dlg1

Summary

Gene Symbol: dlg1
Description: discs large 1
Alias: CG1725, CG1730, CPD, DLG, DLG-A, DLG1, Discs-large, Dlg, Dlg-A, Dlg1, DlgA, DlgS97, Dmel\CG1725, Drodlg, PSD-95, PSD95, SAP97, anon-EST:Posey93, anon-WO03040301.258, anon-WO03040301.260, anon-WO03040301.268, d. lg.-1, dlg, dlg-1, dlg-A, dlgA, dlgS97, l(1)10Bf, l(1)G0276, l(1)G0342, l(1)G0456, l(1)G19, l(1)L11, l(1)bwn, l(1)d.lg-1, l(1)d.lg.-1, l(1)discs large, l(1)dlg, l(1)dlg-1, l(1)dlg1, l(1)l.pr.-2, l(1)lpr-2, misb, CG1725 gene product from transcript CG1725-RL, CG1725-PA, CG1725-PB, CG1725-PC, CG1725-PD, CG1725-PE, CG1725-PF, CG1725-PG, CG1725-PH, CG1725-PI, CG1725-PJ, CG1725-PK, CG1725-PL, CG1725-PM, CG1725-PN, CG1725-PO, CG1725-PP, CG1725-PQ, CG1725-PR, CG1725-PS, CG1725-PT, CG1725-PU, Disc-Large, Discs-large, disc large, disclarge, discs large, discslarge, disk large, dlg1-PA, dlg1-PB, dlg1-PC, dlg1-PD, dlg1-PE, dlg1-PF, dlg1-PG, dlg1-PH, dlg1-PI, dlg1-PJ, dlg1-PK, dlg1-PL, dlg1-PM, dlg1-PN, dlg1-PO, dlg1-PP, dlg1-PQ, dlg1-PR, dlg1-PS, dlg1-PT, dlg1-PU, lethal(1)benign wing imaginal disc neoplasm, lethal(1)discs large, lethal(1)discs-large, lethal(2)discs large
Species: fruit fly

Top Publications

  1. pmc A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction
    Jan Pielage
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 175:491-503. 2006
  2. ncbi Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner
    Giuseppa Pennetta
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 35:291-306. 2002
  3. pmc Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions
    Peri T Kurshan
    F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Neurosci 12:1415-23. 2009
  4. ncbi The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye
    Alexandre Djiane
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 121:621-31. 2005
  5. ncbi Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts
    Sarah E Siegrist
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Cell 123:1323-35. 2005
  6. ncbi Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors
    D Bilder
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 289:113-6. 2000
  7. pmc A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia
    Seonok Lee
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical School, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
    Mol Cell Biol 22:1778-91. 2002
  8. pmc The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiation
    Mary Packard
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Cell 111:319-30. 2002
  9. ncbi Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila
    Madhuri Kango-Singh
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 129:5719-30. 2002
  10. ncbi Planar polarity and actin dynamics in the epidermis of Drosophila
    Julia A Kaltschmidt
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Nat Cell Biol 4:937-44. 2002

Detail Information

Publications194 found, 100 shown here

  1. pmc A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction
    Jan Pielage
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 175:491-503. 2006
    ..We propose a model in which a postsynaptic Spectrin-actin lattice acts as an organizing scaffold upon which pre- and postsynaptic development are arranged...
  2. ncbi Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner
    Giuseppa Pennetta
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 35:291-306. 2002
    ..We propose that a DVAP-33A-mediated interaction between microtubules and presynaptic membrane plays a pivotal role during bouton budding...
  3. pmc Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions
    Peri T Kurshan
    F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Neurosci 12:1415-23. 2009
    ..Our results indicate that alpha(2)delta proteins have functions that are independent of their roles in the biophysics and localization of Ca(2+) channels and that synaptic architecture depends on these functions...
  4. ncbi The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye
    Alexandre Djiane
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 121:621-31. 2005
    ..We propose a model whereby the dPatj/aPKC complex regulates PCP by inhibiting Fz1 in cells where it should not be active...
  5. ncbi Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts
    Sarah E Siegrist
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Cell 123:1323-35. 2005
    ..We show that astral microtubules, kinesin Khc-73, and Discs large (Dlg) induce cortical polarization of Pins/Galphai in Drosophila neuroblasts; this cortical domain is ..
  6. ncbi Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors
    D Bilder
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 289:113-6. 2000
    ..We show that the tumor suppressors lethal giant larvae (lgl) and discs-large (dlg) have identical effects on all three epithelia, and that scrib also acts as a tumor suppressor...
