Dscam

Summary

Gene Symbol: Dscam
Description: Down syndrome cell adhesion molecule
Alias: 43Bc, CG17800, CT39257, DSCAM, DScam, DmDscam, Dm_2R:13612, Dmel\CG17800, Dscam-hv, Dscam1, FBgn0033159, Neu1, dScam, dscam, l(2)05518, l(2)43Bc, p270, CG17800-PA, CG17800-PAA, CG17800-PAB, CG17800-PAC, CG17800-PAD, CG17800-PAE, CG17800-PAF, CG17800-PAG, CG17800-PAH, CG17800-PAI, CG17800-PAJ, CG17800-PAK, CG17800-PAL, CG17800-PAM, CG17800-PAN, CG17800-PAO, CG17800-PAP, CG17800-PAQ, CG17800-PAR, CG17800-PAS, CG17800-PAT, CG17800-PAU, CG17800-PAV, CG17800-PAW, CG17800-PAX, CG17800-PAY, CG17800-PAZ, CG17800-PBA, CG17800-PBB, CG17800-PBC, CG17800-PBD, CG17800-PBE, CG17800-PBF, CG17800-PBG, CG17800-PBH, CG17800-PBI, CG17800-PBJ, CG17800-PBK, CG17800-PBL, CG17800-PBM, CG17800-PBN, CG17800-PBO, CG17800-PBP, CG17800-PBQ, CG17800-PBR, CG17800-PBS, CG17800-PBT, CG17800-PBU, CG17800-PBV, CG17800-PBW, CG17800-PBX, CG17800-PBY, CG17800-PBZ, CG17800-PC, CG17800-PCA, CG17800-PCB, CG17800-PCC, CG17800-PCD, CG17800-PD, CG17800-PE, CG17800-PF, CG17800-PG, CG17800-PH, CG17800-PI, CG17800-PJ, CG17800-PL, CG17800-PM, CG17800-PO, CG17800-PR, CG17800-PT, CG17800-PV, CG17800-PW, CG17800-PX, CG17800-PY, CG17800-PZ, Down's syndrome cell adhesion molecule, Dscam-PA, Dscam-PAA, Dscam-PAB, Dscam-PAC, Dscam-PAD, Dscam-PAE, Dscam-PAF, Dscam-PAG, Dscam-PAH, Dscam-PAI, Dscam-PAJ, Dscam-PAK, Dscam-PAL, Dscam-PAM, Dscam-PAN, Dscam-PAO, Dscam-PAP, Dscam-PAQ, Dscam-PAR, Dscam-PAS, Dscam-PAT, Dscam-PAU, Dscam-PAV, Dscam-PAW, Dscam-PAX, Dscam-PAY, Dscam-PAZ, Dscam-PBA, Dscam-PBB, Dscam-PBC, Dscam-PBD, Dscam-PBE, Dscam-PBF, Dscam-PBG, Dscam-PBH, Dscam-PBI, Dscam-PBJ, Dscam-PBK, Dscam-PBL, Dscam-PBM, Dscam-PBN, Dscam-PBO, Dscam-PBP, Dscam-PBQ, Dscam-PBR, Dscam-PBS, Dscam-PBT, Dscam-PBU, Dscam-PBV, Dscam-PBW, Dscam-PBX, Dscam-PBY, Dscam-PBZ, Dscam-PC, Dscam-PCA, Dscam-PCB, Dscam-PCC, Dscam-PCD, Dscam-PD, Dscam-PE, Dscam-PF, Dscam-PG, Dscam-PH, Dscam-PI, Dscam-PJ, Dscam-PL, Dscam-PM, Dscam-PO, Dscam-PR, Dscam-PT, Dscam-PV, Dscam-PW, Dscam-PX, Dscam-PY, Dscam-PZ, down syndrome cell adhesion molecule, down syndrome cell-adhesion molecule, drosophila down syndrome cell adhesion molecule, drosophila down syndrome cell adhesion molecule 1, lethal(2)43Bc
Species: fruit fly

Top Publications

  1. ncbi Transmembrane/juxtamembrane domain-dependent Dscam distribution and function during mushroom body neuronal morphogenesis
    Jian Wang
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Neuron 43:663-72. 2004
  2. ncbi The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila
    Brian E Chen
    Department of Cancer Biology, Dana Farber Cancer Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Cell 125:607-20. 2006
  3. pmc Dscam2 mediates axonal tiling in the Drosophila visual system
    S Sean Millard
    Howard Hughes Medical Institute, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Nature 447:720-4. 2007
  4. ncbi Specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization
    Lei Shi
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Neurosci 27:6723-8. 2007
  5. ncbi Stochastic yet biased expression of multiple Dscam splice variants by individual cells
    Guilherme Neves
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 36:240-6. 2004
  6. pmc Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms
    Daisuke Hattori
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Nature 461:644-8. 2009
  7. pmc A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms
    Michael R Sawaya
    Howard Hughes Medical Institute, UCLA DOE Institute of Genomics and Proteomics, Los Angeles, CA 90095, USA
    Cell 134:1007-18. 2008
  8. pmc Dscam diversity is essential for neuronal wiring and self-recognition
    Daisuke Hattori
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90049, USA
    Nature 449:223-7. 2007
  9. doi RNA secondary structure in mutually exclusive splicing
    Yun Yang
    Institute of Biochemistry, College of Life Sciences, Zhejiang University Zijingang Campus, Hangzhou, Zhejiang, People s Republic of China
