Genomes and Genes
Gene Symbol: en
Alias: 153867_at, Apa, CG9015, Dmel\CG9015, EnR, Eng, Engr, Engrailed, Engrailed/Invected, en1, spa2, spt, CG9015 gene product from transcript CG9015-RB, CG9015-PA, CG9015-PB, ENGRAILED, apigmented abdomen, en-PA, en-PB, erased, invected, sparse SGPs 2, spermatheca, transcript group V
Species: fruit fly
Publications201 found, 100 shown here
- Stem cells signal to the niche through the Notch pathway in the Drosophila ovaryEllen J Ward
Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, School of Medicine, Box 357350, 1959 NE Pacific Street, University of Washington, Seattle, Washington 98195, USA
Curr Biol 16:2352-8. 2006..Demonstration that stem cells can contribute to niche function has far-reaching consequences for stem cell therapies and may provide insight into how cancer can spread throughout an organism via populations of cancer stem cells...
- Alternative epigenetic chromatin states of polycomb target genesYuri B Schwartz
Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Laboratories, Piscataway, New Jersey, United States of America
PLoS Genet 6:e1000805. 2010..These results have important implications for Polycomb gene regulation, the "bivalent" chromatin state of embryonic stem cells, and gene expression in development...
- Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in DrosophilaKatarzyna Oktaba
EMBL, Gene Expression Programme, Heidelberg, Germany
Dev Cell 15:877-89. 2008..Analysis of cell cycle regulators indicates that the PcG system also dynamically modulates the expression levels of certain genes, providing a possible explanation for the tumor phenotype of PcG mutants...
- Mutations affecting segment number and polarity in DrosophilaC Nusslein-Volhard
Nature 287:795-801. 1980....
- Homeobox genes and axial patterningW McGinnis
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
Cell 68:283-302. 1992
- The Drosophila engrailed and invected genes: partners in regulation, expression and functionE Gustavson
Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA
Genetics 142:893-906. 1996We isolated and characterized numerous engrailed and invected alleles...
- Enhancer-promoter communication at the Drosophila engrailed locusDeborah Kwon
Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Development 136:3067-75. 2009..which gene to activate? We have used homing P[en] constructs to study the enhancer-promoter communication at the engrailed locus...
- Regulation of smoothened by Drosophila G-protein-coupled receptor kinasesShuofei Cheng
Institut de Recherches Cliniques de Montreal, 110 Pine Avenue West, Montreal, QC H2W1R7, Canada
Dev Biol 337:99-109. 2010..G-protein-coupled receptor kinase activity is also important for efficient downstream signaling...
- Early even-skipped stripes act as morphogenetic gradients at the single cell level to establish engrailed expressionM Fujioka
Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
Development 121:4371-82. 1995..borders at the anterior edge of each of its seven stripes by providing a sharp expression boundary, where engrailed is activated on one side and wingless on the other...
- Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genesMaxim Nekrasov
Gene Expression Programme, EMBL, Heidelberg, Germany
EMBO J 26:4078-88. 2007..Pcl-PRC2 is thus the HMTase that generates the high levels of H3-K27 trimethylation in Polycomb target genes that are needed to maintain a Polycomb-repressed chromatin state...
- wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fateE Siegfried
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
Cell 71:1167-79. 1992..The early role of wg is to stabilize engrailed (en) expression by initiating a phase of en autoregulation in the adjacent more posterior cells...
- Evolution and role of Pax genesM Noll
Institute for Molecular Biology II, University of Zurich, Switzerland
Curr Opin Genet Dev 3:595-605. 1993..Their developmental roles are assessed in terms of their participation in conserved gene networks and mechanisms that establish positional information...
- Expression and function of clift in the development of somatic gonadal precursors within the Drosophila mesodermM Boyle
The Rockefeller University, NYC, NY 10021 6399, USA
Development 124:971-82. 1997..Thus, these studies identify essential regulators of gonadal precursor specification and differentiation and reveal novel aspects of the general mechanism whereby distinct fates are allocated within the mesoderm...
- A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wingM Strigini
European Molecular Biology Laboratory, Heidelberg, Germany
Development 124:4697-705. 1997..Comparing the biological activities of secreted and membrane-tethered Hh provides evidence that Hh forms a local concentration gradient and functions as a concentration-dependent morphogen in the fly wing...
