Dll

Summary

Gene Symbol: Dll
Description: Distal-less
Alias: Art, BcDNA:LP01770, CG3629, DLL, Dmel\CG3629, E(Arp), En(Arp), dll, l(2)01092, l(2)387, CG3629 gene product from transcript CG3629-RA, CG3629-PA, CG3629-PB, CG3629-PC, Distall-less, Dll-PA, Dll-PB, Dll-PC, brista, distal-less, distalless, enhancer of Arp
Species: fruit fly

Top Publications

  1. ncbi Direct integration of Hox and segmentation gene inputs during Drosophila development
    Brian Gebelein
    Department of Biochemistry and Molecular Biophysics and Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, HHSC 1104, New York, New York 10032, USA
    Nature 431:653-9. 2004
  2. pmc Establishment of medial fates along the proximodistal axis of the Drosophila leg through direct activation of dachshund by Distalless
    Matt W Giorgianni
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Dev Cell 20:455-68. 2011
  3. pmc Control of the spineless antennal enhancer: direct repression of antennal target genes by Antennapedia
    Dianne Duncan
    Department of Biology, Washington University, 1 Brookings Drive, St Louis, MO 63130, USA
    Dev Biol 347:82-91. 2010
  4. ncbi Intercalation of cell fates during tarsal development in Drosophila
    M I Galindo
    School of Biological Sciences, University of Sussex, Brighton, UK
    Bioessays 22:777-80. 2000
  5. doi Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila
    Katarzyna Oktaba
    EMBL, Gene Expression Programme, Heidelberg, Germany
    Dev Cell 15:877-89. 2008
  6. ncbi Distal-less encodes a homoeodomain protein required for limb development in Drosophila
    S M Cohen
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, FRG
    Nature 338:432-4. 1989
  7. ncbi Hox protein mutation and macroevolution of the insect body plan
    Matthew Ronshaugen
    Section of Cell and Developmental Biology, Universith of California San Diego, Jolla, CA 92093, USA
    Nature 415:914-7. 2002
  8. ncbi The development of crustacean limbs and the evolution of arthropods
    G Panganiban
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706, USA
    Science 270:1363-6. 1995
  9. ncbi Specification of the embryonic limb primordium by graded activity of Decapentaplegic
    S Goto
    Genetic Stock Research Center, National Institute of Genetics, Mishima, Japan
    Development 124:125-32. 1997
  10. ncbi Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling
    X Lin
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 400:281-4. 1999

Research Grants

  1. IN VIVO ROLE OF PROTEOGLYCANS IN GROWTH FACTOR SIGNALING
    J Marsh; Fiscal Year: 2001
  2. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
  3. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
  4. Quantitative genomics of sexual dimorphism
    Sergey Nuzhdin; Fiscal Year: 2005
  5. Molecular Mechanisms of Segmentation
    Cordelia Rauskolb; Fiscal Year: 2005
  6. MOLECULAR BASIS OF DEVELOPMENTAL CELL INTERACTIONS
    J Marsh; Fiscal Year: 2005
  7. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications137 found, 100 shown here

  1. ncbi Direct integration of Hox and segmentation gene inputs during Drosophila development
    Brian Gebelein
    Department of Biochemistry and Molecular Biophysics and Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, HHSC 1104, New York, New York 10032, USA
    Nature 431:653-9. 2004
    ..directly with two different segmentation proteins, Sloppy paired and Engrailed, to repress the Hox target gene Distalless in anterior and posterior compartments, respectively...
  2. pmc Establishment of medial fates along the proximodistal axis of the Drosophila leg through direct activation of dachshund by Distalless
    Matt W Giorgianni
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Dev Cell 20:455-68. 2011
    ..According to this model, high [Wg+Dpp] activates Distalless (Dll) and represses dachshund (dac) in the distal cells of the leg disc, while intermediate [Wg+Dpp] activates ..
  3. pmc Control of the spineless antennal enhancer: direct repression of antennal target genes by Antennapedia
    Dianne Duncan
    Department of Biology, Washington University, 1 Brookings Drive, St Louis, MO 63130, USA
    Dev Biol 347:82-91. 2010
    ..We conclude that the function of Antennapedia in the leg is not to repress homothorax, as has been suggested, but to directly repress spineless and other antennal genes that would otherwise be activated within this ring...
  4. ncbi Intercalation of cell fates during tarsal development in Drosophila
    M I Galindo
    School of Biological Sciences, University of Sussex, Brighton, UK
    Bioessays 22:777-80. 2000
    ....