    Nat Struct Mol Biol 18:159-68. 2011
  10. ncbi Extensive diversity of Ig-superfamily proteins in the immune system of insects
    Fiona L Watson
    Department of Cancer Biology, Dana Farber Cancer Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 309:1874-8. 2005

Scientific Experts

  • BRENTON GRAVELEY
  • Sophie A O Armitage
  • Caroline C G Fabre
  • J M Young
  • Christopher Lee
  • Daniela Brites
  • Elizabeth M Forbes
  • Aya Takahashi
  • S Zipursky
  • Gregory S X E Jefferis
  • Shu Ning Hsu
  • A S Thum
  • D Anastassiou
  • Mary Packard
  • Mack E Crayton
  • Louis Du Pasquier
  • Fen Biao Gao
  • Tzumin Lee
  • Daisuke Hattori
  • James C Clemens
  • Wei Wu
  • Benjamin J Matthews
  • Jian Wang
  • S Sean Millard
  • Woj M Wojtowicz
  • Hung Hsiang Yu
  • Dietmar Schmucker
  • Yun Yang
  • John J Flanagan
  • Andrew Chess
  • Wesley B Grueber
  • David Baker
  • Thomas Hummel
  • Brian E Chen
  • Sara Olson
  • Jacob S Yang
  • Lei Shi
  • Masahiro Kondo
  • Fiona L Watson
  • Xiaoyan Zheng
  • Vedrana Cvetkovska
  • Xuebin Wang
  • Leilei Zhan
  • Yongfeng Jin
  • Wenjing Zhang
  • Jingpei Bi
  • Wenfeng Wang
  • Gemma E May
  • Hsiang Wen Shih
  • Jianhua Huang
  • Christopher T Zugates
  • Holger Pillmann
  • Bridget H Biersmith
  • Paola Cognigni
  • Guilherme Neves
  • Isabella Vlisidou
  • Hong Long
  • Marco Muda
  • Alexander Y Katsov
  • J Chen
  • Javier Morante
  • Jacob Shun Jen Yang
  • Gracie L Andrews
  • Matthias Vömel
  • Carolyn A Worby
  • Michael R Sawaya
  • Christian Wegener
  • Bin Qian
  • Ingemar Andre
  • Jia min Bai
  • Rüdiger Bader
  • Michael E Hughes
  • Peter Soba
  • Michael F Lin
  • Ke Zhang
  • Masahiro Funada
  • Rob Meijers
  • Roland Puettmann-Holgado
  • Koen J T Venken
  • Alex C Keene
  • Rajnish Bharadwaj
  • C A Worby
  • Haitao Zhu
  • Deniz Erturk-Hasdemir
  • Jenny M Kreahling
  • Christopher W J Smith
  • Elizabeth Pennisi
  • Elissa A Hallem
  • Xiao Li Zhan
  • Oliver Hobert

Detail Information

Publications82

  1. ncbi Transmembrane/juxtamembrane domain-dependent Dscam distribution and function during mushroom body neuronal morphogenesis
    Jian Wang
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Neuron 43:663-72. 2004
    Besides 19,008 possible ectodomains, Drosophila Dscam contains two alternative transmembrane/juxtamembrane segments, respectively, derived from exon 17.1 and exon 17.2...
  2. ncbi The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila
    Brian E Chen
    Department of Cancer Biology, Dana Farber Cancer Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Cell 125:607-20. 2006
    Alternative splicing of Dscam generates an enormous molecular diversity with maximally 38,016 different receptors. Whether this large diversity is required in vivo is currently unclear...
  3. pmc Dscam2 mediates axonal tiling in the Drosophila visual system
    S Sean Millard
    Howard Hughes Medical Institute, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Nature 447:720-4. 2007
    ..Our data support a model in which Dscam2 homophilic interactions mediate repulsion between neurites of L1 cells in neighbouring columns. We propose that Dscam2 is a tiling receptor for L1 neurons...
  4. ncbi Specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization
    Lei Shi
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Neurosci 27:6723-8. 2007
    Drosophila Dscam isoforms are derived from two alternative transmembrane/juxtamembrane domains (TMs) in addition to thousands of ectodomain variants...
  5. ncbi Stochastic yet biased expression of multiple Dscam splice variants by individual cells
    Guilherme Neves
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 36:240-6. 2004
    The Drosophila melanogaster gene Dscam is essential for axon guidance and has 38,016 possible alternative splice forms. This diversity can potentially be used to distinguish cells...