- The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogasterReka Albert
School of Mathematics, University of Minnesota, 127 Vincent Hall, Minneapolis, MN 55455, USA
J Theor Biol 223:1-18. 2003..The model gives important insights into the functioning of the segment polarity gene network, such as the crucial role of the wingless and sloppy paired genes, and the network's ability to correct errors in the pre-pattern...
- Multiplex detection of RNA expression in Drosophila embryosDave Kosman
Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
Science 305:846. 2004....
- Lipoprotein-heparan sulfate interactions in the Hh pathwayChristina Eugster
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Dev Cell 13:57-71. 2007..They further suggest that the complement of proteins present on lipoprotein particles can regulate the activity of morphogens...
- Characterization of the polycomb group response elements of the Drosophila melanogaster invected LocusMelissa D Cunningham
Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
Mol Cell Biol 30:820-8. 2010..We have used the computer program jPREdictor to uncover PREs located within the invected (inv) locus...
- Comparison of germline mosaics of genes in the Polycomb group of Drosophila melanogasterM C Soto
Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts 02115, USA
Genetics 140:231-43. 1995..Psc shows unusual effects on two of the targets, Ultrabithorax and abdominal-A. These results show that the PcG genes do not act only in a common complex or pathway; they must have some independent functions...
- wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of ArmadilloM Peifer
Department of Biology, University of North Carolina, Chapel Hill 27599 3280
Development 120:369-80. 1994..We present a model for the role of Armadillo stripes in transduction of wingless signal...
- Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCFM van de Wetering
Department of Immunology, University Hospital, Utrecht, The Netherlands
Cell 88:789-99. 1997..dTCF transgene cause a segment polarity phenotype and affect expression of the Wingless target genes engrailed and Ultrabithorax. Epistasis analysis positions dTCF downstream of armadillo...
- The even-skipped locus is contained in a 16-kb chromatin domainC Sackerson
Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA
Dev Biol 211:39-52. 1999..4) Expression in different sites in the central nervous system is driven by separable elements widely dispersed throughout 8 kb 3' of the gene...
- Developmental roles and molecular characterization of a Drosophila homologue of Arabidopsis Argonaute1, the founder of a novel gene superfamilyY Kataoka
Department of Biophysics, School of Science, Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
Genes Cells 6:313-25. 2001..However, little has been reported about their roles in animal development or about the molecular activities of any of the members...
- The Sox-domain containing gene Dichaete/fish-hook acts in concert with vnd and ind to regulate cell fate in the Drosophila neuroectodermGuoyan Zhao
Program in Molecular Cell Biology, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA
Development 129:1165-74. 2002....
- Sex-specific deployment of FGF signaling in Drosophila recruits mesodermal cells into the male genital imaginal discShaad M Ahmad
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 109:651-61. 2002..The recruited mesodermal cells migrate into the disc late in development and are neither anterior nor posterior...
- Integrin-ECM interactions regulate the changes in cell shape driving the morphogenesis of the Drosophila wing epitheliumPaloma Domínguez-Giménez
Institut de Reserca Biomédica, Barcelona 08028, Spain
J Cell Sci 120:1061-71. 2007..Finally, we show that the ECM has an instructive rather than a structural role, because inhibition of Raf reverses the cell shape changes caused by perturbing integrins...
- A hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of CiPing Dai
Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
Dev Cell 4:917-28. 2003..Thus, Debra defines the border of the Hh-responsive region in the A compartment by inducing the lysosomal degradation of Ci...
- Altering the insertional specificity of a Drosophila transposable elementJ A Kassis
Laboratory of Cellular and Molecular Biology, Food and Drug Administration, Bethesda, MD 20892
Proc Natl Acad Sci U S A 89:1919-23. 1992..During experiments to identify cis-acting regulatory elements of the Drosophila segmentation gene engrailed, we identified a fragment of engrailed DNA that, when included within a P-element vector, strikingly alters the ..
- Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by winglessB Riggleman
Department of Molecular Biology, Princeton University, New Jersey 08544
Cell 63:549-60. 1990..Two other segment polarity genes, porcupine and dishevelled, are required for this effect. We also show that arm protein is closely associated with the plasma membrane in virtually all cell types and often colocalizes with F-actin...
- Smoothened translates Hedgehog levels into distinct responsesJoan E Hooper
Department of Cell and Structural Biology and Program in Cell and Developmental Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
Development 130:3951-63. 2003..Thus, two activities of Smoothened translate different levels of Hedgehog into distinct intracellular responses...
- Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulationYajuan Liu
Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA
Genes Dev 21:1949-63. 2007..Our data suggest that Cos2-Smo interaction blocks Hh-induced Smo phosphorylation, and that Fu promotes Smo phosphorylation by antagonizing Cos2...
- Developmental function of Elf-1: an essential transcription factor during embryogenesis in DrosophilaS J Bray
Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
Genes Dev 5:1672-83. 1991..The results highlight the importance of genetic analysis in the study of proteins required for developmental regulation of gene expression...
- Spatial and temporal control elements of the Drosophila engrailed geneJ A Kassis
Laboratory of Cellular and Molecular Biology, Food and Drug Administration, Bethesda, Maryland 20892
Genes Dev 4:433-43. 1990b>engrailed (en) is a segmentation gene expressed in a series of stripes throughout embryonic development. Here, I show that regulatory sequences for striped expression are present within the first intron of en...
- Molecular cloning of engrailed: a gene involved in the development of pattern in Drosophila melanogasterJ M Kuner
Cell 42:309-16. 1985The engrailed gene acts early in Drosophila embryogenesis and plays an essential role in the processes that establish and maintain the repeating segmental pattern...
- The engrailed locus of D. melanogaster provides an essential zygotic function in precellular embryosT L Karr
Cell 43:591-601. 1985..We show that the engrailed gene is needed for the processes that organize the embryo during the nuclear divisions that precede ..
- Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probesN H Patel
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
Methods Cell Biol 44:445-87. 1994
- The role of Polycomb-group response elements in regulation of engrailed transcription in DrosophilaSarah K DeVido
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20982, USA
Development 135:669-76. 2008..Previous studies have shown that a 2 kb fragment located from -2.4 kb to -395 bp upstream of the Drosophila engrailed promoter contains a multipartite PRE that can mediate mini-white silencing and act as a PRE in an Ubx-reporter ..
- Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epitheliumAinhoa Callejo
Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
Proc Natl Acad Sci U S A 108:12591-8. 2011..We also show that Dlp is needed in Hh-producing cells to allow for Hh release and that Ihog, which has been previously described as an Hh coreceptor, anchors Hh to the basolateral part of the disk epithelium...
- Pattern formation in the Drosophila embryo: allocation of cells to parasegments by even-skipped and fushi tarazuP A Lawrence
MRC Laboratory of Molecular Biology, Cambridge, UK
Development 105:761-7. 1989..The development of these stripes in hairy-, runt-, eve-, ftz- and engrailed- embryos is illustrated. In eve- embryos, the ftz stripes remain symmetric and lack sharp borders...
- Patterns of engrailed protein in early Drosophila embryosT L Karr
Department of Biochemistry and Biophysics, University of California, San Francisco 94143
Development 105:605-12. 1989By the onset of gastrulation during nuclear cycle 14 of Drosophila embryogenesis, the engrailed gene is expressed in fourteen one-cell-wide stripes. Each stripe defines the anlagen of the posterior compartment of a metameric segment...
- Rescue of Drosophila engrailed mutants with a highly divergent mosquito engrailed cDNA using a homing, enhancer-trapping transposonM Whiteley
Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 4555, USA
Development 124:1531-41. 1997..We constructed a P-element-based transposon in which an engrailed cDNA from Anopheles gambiae (a mosquito) is expressed from a Drosophila engrailed minimal promoter...
- Segmentation and specification of the Drosophila mesodermN Azpiazu
Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
Genes Dev 10:3183-94. 1996..Hence, hh and wg play opposing roles in mesoderm segmentation...
- Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptusG Wang
Center for Developmental Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9133, USA
Genes Dev 13:2828-37. 1999....
- Divide and conquer: pattern formation in Drosophila embryonic epidermisV Hatini
Dept Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Trends Genet 17:574-9. 2001..Here, we review several recent reports that help to elucidate the regulatory principles used to control this pattern. Because organizers are conserved, the same fundamental principles might operate in other organizers...
- The repressor activity of Even-skipped is highly conserved, and is sufficient to activate engrailed and to regulate both the spacing and stability of parasegment boundariesMiki Fujioka
Department of Microbiology and Immunology, Thomas Jefferson University, JAH490, Philadelphia, PA 19107, USA
Development 129:4411-21. 2002During segmentation of the Drosophila embryo, even skipped is required to activate engrailed stripes and to organize odd-numbered parasegments...
