ftz

Summary

Gene Symbol: ftz
Description: fushi tarazu
Alias: BG:DS07876.1, CG2047, Dm-Ftz, Dm-ftz, DmFtz, Dmel\CG2047, Dmftz, FTZ, Ftz, Ual, l(3)84Ag, CG2047 gene product from transcript CG2047-RA, CG2047-PA, Fushi-Tarazu, Ultra-abdominal-like, ftz-PA, fushitarazu
Species: fruit fly

Top Publications

  1. pmc Characterization of the cis-regulatory region of the Drosophila homeotic gene Sex combs reduced
    J G Gindhart
    Howard Hughes Medical Institute, Indiana University, Bloomington 47405, USA
    Genetics 139:781-95. 1995
  2. pmc DNA binding specificity of two homeodomain proteins in vitro and in Drosophila embryos
    J Walter
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 8114, USA
    Proc Natl Acad Sci U S A 93:2680-5. 1996
  3. ncbi The Drosophila fish-hook gene encodes a HMG domain protein essential for segmentation and CNS development
    P A Nambu
    Biology Department, University of Massachusetts, Amherst 01003, USA
    Development 122:3467-75. 1996
  4. ncbi Ftz-F1 is a cofactor in Ftz activation of the Drosophila engrailed gene
    B Florence
    Department of Genetics, University of Wisconsin, Madison 53706, USA
    Development 124:839-47. 1997
  5. pmc Different core promoters possess distinct regulatory activities in the Drosophila embryo
    S Ohtsuki
    Department of Molecular and Cell Biology, Division of Genetics, University of California, Berkeley, California 94720, USA
    Genes Dev 12:547-56. 1998
  6. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  7. pmc Long-range enhancer-promoter interactions in the Scr-Antp interval of the Drosophila Antennapedia complex
    Vincent C Calhoun
    Department of Molecular and Cell Biology, Division of Genetics and Development, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 100:9878-83. 2003
  8. ncbi Developmental function of Elf-1: an essential transcription factor during embryogenesis in Drosophila
    S J Bray
    Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
    Genes Dev 5:1672-83. 1991
  9. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline
    Cris L Luengo Hendriks
    Berkeley Drosophila Transcription Network Project, Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Genome Biol 7:R123. 2006
  10. ncbi The rise and fall of Hox gene clusters
    Denis Duboule
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Development 134:2549-60. 2007