  5. doi Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila
    Katarzyna Oktaba
    EMBL, Gene Expression Programme, Heidelberg, Germany
    Dev Cell 15:877-89. 2008
    ..Analysis of cell cycle regulators indicates that the PcG system also dynamically modulates the expression levels of certain genes, providing a possible explanation for the tumor phenotype of PcG mutants...
  6. ncbi Distal-less encodes a homoeodomain protein required for limb development in Drosophila
    S M Cohen
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, FRG
    Nature 338:432-4. 1989
    ..The molecular structure of the Distal-less locus indicates that the gene encodes a homoeodomain-containing protein which is therefore likely to specify limb development through differential regulation of subordinate genes...
  7. ncbi Hox protein mutation and macroevolution of the insect body plan
    Matthew Ronshaugen
    Section of Cell and Developmental Biology, Universith of California San Diego, Jolla, CA 92093, USA
    Nature 415:914-7. 2002
    ..Here we show that naturally selected alteration of the Ubx protein is linked to the evolutionary transition to hexapod limb pattern...
  8. ncbi The development of crustacean limbs and the evolution of arthropods
    G Panganiban
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706, USA
    Science 270:1363-6. 1995
    ..the use of molecular probes, including an antibody to proteins encoded by arthropod and vertebrate Distal-less (Dll and Dlx) genes, provided evidence that common genetic mechanisms underlie the development of all arthropod limbs ..
  9. ncbi Specification of the embryonic limb primordium by graded activity of Decapentaplegic
    S Goto
    Genetic Stock Research Center, National Institute of Genetics, Mishima, Japan
    Development 124:125-32. 1997
    ..We propose that Wingless and Decapentaplegic act sequentially to initiate the proximodistal axis...
  10. ncbi Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling
    X Lin
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 400:281-4. 1999
    ..Our results indicate that Dally may act as a co-receptor for Wg, and that Dally, together with Drosophila Frizzled 2, modulates both short- and long-range activities of Wg...
  11. ncbi Limb type-specific regulation of bric a brac contributes to morphological diversity
    Jessie Chu
    Department of Anatomy, University of Wisconsin, Madison, WI 53706, USA
    Development 129:695-704. 2002
    ..We propose that the limb type-specific variations in expression of bric a brac repressors contribute to morphological variations by controlling distal limb segment number...
  12. ncbi The roles of the homeobox genes aristaless and Distal-less in patterning the legs and wings of Drosophila
    G Campbell
    Department of Genetics and Development, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, HHSC, Room 1120, New York, NY 10032, USA columbia edu
    Development 125:4483-93. 1998
    ..wing imaginal discs of Drosophila, the expression domains of the homeobox genes aristaless (al) and Distal-less (Dll) are defined by the secreted signaling molecules Wingless (Wg) and Decapentaplegic (Dpp)...
  13. ncbi Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila
    David S Parker
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor 48109, USA
    Development 129:2565-76. 2002
    ..Our data argue strongly that Pygopus is a new core component of the Wg signaling pathway that acts downstream or at the level of TCF...
  14. pmc Inhibition of Drosophila Wg signaling involves competition between Mad and Armadillo/beta-catenin for dTcf binding
    Yi Arial Zeng
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    PLoS ONE 3:e3893. 2008
    ....
  15. ncbi Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less
    G Vachon
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030
    Cell 71:437-50. 1992
    ..Repression of limb development in the abdomen appears to be controlled at the DII enhancer. Thus DII may serve as a downstream target gene through which the homeotic genes control abdominal segment identity in the Drosophila embryo...
  16. ncbi Mediation of Drosophila head development by gap-like segmentation genes
    S M Cohen
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
    Nature 346:482-5. 1990
    ..We report here that three previously identified zygotic genes buttonhead (btd), empty spiracles (ems) and orthodenticle (otd) may behave like gap genes that mediate bcd function in the embryonic head...
  17. ncbi Specification of limb development in the Drosophila embryo by positional cues from segmentation genes
    S M Cohen
    Lehrstuhl fur Genetik, Universitat Munchen, FRG
    Nature 343:173-7. 1990
    ..This analysis allows a direct molecular visualization of the compartments that subdivide the limb primordia into discrete developmental domains...
  18. ncbi The role of the Distal-less gene in the development and evolution of insect limbs
    G Panganiban
    Howard Hughes Medical Institute, University of Wisconsin Madison 53706
    Curr Biol 4:671-5. 1994
    ..Comparative studies of the expression and regulation during development of limb-patterning genes, such as Distal-less (Dll), may provide insights into arthropod evolution.
  19. ncbi Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing
    F J Diaz-Benjumea
    Differentiation Program, European Molecular Biology Laboratory, Heidelberg, Germany
    Development 121:4215-25. 1995
    ..Ligand independent activation of Notch is sufficient to direct Wg expression, which in turn mediates the organizing activity of the D/V boundary...