  7. pmc A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia
    Seonok Lee
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical School, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
    Mol Cell Biol 22:1778-91. 2002
    ..We also report the identification of a novel isoform of Discs Large, a Drosophila melanogaster orthologue of SAP97, which contains a region highly related to the SAP97 N terminus ..
  8. pmc The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiation
    Mary Packard
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Cell 111:319-30. 2002
    ..We suggest that Wg signals the coordinated development of pre- and postsynaptic compartments...
  9. ncbi Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila
    Madhuri Kango-Singh
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 129:5719-30. 2002
    ..shar-pei encodes a WW-domain-containing protein that has homologs in worms, mice and humans, suggesting that mechanisms of organ growth control are evolutionarily conserved...
  10. ncbi Planar polarity and actin dynamics in the epidermis of Drosophila
    Julia A Kaltschmidt
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Nat Cell Biol 4:937-44. 2002
    ..We show that Wingless (Wg) signalling and Jun amino-terminal kinase (JNK) signalling have overlapping but different roles in these events...
  11. pmc A Drosophila resource of transgenic RNAi lines for neurogenetics
    Jian Quan Ni
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia 20147, USA
    Genetics 182:1089-100. 2009
    ....
  12. pmc The Hippo pathway regulates apical-domain size independently of its growth-control function
    Alice Genevet
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 122:2360-70. 2009
    ..Therefore, Hippo signalling controls growth and apical domain size by distinct mechanisms...
  13. doi Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis
    Nicole A Kaplan
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 423, New York, NY 10021, USA
    J Cell Sci 123:3157-65. 2010
    ..We conclude that apical-basal proteins, used to establish polarity within a cell, can be independently co-opted to function in epithelial morphogenesis...
  14. doi Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila
    Katarína Tiklová
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
    Nat Cell Biol 12:1071-7. 2010
    ..Mouse MTf complements the defects of Drosophila MTf mutants. Drosophila provides the first genetic model for the functional dissection of MTf in epithelial junction assembly and morphogenesis...
  15. ncbi Dynactin is necessary for synapse stabilization
    Benjamin A Eaton
    Department of Biochemistry and Biophysics, San Francisco, California 94143, USA
    Neuron 34:729-41. 2002
    ..Our data suggests that dynactin functions locally within the presynaptic arbor to promote synapse stability...
  16. ncbi The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size
    Maria Willecke
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 16:2090-100. 2006
    ..However, components acting upstream of Expanded and Merlin, such as transmembrane receptors, have not yet been identified...
  17. pmc Dynamic control of cell cycle and growth coupling by ecdysone, EGFR, and PI3K signaling in Drosophila histoblasts
    Nikolay Ninov
    Instituto de Biologia Molecular de Barcelona, Consejo Superior de Investigaciones Cientificas, Barcelona, Spain
    PLoS Biol 7:e1000079. 2009
    ..It sets the stage for the comprehensive understanding of the coordination of cell growth and cell-cycle progression in complex multicellular eukaryotes...
  18. ncbi Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases
    E Kim
    Howard Hughes Medical Institute, Massachusetts General Hospital, Department of Neurobiology, Harvard Medical School, Boston 02114, USA
    Nature 378:85-8. 1995
    ..3) and syntrophin), suggest that PDZ-domain-containing polypeptides may be widely involved in the organization of proteins at sites of membrane specialization...
  19. pmc Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing
    David D O'Keefe
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 311:25-39. 2007
    ..Ras, therefore, regulates both the transcriptional responses necessary for vein cell identity, and the cell adhesive changes that determine vein and intervein cell morphology...
  20. pmc Synergy between bacterial infection and genetic predisposition in intestinal dysplasia
    Yiorgos Apidianakis
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:20883-8. 2009
    ..Assessment of progenitor cell responses to pathogenic intestinal bacteria could provide a measure of predisposition for apoptotic enterocyte-assisted intestinal dysplasias in humans...
  21. doi Echinoid regulates Flamingo endocytosis to control ommatidial rotation in the Drosophila eye
    Yu Huei Ho
    Institute of Molecular Medicine, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 30034, Republic of China
    Development 137:745-54. 2010
    ..Thus, co-endocytosis of Ed and Fmi provides a link between apicobasal polarity and PCP...
  22. ncbi Malignant neoplasms of genetic origin in Drosophila melanogaster
    E Gateff
    Science 200:1448-59. 1978
    ..Thus Drosophila and vertebrate neoplasms show striking similarities...