Research Grants

Detail Information

Publications152 found, 100 shown here

  1. pmc Characterization of the cis-regulatory region of the Drosophila homeotic gene Sex combs reduced
    J G Gindhart
    Howard Hughes Medical Institute, Indiana University, Bloomington 47405, USA
    Genetics 139:781-95. 1995
    ..pattern in the anterior and posterior midgut are imbedded in the regulatory region of the segmentation gene fushi tarazu (ftz), which is normally located between 10 and 20 kb 5' of the Scr transcription start site...
  2. pmc DNA binding specificity of two homeodomain proteins in vitro and in Drosophila embryos
    J Walter
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 8114, USA
    Proc Natl Acad Sci U S A 93:2680-5. 1996
    ....
  3. ncbi The Drosophila fish-hook gene encodes a HMG domain protein essential for segmentation and CNS development
    P A Nambu
    Biology Department, University of Massachusetts, Amherst 01003, USA
    Development 122:3467-75. 1996
    ..These results indicate an essential role for fish in anterior/posterior pattern formation and nervous system development, and suggest a potential function in modulating the activities of gap and pair-rule proteins...
  4. ncbi Ftz-F1 is a cofactor in Ftz activation of the Drosophila engrailed gene
    B Florence
    Department of Genetics, University of Wisconsin, Madison 53706, USA
    Development 124:839-47. 1997
    The fushi tarazu pair-rule gene is required for the formation of alternating parasegmental boundaries in the Drosophila embryo...
  5. pmc Different core promoters possess distinct regulatory activities in the Drosophila embryo
    S Ohtsuki
    Department of Molecular and Cell Biology, Division of Genetics, University of California, Berkeley, California 94720, USA
    Genes Dev 12:547-56. 1998
    ..Thus, certain upstream activators, such as Ftz, prefer TATA-containing promoters, whereas other activators, including Dorsal, work equally well on both classes of ..
  6. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  7. pmc Long-range enhancer-promoter interactions in the Scr-Antp interval of the Drosophila Antennapedia complex
    Vincent C Calhoun
    Department of Molecular and Cell Biology, Division of Genetics and Development, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 100:9878-83. 2003
    ..In the case of the Drosophila Antennapedia complex, the T1 enhancer bypasses the neighboring ftz gene and interacts with the distant Scr promoter to activate expression in posterior head segments...
  8. ncbi Developmental function of Elf-1: an essential transcription factor during embryogenesis in Drosophila
    S J Bray
    Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
    Genes Dev 5:1672-83. 1991
    ..The results highlight the importance of genetic analysis in the study of proteins required for developmental regulation of gene expression...
  9. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline
    Cris L Luengo Hendriks
    Berkeley Drosophila Transcription Network Project, Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Genome Biol 7:R123. 2006
    ..To model and thoroughly understand animal transcription networks, it is essential to derive accurate spatial and temporal descriptions of developing gene expression patterns with cellular resolution...
  10. ncbi The rise and fall of Hox gene clusters
    Denis Duboule
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Development 134:2549-60. 2007
    ..By integrating these parameters, general conclusions emerge that can help solve the aforementioned dilemma...
  11. ncbi The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz
    Y Yu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 385:552-5. 1997
    ..Here we use a native binding site for the homeodomain protein Fushi tarazu (Ftz) to isolate Ftz-F1, a protein of the nuclear hormone-receptor superfamily and a new Ftz cofactor...
  12. pmc A novel boundary element may facilitate independent gene regulation in the Antennapedia complex of Drosophila
    Vladimir E Belozerov
    Department of Cellular Biology, The University of Georgia, Athens, GA 30602, USA
    EMBO J 22:3113-21. 2003
    ..The regulatory region of the Scr gene in the Drosophila Antennapedia complex is interrupted by the neighboring ftz transcription unit, yet both genes are specifically activated by their respective enhancers from such juxtaposed ..
  13. ncbi Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system
    C Q Doe
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    Development 116:855-63. 1992
    ..These results set the stage for investigating neuroblast specification and the mechanisms controlling neuroblast cell lineages...
  14. ncbi Activation and repression of transcription by the gap proteins hunchback and Krüppel in cultured Drosophila cells
    P Zuo
    Department of Biological Sciences, Columbia University, New York, New York 10027
    Genes Dev 5:254-64. 1991
    ..of transcription, capable of functioning both by itself and also synergistically with the pair-rule proteins fushi tarazu and paired...
  15. ncbi Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patterns
    A Lloyd
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
    Mech Dev 36:87-102. 1991
    ..This pattern of expression is altered in mutants for a gap gene (hunchback) and a pair-rule gene (fushi tarazu)...
  16. ncbi Transcriptional control of Drosophila fushi tarazu zebra stripe expression
    C R Dearolf
    Division of Chemistry, California Institute of Technology, Pasadena 91125
    Genes Dev 3:384-98. 1989
    The Drosophila segmentation gene fushi tarazu (ftz) is expressed in a characteristic pattern of seven stripes during early embryogenesis...
  17. ncbi Functional analysis of NTF-1, a developmentally regulated Drosophila transcription factor that binds neuronal cis elements
    B D Dynlacht
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Genes Dev 3:1677-88. 1989
    ..of the Ultrabithorax (Ubx) promoter and to the neurogenic elements of both the dopa decarboxylase (Ddc) and fushi tarazu (ftz) promoter/enhancer regions...
  18. ncbi A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans
    W McGinnis
    Cell 37:403-8. 1984
    ..We have previously reported weak DNA sequence homology between 3' portions of the Antennapedia and fushi tarazu genes of the ANT-C and the Ultrabithorax gene of the BX-C...
  19. pmc Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed
    G Jimenez
    Imperial Cancer Research Fund ICRF, London WC2A 3PX, England
    Genes Dev 11:3072-82. 1997
    ..These results show that Gro is not generally required for repression, but acts as a specific corepressor for a fraction of negative regulators, including Hairy and En...
  20. ncbi Regulation of segmentation and segmental identity by Drosophila homeoproteins: the role of DNA binding in functional activity and specificity
    M D Biggin
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 208114, USA
    Development 124:4425-33. 1997
    ..In this 'widespread binding' model, cofactors act mainly by helping to distinguish the way in which homeoproteins regulate targets to which they are already bound...