  20. ncbi Visualization of gene expression in living adult Drosophila
    M Calleja
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, Madrid 28049, Spain
    Science 274:252-5. 1996
    ..The boundary between two of these domains coincides with localized expression of the signaling molecule wingless...
  21. ncbi Direct and long-range action of a wingless morphogen gradient
    M Zecca
    Zoologisches Institut der Universitat Zurich, Switzerland
    Cell 87:833-44. 1996
    ..We interpret these findings as evidence that Wg can act directly and at long range as a gradient morphogen during normal development...
  22. ncbi Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing
    C J Neumann
    European Molecular Biology Laboratory, Heidelberg, Germany
    Development 124:871-80. 1997
    ..We propose that Wg acts as a morphogen in patterning the D/V axis of the wing...
  23. ncbi Proximal-distal axis formation in the Drosophila leg
    T Lecuit
    European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 388:139-45. 1997
    ..Subsequent modulation of the relative sizes of these domains by growth of the leg is required to form the mature pattern...
  24. pmc The homeobox gene Distal-less induces ventral appendage development in Drosophila
    N Gorfinkiel
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Genes Dev 11:2259-71. 1997
    This study investigates the role of the homeobox gene Distal-less (Dll) in the development of the legs, antennae, and wings of Drosophila...
  25. pmc Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor
    D M Duncan
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Genes Dev 12:1290-303. 1998
    ..In both the antenna and leg, ss expression is shown to depend on Distal-less (Dll), a master regulator of ventral appendage formation...
  26. ncbi Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing
    K M Cadigan
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University Medical Center, California 94305, USA
    Cell 93:767-77. 1998
    ..In contrast to other ligand-receptor relationships where the receptor limits diffusion of the ligand, Dfz2 broadens the range of Wg action by protecting it from degradation...
  27. ncbi Proximo-distal development in the legs of Drosophila
    J P Couso
    School of Biological Sciences, Royal Holloway College, University of London, Surrey, United Kingdom
    Int J Dev Biol 42:345-52. 1998
    ..The data suggest a process of regionalization and progressive subdivision of an anlage similar to both insect embryonic segmentation and vertebrate somitogenesis...
  28. ncbi Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development
    M Abu-Shaar
    Department of Biochemistry and Molecular Biophysics, Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 125:3821-30. 1998
    ..We demonstrate that WG and DPP act together through their targets Distal-less (Dll) and dachshund (dac) to restrict hth expression, and therefore EXD's nuclear localization, to the most proximal ..
  29. ncbi Notch signalling mediates segmentation of the Drosophila leg
    J F de Celis
    Department of Genetics and Department of Anatomy, University of Cambridge, Downing Street, Cambridge, UK
    Development 125:4617-26. 1998
    ....
  30. ncbi Proximodistal axis formation in the Drosophila leg: subdivision into proximal and distal domains by Homothorax and Distal-less
    J Wu
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Germany
    Development 126:109-17. 1999
    ..into proximal and distal domains by the activity of the homeodomain proteins Homothorax (Hth) and Distal-less (Dll). The expression domains of Dll and Hth are initially reciprocal...
  31. ncbi Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin
    F Hamada
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita 565 0871, Japan
    Science 283:1739-42. 1999
    ..Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in Drosophila...
  32. ncbi Patterning mechanisms in the body trunk and the appendages of Drosophila
    G Morata
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Development 126:2823-8. 1999
    ..We speculate that, although the basic mechanisms are similar, there are significant differences in the manner the body trunk and appendages respond to them...
  33. ncbi Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants
    A Sato
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 126:4421-30. 1999
    ..Wingless signaling may thus be attenuated by Dfrizzled-3 at least in wingless hypomorphic mutants...
  34. ncbi Coexpression of the homeobox genes Distal-less and homothorax determines Drosophila antennal identity
    P D Dong
    Department of Anatomy, University of Wisconsin, Madison, WI 53706, USA
    Development 127:209-16. 2000
    ..Based on their genetic and biochemical properties, we propose that Homothorax and Extradenticle may serve as antenna-specific cofactors for Distal-less...
  35. ncbi A dual role for homothorax in inhibiting wing blade development and specifying proximal wing identities in Drosophila
    F Casares
    Department of Biochemistry and Molecular Biophysics, Columbia University, HHSC 1108, New York, NY 10032 USA
    Development 127:1499-508. 2000
    ..Our results suggest that tsh and hth block wing blade development by repressing some of the activities of the Notch pathway at the D/V compartment boundary...