  6. pmc Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms
    Daisuke Hattori
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Nature 461:644-8. 2009
    b>Down Syndrome cell adhesion molecule (Dscam) genes encode neuronal cell recognition proteins of the immunoglobulin superfamily...
  7. pmc A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms
    Michael R Sawaya
    Howard Hughes Medical Institute, UCLA DOE Institute of Genomics and Proteomics, Los Angeles, CA 90095, USA
    Cell 134:1007-18. 2008
    Drosophila Dscam encodes a vast family of immunoglobulin (Ig)-containing proteins that exhibit isoform-specific homophilic binding. This diversity is essential for cell recognition events required for wiring the brain...
  8. pmc Dscam diversity is essential for neuronal wiring and self-recognition
    Daisuke Hattori
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90049, USA
    Nature 449:223-7. 2007
    ..In Drosophila, alternative splicing of the Down syndrome cell adhesion molecule (Dscam) gene potentially generates 38,016 closely related transmembrane proteins of the ..
  9. doi RNA secondary structure in mutually exclusive splicing
    Yun Yang
    Institute of Biochemistry, College of Life Sciences, Zhejiang University Zijingang Campus, Hangzhou, Zhejiang, People s Republic of China
    Nat Struct Mol Biol 18:159-68. 2011
    ..Additionally, under this model, we also deciphered a similar structural code in exon clusters 4 and 9 of Dscam (38,016 isoforms) and Mhc (480 isoforms)...
  10. ncbi Extensive diversity of Ig-superfamily proteins in the immune system of insects
    Fiona L Watson
    Department of Cancer Biology, Dana Farber Cancer Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 309:1874-8. 2005
    ..the potential to express more than 18,000 isoforms of the immunoglobulin (Ig)-superfamily receptor Down syndrome cell adhesion molecule (Dscam)...
  11. ncbi Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity
    D Schmucker
    Howard Hughes Medical Institute, Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, California 90095, USA
    Cell 101:671-84. 2000
    A Drosophila homolog of human Down syndrome cell adhesion molecule (DSCAM), an immunoglobulin superfamily member, was isolated by its affinity to Dock, an SH3/SH2 adaptor protein required for axon guidance...
  12. pmc Massive expansions of Dscam splicing diversity via staggered homologous recombination during arthropod evolution
    Christopher Lee
    Department of Chemistry and Biochemistry, Center for Computational Biology, Institute for Genomics and Proteomics, Molecular BiologyInstitute, University of California at Los Angeles, Los Angeles, California 90095 1570, USA
    RNA 16:91-105. 2010
    The arthropod Down syndrome cell adhesion molecule (Dscam) gene can generate tens of thousands of protein isoforms via combinatorial splicing of numerous alternative exons encoding immunoglobulin variable domains organized into three ..
  13. ncbi Dopamine-mushroom body circuit regulates saliency-based decision-making in Drosophila
    Ke Zhang
    Institute of Neuroscience, Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences CAS, 320 Yueyang Road, Shanghai 200031, China
    Science 316:1901-4. 2007
    ..Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila...
  14. pmc Competing RNA secondary structures are required for mutually exclusive splicing of the Dscam exon 6 cluster
    Gemma E May
    Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    RNA 17:222-9. 2011
    ..The Drosophila melanogaster Down Syndrome Cell Adhesion Molecule (Dscam) gene is an extreme example of mutually exclusive splicing...
  15. ncbi Dendrite self-avoidance is controlled by Dscam
    Benjamin J Matthews
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Cell 129:593-604. 2007
    ..that dendrite self-avoidance in Drosophila da sensory neurons requires cell-recognition molecules encoded by the Dscam locus...
  16. pmc Alternative splicing of the Drosophila Dscam pre-mRNA is both temporally and spatially regulated
    A M Celotto
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Genetics 159:599-608. 2001
    The Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam) gene encodes an axon guidance receptor that can express 38,016 different mRNAs by virtue of alternative splicing...
  17. pmc Population genetics of duplicated alternatively spliced exons of the Dscam gene in Daphnia and Drosophila
    Daniela Brites
    Zoologisches Institut, Evolutionsbiologie, University of Basel, Basel, Switzerland
    PLoS ONE 6:e27947. 2011
    In insects and crustaceans, the Down syndrome cell adhesion molecule (Dscam) occurs in many different isoforms...
  18. pmc Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding
    Woj M Wojtowicz
    Howard Hughes Medical Institute, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 118:619-33. 2004
    b>Dscam is an immunoglobulin (Ig) superfamily protein required for the formation of neuronal connections in Drosophila...
  19. ncbi Alternative splicing--when two's a crowd
    Christopher W J Smith
    Department of Biochemistry, Cambridge, UK
    Cell 123:1-3. 2005
    ..A paper in this issue of Cell (Graveley, 2005) provides a fascinating insight into the perplexing question of how only one exon at a time is chosen from an array of 48 exons in the Drosophila Dscam gene.