  23. pmc Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation
    Y H Koh
    Department of Biology, University of Massachusetts, Amherst 01003, USA
    Cell 98:353-63. 1999
    b>Discs large (DLG) mediates the clustering of synaptic molecules. Here we demonstrate that synaptic localization of DLG itself is regulated by CaMKII...
  24. ncbi Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function
    Y Q Zhang
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Cell 107:591-603. 2001
    ..dfxr futsch double mutants restore normal synaptic structure and function. We propose that dFXR acts as a translational repressor of Futsch to regulate microtubule-dependent synaptic growth and function...
  25. ncbi Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila
    Ian P Coyle
    Laboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Neuron 41:521-34. 2004
    ..We propose that Nwk controls synapse morphology by regulating actin dynamics downstream of growth signals in presynaptic terminals...
  26. ncbi The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
    Fisun Hamaratoglu
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Nat Cell Biol 8:27-36. 2006
    ..Our genetic and biochemical data place Merlin and Expanded upstream of Hippo and identify a pathway through which they act as tumour-suppressor genes...
  27. ncbi The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain
    Andrea Mahr
    Max Planck Institut fur Entwicklungsbiologie, Abt III Genetik, Spemannstr 35, 72076 Tubingen, Germany
    Gene Expr Patterns 6:299-309. 2006
    ..Given that vesicular glutamate transporters are essential for the uptake of the neurotransmitter glutamate into synaptic vesicles these tools provide a means to test gene function in these functionally important neurons...
  28. ncbi GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo
    Erika A Bach
    Pharmacology Department, New York University School of Medicine, New York, NY 10016 6402, USA
    Gene Expr Patterns 7:323-31. 2007
    ..These reporters are valuable tools to further investigate and understand the role of JAK/STAT signaling in Drosophila...
  29. pmc Nervous wreck interacts with thickveins and the endocytic machinery to attenuate retrograde BMP signaling during synaptic growth
    Kate M O'Connor-Giles
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Neuron 58:507-18. 2008
    ..We propose that Nwk functions at the interface of endocytosis and BMP signaling to ensure proper synaptic growth by negatively regulating Tkv to set limits on this positive growth signal...
  30. ncbi Mbt, a Drosophila PAK protein, combines with Cdc42 to regulate photoreceptor cell morphogenesis
    Daniela Schneeberger
    University of Wurzburg, Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Versbacherstr 5, 97078 Wurzburg, Germany
    Development 130:427-37. 2003
    ..Besides regulation of kinase activity, another important function of Cdc42 is to recruit Mbt to adherens junctions. We propose a role for Mbt as a downstream effector of Cdc42 in photoreceptor cell morphogenesis...
  31. pmc Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg
    V Budnik
    Department of Biology, University of Massachusetts, Amherst 01003, USA
    Neuron 17:627-40. 1996
    Mutations of the tumor suppressor gene discs-large (dlg) lead to postsynaptic structural defects. Here, we report that mutations in dlg also result in larger synaptic currents at fly neuromuscular junctions...
  32. pmc Regulation of cadherin adhesive activity
    B M Gumbiner
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Cell Biol 148:399-404. 2000
  33. ncbi Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway
    F Christian Bennett
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Curr Biol 16:2101-10. 2006
    ..A newly emerging signaling pathway that controls organ size during development is the Salvador/Warts/Hippo pathway...
  34. ncbi The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal system
    Sarah M Paul
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Development 130:4963-74. 2003
    ....
  35. ncbi The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4E
    Kaushiki P Menon
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 44:663-76. 2004
    ..The GluRIIa glutamate receptor is upregulated in pum mutants. These results, together with genetic epistasis studies, suggest that postsynaptic Pum modulates synaptic function via direct control of eIF-4E expression...
  36. ncbi Drosophila Knickkopf and Retroactive are needed for epithelial tube growth and cuticle differentiation through their specific requirement for chitin filament organization
    Bernard Moussian
    Department of Genetics, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Development 133:163-71. 2006
    ..We propose a model in which Knk and the predicted chitin-binding protein Rtv form membrane complexes essential for epithelial tubulogenesis and cuticle formation through their specific role in directing chitin filament assembly...
  37. ncbi Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila
    Shovon I Ashraf
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Cell 124:191-205. 2006
    ..Therefore, we propose that degradative control of the RISC pathway underlies the pattern of synaptic protein synthesis associated with a stable memory...
  38. pmc Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epithelium
    Robert P Simone
    University of Pennsylvania Medical School, Department of Cell and Developmental Biology, 421 Curie Boulevard, Philadelphia, PA 19104 6048, USA
    Development 137:1385-94. 2010
    ..Additionally, we show that non-muscle Myosin II and the polarity proteins Discs large (Dlg) and Bazooka are enriched along cell interfaces in a complex but reproducible pattern that suggests their ..