  36. ncbi EGF receptor attenuates Dpp signaling and helps to distinguish the wing and leg cell fates in Drosophila
    K Kubota
    Genetic Strain Research Center and The Graduate University for Advanced Studies, National Institute of Genetics, Mishima 411 8540, Japan
    Development 127:3769-76. 2000
    ..and leg precursors of Drosophila are recruited from a common pool of ectodermal cells expressing the homeobox gene Dll. Induction by Dpp promotes this cell fate decision toward the wing and proximal leg...
  37. ncbi The Hox gene Abdominal-B antagonizes appendage development in the genital disc of Drosophila
    B Estrada
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Development 128:331-9. 2001
    ..We propose that the genital primordia should be subdivided into two regions, one of them competent to be transformed into an appendage in the absence of Abdominal-B...
  38. ncbi Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex
    Thomas Kramps
    Institut fur Molekularbiologie, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Cell 109:47-60. 2002
    ....
  39. ncbi HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient
    Antonio J Giraldez
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Dev Cell 2:667-76. 2002
    ..High levels of Wingless signaling induce Notum expression. Thus, Wingless contributes to shaping its own gradient by regulating expression of a protein that modifies its interaction with cell surface proteoglycans...
  40. ncbi Hox repression of a target gene: extradenticle-independent, additive action through multiple monomer binding sites
    Ron Galant
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    Development 129:3115-26. 2002
    ....
  41. ncbi Leg patterning driven by proximal-distal interactions and EGFR signaling
    M I Galindo
    School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Science 297:256-9. 2002
    ..signaling establishes the proximal-distal axis of Drosophila legs by activating the expression of genes such as Distalless and dachshund in broad proximal-distal domains during early leg development...
  42. ncbi Distalization of the Drosophila leg by graded EGF-receptor activity
    Gerard Campbell
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nature 418:781-5. 2002
    ..This similarity between proximodistal patterning in vertebrates and flies supports previous suggestions of an evolutionary relationship between appendages/body-wall outgrowths in animals...
  43. ncbi Developmental functions of the Distal-less/Dlx homeobox genes
    Grace Panganiban
    Department of Anatomy, University of Wisconsin, Madison, WI 53706, USA
    Development 129:4371-86. 2002
    ..We review what is known about the invertebrate and vertebrate Dll/Dlx genes and their varied roles during development...
  44. ncbi Specificity of Distalless repression and limb primordia development by abdominal Hox proteins
    Brian Gebelein
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Dev Cell 3:487-98. 2002
    ..The Hox protein Ultrabithorax (Ubx) suppresses limb formation in the abdomen by repressing the leg selector gene Distalless, whereas Antennapedia (Antp), a thoracic Hox protein, does not repress Distalless...
  45. ncbi Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila
    Joaquim Culi
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Cell 112:343-54. 2003
    ..Consequently, boca is an essential component of the Wingless pathway but is more generally required for the activities of multiple LDL receptor family members...
  46. ncbi The hexapeptide and linker regions of the AbdA Hox protein regulate its activating and repressive functions
    Samir Merabet
    Laboratoire de Genetique et Physiologie du Developpement, IBDM, CNRS, Universite de la Mediterranee, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Dev Cell 4:761-8. 2003
    ..Our in vivo data thus reveal functions not previously anticipated from in vitro analyses for the hexapeptide motif in the regulation of Hox activity...
  47. ncbi Comparative analysis of leg and antenna development in wild-type and homeotic Drosophila melanogaster
    Mark Cummins
    School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Dev Genes Evol 213:319-27. 2003
    ..The partial conservation of pattern-forming genes in both appendages ensures a predictable re-specification of positional clues, producing the observed positional specificity of homeotic transformations...
  48. ncbi Wingless promotes cell survival but constrains growth during Drosophila wing development
    Laura A Johnston
    Department of Genetics and Development, College of Physicians and Surgeons Columbia University 701 West 168th Street, New York, NY 10032, USA
    Nat Cell Biol 5:827-33. 2003
    ..We propose that the cell-survival- and growth-constraining activities of Wg function to sculpt and delimit final wing size as part of its overall patterning programme...
  49. ncbi The role of buttonhead and Sp1 in the development of the ventral imaginal discs of Drosophila
    Carlos Estella
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Development 130:5929-41. 2003
    ..They act as activators of the headcase (hdc) and Distal-less (Dll) genes, which allocate the cells of the disc primordia...
  50. ncbi Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans
    Yuki Takei
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Development 131:73-82. 2004
    ..We propose that HSPGs facilitate the spreading of morphogens and therefore, function to generate morphogen concentration gradients...