  20. ncbi Structural basis of Dscam isoform specificity
    Rob Meijers
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 449:487-91. 2007
    The Dscam gene gives rise to thousands of diverse cell surface receptors thought to provide homophilic and heterophilic recognition specificity for neuronal wiring and immune responses...
  21. pmc The iStem, a long-range RNA secondary structure element required for efficient exon inclusion in the Drosophila Dscam pre-mRNA
    Jenny M Kreahling
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3301, USA
    Mol Cell Biol 25:10251-60. 2005
    The Drosophila Dscam gene encodes 38,016 different proteins, due to alternative splicing of 95 of its 115 exons, that function in axon guidance and innate immunity...
  22. pmc Drosophila embryos as model systems for monitoring bacterial infection in real time
    Isabella Vlisidou
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS Pathog 5:e1000518. 2009
    ..We find that embryonic hemocytes both recognise and phagocytose injected wild type, non-pathogenic E. coli in a Dscam independent manner, proving that embryonic hemocytes are phagocytically competent...
  23. ncbi Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam
    Thomas Hummel
    Howard Hughes Medical Institute, Department of Biological Chemistry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuron 37:221-31. 2003
    ..Here we demonstrate that specific ORN classes require the cell surface protein Dscam (Down Syndrome Cell Adhesion Molecule) to synapse in the correct glomeruli...
  24. pmc Dscam guides embryonic axons by Netrin-dependent and -independent functions
    Gracie L Andrews
    Department of Biology MS 314, University of Nevada, Reno, NV 89557, USA
    Development 135:3839-48. 2008
    ..Analysis of Bolwig's nerve reveals that Netrin mutants have a similar phenotype to Down Syndrome Cell Adhesion Molecule (Dscam) mutants...
  25. pmc A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains
    Woj M Wojtowicz
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1662, USA
    Cell 130:1134-45. 2007
    b>Dscam encodes a family of cell surface proteins required for establishing neural circuits in Drosophila...
  26. ncbi Alternative splicing: increasing diversity in the proteomic world
    B R Graveley
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA neuron uchc edu
    Trends Genet 17:100-7. 2001
    ..Developing a full catalog of alternatively spliced transcripts and determining each of their functions will be a major challenge of the upcoming proteomic era...
  27. pmc Mutually exclusive splicing of the insect Dscam pre-mRNA directed by competing intronic RNA secondary structures
    Brenton R Graveley
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Famington, CT 06030, USA
    Cell 123:65-73. 2005
    Drosophila Dscam encodes 38,016 distinct axon guidance receptors through the mutually exclusive alternative splicing of 95 variable exons...
  28. ncbi Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons
    Jian Wang
    Department of Cell and Structural Biology, University of Illinois, Urbana, IL 61801, USA
    Neuron 33:559-71. 2002
    ..From a genetic mosaic screen, we find that a lethal mutation in the Drosophila Down syndrome cell adhesion molecule (Dscam) specifically perturbs segregation of axonal branches in the mushroom bodies...
  29. pmc The organization and evolution of the dipteran and hymenopteran Down syndrome cell adhesion molecule (Dscam) genes
    Brenton R Graveley
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3301, USA
    RNA 10:1499-506. 2004
    The Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam) gene encodes an axon guidance receptor and can generate 38,016 different isoforms via the alternative splicing of 95 variable exons...
  30. pmc Variable window binding for mutually exclusive alternative splicing
    Dimitris Anastassiou
    Center for Computational Biology and Bioinformatics, and Department of Electrical Engineering, Columbia University, New York, NY 07670, USA
    Genome Biol 7:R2. 2006
    ..In many cases, however, the details of the underlying biologic mechanisms are unknown...
  31. pmc Tracking the evolution of alternatively spliced exons within the Dscam family
    Mack E Crayton
    Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Evol Biol 6:16. 2006
    The Dscam gene in the fruit fly, Drosophila melanogaster, contains twenty-four exons, four of which are composed of tandem arrays that each undergo mutually exclusive alternative splicing (4, 6, 9 and 17), potentially generating 38,016 ..
  32. pmc Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization
    Peter Soba
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, Rock Hall, 1550 4th Street, San Francisco, CA 94143, USA
    Neuron 54:403-16. 2007
    ..We found that Down's syndrome Cell Adhesion Molecule (Dscam) is required for dendritic self-avoidance of all four classes of Drosophila dendritic arborization (da) neurons...
  33. pmc Endodomain diversity in the Drosophila Dscam and its roles in neuronal morphogenesis
    Hung Hsiang Yu
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Neurosci 29:1904-14. 2009
    b>Drosophila Down syndrome cell adhesion molecule (Dscam) can be variably spliced to encode 152,064 distinct single-pass transmembrane proteins...
  34. ncbi A honey bee Dscam family member, AbsCAM, is a brain-specific cell adhesion molecule with the neurite outgrowth activity which influences neuronal wiring during development
    Masahiro Funada
    Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464 8601, Japan
    Eur J Neurosci 25:168-80. 2007
    ..in the brain of an invertebrate with more complex behavior, we identified and characterized a novel brain-specific Dscam family member, AbsCAM, from honey bee (Apis mellifera)...
