth signals in presynaptic terminals...
- The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosisFisun Hamaratoglu
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
Nat Cell Biol 8:27-36. 2006..Our genetic and biochemical data place Merlin and Expanded upstream of Hippo and identify a pathway through which they act as tumour-suppressor genes...
- The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brainAndrea Mahr
Max Planck Institut fur Entwicklungsbiologie, Abt III Genetik, Spemannstr 35, 72076 Tubingen, Germany
Gene Expr Patterns 6:299-309. 2006..Given that vesicular glutamate transporters are essential for the uptake of the neurotransmitter glutamate into synaptic vesicles these tools provide a means to test gene function in these functionally important neurons...
- GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivoErika A Bach
Pharmacology Department, New York University School of Medicine, New York, NY 10016 6402, USA
Gene Expr Patterns 7:323-31. 2007..These reporters are valuable tools to further investigate and understand the role of JAK/STAT signaling in Drosophila...
- Nervous wreck interacts with thickveins and the endocytic machinery to attenuate retrograde BMP signaling during synaptic growthKate M O'Connor-Giles
Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
Neuron 58:507-18. 2008..We propose that Nwk functions at the interface of endocytosis and BMP signaling to ensure proper synaptic growth by negatively regulating Tkv to set limits on this positive growth signal...
- Mbt, a Drosophila PAK protein, combines with Cdc42 to regulate photoreceptor cell morphogenesisDaniela Schneeberger
University of Wurzburg, Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Versbacherstr 5, 97078 Wurzburg, Germany
Development 130:427-37. 2003..Besides regulation of kinase activity, another important function of Cdc42 is to recruit Mbt to adherens junctions. We propose a role for Mbt as a downstream effector of Cdc42 in photoreceptor cell morphogenesis...
- Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlgV Budnik
Department of Biology, University of Massachusetts, Amherst 01003, USA
Neuron 17:627-40. 1996Mutations of the tumor suppressor gene discs-large (dlg) lead to postsynaptic structural defects. Here, we report that mutations in dlg also result in larger synaptic currents at fly neuromuscular junctions...
- Regulation of cadherin adhesive activityB M Gumbiner
Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Cell Biol 148:399-404. 2000
- Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathwayF Christian Bennett
Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
Curr Biol 16:2101-10. 2006..A newly emerging signaling pathway that controls organ size during development is the Salvador/Warts/Hippo pathway...
- The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal systemSarah M Paul
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
Development 130:4963-74. 2003....
- The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4EKaushiki P Menon
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Neuron 44:663-76. 2004..The GluRIIa glutamate receptor is upregulated in pum mutants. These results, together with genetic epistasis studies, suggest that postsynaptic Pum modulates synaptic function via direct control of eIF-4E expression...
- Drosophila Knickkopf and Retroactive are needed for epithelial tube growth and cuticle differentiation through their specific requirement for chitin filament organizationBernard Moussian
Department of Genetics, Max Planck Institute for Developmental Biology, Tubingen, Germany
Development 133:163-71. 2006..We propose a model in which Knk and the predicted chitin-binding protein Rtv form membrane complexes essential for epithelial tubulogenesis and cuticle formation through their specific role in directing chitin filament assembly...
- Synaptic protein synthesis associated with memory is regulated by the RISC pathway in DrosophilaShovon I Ashraf
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Cell 124:191-205. 2006..Therefore, we propose that degradative control of the RISC pathway underlies the pattern of synaptic protein synthesis associated with a stable memory...
- Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epitheliumRobert P Simone
University of Pennsylvania Medical School, Department of Cell and Developmental Biology, 421 Curie Boulevard, Philadelphia, PA 19104 6048, USA
Development 137:1385-94. 2010..Additionally, we show that non-muscle Myosin II and the polarity proteins Discs large (Dlg) and Bazooka are enriched along cell interfaces in a complex but reproducible pattern that suggests their ..
- Energy-dependent regulation of cell structure by AMP-activated protein kinaseJun Hee Lee
National Creative Research Initiatives Center for Cell Growth Regulation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong gu, Taejon 305 701, Korea
Nature 447:1017-20. 2007..Taken together, our results demonstrate that AMPK has highly conserved roles across metazoan species not only in the control of metabolism, but also in the regulation of cellular structures...
- Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobeBoris Egger
The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Neural Dev 2:1. 2007..In some tissues cell fate appears to dictate the type of cell division, whereas in other tissues it is thought that stochastic variation in spindle position dictates subsequent sibling cell fate...
- The role of the actomyosin cytoskeleton in coordination of tissue growth during Drosophila oogenesisYing Wang
Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstrasse 17, D 50931 Köln, Germany
Curr Biol 17:1349-55. 2007..Myosin is activated at the apical cortex by localized Rho kinase and inhibited at the basolateral cortex by PP1beta9C. In addition, our data indicate that active myosin is apically anchored by the Baz/Par-6/aPKC complex...
- Grainy head promotes expression of septate junction proteins and influences epithelial morphogenesisMaithreyi Narasimha
Wellcome Trust Cancer Research UK Gurdon Institute of Developmental Biology and Cancer, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
J Cell Sci 121:747-52. 2008..The fact that ectopic Grh arrests dorsal closure also suggests that this dynamic process relies on epithelia having distinct adhesive properties conferred by differential deployment of Grh...
- The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growthFisun Hamaratoglu
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
J Cell Sci 122:2351-9. 2009..Therefore, Hippo signaling regulates cell polarity complexes in addition to and independently of its growth control function in imaginal disc cells...
- Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK familyS D Dimitratos
Developmental Biology Center, University of California, Irvine, California
Bioessays 21:912-21. 1999..BioEssays 1999;21:912-921...
- The positioning and segregation of apical cues during epithelial polarity establishment in DrosophilaTony J C Harris
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Cell Biol 170:813-23. 2005..These results reveal key steps in the assembly of the apical domain in Drosophila...
- Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notchCedric Polesello
Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2 3PX, United Kingdom
Curr Biol 17:1864-70. 2007..The PCP members of the SWH network are not involved in this process, indicating that signaling upstream of Hpo varies according to developmental context...
- Combinatorial signaling in the specification of primary pigment cells in the Drosophila eyeRaghavendra Nagaraj
Department of Molecular, Cell and Developmental Biology, Department of Biological Chemistry, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
Development 134:825-31. 2007..Combined with previous work, these data show that unique combinations of only two pathways--Notch and EGFR--can specify at least five different cell types within the Drosophila eye...
- Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in DrosophilaLi Lun Ho
Intercollege Graduate Degree Program in Cell and Developmental Biology, The Pennsylvania State University, University Park, PA 16802, USA
Dev Biol 337:274-83. 2010..These results support a model in which the plasma membrane is an important site of action for Mats tumor suppressor to control tissue growth and organ size...
- Molecular cloning of the lethal(1)discs large-1 oncogene of DrosophilaD F Woods
Developmental Biology Center, University of California, Irvine 92717
Dev Biol 134:222-35. 1989We present a genetic, developmental and molecular analysis of lethal(1)discs large-1[l(1)d.lg-1; Stewart et al., 1972], an oncogene of Drosophila...
- A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and functionS Baumgartner
Friedrich Miescher Institute, Basel, Switzerland
Cell 87:1059-68. 1996..These studies identify NRX as the first transmembrane protein of SJ and demonstrate a requirement for NRX in the formation of septate-junction septa and intercellular barriers...
- Localization of proteins to the apico-lateral junctions of Drosophila epitheliaD F Woods
Developmental Biology Center, University of California, Irvine, USA
Dev Genet 20:111-8. 1997..as FITC phalloidin marking filamentous actin, labeled the site of the adherens junction, whereas antibodies to Discs large (DIg), Fasciclin III (FasIII) and Coracle (Cor) labeled the more basal septate junction...
- Synaptic clustering of the cell adhesion molecule fasciclin II by discs-large and its role in the regulation of presynaptic structureU Thomas
Department of Neurochemistry and Molecular Biology, Federal Institute for Neurobiology, Magdeburg, Germany
Neuron 19:787-99. 1997..by binding between the intracellular tSXV bearing C-terminal tail of FASII and the PDZ1-2 domains of Discs-Large (DLG)...
- Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs largeC D Hough
Developmental Biology Center, University of California, Irvine, California 92697 2275, USA
Genes Dev 11:3242-53. 1997b>Discs large (Dlg) was the first identified member of an increasingly important class of proteins called membrane-associated guanylate kinase homologs (MAGUKs), which are often concentrated at cell junctions and contain distinct peptide ..