  51. ncbi Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development
    Antonio J Giraldez
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 130:6533-43. 2003
    ..However, only part of this effect was attributable to Notch-dependent induction of Wg, suggesting that other Notch-inducible signaling molecules contribute to the control of cell proliferation in the wing...
  52. ncbi Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation
    Chun Han
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 131:1563-75. 2004
    ..Our results also suggest that HSPGs have two distinct roles in Wg morphogen distribution and signalling...
  53. ncbi Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development
    Yi A Zeng
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada
    Development 131:2911-20. 2004
    ..These observations suggest that the patterning mechanism governed by Wg involves a negative feedback circuit in which Wg induces expression of its own antagonist Nemo...
  54. ncbi Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity
    Johan Kreuger
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Cell 7:503-12. 2004
    ..Notum-induced shedding of Dlp could convert Dlp from a membrane-tethered coreceptor to a secreted antagonist...
  55. ncbi Distal-less functions in subdividing the Drosophila thoracic limb primordium
    Reese A Bolinger
    Department of Anatomy, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Dev Dyn 232:801-16. 2005
    ..We propose that central cells of the primordium previously thought to contribute to the distal leg are Keilin's organ precursors, while both proximal and distal leg precursors are located more peripherally and within the escargot domain...
  56. ncbi Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax
    Ella Tour
    Section in Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Development 132:5271-81. 2005
    ..These results suggest that the N-terminal region containing the SSYF motif has been conserved in many Hox proteins for its role in transcriptional activation...
  57. ncbi Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs
    Eugenia Piddini
    National Institute for Medical Research, The Ridgeway Mill Hill, London NW7 1AA, UK
    Development 132:5479-89. 2005
    ..Overall, Frizzled2 achieves ligand capture and internalization, whereas Arrow, and perhaps downstream signalling, are essential for lysosomal targeting...
  58. pmc Internalization is required for proper Wingless signaling in Drosophila melanogaster
    Elaine S Seto
    Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 173:95-106. 2006
    ..As these data indicate that endosomal transport promotes Wg signaling, our findings suggest that the regulation of endocytosis is a novel mechanism through which Wg signaling levels are determined...
  59. pmc Control of growth and positional information by the graded vestigial expression pattern in the wing of Drosophila melanogaster
    L A Baena-Lopez
    Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma de Madrid Edificio Ciencias, CX 504 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 103:13734-9. 2006
    ..Our observations provide evidence that local cell interactions, triggered by differences in vestigial expression between neighboring cells, confer positional values operating in the control of growth and shape of the wing...
  60. pmc Logic of Wg and Dpp induction of distal and medial fates in the Drosophila leg
    Carlos Estella
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Development 135:627-36. 2008
    ..Wg and Dpp are also required to pattern the dorsoventral (DV) axis of the leg. Here, we show that Distalless (Dll) and dachshund (dac), genes expressed at different positions along the PD axis, are activated by Wg ..
  61. pmc Molecular integration of wingless, decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development
    Carlos Estella
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Dev Cell 14:86-96. 2008
    ..and Wingless (Wg), two signals that establish the proximo-distal (PD) axis by activating target genes such as Distalless (Dll)...
  62. pmc A Wingless and Notch double-repression mechanism regulates G1-S transition in the Drosophila wing
    Héctor Herranz
    ICREA and Institute for Research in Biomedicine, Barcelona, Spain
    EMBO J 27:1633-45. 2008
    ..Our results demonstrate that Notch acts in this cellular context as a repressor of cell-cycle progression and Wg has a permissive role in alleviating Notch-mediated repression of G1-S progression in wing cells...
  63. doi Timing of Wingless signalling distinguishes maxillary and antennal identities in Drosophila melanogaster
    Gaelle Lebreton
    Centre de Biologie du Developpement, UMR 5547 and IFR 109, Université de Toulouse and CNRS, 118 route de Narbonne, Bâtiment 4R3, 31062 Toulouse Cedex, France
    Development 135:2301-9. 2008
    ..We characterised: (1) the action of Wg through ss selector function in distinguishing maxillary from antenna; and (2) its direct contribution to identity choice...
  64. doi The 11-aminoacid long Tarsal-less peptides trigger a cell signal in Drosophila leg development
    Jose Ignacio Pueyo
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Dev Biol 324:192-201. 2008
    ..These regulatory effects complement the known genetic scenario required for distal leg development and explain the requirements for tarsal-less in this process...
  65. pmc The origins of the Drosophila leg revealed by the cis-regulatory architecture of the Distalless gene
    Daniel J Mckay
    Department of Biochemistry and Molecular Biophysics, Integrated Program in Cellular, Molecular, Structural and Genetic Studies, Columbia University, 701 W 168th Street, HHSC 1104, New York, NY 10032, USA
    Development 136:61-71. 2009
    ..into these two domains occurs during embryogenesis and is reflected in the cis-regulatory architecture of the Distalless (Dll) gene...