  35. ncbi Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies
    Xiao Li Zhan
    Howard Hughes Medical Institute, Department of Biological Chemistry, The David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
    Neuron 43:673-86. 2004
    b>Dscam is an immunoglobulin (Ig) superfamily member that regulates axon guidance and targeting in Drosophila. Alternative splicing potentially generates 38,016 isoforms differing in their extracellular Ig and transmembrane domains...
  36. ncbi Immunology. Insects diversify one molecule to serve two systems
    Louis Du Pasquier
    Institute of Zoology and Evolutionary Biology, University of Basel, Vesalgasse 1, CH 4051 Basel, Switzerland
    Science 309:1826-7. 2005
  37. pmc Dscam1-mediated self-avoidance counters netrin-dependent targeting of dendrites in Drosophila
    Benjamin J Matthews
    Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Biol 21:1480-7. 2011
    ..Neurons that lack Drosophila Down syndrome cell adhesion molecule 1 (Dscam1) show aberrant overlap, fasciculation, and accumulation of dendrites and axons, ..
  38. pmc An RNA architectural locus control region involved in Dscam mutually exclusive splicing
    Xuebin Wang
    Institute of Biochemistry, College of Life Sciences, Zhejiang University Zijingang Campus, Hangzhou, Zhejiang ZJ310058, China
    Nat Commun 3:1255. 2012
    ..most striking example of alternative splicing in a Drosophila melanogaster gene is observed in the Down syndrome cell adhesion molecule, which can generate 38,016 different isoforms...
  39. pmc Complementary chimeric isoforms reveal Dscam1 binding specificity in vivo
    Wei Wu
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1662, USA
    Neuron 74:261-8. 2012
    b>Dscam1 potentially encodes 19,008 ectodomains of a cell recognition molecule of the immunoglobulin (Ig) superfamily through alternative splicing...
  40. doi Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting
    Vedrana Cvetkovska
    Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Nat Neurosci 16:677-82. 2013
    ..We found that FMRP binds to Down syndrome cell adhesion molecule (Dscam) RNA, a molecule that is involved in neural development and has been implicated in Down ..
  41. pmc The immunoglobulin-like domains 1 and 2 of the protein tyrosine phosphatase LAR adopt an unusual horseshoe-like conformation
    Bridget H Biersmith
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, 5100 Rockhill Road, Kansas City, MO 64110, USA
    J Mol Biol 408:616-27. 2011
    ..These two domains adopt an unusual antiparallel arrangement that has not been reported in tandem repeats of immunoglobulin-like domains and that is presumably conserved in all type IIa receptor protein tyrosine phosphatases...
  42. pmc Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis
    Paola Cognigni
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Cell Metab 13:92-104. 2011
    ....
  43. doi Anatomical characterization of thermosensory AC neurons in the adult Drosophila brain
    Hsiang Wen Shih
    Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan
    J Neurogenet 25:1-6. 2011
    ..In conclusion, by morphological analysis of the AC neurons, the authors show a general strategy for predicting brain circuits orchestrating thermosensory behaviors...
  44. pmc Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology
    Holger Pillmann
    Abteilung NMR basierte Strukturbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, D 37077 Gottingen, Germany
    BMC Bioinformatics 12:270. 2011
    ..The latter term is used for clusters of internal exons that are spliced in a mutually exclusive manner...
  45. doi The combinatorics of neurite self-avoidance
    Elizabeth M Forbes
    Queensland Brain Institute, University of Queensland, St Lucia, QLD 4072, Australia
    Neural Comput 23:2746-69. 2011
    ..branches to recognize whether they are from the same or different neurons depends crucially on the molecule Dscam1. In particular, this recognition depends on the stochastic acquisition of a unique combination of Dscam1 isoforms ..
  46. pmc Mechanosensilla in the adult abdomen of Drosophila: engrailed and slit help to corral the peripheral sensory axons into segmental bundles
    Caroline C G Fabre
    Department of Zoology, University of Cambridge, Cambridge, UK
    Development 137:2885-94. 2010
    ..We conclude that, during normal development, gradients of Slit protein repel axons away from compartment boundaries - in consequence, the bristles from each segment send their nerves to the CNS in separated sets...
  47. doi Structure of the adult central complex in Drosophila: organization of distinct neuronal subsets
    J M Young
    Institute for Adaptive and Neural Computation, University of Edinburgh, Edinburgh, UK
    J Comp Neurol 518:1500-24. 2010
    ..Small-field neurons were observed in clearly organized layers. This study provides a novel insight into CX structure and connectivity and provides a set of characterized enhancer trap lines that will be valuable for future study...
  48. ncbi Comparative neuroanatomy and genomics of hugin and pheromone biosynthesis activating neuropeptide (PBAN)
    Rüdiger Bader
    Institut fur Genetik, Forschungszentrum Karlsruhe, Karlsruhe, Germany
    Fly (Austin) 1:228-31. 2007
    ..One concerns the polarity of hugin neurons. The other is an evolutionary perspective on the processing of hugin neuropeptides in light of new data from mass spectrometric and genomic analyses...