  39. ncbi Energy-dependent regulation of cell structure by AMP-activated protein kinase
    Jun Hee Lee
    National Creative Research Initiatives Center for Cell Growth Regulation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong gu, Taejon 305 701, Korea
    Nature 447:1017-20. 2007
    ..Taken together, our results demonstrate that AMPK has highly conserved roles across metazoan species not only in the control of metabolism, but also in the regulation of cellular structures...
  40. pmc Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe
    Boris Egger
    The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Neural Dev 2:1. 2007
    ..In some tissues cell fate appears to dictate the type of cell division, whereas in other tissues it is thought that stochastic variation in spindle position dictates subsequent sibling cell fate...
  41. ncbi The role of the actomyosin cytoskeleton in coordination of tissue growth during Drosophila oogenesis
    Ying Wang
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstrasse 17, D 50931 Köln, Germany
    Curr Biol 17:1349-55. 2007
    ..Myosin is activated at the apical cortex by localized Rho kinase and inhibited at the basolateral cortex by PP1beta9C. In addition, our data indicate that active myosin is apically anchored by the Baz/Par-6/aPKC complex...
  42. doi Grainy head promotes expression of septate junction proteins and influences epithelial morphogenesis
    Maithreyi Narasimha
    Wellcome Trust Cancer Research UK Gurdon Institute of Developmental Biology and Cancer, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    J Cell Sci 121:747-52. 2008
    ..The fact that ectopic Grh arrests dorsal closure also suggests that this dynamic process relies on epithelia having distinct adhesive properties conferred by differential deployment of Grh...
  43. pmc The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth
    Fisun Hamaratoglu
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Sci 122:2351-9. 2009
    ..Therefore, Hippo signaling regulates cell polarity complexes in addition to and independently of its growth control function in imaginal disc cells...
  44. ncbi Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family
    S D Dimitratos
    Developmental Biology Center, University of California, Irvine, California
    Bioessays 21:912-21. 1999
    ..BioEssays 1999;21:912-921...
  45. pmc The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila
    Tony J C Harris
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 170:813-23. 2005
    ..These results reveal key steps in the assembly of the apical domain in Drosophila...
  46. ncbi Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch
    Cedric Polesello
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2 3PX, United Kingdom
    Curr Biol 17:1864-70. 2007
    ..The PCP members of the SWH network are not involved in this process, indicating that signaling upstream of Hpo varies according to developmental context...
  47. ncbi Combinatorial signaling in the specification of primary pigment cells in the Drosophila eye
    Raghavendra Nagaraj
    Department of Molecular, Cell and Developmental Biology, Department of Biological Chemistry, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Development 134:825-31. 2007
    ..Combined with previous work, these data show that unique combinations of only two pathways--Notch and EGFR--can specify at least five different cell types within the Drosophila eye...
  48. doi Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila
    Li Lun Ho
    Intercollege Graduate Degree Program in Cell and Developmental Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Dev Biol 337:274-83. 2010
    ..These results support a model in which the plasma membrane is an important site of action for Mats tumor suppressor to control tissue growth and organ size...
  49. ncbi Molecular cloning of the lethal(1)discs large-1 oncogene of Drosophila
    D F Woods
    Developmental Biology Center, University of California, Irvine 92717
    Dev Biol 134:222-35. 1989
    We present a genetic, developmental and molecular analysis of lethal(1)discs large-1[l(1)d.lg-1; Stewart et al., 1972], an oncogene of Drosophila...
  50. ncbi A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function
    S Baumgartner
    Friedrich Miescher Institute, Basel, Switzerland
    Cell 87:1059-68. 1996
    ..These studies identify NRX as the first transmembrane protein of SJ and demonstrate a requirement for NRX in the formation of septate-junction septa and intercellular barriers...
  51. ncbi Localization of proteins to the apico-lateral junctions of Drosophila epithelia
    D F Woods
    Developmental Biology Center, University of California, Irvine, USA
    Dev Genet 20:111-8. 1997
    ..as FITC phalloidin marking filamentous actin, labeled the site of the adherens junction, whereas antibodies to Discs large (DIg), Fasciclin III (FasIII) and Coracle (Cor) labeled the more basal septate junction...
  52. pmc Synaptic clustering of the cell adhesion molecule fasciclin II by discs-large and its role in the regulation of presynaptic structure
    U Thomas
    Department of Neurochemistry and Molecular Biology, Federal Institute for Neurobiology, Magdeburg, Germany
    Neuron 19:787-99. 1997
    ..by binding between the intracellular tSXV bearing C-terminal tail of FASII and the PDZ1-2 domains of Discs-Large (DLG)...