  66. pmc The core protein of glypican Dally-like determines its biphasic activity in wingless morphogen signaling
    Dong Yan
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Dev Cell 17:470-81. 2009
    ..Based on these data, we propose that the principal function of Dlp is to retain Wg on the cell surface. As such, it can either compete with the receptor or provide ligands to the receptor, depending on the ratios of Wg, Fz2, and Dlp...
  67. pmc Control of Distal-less expression in the Drosophila appendages by functional 3' enhancers
    Maximo Ibo Galindo
    Instituto de Biomedicina de Valencia IBV CSIC, Jaime Roig, 11, 46010 Valencia, Spain
    Dev Biol 353:396-410. 2011
    The expression of the Hox gene Distal-less (Dll) directs the development of appendages in a wide variety of animals. In Drosophila, its expression is subjected to a complex developmental control...
  68. pmc Variable motif utilization in homeotic selector (Hox)-cofactor complex formation controls specificity
    Katherine M Lelli
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 108:21122-7. 2011
    ..We propose that using different binding mechanisms with the same cofactor may be one strategy to achieve functional specificity in vivo...
  69. pmc Developmental regulation of chromatin conformation by Hox proteins in Drosophila
    Marios Agelopoulos
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 W 168th Street, HHSC 1104, New York, NY 10032, USA
    Cell Rep 1:350-9. 2012
    ..We applied this approach to Distalless (Dll), a gene required for limb development in Drosophila...
  70. doi A statistical fat-tail test of predicting regulatory regions in the Drosophila genome
    Jian Jun Shu
    School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    Comput Biol Med 42:935-41. 2012
    ..These two fatness coefficients may serve as valuable filtering indexes to predict CRMs experimentally...
  71. ncbi Allocation of the thoracic imaginal primordia in the Drosophila embryo
    B Cohen
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Development 117:597-608. 1993
    ..We have used a molecular probe derived from the Distal-less (Dll) gene to show that this population contains progenitor cells for both the dorsal (i.e. wing) and ventral (i.e...
  72. ncbi Formation and specification of distal leg segments in Drosophila by dual Bar homeobox genes, BarH1 and BarH2
    T Kojima
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 127:769-78. 2000
    ..Bar homeobox genes are also required for specification of distal tarsi. Bar expression requires Distal-less but not dachshund, while early circular dachshund expression is delimited interiorly by BarH1 and BarH2...
  73. pmc Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members
    R M Marquez
    Department of Biology, Arizona State University, Tempe, Arizona 85287, USA
    Genetics 157:1639-48. 2001
    ..Overall, the study demonstrates that transgenic methods in Drosophila can provide new information about non-Drosophila members of developmentally important multigene families...
  74. ncbi Bowl is required downstream of Notch for elaboration of distal limb patterning
    Jesus M de Celis Ibeas
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Development 130:5943-52. 2003
    ..This mechanism might be important in the diversification of arthropod limbs, because it explains how segmented tarsomeres could have arisen from an ancestral limb with an unsegmented tarsus...
  75. ncbi Cell interaction between compartments establishes the proximal-distal axis of Drosophila legs
    F J Diaz-Benjumea
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 372:175-9. 1994
    ..These results demonstrate that sequential interaction between anterior-posterior and dorsal-ventral compartments establishes the proximal-distal axis of the limbs...
  76. ncbi Glypicans shunt the Wingless signal between local signalling and further transport
    Xavier Franch-Marro
    National Institute for Medical Research, The Ridgeway Mill Hill, London NW7 1AA, UK
    Development 132:659-66. 2005
    ..signalling is increased at the expense of long-range signalling (reported by the expression of the target gene distalless) while the reverse is caused by Dally-like overexpression...
  77. ncbi Lipoprotein particles are required for Hedgehog and Wingless signalling
    Daniela Panàkovà
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Nature 435:58-65. 2005
    ..Similarly, the range of Wingless signalling is narrowed. We propose a novel function for lipoprotein particles, in which they act as vehicles for the movement of lipid-linked morphogens and glycophosphatidylinositol-linked proteins...
  78. ncbi Pleiotropic functions of a conserved insect-specific Hox peptide motif
    Chris Todd Hittinger
    Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 132:5261-70. 2005
    ....
  79. pmc A unique Extradenticle recruitment mode in the Drosophila Hox protein Ultrabithorax
    Samir Merabet
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique, Universite de la Mediterranee, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 104:16946-51. 2007
    ....