  49. pmc Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam
    Jacob Shun Jen Yang
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA
    PLoS ONE 3:e3504. 2008
    Many membrane proteins, including Drosophila Dscam, are enriched in dendrites or axons within neurons. However, little is known about how the differential distribution is established and maintained.
  50. pmc Exon-specific RNAi: a tool for dissecting the functional relevance of alternative splicing
    Alicia M Celotto
    University of Connecticut Health Center, Department of Genetics and Developmental Biology, Farmington 06030 3301, USA
    RNA 8:718-24. 2002
    ..This technique may prove to be a powerful tool to assess the function of proteins synthesized from alternatively spliced mRNAs. In addition, these results have implications regarding the mechanism of RNAi in Drosophila...
  51. doi Dendrite branching and self-avoidance are controlled by Turtle, a conserved IgSF protein in Drosophila
    Hong Long
    Centre for Research in Neuroscience and Department of Neurology and Neurosurgery, McGill University, and the McGill University Health Centre Research Institute, QC, Canada
    Development 136:3475-84. 2009
    ....
  52. pmc A regulator of Dscam mutually exclusive splicing fidelity
    Sara Olson
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 3301, USA
    Nat Struct Mol Biol 14:1134-40. 2007
    The Down syndrome cell adhesion molecule (Dscam) gene has essential roles in neural wiring and pathogen recognition in Drosophila melanogaster. Dscam encodes 38,016 distinct isoforms via extensive alternative splicing...
  53. doi Human down syndrome cell adhesion molecules (DSCAMs) are functionally conserved with Drosophila Dscam[TM1] isoforms in controlling neurodevelopment
    Jianhua Huang
    Department of Entomology, University of Maryland, College Park, MD 20742, USA
    Insect Biochem Mol Biol 41:778-87. 2011
    b>Drosophila Down syndrome cell adhesion molecule (Dscam) potentially produces more than 150,000 cell adhesion molecules that share two alternative transmembrane/juxtamembrane (TM) domains, which dictate the dendrite versus axon ..
  54. pmc Drosophila dscam proteins regulate postsynaptic specificity at multiple-contact synapses
    S Sean Millard
    Howard Hughes Medical Institute, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Neuron 67:761-8. 2010
    ..Here, we demonstrate that Drosophila Dscam1 and Dscam2, genes encoding homophilic repulsive proteins, act redundantly to ensure the invariable combination of ..
  55. pmc Conserved alternative splicing and expression patterns of arthropod N-cadherin
    Shu Ning Hsu
    Neuroscience Program, University of Illinois, Urbana, Illinois, United States of America
    PLoS Genet 5:e1000441. 2009
    ..Ectopic muscle expression of either isoform beyond the time it normally ceases leads to paralysis and lethality. Together, our results offer an example of well-conserved alternative splicing increasing cellular diversity in metazoans...
  56. doi A protein kinase C activity localized to neuropeptide Y-like neurons mediates ethanol intoxication in Drosophila melanogaster
    J Chen
    The Department of Cellular Biology, and Biomedical and Health Sciences Institute, 500 D W Brooks Drive, University of Georgia, Athens, GA 30602, USA
    Neuroscience 156:42-7. 2008
    ..These findings reveal an uncharacterized role of PKC in NPY/NPF-mediated acute ethanol sensitivity in flies and possibly mammals...
  57. ncbi Immunology. Versatile development gene aids insect immune response
    Elizabeth Pennisi
    Science 309:1166-7. 2005
  58. ncbi Monoallelic expression of protocadherin genes
    Andrew Chess
    Nat Genet 37:120-1. 2005
  59. pmc Genetic and cytogenetic analysis of the 43A-E region containing the segment polarity gene costa and the cellular polarity genes prickle and spiny-legs in Drosophila melanogaster
    P Heitzler
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medicine, Strasbourg, France
    Genetics 135:105-15. 1993
    ..In addition 19 novel lethal complementation groups and two semi-lethal complementation groups with morphogenetic escaper phenotypes are described...
  60. ncbi The immunoglobulin superfamily in Caenorhabditis elegans and Drosophila melanogaster
    Oliver Hobert
    Development 131:2237-8; author reply 2238-40. 2004
  61. ncbi FASt remodeling of synapses in Drosophila
    Mary Packard
    Department of Neurobiology, University of Massachusetts Medical School, Aaron Lazare Medical Research Building, 364 Plantation Street, Worcester, MA 01605 2324, USA
    Curr Opin Neurobiol 13:527-34. 2003
    ..These studies offer convincing evidence that synaptic cell adhesion brings about both negative and positive forces that stabilize synapses, while maintaining their ability to change in an activity-dependent manner...
  62. ncbi Molecular cloning of the pawn locus from Drosophila melanogaster
    Susan E Arruda
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Gene 310:169-73. 2003
    ..The gene is expressed throughout development with highest expression found in the late embryonic and larval stages...