  53. pmc Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs large
    C D Hough
    Developmental Biology Center, University of California, Irvine, California 92697 2275, USA
    Genes Dev 11:3242-53. 1997
    b>Discs large (Dlg) was the first identified member of an increasingly important class of proteins called membrane-associated guanylate kinase homologs (MAGUKs), which are often concentrated at cell junctions and contain distinct peptide ..
  54. ncbi Protein modules as organizers of membrane structure
    A S Fanning
    Departments of Internal Medicine and Cell Biology, Yale University School of Medicine, PO Box 208019, New Haven, CT 06520 8019, USA
    Curr Opin Cell Biol 11:432-9. 1999
    ..The organization of these proteins into discreet structures has functional consequences for downstream signaling...
  55. ncbi A role for PS integrins in morphological growth and synaptic function at the postembryonic neuromuscular junction of Drosophila
    K J Beumer
    Biology Department, University of Utah, Salt Lake City, UT 84112, USA
    Development 126:5833-46. 1999
    ..These data provide the first genetic evidence for a functional role of integrins at the postembryonic synapse...
  56. ncbi Synaptic development is controlled in the periactive zones of Drosophila synapses
    M Sone
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Development 127:4157-68. 2000
    ..BetaPS integrin and discs large (DLG), both involved in synaptic development, also decorated the zone...
  57. ncbi Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast
    T Ohshiro
    CREST, Japan Science and Technology Corporation, Sendai
    Nature 408:593-6. 2000
    ..Another tumour-suppressor protein, Lethal discs large (Dlg), participates in this process by regulating the localization of Lgl...
  58. ncbi Asymmetric cell division: fly neuroblast meets worm zygote
    C Q Doe
    Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Curr Opin Cell Biol 13:68-75. 2001
    ..Mammalian epithelia also use this complex to regulate apical/basal polarity. Recent results have allowed us to compare the mechanisms regulating asymmetric cell division in Drosophila neuroblasts and the C. elegans zygote...
  59. ncbi Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts
    Y Hong
    Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California San Francisco, San Francisco, California 94143 0725, USA
    Nature 414:634-8. 2001
    ..However, for the subset of ectodermal cells that delaminate and form neuroblasts, their polarity requires the function of Bazooka, but not of Stardust or Crumbs...
  60. ncbi Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in synaptic vesicle endocytosis
    A C Zelhof
    Institute of Neuroscience, HHMI, University of Oregon 1254, Eugene, OR 97403, USA
    Development 128:5005-15. 2001
    ..are viable, lack any observable endocytic defects, but have abnormal localization of the postsynaptic proteins Discs large, Lethal giant larvae and Scribble, altered synaptic physiology, and behavioral defects...
  61. ncbi Rap1 GTPase regulation of adherens junction positioning and cell adhesion
    Andrea L Knox
    Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, UK
    Science 295:1285-8. 2002
    ..Rap1 is enriched at adherens junctions, particularly between newly divided sister cells where it may reseal the adherens junction ring. The regulation of adherens junction positioning could play a role in cell mobility and cell division...
  62. ncbi Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells
    Emmanuelle Médina
    NMDA IBDM, UMR 6156, Campus de Luminy, Universite de la Mediterranee, Case 907, 13288 Marseille Cedex 09, France
    Biol Cell 94:305-13. 2002
    ..Finding an answer to these questions will help to find new therapies for Retinitis pigmentosa and other retina degeneration in which CRB1, the human homologue of crb, has been involved...
  63. ncbi A genetic hierarchy controlling cell polarity
    Kevin Johnson
    Nat Cell Biol 5:12-4. 2003
  64. ncbi Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia
    Salim Abdelilah-Seyfried
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, D 13125 Berlin Buch, Germany
    Development 130:1927-35. 2003
    ..bazooka function is required during cell invasion of epithelial follicle cells mutant for the tumor suppressor discs large. Clonal studies indicate that follicle cell Bazooka acts as a permissive factor during cell invasion, possibly ..
  65. ncbi Novel isoforms of Dlg are fundamental for neuronal development in Drosophila
    Carolina Mendoza
    Programa de Fisiologia y Biofisica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile 6530499
    J Neurosci 23:2093-101. 2003
    ..cDNAs that include novel exons encoding a peptide homologous to the N terminus of the mammalian protein SAP97/hDLG (S97N)...