  80. ncbi Two distal-less related homeobox-containing genes expressed in regeneration blastemas of the newt
    M Beauchemin
    Unité de recherche en Ontogénèse et Génétique Moléculaire, Centre de recherche du CHU Laval, Sainte Foy, Canada
    Dev Biol 154:55-65. 1992
    ..This work is a first step toward understanding the possible relation between sustained expression of homeobox-containing genes in adult newt tissues and regeneration potential...
  81. ncbi The polar coordinate model goes molecular
    P J Bryant
    Developmental Biology Center, University of California, Irvine 92717
    Science 259:471-2. 1993
  82. ncbi Wing development and specification of dorsal cell fates in the absence of apterous in Drosophila
    T Klein
    Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK
    Curr Biol 8:417-20. 1998
    ..In ap mutants, the wing is lost [5] [9], and here we report that this phenotype can be rescued by ectopic expression of either Ser or fng and that, surprisingly, the resulting wings have both dorsal and ventral cell fates...
  83. ncbi Evolution of the interaction between Hox genes and a downstream target
    M F Palopoli
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
    Curr Biol 8:587-90. 1998
    ..In Drosophila melanogaster, one well-studied Hox regulatory target is Distal-less (Dll), which is required for the development of distal limb structures [3]...
  84. ncbi Selector genes and limb identity in arthropods and vertebrates
    S D Weatherbee
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison 53706, USA
    Cell 97:283-6. 1999
  85. ncbi A common mechanism for antenna-to-Leg transformation in Drosophila: suppression of homothorax transcription by four HOM-C genes
    L C Yao
    Institute of Genetics, Department of Life Science, National Yang Ming University, Shipai, Taipei, 112, Taiwan, Republic of China
    Dev Biol 211:268-76. 1999
    ..We also show that ectopic hth expression can cause duplication of the proximodistal axis of the antenna, suggesting that it is involved in proximodistal development of the antenna...
  86. ncbi Lineage-tracing cells born in different domains along the PD axis of the developing Drosophila leg
    K Weigmann
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany
    Development 126:3823-30. 1999
    ..In other systems, where growth and patterning are uncoupled, nonreversible specification events or 'ratchet' effects may be of functional significance...
  87. ncbi Fringe, Notch, and making developmental boundaries
    K D Irvine
    Waksman Institute, Department of Molecular Biology and Biochemistry, 190 Frelinghuysen Rd, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Opin Genet Dev 9:434-41. 1999
    ..Lunatic Fringe has been shown to be required for vertebrate somitogenesis, where it appears to act as a crucial link between a molecular clock and the regulation of Notch signaling...
  88. ncbi Regeneration in insects
    J L Marsh
    Developmental Biology Center and Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA
    Semin Cell Dev Biol 10:365-75. 1999
    ..Each of the regulatory networks could themselves serve as the subject of a detailed review and that is beyond the scope of this discussion. Here we will focus on the interplay between the regulatory networks in patterning the tissue...
  89. ncbi Leg development in flies versus grasshoppers: differences in dpp expression do not lead to differences in the expression of downstream components of the leg patterning pathway
    E L Jockusch
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
    Development 127:1617-26. 2000
    ..patterning, which are distinguished by interactions among the genes wingless (wg), decapentaplegic (dpp) and distalless (dll). In the allocation phase, dll is activated by wg but repressed by dpp...
  90. ncbi Morphogen gradient interpretation
    J B Gurdon
    Wellcome CRC Institute, Cambridge, UK
    Nature 413:797-803. 2001
    ....
  91. ncbi Grunge, related to human Atrophin-like proteins, has multiple functions in Drosophila development
    Alfrun Erkner
    Laboratoire de Genetique et Physiologie du Developpement, UMR 9943 C N R S Université, I B D M CNRS INSERM Université de la Méditerranée, Campus de Luminy Case 907, F 13288 Marseille, Cedex 09, France
    Development 129:1119-29. 2002
    ..Grunge has other regulatory functions in the leg, including the patterning of ventral parts along the entire proximodistal axis and the proper spacing of bristles in all regions...
  92. ncbi Different mechanisms initiate and maintain wingless expression in the Drosophila wing hinge
    David del Alamo Rodríguez Dd
    Centro de Biología Molecular Severo Ochoa C S I C, Facultad de Ciencias CV, Universidad Autónoma Cantoblanco, 28049 Madrid, Spain
    Development 129:3995-4004. 2002
    ..We discuss the role of wingless in patterning the wing hinge...
  93. ncbi Development of the Drosophila genital disc requires interactions between its segmental primordia
    Nicole Gorfinkiel
    Centro de Biologia Molecular Severo Ochoa, C S I C, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Development 130:295-305. 2003
    ..Collectively, these findings suggest that interaction between segmental primordia is required for the normal development of the genital disc...