  63. ncbi Genetic control of dendritic morphogenesis in Drosophila
    Fen Biao Gao
    Gladstone Institute of Neurological Disease, Neuroscience Graduate Program, University of California, San Francisco, CA 94141 9100, USA
    Trends Neurosci 26:262-8. 2003
    ....
  64. pmc Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases
    Marco Muda
    Serono Reproductive Biology Institute, Inc, Randolph, MA 02368, U S A
    Biochem J 366:73-7. 2002
    ..to identify the cellular tyrosine kinases upstream of the phosphorylation of Down-Syndrome cell-adhesion molecule (Dscam), a novel cell-surface molecule of the immunoglobulin-fibronectin super family, which has been shown to be ..
  65. ncbi Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance
    Carolyn A Worby
    Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 0606, USA
    J Biol Chem 277:9422-8. 2002
    ..These results suggest that the phosphorylation of DSH3PX1 by DAck targets this sorting nexin to a protein complex that includes Dock, an adaptor protein important for axonal guidance...
  66. ncbi The sorting nexin, DSH3PX1, connects the axonal guidance receptor, Dscam, to the actin cytoskeleton
    C A Worby
    Life Sciences Institute and the Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0606, USA
    J Biol Chem 276:41782-9. 2001
    ..The largest protein in the complex was identified as Dscam (Down syndrome cell adhesion molecule), which was subsequently shown to play a key role in directing neurons of the fly embryo to correct ..
  67. ncbi The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance
    J Bateman
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    J Cell Sci 114:1973-80. 2001
    ..Future studies of these mechanisms promise to yield insights not only into neural development but also into the ongoing function and remodeling of the adult nervous system...
  68. ncbi Eater: a big bite into phagocytosis
    Deniz Erturk-Hasdemir
    Division of Infectious Disease, University of Massachusetts Medical School, Worcester 01605, USA
    Cell 123:190-2. 2005
    ..In this issue of Cell, Kocks et al. (2005) demonstrate that Eater, a scavenger receptor, plays an important role in the recognition and phagocytosis of bacteria in the fruit fly Drosophila...
  69. ncbi Identification of an essential gene encoding a class-V unconventional myosin in Drosophila melanogaster
    B MacIver
    Department of Biology, Eberly College of Science, Pennsylvania State University, USA
    Eur J Biochem 257:529-37. 1998
    ..Genetic and in situ hybridisation experiments have determined that this gene is located in the 43C region. We have evidence that it maps to a mutation in this region with an embryonic lethal phenotype...
  70. pmc Motion processing streams in Drosophila are behaviorally specialized
    Alexander Y Katsov
    Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
    Neuron 59:322-35. 2008
    ..Thus, behavioral responses to complex stimuli can rely on surprising neural specialization from even the earliest sensory processing stages...
  71. pmc The color-vision circuit in the medulla of Drosophila
    Javier Morante
    Center for Developmental Genetics, Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA
    Curr Biol 18:553-65. 2008
    ..This paper analyzes the neural network underlying color vision into the medulla...
  72. pmc Neuroarchitecture of aminergic systems in the larval ventral ganglion of Drosophila melanogaster
    Matthias Vömel
    Emmy Noether Neuropeptide Group, Animal Physiology, Department of Biology, Philipps University Marburg, Marburg, Germany
    PLoS ONE 3:e1848. 2008
    ....
  73. pmc Revisiting the protein-coding gene catalog of Drosophila melanogaster using 12 fly genomes
    Michael F Lin
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Genome Res 17:1823-36. 2007
    ..These results affect >10% of annotated fly genes and demonstrate the power of comparative genomics to enhance our understanding of genome organization, even in a model organism as intensively studied as Drosophila melanogaster...
  74. pmc Homophilic Dscam interactions control complex dendrite morphogenesis
    Michael E Hughes
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Neuron 54:417-27. 2007
    Alternative splicing of the Drosophila gene Dscam results in up to 38,016 different receptor isoforms proposed to interact by isoform-specific homophilic binding...
  75. ncbi Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe
    Haitao Zhu
    Howard Hughes Medical Institute and Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 9:349-55. 2006
    ..b>Dscam, an immunoglobulin superfamily protein, acts in ORNs to regulate axon targeting...
  76. ncbi Got diversity? Wiring the fly brain with Dscam
    S Lawrence Zipursky
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1662, USA
    Trends Biochem Sci 31:581-8. 2006
    The Drosophila gene Dscam, encoding Down syndrome cell-adhesion molecule, is required for the development of neural circuits...
  77. ncbi Drosophila dorsal paired medial neurons provide a general mechanism for memory consolidation
    Alex C Keene
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Curr Biol 16:1524-30. 2006
    ..We further examined DPM-MB connectivity by overexpressing a DScam variant that reduces DPM neuron projections to the MB alpha, beta, and gamma lobes...