- Searching for pattern and mutation in the Drosophila genome with a P-lacZ vectorE Bier
Howard Hughes Medical Institute, San Francisco, California
Genes Dev 3:1273-87. 1989..This type of screen appears to be an effective way to find new loci that may play a role in the development of the Drosophila nervous system...
- Ectopic expression of homeotic genes caused by the elimination of the Polycomb gene in Drosophila imaginal epidermisA Busturia
Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
Development 104:713-20. 1988..We have established a hierarchical order among these genes: Antp less than Scr less than Ubx less than abd-A less than Abd-B. In addition, we show that the engrailed gene is ectopically active in Pc- imaginal cells.
- Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesisT Tabata
Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA
Development 121:3359-69. 1995Anterior/posterior compartment borders bisect every Drosophila imaginal disc, and the engrailed gene is essential for their function...
- Control of Drosophila head segment identity by the bZIP homeotic gene cncJ Mohler
Department of Biological Sciences, Barnard College, New York, NY 10027
Development 121:237-47. 1995..This role of homeotic selector genes for the segment-specific maintenance of segment polarity gene expression is a unique feature of segmentation in the preoral head region of Drosophila...
- Hedgehog organises the pattern and polarity of epidermal cells in the Drosophila abdomenG Struhl
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Development 124:2143-54. 1997..is subdivided into an anterior (A) and posterior (P) compartment, distinguished by activity of the selector gene engrailed (en) in P but not A compartment cells...
- eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteinsJ E Treisman
Skirball Institute of Biomolecular Medicine, NYU Medical Center, New York, New York 10016, USA
Genes Dev 11:1949-62. 1997..Based on this homology and on the phenotypic analysis, we suggest that Eld could act as a transcription factor antagonistic to the Wg pathway...
- Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonadTony J DeFalco
Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
Dev Cell 5:205-16. 2003..Our work furthers the hypotheses that a conserved pathway controls gonad sexual dimorphism in diverse species and that sex-specific cell recruitment and programmed cell death are common mechanisms for creating sexual dimorphism...
- Extensive phosphorylation of Smoothened in Hedgehog pathway activationChi Zhang
Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 101:17900-7. 2004..Our studies confirm and extend previous studies showing a positive effect for cAMP-dependent protein kinase and uncover a positive role for casein kinase 1alpha in Hh pathway activation...
- Genome-wide analysis of Polycomb targets in Drosophila melanogasterYuri B Schwartz
Rutgers University, Department of Molecular Biology and Biochemistry, 604 Allison Road, Piscataway, New Jersey 08854, USA
Nat Genet 38:700-5. 2006..PcG targets are highly enriched in genes encoding transcription factors, but they also include genes coding for receptors, signaling proteins, morphogens and regulators representing all major developmental pathways...
- Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryosBernd Schuettengruber
Institut de Genetique Humaine, CNRS, Montpellier, France
PLoS Biol 7:e13. 2009..Furthermore, several DNA sequence features discriminate between PcG- and TRX-N-bound regions, indicating that underlying DNA sequence contains critical information to drive PREs and TREs towards silencing or activation...
- buttonhead does not contribute to a combinatorial code proposed for Drosophila head developmentE A Wimmer
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021 6399, USA
Development 124:1509-17. 1997..We conclude that the spatial limits of btd expression are not instructive for metamerization of the head region and that btd activity does not contribute to a combinatorial code for specification of segment identity...
- Control of compartment development by the engrailed gene in DrosophilaG Morata
Nature 255:614-7. 1975
- Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous systemC Q Doe
Department of Cell and Structural Biology, University of Illinois, Urbana 61801
Development 116:855-63. 1992..These results set the stage for investigating neuroblast specification and the mechanisms controlling neuroblast cell lineages...
- Maintenance of the engrailed expression pattern by Polycomb group genes in DrosophilaD Moazed
UCSF School of Medicine, Department of Biochemistry and Biophysics 94143
Development 116:805-10. 1992..We have examined the pattern of expression of the Drosophila segment polarity gene, engrailed (en), in embryos mutant for several different members of the Pc group...
- Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patchedA Hidalgo
Molecular Embryology Laboratory, ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK
Development 110:291-301. 1990..to the evolution of this pattern; we find that the first step in patched regulation is under the control of engrailed whereas the second requires the activity of both cubitus interruptusD and patched itself...