  94. ncbi Wnts as morphogens? The view from the wing of Drosophila
    Alfonso Martinez Arias
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Nat Rev Mol Cell Biol 4:321-5. 2003
    ..However, a close analysis of their activity indicates that they do not fulfil all of the critera that are associated with the classical definition...
  95. ncbi Programmed cell death and context dependent activation of the EGF pathway regulate gliogenesis in the Drosophila olfactory system
    Anindya Sen
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400005, India
    Mech Dev 121:65-78. 2004
    ..These results underscore the importance of developmental context of cell lineages in their responses to non-autonomous signaling in the choice between survival and death...
  96. ncbi Proximodistal subdivision of Drosophila legs and wings: the elbow-no ocelli gene complex
    Ulrich Weihe
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 131:767-74. 2004
    ..We present evidence that the zinc-finger proteins encoded by the elbow and no ocelli genes act in leg and wing primordia to repress body wall-specifying genes and thereby direct appendage formation...
  97. ncbi An interactive network of zinc-finger proteins contributes to regionalization of the Drosophila embryo and establishes the domains of HOM-C protein function
    Lisa K Robertson
    Department of Genetics, Campus Box 7614, North Carolina State University, Raleigh, NC 27695 7614, USA
    Development 131:2781-9. 2004
    ..We conclude that a combination of regionalizing factors, in concert with the HOM-C proteins, promotes the specification of individual segment identity...
  98. ncbi EGFR signaling attenuates Groucho-dependent repression to antagonize Notch transcriptional output
    Peleg Hasson
    Department of Biochemistry, Faculty of Medicine, The Hebrew University, PO Box 12272, Jerusalem 91120, Israel
    Nat Genet 37:101-5. 2005
    ..Thus, Gro is a new junction between signaling pathways, enabling EGFR signaling to antagonize transcriptional output by Notch and potentially other Gro-dependent pathways...
  99. pmc Eyg and Ey Pax proteins act by distinct transcriptional mechanisms in Drosophila development
    Jih Guang Yao
    Institute of Genetics, National Yang Ming University, Shipai, Taipei, Taiwan, Republic of China
    EMBO J 24:2602-12. 2005
    ..Vertebrates produce a Pax6 isoform, Pax6-5a, differing from Pax6 in DNA-binding properties and functions and structurally similar to Eyg/Toe. We found that Pax6-5a acts as an activator like Ey, but has DNA-binding specificity like Eyg...
  100. ncbi Association of tracheal placodes with leg primordia in Drosophila and implications for the origin of insect tracheal systems
    Xavier Franch-Marro
    Institut de Biologia Molecular de Barcelona, CSIC, Barcelona, C Josep Samitier 1 5, 08028 Barcelona, Spain
    Development 133:785-90. 2006
    ..We propose an evolutionary scenario that accommodates the available data...
  101. ncbi How functions in leg development during Drosophila metamorphosis
    Tina M Fortier
    Department of Biological Sciences, Mount Holyoke College, South Hadley, Massachusetts 01075, USA
    Dev Dyn 235:2248-59. 2006
    ..Consequently, how mutants exhibit short, crooked legs. Our findings suggest that how functions in interactions between imaginal epithelium, peripodial epithelium, and larval epidermal cells during imaginal disc eversion...

Research Grants7

  1. IN VIVO ROLE OF PROTEOGLYCANS IN GROWTH FACTOR SIGNALING
    J Marsh; Fiscal Year: 2001
    ..Further, these in vivo studies may help in understanding the basis of some dysmorphologies in humans. ..
  2. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
    ..Consequently, the present research should have direct relevance to our understanding of how defects in TGF-B signaling can lead to disease. ..
  3. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ....
  4. Quantitative genomics of sexual dimorphism
    Sergey Nuzhdin; Fiscal Year: 2005
    ..We expect our results to have a profound impact on our understanding of the evolution of sexual dimorphism, and the role that sexual differentiation plays in the generation of phenotypic diversity. ..
  5. Molecular Mechanisms of Segmentation
    Cordelia Rauskolb; Fiscal Year: 2005
    ..abstract_text> ..
  6. MOLECULAR BASIS OF DEVELOPMENTAL CELL INTERACTIONS
    J Marsh; Fiscal Year: 2005
    ..Finally, we have identified a collection of mutants affecting disc growth patterns that serve as an enriched collection of new candidate genes to participate in these events. ..
  7. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010
    ..Consequently, the proposed studies should provide insights into diseases such as these, potentially leading to improved diagnosis and treatment. ..