  66. ncbi Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning
    Rebecca Bastock
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 130:3007-14. 2003
    ..In the second phase, Dishevelled and Prickle are required for these proteins to become asymmetrically distributed on the proximodistal axis...
  67. pmc Discs-Large and Strabismus are functionally linked to plasma membrane formation
    Ok kyung Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Nat Cell Biol 5:987-93. 2003
    ..ectopic co-expression of Stbm (which associated with post-Golgi vesicles) and the mammalian Dlg homologue SAP97/hDlg promoted translocation of SAP97 from the cytoplasm to both post-Golgi vesicles and the plasma membrane...
  68. pmc Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia
    Melissa M Rolls
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, OR 97403, USA
    J Cell Biol 163:1089-98. 2003
    ..Miranda from the apical cortex; yet, they show normal apical crescents of Baz/Par3, Pins, Inscuteable, and Discs large and normal spindle orientation...
  69. ncbi Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97
    ANDRE BACHMANN
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    J Cell Sci 117:1899-909. 2004
    Stardust (Sdt) and Discs-Large (Dlg) are membrane-associated guanylate kinases (MAGUKs) involved in the organization of supramolecular protein complexes at distinct epithelial membrane compartments in Drosophila...
  70. pmc Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth
    David R Hipfner
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genes Dev 18:2243-8. 2004
    ..This is distinct from Slik's effects on cell proliferation, which are mediated by Raf. Thus Slik acts via distinct pathways to coordinate cell proliferation with epithelial cell behavior during tissue growth...
  71. ncbi glaikit is essential for the formation of epithelial polarity and neuronal development
    John Dunlop
    Medical Research Council, Centre for Developmental Neurobiology, 4th Floor, New Hunts House, Guys Campus, King s College London, London SE1 1UL, United Kingdom
    Curr Biol 14:2039-45. 2004
    ..A mutation in the human homolog of gkt causes the neurodegenerative disease spinocerebellar ataxia with neuropathy (SCAN1), making it possible that a failure of membrane protein localization is a cause of this disease...
  72. ncbi mummy/cystic encodes an enzyme required for chitin and glycan synthesis, involved in trachea, embryonic cuticle and CNS development--analysis of its role in Drosophila tracheal morphogenesis
    Sofia J Araújo
    Institut de Biologia Molecular de Barcelona CSIC, Parc Cientific de Barcelona, Carrer Josep Samitier 1 5, 08028 Barcelona, Spain
    Dev Biol 288:179-93. 2005
    ..We discuss the implications of these new data in the mechanism of size control in the Drosophila trachea...
  73. ncbi Dystrophin is required for appropriate retrograde control of neurotransmitter release at the Drosophila neuromuscular junction
    Mariska C van der Plas
    Department of Molecular and Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Neurosci 26:333-44. 2006
    ..Our results indicate that the postsynaptically localized scaffolding protein Dystrophin is required for appropriate control of neuromuscular synaptic homeostasis...
  74. ncbi Postsynaptic mad signaling at the Drosophila neuromuscular junction
    Veronica Dudu
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Curr Biol 16:625-35. 2006
    ..There is evidence that a retrograde, presynaptic transforming growth factor-beta (TGF-beta) signaling event regulates synapse development and function in Drosophila...
  75. pmc Drosophila melanogaster Scramblases modulate synaptic transmission
    Usha Acharya
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Cell Biol 173:69-82. 2006
    ..The lack of phenotypes related to failure of scrambling and the neurophysiological analysis lead us to propose that Scramblases play a modulatory role in the process of neurotransmission...
  76. ncbi The adult abdominal neuromuscular junction of Drosophila: a model for synaptic plasticity
    Sarita Hebbar
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    J Neurobiol 66:1140-55. 2006
    ..Our results indicate that both activity and FasII affect development at the adult abdominal NMJ in ways that are distinct from their larval and adult thoracic counterparts..
  77. pmc Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte
    John S Poulton
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4370, USA
    Proc Natl Acad Sci U S A 103:12775-80. 2006
    ..Our data indicate that Dystroglycan links EGFR-induced repression of the anterior follicle cell fate and anterior-posterior polarity formation in the oocyte...
  78. ncbi The B' protein phosphatase 2A regulatory subunit well-rounded regulates synaptic growth and cytoskeletal stability at the Drosophila neuromuscular junction
    Natasha M Viquez
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:9293-303. 2006
    ..Hence, wrd promotes the function of PP2A and is required for normal cytoskeletal organization, synaptic growth, and synaptic function at the Drosophila NMJ...