- Trithorax is required to maintain engrailed expression in a subset of engrailed-expressing cellsT R Breen
Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4955, USA
Mech Dev 52:89-98. 1995We show that maintenance but not initiation of engrailed (en) gene expression in the Drosophila embryo requires trithorax (trx), which is also required to maintain stable long-term expression of the homeotic genes throughout the ..
- polyhomeotic appears to be a target of engrailed regulation in DrosophilaN Serrano
Departement de Biologie du Developpement, Institut Jacques Monod, CNRS et Université Paris 7, France
Development 121:1691-703. 1995In Drosophila, Engrailed is a nuclear regulatory protein with essential roles in embryonic segmentation and in normal development of posterior compartments...
- Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wingM Zecca
Zoologisches Institut, Universitat Zurich, Switzerland
Development 121:2265-78. 1995..the anterior and posterior compartments, which are distinguished by the activity of the selector gene engrailed (en) in posterior cells...
- Segment polarity gene interactions modulate epidermal patterning in Drosophila embryosA Bejsovec
Department of Molecular Biology, Princeton University, New Jersey 08544
Development 119:501-17. 1993..We have analyzed embryos that are multiply mutant for five key patterning genes: wingless, patched, engrailed, naked and hedgehog...
- Selection and characterization of sequences with high affinity for the engrailed protein of DrosophilaM T Saenz-Robles
Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA
Mech Dev 53:185-95. 1995The engrailed gene helps to direct Drosophila melanogaster development by encoding a homeodomain-containing DNA binding protein...
- Segmental patterning of heart precursors in DrosophilaP A Lawrence
Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK
Development 121:4303-8. 1995..We conclude that the mesoderm is segmented in some way not dependent on the distribution of Wingless, suggesting a more permissive and less instructive role for the protein in this instance...
- hedgehog signaling independent of engrailed and wingless required for post-S1 neuroblast formation in Drosophila CNSM Matsuzaki
Department of Biophysics and Biochemistry, University of Tokyo, Bunkyo ku, Japan
Development 122:3567-75. 1996The hedgehog gene product, secreted from engrailed-expressing neuroectoderm, is required for the formation of post-S1 neuroblasts in rows 2, 5 and 6...
- branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branchingD Sutherland
Department of Biochemistry, Beckman Center, Stanford University School of Medicine, California 94305 5307, USA
Cell 87:1091-101. 1996....
- Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressorP Aza-Blanc
Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA
Cell 89:1043-53. 1997..Hh inhibits proteolysis of Ci, and we suggest that this inhibition leads to the observed patterns of expression of key target genes at the compartment border...
- Costal2, a novel kinesin-related protein in the Hedgehog signaling pathwayJ C Sisson
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305 5427, USA
Cell 90:235-45. 1997..COS2 is cytoplasmic and binds microtubules. We find that CI associates with COS2 in a large protein complex, suggesting that COS2 directly controls the activity of CI...
- Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermisL O'Keefe
The Rockefeller University, New York City, NY 10021 6399, USA
Development 124:4837-45. 1997..parasegment boundary, cells expressing the Wnt family member Wingless confront cells expressing the homeoprotein Engrailed. The Engrailed-expressing cells normally differentiate as one of two alternative cell types...
- The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1J L Brown
Laboratory of Developmental Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
Mol Cell 1:1057-64. 1998..We have identified a sequence-specific DNA binding protein that interacts with a PRE from the Drosophila engrailed gene...
- Compartment boundaries: where, why and how?J P Vincent
National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
Int J Dev Biol 42:311-5. 1998..Here, I review the work that demonstrated the existence of compartments. I then conjecture on why compartments exist and review the roles of various gene products in the maintenance of compartment boundaries...
- Drosophila Tcf and Groucho interact to repress Wingless signalling activityR A Cavallo
Department of Biology, University of North Carolina, Chapel Hill 27599, USA
Nature 395:604-8. 1998..Finally, mutations in the Drosophila groucho gene also suppress wingless and armadillo mutant phenotypes as Groucho physically interacts with dTcf and is required for its full repressor activity...
- Segment polarity genes in neuroblast formation and identity specification during Drosophila neurogenesisK M Bhat
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Bioessays 21:472-85. 1999....
- Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycanI The
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell 4:633-9. 1999..This demonstrates an unexpected level of specificity in the regulation of the distribution of extracellular signals by HSPGs...
- An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb developmentJ D Lee
Skirball Institute Developmental Genetics Program, Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, New York 10016, USA
Dev Biol 233:122-36. 2001..Furthermore, overexpression of the mutant form has dominant negative effects on Hedgehog signaling. These data suggest that the importance of the N-terminal cysteine of mature Hedgehog in patterning appendages differs between species...