- Protein modules as organizers of membrane structureA S Fanning
Departments of Internal Medicine and Cell Biology, Yale University School of Medicine, PO Box 208019, New Haven, CT 06520 8019, USA
Curr Opin Cell Biol 11:432-9. 1999..The organization of these proteins into discreet structures has functional consequences for downstream signaling...
- A role for PS integrins in morphological growth and synaptic function at the postembryonic neuromuscular junction of DrosophilaK J Beumer
Biology Department, University of Utah, Salt Lake City, UT 84112, USA
Development 126:5833-46. 1999..These data provide the first genetic evidence for a functional role of integrins at the postembryonic synapse...
- Synaptic development is controlled in the periactive zones of Drosophila synapsesM Sone
Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
Development 127:4157-68. 2000..BetaPS integrin and discs large (DLG), both involved in synaptic development, also decorated the zone...
- Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblastT Ohshiro
CREST, Japan Science and Technology Corporation, Sendai
Nature 408:593-6. 2000..Another tumour-suppressor protein, Lethal discs large (Dlg), participates in this process by regulating the localization of Lgl...
- Asymmetric cell division: fly neuroblast meets worm zygoteC Q Doe
Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, Oregon 97403, USA
Curr Opin Cell Biol 13:68-75. 2001..Mammalian epithelia also use this complex to regulate apical/basal polarity. Recent results have allowed us to compare the mechanisms regulating asymmetric cell division in Drosophila neuroblasts and the C. elegans zygote...
- Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblastsY Hong
Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California San Francisco, San Francisco, California 94143 0725, USA
Nature 414:634-8. 2001..However, for the subset of ectodermal cells that delaminate and form neuroblasts, their polarity requires the function of Bazooka, but not of Stardust or Crumbs...
- Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in synaptic vesicle endocytosisA C Zelhof
Institute of Neuroscience, HHMI, University of Oregon 1254, Eugene, OR 97403, USA
Development 128:5005-15. 2001..are viable, lack any observable endocytic defects, but have abnormal localization of the postsynaptic proteins Discs large, Lethal giant larvae and Scribble, altered synaptic physiology, and behavioral defects...
- Rap1 GTPase regulation of adherens junction positioning and cell adhesionAndrea L Knox
Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, UK
Science 295:1285-8. 2002..Rap1 is enriched at adherens junctions, particularly between newly divided sister cells where it may reseal the adherens junction ring. The regulation of adherens junction positioning could play a role in cell mobility and cell division...
- Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cellsEmmanuelle Médina
NMDA IBDM, UMR 6156, Campus de Luminy, Universite de la Mediterranee, Case 907, 13288 Marseille Cedex 09, France
Biol Cell 94:305-13. 2002..Finding an answer to these questions will help to find new therapies for Retinitis pigmentosa and other retina degeneration in which CRB1, the human homologue of crb, has been involved...
- A genetic hierarchy controlling cell polarityKevin Johnson
Nat Cell Biol 5:12-4. 2003
- Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epitheliaSalim Abdelilah-Seyfried
Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, D 13125 Berlin Buch, Germany
Development 130:1927-35. 2003..bazooka function is required during cell invasion of epithelial follicle cells mutant for the tumor suppressor discs large. Clonal studies indicate that follicle cell Bazooka acts as a permissive factor during cell invasion, possibly ..
- Novel isoforms of Dlg are fundamental for neuronal development in DrosophilaCarolina Mendoza
Programa de Fisiologia y Biofisica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile 6530499
J Neurosci 23:2093-101. 2003..cDNAs that include novel exons encoding a peptide homologous to the N terminus of the mammalian protein SAP97/hDLG (S97N)...
- Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterningRebecca Bastock
Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
Development 130:3007-14. 2003..In the second phase, Dishevelled and Prickle are required for these proteins to become asymmetrically distributed on the proximodistal axis...
- Discs-Large and Strabismus are functionally linked to plasma membrane formationOk kyung Lee
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Nat Cell Biol 5:987-93. 2003..ectopic co-expression of Stbm (which associated with post-Golgi vesicles) and the mammalian Dlg homologue SAP97/hDlg promoted translocation of SAP97 from the cytoplasm to both post-Golgi vesicles and the plasma membrane...
- Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epitheliaMelissa M Rolls
Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, OR 97403, USA
J Cell Biol 163:1089-98. 2003..Miranda from the apical cortex; yet, they show normal apical crescents of Baz/Par3, Pins, Inscuteable, and Discs large and normal spindle orientation...
- Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97ANDRE BACHMANN
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
J Cell Sci 117:1899-909. 2004Stardust (Sdt) and Discs-Large (Dlg) are membrane-associated guanylate kinases (MAGUKs) involved in the organization of supramolecular protein complexes at distinct epithelial membrane compartments in Drosophila...
- Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growthDavid R Hipfner
European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Genes Dev 18:2243-8. 2004..This is distinct from Slik's effects on cell proliferation, which are mediated by Raf. Thus Slik acts via distinct pathways to coordinate cell proliferation with epithelial cell behavior during tissue growth...
- glaikit is essential for the formation of epithelial polarity and neuronal developmentJohn Dunlop
Medical Research Council, Centre for Developmental Neurobiology, 4th Floor, New Hunts House, Guys Campus, King s College London, London SE1 1UL, United Kingdom
Curr Biol 14:2039-45. 2004..A mutation in the human homolog of gkt causes the neurodegenerative disease spinocerebellar ataxia with neuropathy (SCAN1), making it possible that a failure of membrane protein localization is a cause of this disease...
- mummy/cystic encodes an enzyme required for chitin and glycan synthesis, involved in trachea, embryonic cuticle and CNS development--analysis of its role in Drosophila tracheal morphogenesisSofia J Araújo
Institut de Biologia Molecular de Barcelona CSIC, Parc Cientific de Barcelona, Carrer Josep Samitier 1 5, 08028 Barcelona, Spain
Dev Biol 288:179-93. 2005..We discuss the implications of these new data in the mechanism of size control in the Drosophila trachea...
- Dystrophin is required for appropriate retrograde control of neurotransmitter release at the Drosophila neuromuscular junctionMariska C van der Plas
Department of Molecular and Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
J Neurosci 26:333-44. 2006..Our results indicate that the postsynaptically localized scaffolding protein Dystrophin is required for appropriate control of neuromuscular synaptic homeostasis...
- Postsynaptic mad signaling at the Drosophila neuromuscular junctionVeronica Dudu
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Curr Biol 16:625-35. 2006..There is evidence that a retrograde, presynaptic transforming growth factor-beta (TGF-beta) signaling event regulates synapse development and function in Drosophila...
- Drosophila melanogaster Scramblases modulate synaptic transmissionUsha Acharya
Laboratory of Protein Dynamics and Signaling, National Cancer Institute Frederick, Frederick, MD 21702, USA
J Cell Biol 173:69-82. 2006..The lack of phenotypes related to failure of scrambling and the neurophysiological analysis lead us to propose that Scramblases play a modulatory role in the process of neurotransmission...
- The adult abdominal neuromuscular junction of Drosophila: a model for synaptic plasticitySarita Hebbar
Department of Zoology, Miami University, Oxford, Ohio 45056, USA
J Neurobiol 66:1140-55. 2006..Our results indicate that both activity and FasII affect development at the adult abdominal NMJ in ways that are distinct from their larval and adult thoracic counterparts..
- Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyteJohn S Poulton
Department of Biological Science, Florida State University, Tallahassee, FL 32306 4370, USA
Proc Natl Acad Sci U S A 103:12775-80. 2006..Our data indicate that Dystroglycan links EGFR-induced repression of the anterior follicle cell fate and anterior-posterior polarity formation in the oocyte...
- The B' protein phosphatase 2A regulatory subunit well-rounded regulates synaptic growth and cytoskeletal stability at the Drosophila neuromuscular junctionNatasha M Viquez
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 26:9293-303. 2006..Hence, wrd promotes the function of PP2A and is required for normal cytoskeletal organization, synaptic growth, and synaptic function at the Drosophila NMJ...
- aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during developmentTony J C Harris
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
Dev Cell 12:727-38. 2007..aPKC apparently regulates this balance. Without aPKC, abnormally strong microtubule interactions break AJ symmetry and epithelial structure is lost...
- A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growthSarah Huntwork
The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Building 46, Room 3243, Cambridge, Massachusetts 02139, USA
Nat Neurosci 10:1235-7. 2007....