  79. pmc aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Dev Cell 12:727-38. 2007
    ..aPKC apparently regulates this balance. Without aPKC, abnormally strong microtubule interactions break AJ symmetry and epithelial structure is lost...
  80. ncbi A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth
    Sarah Huntwork
    The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Building 46, Room 3243, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 10:1235-7. 2007
    ....
  81. pmc Cellular behavior in the developing Drosophila pupal retina
    David E Larson
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, Saint Louis, MO 63110, USA
    Mech Dev 125:223-32. 2008
    ..Based upon our live visualization of the P120-Catenin mutant as well as genetic data, we conclude that P120-Catenin is acting to stabilize E-cadherin and adherens junction integrity during eye development...
  82. doi Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis
    Catarina C F Homem
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 135:1005-18. 2008
    ..These effects also are mediated through coordinated effects on myosin activity and adhesion, suggesting a common mechanism for Diaphanous action during morphogenesis...
  83. pmc The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity
    Jianzhong Yu
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS ONE 3:e1761. 2008
    ....
  84. pmc Septate junctions are required for ommatidial integrity and blood-eye barrier function in Drosophila
    Swati Banerjee
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Dev Biol 317:585-99. 2008
    ..Our studies may provide clues towards understanding the vertebrate BEB formation and function...
  85. pmc Basolateral junctions utilize warts signaling to control epithelial-mesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cells
    Min Zhao
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 178:1947-71. 2008
    Fasciclin2 (Fas2) and Discslarge (Dlg) localize to the basolateral junction (BLJ) of Drosophila follicle epithelial cells and inhibit their proliferation and invasion...
  86. doi The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitors
    Stephan Speicher
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas University Miguel Hernandez, Sant Joan d Alacant, 03550 Alicante, Spain
    Curr Biol 18:831-7. 2008
    ....
  87. pmc Nuf, a Rab11 effector, maintains cytokinetic furrow integrity by promoting local actin polymerization
    Jian Cao
    Sinsheimer Laboratories, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    J Cell Biol 182:301-13. 2008
    ..We propose a model in which RE-derived vesicles promote furrow integrity by regulating the rate of actin polymerization through the RhoGEF2-Rho1 pathway...
  88. pmc Crumbs stabilises epithelial polarity during tissue remodelling
    Kyra Campbell
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    J Cell Sci 122:2604-12. 2009
    ....
  89. pmc Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia
    D F Woods
    Developmental Biology Center, University of California, Irvine 92717 2274, USA
    J Cell Biol 134:1469-82. 1996
    The Discs large (Dlg) protein of Drosophila is the prototypic member of a growing family of proteins termed membrane-associated guanylate kinase homologs (MAGUKs)...
  90. ncbi The neurogenic genes egghead and brainiac define a novel signaling pathway essential for epithelial morphogenesis during Drosophila oogenesis
    S Goode
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Development 122:3863-79. 1996
    ....
  91. ncbi Cell polarity: the PARty expands
    C Q Doe
    Institute of Molecular Biology and the Institute of Neuroscience, HHMI, University of Oregon, Eugene, Oregon 97403, USA
    Nat Cell Biol 3:E7-9. 2001
    ..This common cell-polarity mechanism is used in cell-specific ways, as highlighted by the recent finding that at least two different types of asymmetric division are observed in Drosophila neural precursors...
  92. ncbi Drosophila alpha- and beta-spectrin mutations disrupt presynaptic neurotransmitter release
    D E Featherstone
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    J Neurosci 21:4215-24. 2001
    ....
  93. ncbi Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix
    D Parnas
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 32:415-24. 2001
    ..dpix mutations lead to decreased synaptic levels of the PDZ protein Dlg, the cell adhesion molecule Fas II, and the glutamate receptor subunit GluRIIA, and to a complete reduction of the ..
  94. pmc Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila
    A Razzaq
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Genes Dev 15:2967-79. 2001
    ..We therefore propose that muscle amphiphysin is not involved in clathrin-mediated endocytosis, but in the structural organization of the membrane-bound compartments of the excitation-contraction coupling machinery of muscles...
  95. ncbi Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release
    Patrik Verstreken
    Program in Developmental Biology, Houston, TX, USA
    Cell 109:101-12. 2002
    ..We propose that kiss-and-run maintains neurotransmission at active zones of the larval NMJ in endophilin animals...
  96. ncbi Genetic studies define MAGUK proteins as regulators of epithelial cell polarity
    Georgina Caruana
    Department of Anatomy and Cell Biology, Monash University, Clayton, Victoria, Australia
    Int J Dev Biol 46:511-8. 2002
    ..review will focus on the genetic studies that have contributed to our understanding of the MAGUK family members, Dlg and Lin-2/CASK, in controlling these processes...