- Successive specification of Drosophila neuroblasts NB 6-4 and NB 7-3 depends on interaction of the segment polarity genes wingless, gooseberry and naked cuticleN Deshpande
Institut fur Genetik, Universitat Mainz, Saarstrasse 21, D 55122 Mainz, Germany
Development 128:3253-61. 2001..fate specification of a set of late delaminating neuroblasts, NB 6-4 and NB 7-3, both of which arise from the engrailed (en) expression domain, with NB 6-4 delaminating first...
- Pygopus, a nuclear PHD-finger protein required for Wingless signaling in DrosophilaDavid S Parker
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor 48109, USA
Development 129:2565-76. 2002..Our data argue strongly that Pygopus is a new core component of the Wg signaling pathway that acts downstream or at the level of TCF...
- The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of DrosophilaHo Juhn Song
Department of Zoology, Oregon State University, Corvallis, Oregon 97331 2914, USA
Genetics 162:1703-24. 2002..Our results suggest that one of fru's sex-nonspecific roles is to regulate the pathfinding ability of axons in the embryonic CNS...
- Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehogArmel Gallet
Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre de Biochimie, Parc Valrose, 06108 Nice Cedex 02, France
Dev Cell 4:191-204. 2003....
- Segment boundary formation in Drosophila embryosCamilla W Larsen
National Institute for Medical Research, The Ridgeway Mill Hill, London NW7 1AA, UK
Development 130:5625-35. 2003In Drosophila embryos, segment boundaries form at the posterior edge of each stripe of engrailed expression...
- FGF8-like1 and FGF8-like2 encode putative ligands of the FGF receptor Htl and are required for mesoderm migration in the Drosophila gastrulaTanja Gryzik
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
Curr Biol 14:659-67. 2004..After gastrulation Htl is essential for the differentiation of dorsal mesodermal derivatives. It is not known how Htl is activated, because its ligand has not yet been identified...
- Engrailed and polyhomeotic maintain posterior cell identity through cubitus-interruptus regulationGrégory Chanas
Institut de Genetique Humaine, UPR1142, Montpellier, Herault, France
Dev Biol 272:522-35. 2004In Drosophila, the subdivision into compartments requires the expression of engrailed (en) and hedgehog (hh) in the posterior cells and of cubitus-interruptus (ci) in the anterior cells...
- The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified HedgehogNicole Gorfinkiel
Centro de Biologia Molecular, Severo Ochoa, C S I C, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
Dev Cell 8:241-53. 2005..We also show that human WIF inhibits Wg signaling in Drosophila without affecting the Hh pathway, indicating that different WIF family members might have divergent functions in each pathway...
- Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of HedgehogBruno Glise
Centre de Biologie du Developpement, UMR 5547 and IFR 109 CNRS UPS, 118 route de Narbonne, 31062 Toulouse Cedex 4, France
Dev Cell 8:255-66. 2005..Our data further indicate that Shf interacts with Hh and the heparan sulfate proteoglycans. Therefore, we propose that Shf stabilizes the interaction between Hh and the proteoglycans, an unexpected role for a member of the WIF-1 family...
- RanBP3 enhances nuclear export of active (beta)-catenin independently of CRM1Jolita Hendriksen
Department of Tumor Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
J Cell Biol 171:785-97. 2005..We conclude that RanBP3 is a direct export enhancer for beta-catenin, independent of its role as a CRM1-associated nuclear export cofactor...
- Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryoJennifer Bayraktar
Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, IL 60208, USA
J Cell Sci 119:711-21. 2006..Epistasis analysis indicates that Par-1 functions upstream of Notch and is critical for proper localization of the Notch ligand Delta...
- Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterningStephane Vincent
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Development 135:2767-75. 2008..The combination of independent progression of cell identity and arrest of progression by signals facilitates accurate patterning of an extremely plastic developing epidermis...
- Pdm and Castor close successive temporal identity windows in the NB3-1 lineageKhoa D Tran
Institute of Neuroscience, Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
Development 135:3491-9. 2008..Our results provide a new neuroblast lineage for investigating temporal identity and reveal the importance of Pdm and Cas as timing factors that close temporal identity windows...