- Cellular behavior in the developing Drosophila pupal retinaDavid E Larson
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, Saint Louis, MO 63110, USA
Mech Dev 125:223-32. 2008..Based upon our live visualization of the P120-Catenin mutant as well as genetic data, we conclude that P120-Catenin is acting to stabilize E-cadherin and adherens junction integrity during eye development...
- Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesisCatarina C F Homem
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
Development 135:1005-18. 2008..These effects also are mediated through coordinated effects on myosin activity and adhesion, suggesting a common mechanism for Diaphanous action during morphogenesis...
- The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarityJianzhong Yu
Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
PLoS ONE 3:e1761. 2008....
- Septate junctions are required for ommatidial integrity and blood-eye barrier function in DrosophilaSwati Banerjee
Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Dev Biol 317:585-99. 2008..Our studies may provide clues towards understanding the vertebrate BEB formation and function...
- Basolateral junctions utilize warts signaling to control epithelial-mesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cellsMin Zhao
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
Genetics 178:1947-71. 2008Fasciclin2 (Fas2) and Discslarge (Dlg) localize to the basolateral junction (BLJ) of Drosophila follicle epithelial cells and inhibit their proliferation and invasion...
- The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitorsStephan Speicher
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas University Miguel Hernandez, Sant Joan d Alacant, 03550 Alicante, Spain
Curr Biol 18:831-7. 2008....
- Nuf, a Rab11 effector, maintains cytokinetic furrow integrity by promoting local actin polymerizationJian Cao
Sinsheimer Laboratories, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
J Cell Biol 182:301-13. 2008..We propose a model in which RE-derived vesicles promote furrow integrity by regulating the rate of actin polymerization through the RhoGEF2-Rho1 pathway...
- Crumbs stabilises epithelial polarity during tissue remodellingKyra Campbell
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
J Cell Sci 122:2604-12. 2009....
- Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epitheliaD F Woods
Developmental Biology Center, University of California, Irvine 92717 2274, USA
J Cell Biol 134:1469-82. 1996The Discs large (Dlg) protein of Drosophila is the prototypic member of a growing family of proteins termed membrane-associated guanylate kinase homologs (MAGUKs)...
- The neurogenic genes egghead and brainiac define a novel signaling pathway essential for epithelial morphogenesis during Drosophila oogenesisS Goode
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Development 122:3863-79. 1996....
- Cell polarity: the PARty expandsC Q Doe
Institute of Molecular Biology and the Institute of Neuroscience, HHMI, University of Oregon, Eugene, Oregon 97403, USA
Nat Cell Biol 3:E7-9. 2001..This common cell-polarity mechanism is used in cell-specific ways, as highlighted by the recent finding that at least two different types of asymmetric division are observed in Drosophila neural precursors...
- Drosophila alpha- and beta-spectrin mutations disrupt presynaptic neurotransmitter releaseD E Featherstone
Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
J Neurosci 21:4215-24. 2001....
- Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPixD Parnas
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
Neuron 32:415-24. 2001..dpix mutations lead to decreased synaptic levels of the PDZ protein Dlg, the cell adhesion molecule Fas II, and the glutamate receptor subunit GluRIIA, and to a complete reduction of the ..
- Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in DrosophilaA Razzaq
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
Genes Dev 15:2967-79. 2001..We therefore propose that muscle amphiphysin is not involved in clathrin-mediated endocytosis, but in the structural organization of the membrane-bound compartments of the excitation-contraction coupling machinery of muscles...
- Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter releasePatrik Verstreken
Program in Developmental Biology, Houston, TX, USA
Cell 109:101-12. 2002..We propose that kiss-and-run maintains neurotransmission at active zones of the larval NMJ in endophilin animals...
- Genetic studies define MAGUK proteins as regulators of epithelial cell polarityGeorgina Caruana
Department of Anatomy and Cell Biology, Monash University, Clayton, Victoria, Australia
Int J Dev Biol 46:511-8. 2002..review will focus on the genetic studies that have contributed to our understanding of the MAGUK family members, Dlg and Lin-2/CASK, in controlling these processes...