  78. ncbi Wiring specificity: axon-dendrite matching refines the olfactory map
    Gregory S X E Jefferis
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Curr Biol 16:R373-6. 2006
    ..A recent study has shown that genetic manipulations that shift the position of one class of postsynaptic dendrites can cause an exact corresponding shift in the location of their partner axons...
  79. ncbi Descrambling Dscam diversity
    Rajnish Bharadwaj
    Howard Hughes Medical Institute, The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 N Wolfe St 1001 PCTB, Baltimore, MD 21205, USA
    Cell 125:421-4. 2006
    ..In this issue of Cell, Chen et al. (2006) show that the isoform diversity of the Dscam protein in Drosophila is required to establish stereotypical axonal branching patterns, suggesting that nonrandom ..
  80. ncbi P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster
    Koen J T Venken
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 314:1747-51. 2006
    ..This transgenesis platform should greatly facilitate structure/function analyses of most Drosophila genes...
  81. ncbi The odor coding system of Drosophila
    Elissa A Hallem
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Trends Genet 20:453-9. 2004
    ..Thus, functional, anatomical and developmental studies are rapidly being integrated to form a unified picture of odor coding in this model olfactory system...
  82. pmc Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons
    Xiaoyan Zheng
    Department of Cell and Developmental Biology, School of Molecular and Cellular Biology, University of Illinois, Urbana, IL, USA
    EMBO J 25:615-27. 2006
    ..Our results suggest that Babo/dSmad2 signaling prior to metamorphosis may be widely required to prepare neurons for the dynamic environment present during metamorphosis...

Research Grants37

  1. Target Specificity in the Drosophila Olfactory System
    S Zipursky; Fiscal Year: 2007
    ..that different neurons use different constellations of cell surface proteins to control specificity including Dscam, N-cadherin, Lar receptor tyrosine phosphatase and the novel cadherin, Flamingo...
  2. Cell Recognition in the developing Drosophila Brain
    S Zipursky; Fiscal Year: 2009
    The Drosophila Dscam gene encodes a vast family of immunoglobulin (Ig) superfamily proteins and plays a crucial role in regulating the formation of precisely organized neural circuits during development...
  3. The Mechanisms and Regulatory Networks of Alternative Splicing in Drosophila
    BRENTON GRAVELEY; Fiscal Year: 2009
    ....
  4. Alternative Splicing of the Drosophila Dscam Pre-mRNA
    BRENTON GRAVELEY; Fiscal Year: 2006
    The long-term goals of this proposal are to understand how the alternative splicing of the Drosophila Down syndrome cell adhesion molecule (Dscam) gene is regulated and to determine the mechanism by which Dscam alternative splicing is ..
  5. Alternative Splicing of the Drosophila DSCAM Pre-DRNA
    BRENTON GRAVELEY; Fiscal Year: 2007
    The long term goals of this proposal are to understand how the alternative splicing of the Drosophila Down syndrome cell adhesion molecule (Dscam) gene is regulated and to determine the mechanism which Dscam alternative splicing is ..
  6. Alternative Splicing of the Drosophila DSCAM Pre-DRNA
    Brenton R Graveley; Fiscal Year: 2010
    The long term goals of this proposal are to understand how the alternative splicing of the Drosophila Down syndrome cell adhesion molecule (Dscam) gene is regulated and to determine the mechanism which Dscam alternative splicing is ..
  7. The Mechanisms and Regulatory Networks of Alternative Splicing in Drosophila
    BRENTON GRAVELEY; Fiscal Year: 2009
    ....
  8. THE FUNCTION OF PRE-MRNA SPLICING ACTIVATORS
    BRENTON GRAVELEY; Fiscal Year: 2005
    ..In addition, at least 35 percent of human genes are alternatively spliced. Our results will increase our understanding of how this important means of gene regulation is controlled. ..
  9. Cell Recognition in the developing Drosophila Brain
    S L Zipursky; Fiscal Year: 2010
    The Drosophila Dscam gene encodes a vast family of immunoglobulin (Ig) superfamily proteins and plays a crucial role in regulating the formation of precisely organized neural circuits during development...
  10. GORDON RESEARCH CONFERENCE ON NEURAL DEVELOPMENT
    S Zipursky; Fiscal Year: 2002
    ..Participants will be encouraged to present posters, which serves as an excellent training and scientific function. ..
  11. AXON GIUDANCE AND TARGETING IN DROSOPHILA
    S Zipursky; Fiscal Year: 2005
    b>Dscam is an axon guidance receptor that is required for the formation of neuronal connections in the Drosophila nervous system...
  12. Genetic Analysis of Heavy Metals Neurotoxicity
    Fen Biao Gao; Fiscal Year: 2005
    ....
  13. Animal Models For Studying Angelman Syndrome, A Developmental Brain Disorder
    Fen Biao Gao; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page J Description, ..
  14. Cell Recognition in the developing Drosophila Brain
    S L Zipursky; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The Drosophila Dscam gene encodes a vast family of immunoglobulin (Ig) superfamily proteins and plays a crucial role in regulating the formation of precisely organized neural circuits during ..