- The consequences of ubiquitous expression of the wingless gene in the Drosophila embryoJ Noordermeer
Howard Hughes Medical Institute, Stanford University, California 94305 5428
Development 116:711-9. 1992..wingless expression results in a complete naked cuticle, uniform armadillo accumulation and broadening of the engrailed domain...
- The state of engrailed expression is not clonally transmitted during early Drosophila developmentJ P Vincent
Department of Biochemistry, University of California, San Francisco 94143 0448
Cell 68:923-31. 1992In Drosophila embryos, boundaries of lineage restriction separate groups of cells, or compartments. Engrailed is essential for specification of the posterior compartment of each segment, and its expression is thought to mark this ..
- Drosophila single-minded gene and the molecular genetics of CNS midline developmentS Crews
Department of Biology, University of California, Los Angeles 90024
J Exp Zool 261:234-44. 1992..This should permit elucidation of the genetic hierarchy which acts in the specification, differentiation, and function of these CNS midline cells...
- Roles of wingless in patterning the larval epidermis of DrosophilaA Bejsovec
Department of Zoology, University of Cambridge, UK
Development 113:471-85. 1991..We present evidence for four distinct phases of wg function in epidermal cells: (1) an early requirement in engrailed-expressing cells to establish and maintain stable expression of en, (2) a discrete period when wg and en gene ..
- The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formationM Peifer
Department of Molecular Biology, Princeton University, New Jersey 08544 1014
Development 111:1029-43. 1991..We present a description of the patterns of arm protein accumulation in imaginal discs. Finally, we discuss the implications of these results for the role of arm and wingless in pattern formation...
- Mediation of Drosophila head development by gap-like segmentation genesS M Cohen
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
Nature 346:482-5. 1990..We report here that three previously identified zygotic genes buttonhead (btd), empty spiracles (ems) and orthodenticle (otd) may behave like gap genes that mediate bcd function in the embryonic head...
- Region-specific recombination and expression are directed by portions of the Drosophila engrailed promoterC Hama
Department of Biochemistry and Biophysics, University of California, San Francisco 94143
Genes Dev 4:1079-93. 1990The Drosophila engrailed gene is expressed in the cells of the posterior developmental compartments...
- Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesisS Baumgartner
Department of Cell Biology, Biocenter, University of Basel, Switzerland
Genes Dev 1:1247-67. 1987..BSH9, BSH4, and prd are activated in cells that are in register along the anteroposterior axis of the embryo in the posterior parts of primordial segments comprising the posterior compartments of engrailed expression.
- Engrailed gene expression in Drosophila imaginal discsD L Brower
EMBO J 5:2649-56. 1986Genetic and molecular analyses indicate that the Drosophila engrailed gene is required to distinguish posterior from anterior compartments in each segment of the developing animal...
- Posterior-to-anterior transformation in engrailed wing imaginal disks of DrosophilaD L Brower
Nature 310:496-7. 1984..Mutations at the engrailed locus can affect the pattern of cuticular structures in the posterior compartments of segments, but have no ..
- Different requirements for homeotic genes in the soma and germ line of DrosophilaP A Lawrence
Cell 35:27-34. 1983..We find that none of four selector genes (Ultrabithorax+, Antennapedia+, Sex combs reduced+, and engrailed+) is required for the development of viable eggs, and none contributes detectable product to the fertilized ..
- HOW DOES VND INTEGRATE POSITIONAL INFORMATION?DERVLA MELLERICK DRESSLER; Fiscal Year: 2003..These studies address the structure and function of vnd, a critical regulator of early neuronal development, and may serve as a prototype for vertebrate vnd-like genes. ..
- Pancreas-specific primary regulatory targets of Nkx2.2DERVLA MELLERICK DRESSLER; Fiscal Year: 2004..2 target genes. This knowledge may be highly instructive in defining those regulatory networks required for beta islet specification. ..
- Liver Biology, Development and DiseaseKLAUS KAESTNER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- FUNCTIONAL GENOMICS OF THE BETA-CELLKLAUS KAESTNER; Fiscal Year: 2007..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
- Biology and biochemistry of Jelly belly signalingJoseph Weiss; Fiscal Year: 2008..Analysis of the phenotype of Ptn/Mk mutants in Drosophila will clarify the signaling function of these molecules both with respect to the pathways in which they participate and their functions in those pathways. [unreadable] [unreadable]..
- SUMO conjugation in cell biology and DevelopmentAlbert J Courey; Fiscal Year: 2010..Consequently, the research proposed here will advance our understanding of human disease. ..