- DLG differentially localizes Shaker K+-channels in the central nervous system and retina of DrosophilaC Ruiz-Canada
Instituto de Neurociencias, Universidad Miguel Hernandez CSIC, San Juan, Alicante, Spain
J Neurochem 82:1490-501. 2002..Here we show that Discs-Large (DLG), a member of the MAGUK (membrane-associated guanylate kinases) family in Drosophila, co-localizes with Shaker ..
- CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X proteinAnnette Schenck
Department of Molecular Pathology, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Boite Postale 10142, 67404 Illkirch, Cedex, France
Neuron 38:887-98. 2003..CYFIP interacts biochemically and genetically with dFMR1 and dRac1. Finally, CYFIP acts as a dRac1 effector that antagonizes FMR1 function, providing a bridge between signal-dependent cytoskeleton remodeling and translation...
- Frizzled signalling and cell polarisation in Drosophila and vertebratesDavid Strutt
Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
Development 130:4501-13. 2003..This review discusses recent findings regarding non-canonical Frizzled signalling and cell polarisation...
- The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosisKieran F Harvey
Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
Cell 114:457-67. 2003..Hpo, Sav, and Wts interact physically and functionally, and regulate DIAP1 levels, likely by Hpo-mediated phosphorylation and subsequent degradation. Thus, Hpo links Sav and Wts to a key regulator of apoptosis...
- Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cellsRichard Benton
The Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, CB2 1QR Cambridge, United Kingdom
Cell 115:691-704. 2003..Thus, antagonism of Bazooka by PAR-1/14-3-3 may represent a general mechanism for establishing complementary cortical domains in polarized cells...
- CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORKMark Peifer; Fiscal Year: 2001..Our proposal seeks to meet these new needs, by the creation of a multi-user facility that will provide a state-of-the art confocal microscope to a large group of NIH funded investigators. ..
- Wnt and beta-Catenin Signaling in Development/DiseaseMariann Bienz; Fiscal Year: 2006..Basic researchers and the pharmaceutical and biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development. [unreadable] [unreadable]..
- A novel Dlg isoform and identification of its interacting proteinsKyung Ok Cho; Fiscal Year: 2007..The Discs-Large (Dlg) family of proteins was originally identified as a tumor suppressor in flies, and multiple mammalian Dlg homologs ..
- Thermoprotected mechanisms regulating neurotransmitter release following heat preShanker Karunanithi; Fiscal Year: 2007..The general findings of our investigations will ultimately lead to the development of therapies to prevent stress-induced synaptic damage. [unreadable] [unreadable]..
- Regulation of synaptic growth and plasticity in DrosophilaKATHALEEN O CONNOR GILES; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Novel Cilia Trafficking MechanismsBENJAMIN L MARGOLIS; Fiscal Year: 2010..Cystic diseases of the kidney, where the normal kidney is replaced by non-functioning fluid filled cysts, are a major cause of kidney failure. ..
- MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONSChris Doe; Fiscal Year: 2002..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
- Molecular Mechanisms of Drosophila Gonad MorphogenesisMark Van Doren; Fiscal Year: 2005..The completion of these aims will provide the first comprehensive analysis of gonad morphogenesis in Drosophila and provide insight into the molecular mechanisms that control this process. ..
- Sexual Dimorphism in the Drosophila GonadMark Van Doren; Fiscal Year: 2008..It will also provide a basis for understanding human syndromes, such as the one caused by loss of Sox9, where sexual dimorphism is disrupted, resulting in sex reversal and infertility. [unreadable] [unreadable]..
- Tight Junction Proteins and Epithelial PolarityBenjamin Margolis; Fiscal Year: 2009..These studies will shed new light on the processes necessary for early epithelial polarization and have important implication for renal epithelial function in health and disease. ..
- MOLECULAR DISSECTION OF TUMOR INVASIONSCOTT A GOODE; Fiscal Year: 2010..Immunoglobulin superfamily members Fasciclin2 (human NCAM) and Neuroglian (human L1), and scaffolding molecules Discslarge (hDIg) and Lethal Giant larvae (hLgl)...
- Role of the Archipelago gene in Drosophila tracheal morphogenesisKenneth H Moberg; Fiscal Year: 2010..Thus, we hypothesize that ago plays an important role in the homeostatic mechanisms that restrain tracheal branching. Our goal in Specific Aim 3 is to define this role and elucidate its molecular basis. ..