  97. ncbi DLG differentially localizes Shaker K+-channels in the central nervous system and retina of Drosophila
    C Ruiz-Canada
    Instituto de Neurociencias, Universidad Miguel Hernandez CSIC, San Juan, Alicante, Spain
    J Neurochem 82:1490-501. 2002
    ..Here we show that Discs-Large (DLG), a member of the MAGUK (membrane-associated guanylate kinases) family in Drosophila, co-localizes with Shaker ..
  98. ncbi CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein
    Annette Schenck
    Department of Molecular Pathology, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Boite Postale 10142, 67404 Illkirch, Cedex, France
    Neuron 38:887-98. 2003
    ..CYFIP interacts biochemically and genetically with dFMR1 and dRac1. Finally, CYFIP acts as a dRac1 effector that antagonizes FMR1 function, providing a bridge between signal-dependent cytoskeleton remodeling and translation...
  99. ncbi Frizzled signalling and cell polarisation in Drosophila and vertebrates
    David Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 130:4501-13. 2003
    ..This review discusses recent findings regarding non-canonical Frizzled signalling and cell polarisation...
  100. ncbi The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
    Kieran F Harvey
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
    Cell 114:457-67. 2003
    ..Hpo, Sav, and Wts interact physically and functionally, and regulate DIAP1 levels, likely by Hpo-mediated phosphorylation and subsequent degradation. Thus, Hpo links Sav and Wts to a key regulator of apoptosis...
  101. ncbi Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells
    Richard Benton
    The Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, CB2 1QR Cambridge, United Kingdom
    Cell 115:691-704. 2003
    ..Thus, antagonism of Bazooka by PAR-1/14-3-3 may represent a general mechanism for establishing complementary cortical domains in polarized cells...

Research Grants13

  1. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
    ..Our proposal seeks to meet these new needs, by the creation of a multi-user facility that will provide a state-of-the art confocal microscope to a large group of NIH funded investigators. ..
  2. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
    ..Basic researchers and the pharmaceutical and biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development. [unreadable] [unreadable]..
  3. A novel Dlg isoform and identification of its interacting proteins
    Kyung Ok Cho; Fiscal Year: 2007
    ..The Discs-Large (Dlg) family of proteins was originally identified as a tumor suppressor in flies, and multiple mammalian Dlg homologs ..
  4. Thermoprotected mechanisms regulating neurotransmitter release following heat pre
    Shanker Karunanithi; Fiscal Year: 2007
    ..The general findings of our investigations will ultimately lead to the development of therapies to prevent stress-induced synaptic damage. [unreadable] [unreadable]..
  5. Regulation of synaptic growth and plasticity in Drosophila
    KATHALEEN O CONNOR GILES; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. Novel Cilia Trafficking Mechanisms
    BENJAMIN L MARGOLIS; Fiscal Year: 2010
    ..Cystic diseases of the kidney, where the normal kidney is replaced by non-functioning fluid filled cysts, are a major cause of kidney failure. ..
  7. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  8. Molecular Mechanisms of Drosophila Gonad Morphogenesis
    Mark Van Doren; Fiscal Year: 2005
    ..The completion of these aims will provide the first comprehensive analysis of gonad morphogenesis in Drosophila and provide insight into the molecular mechanisms that control this process. ..
  9. Sexual Dimorphism in the Drosophila Gonad
    Mark Van Doren; Fiscal Year: 2008
    ..It will also provide a basis for understanding human syndromes, such as the one caused by loss of Sox9, where sexual dimorphism is disrupted, resulting in sex reversal and infertility. [unreadable] [unreadable]..
  10. Tight Junction Proteins and Epithelial Polarity
    Benjamin Margolis; Fiscal Year: 2009
    ..These studies will shed new light on the processes necessary for early epithelial polarization and have important implication for renal epithelial function in health and disease. ..
  11. MOLECULAR DISSECTION OF TUMOR INVASION
    SCOTT A GOODE; Fiscal Year: 2010
    ..Immunoglobulin superfamily members Fasciclin2 (human NCAM) and Neuroglian (human L1), and scaffolding molecules Discslarge (hDIg) and Lethal Giant larvae (hLgl)...
  12. Role of the Archipelago gene in Drosophila tracheal morphogenesis
    Kenneth H Moberg; Fiscal Year: 2010
    ..Thus, we hypothesize that ago plays an important role in the homeostatic mechanisms that restrain tracheal branching. Our goal in Specific Aim 3 is to define this role and elucidate its molecular basis. ..