- Mechanism of Hedgehog signal transductionJOAN HOOPER; Fiscal Year: 2007..Their successful completion would significantly advance our understanding of this fundamental signal transduction pathway and may pinpoint therapeutic targets for Hh-based pathologies. [unreadable] [unreadable] [unreadable]..
- Regulation of epidermal barrier wound repairWILLIAM JAMES MCGINNIS; Fiscal Year: 2010..abstract_text> ..
- Methylmercury toxicity in neural developmentMATTHEW RAND; Fiscal Year: 2006..This information will help direct strategies for prevention of MeHg toxicity, for example through pharmacologic administration of protease inhibitors. ..
- SPECIFICITY IN HOMEOTIC RESPONSE ELEMENTSWilliam McGinnis; Fiscal Year: 2005..We will apply microarrays to test whether this combination of transcription factors regulates a common group of "skeletal" and/or "collagen and cross-linking" genes in Drosophila and other animals. ..
- Hedgehog Signaling and Sex-lethal Protein LocalizationJAMILA HORABIN; Fiscal Year: 2004..Understanding the Hh signaling pathway and the different processes it regulates will be important to understanding and curing various cancers. ..
- MOLECULAR BASIS OF DEVELOPMENTAL CELL INTERACTIONSJ Marsh; Fiscal Year: 2005..Finally, we have identified a collection of mutants affecting disc growth patterns that serve as an enriched collection of new candidate genes to participate in these events. ..
- Molecular Genetics of Drosophila MAGUK'sPeter Bryant; Fiscal Year: 2005..The work will provide a genetic approach to understanding the functions of Dlg and its mammalian homologs, some of which are strongly implicated in a variety of human cancers. ..
- High-Volume Confocal Imaging SystemStephen Crews; Fiscal Year: 2005..The Pascal will allow the labs to expeditiously and comprehensively study the cellular basis of embryonic development in combination with existing bright-field and spinning disk microscopes. ..
- Gene Activation by Remote Transcriptional EnhancersDale Dorsett; Fiscal Year: 2004..This will help illuminate the basic mechanisms underlying gene expression defects that occur in some human diseases. ..
- CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKERGerard Campbell; Fiscal Year: 2004..Consequently, the present research should have direct relevance to our understanding of how defects in TGF-B signaling can lead to disease. ..
- FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATIONKLAUS KAESTNER; Fiscal Year: 2003....
- Signaling Mechanisms of the Drosophila JAK/STAT PathwayHong Luo; Fiscal Year: 2003..abstract_text> ..
- GENETIC CONTROL OF CELL FATE DIVERSITY IN DROSOPHILAAmy Bejsovec; Fiscal Year: 2003..This specificity may indicate a novel function in the Wg pathway. Aim 4 describes a plan for the molecular cloning of this new gene and for the subsequent characterization of its gene product. ..
- MOLECULAR MECHANISM OF WINGLESS SIGNALINGSusan Cumberledge; Fiscal Year: 2002....
- MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILAGERARD L CAMPBELL; Fiscal Year: 2010..single RD could provide all the activity required for a TF to function, but real TFs such as the Brinker (Brk), Engrailed (En) and C15 proteins of Drosophila possess multiple RDs and appear to be able to recruit more than one ..
- IN VIVO ROLE OF PROTEOGLYCANS IN GROWTH FACTOR SIGNALINGJ Marsh; Fiscal Year: 2001..Further, these in vivo studies may help in understanding the basis of some dysmorphologies in humans. ..
- Molecular Genetics of Midline Glial DevelopmentStephen T Crews; Fiscal Year: 2010..abstract_text> ..
- Molecular and genetic analysis of sanpodoJames B Skeath; Fiscal Year: 2010..Such insight should help us understand the etiology of diseases in which this process is de-regulated and design new methods to treat these diseases. ..
- Development of C57BL/6 ES cell technology for high thoughput use.KLAUS KAESTNER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONSChris Doe; Fiscal Year: 2002..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
- SPECTRAL CONFOCAL MICROSCOPEPeter Bryant; Fiscal Year: 2002..abstract_text> ..
- HOMEODOMAIN PROTEIN AND CELL TYPE SPECIFICITYMELODY SIEGLER; Fiscal Year: 2001..We wish to determine whether cell types are altered, and whether there are other effects on formation of neuronal circuits. ..
- Expression profiling of human isletsKLAUS KAESTNER; Fiscal Year: 2006....