  21. pmc A binding site for multiple transcriptional activators in the fushi tarazu proximal enhancer is essential for gene expression in vivo
    W Han
    Brookdale Center for Developmental and Molecular Biology, Mt Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell Biol 18:3384-94. 1998
    The Drosophila homeobox gene fushi tarazu (ftz) is expressed in a highly dynamic striped pattern in early embryos...
  22. pmc Accessibility of transcriptionally inactive genes is specifically reduced at homeoprotein-DNA binding sites in Drosophila
    A Carr
    Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208114, 260 Whitney Avenue, New Haven, CT 06520 8114, USA
    Nucleic Acids Res 28:2839-46. 2000
    ....
  23. pmc Small bristles, the Drosophila ortholog of NXF-1, is essential for mRNA export throughout development
    G S Wilkie
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Scotland, United Kingdom
    RNA 7:1781-92. 2001
    ..We conclude that NXF-1 is an essential ubiquitous export factor for all mRNAs throughout development in higher eukaryotes...
  24. ncbi Differential cytoplasmic mRNA localisation adjusts pair-rule transcription factor activity to cytoarchitecture in dipteran evolution
    Simon L Bullock
    Cancer Research UK, Developmental Genetics Laboratory, PO Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 131:4251-61. 2004
    ..Our data suggest that mRNA localisation signals in pair-rule transcripts affect nuclear protein uptake and thereby adjust gene activity to a variety of dipteran blastoderm cytoarchitectures...
  25. pmc Transcriptional control in the segmentation gene network of Drosophila
    Mark D Schroeder
    Laboratory of Developmental Neurogenetics, Rockefeller University, New York, New York, USA
    PLoS Biol 2:E271. 2004
    ..The study demonstrates that computational methods are a powerful complement to experimental approaches in the analysis of transcription networks...
  26. pmc Estimation of errors introduced by confocal imaging into the data on segmentation gene expression in Drosophila
    Ekaterina Myasnikova
    St Petersburg State Polytechnic University, St Petersburg, 195251, Russia
    Bioinformatics 25:346-52. 2009
    ..This article deals with errors introduced by confocal microscope...
  27. pmc The bx region enhancer, a distant cis-control element of the Drosophila Ubx gene and its regulation by hunchback and other segmentation genes
    S Qian
    Department of Cell Biology, Baylor College of Medicine, Texas Medical Center, Houston 77030
    EMBO J 10:1415-25. 1991
    ..In addition, the BRE pattern requires input from other segmentation genes, among them tailless and fushi tarazu but not Krüppel and knirps.
  28. ncbi A sequence-specific DNA-binding protein that activates fushi tarazu segmentation gene expression
    H Ueda
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genes Dev 4:624-35. 1990
    The Drosophila segmentation gene fushi tarazu (ftz) is expressed at the cellular blastoderm stage in a pattern of seven transverse stripes; the stripes lie out of register with the segmental primordia, spanning alternate segmental ..
  29. ncbi Zebra patterns in fly embryos: activation of stripes or repression of interstripes?
    S B Carroll
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Cell 60:9-16. 1990
    ..Certain genes, such as ftz, are largely negatively regulated in the interstripes through proximal upstream elements by the striped expression ..
  30. ncbi Localization of the fushi tarazu protein during Drosophila embryogenesis
    S B Carroll
    Cell 43:47-57. 1985
    The fushi tarazu (ftz) gene of Drosophila acts early in embryogenesis to regulate body segmentation. The localization of the ftz protein product in embryos was examined using indirect immunofluorescence microscopy...
  31. ncbi Control elements of the Drosophila segmentation gene fushi tarazu
    Y Hiromi
    Cell 43:603-13. 1985
    b>Fushi tarazu (ftz) is one of the Drosophila homeo-box-containing genes required to establish the segmental pattern. Ftz+ transcripts accumulate in cells that form seven equally spaced bands at the blastoderm stage...
  32. ncbi A molecular analysis of fushi tarazu, a gene in Drosophila melanogaster that encodes a product affecting embryonic segment number and cell fate
    A J Weiner
    Cell 37:843-51. 1984
    Mutations at the fushi tarazu locus in Drosophila melanogaster affect both segment number and the pattern of cuticular structures on alternating segments of embryos. The ftz gene has been cloned and characterized...
  33. ncbi Gap gene properties of the pair-rule gene runt during Drosophila segmentation
    C Tsai
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook 11794 5215
    Development 120:1671-83. 1994
    ..of the pair-rule genes hairy and even-skipped but had a more uniform effect on the secondary pair-rule gene fushi tarazu. Surprisingly, the expression of the gap segmentation genes, which are upstream of runt in the segmentation ..
  34. pmc Silencers in abdominal-B, a homeotic Drosophila gene
    A Busturia
    Zoological Institute, University of Zurich, Switzerland
    EMBO J 12:1415-25. 1993
    ..The striking similarities between the control of Abd-B and of Ultrabithorax, another homeotic Drosophila gene, may point to a universal principle underlying homeotic gene regulation...
  35. ncbi Double labeling with fluorescence in situ hybridization in Drosophila whole-mount embryos
    S C Hughes
    Banting and Best Department of Medical Research, University of Toronto, ON, Canada
    Biotechniques 24:530-2. 1998
  36. ncbi Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans
    M Muckenthaler
    European Molecular Biology Laboratory, Heidelberg, Germany
    Eur J Biochem 254:230-7. 1998
    ..elegans will facilitate a genetic analysis of the IRE/IRP system, thus opening a new avenue to explore this regulatory network...
  37. pmc A comparison of in vivo and in vitro DNA-binding specificities suggests a new model for homeoprotein DNA binding in Drosophila embryos
    A Carr
    Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208114, New Haven, CT 06520 8114, USA
    EMBO J 18:1598-608. 1999
    ..These genes are bound poorly in vivo, even though they contain many high affinity homeoprotein-binding sites. Based on these results, we suggest how the in vivo pattern of homeoprotein DNA binding is determined...
  38. pmc Analysis of an even-skipped rescue transgene reveals both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradients
    M Fujioka
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 126:2527-38. 1999
    ..Additionally, a strong pairing-sensitive repression element was localized to the 3' end of the locus, but was not found to contribute to efficient functional rescue...
  39. ncbi Segmenting the fly embryo: a logical analysis of the pair-rule cross-regulatory module
    Lucas Sanchez
    Centro de Investigaciones Biologicas, Velazquez 144, 28006 Madrid, Spain
    J Theor Biol 224:517-37. 2003
    ..Finally, it provides new insights into the roles and evolutionary origins of the apparent redundancies in the regulatory architecture of the pair-rule module...
  40. pmc Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
    Katsutomo Okamura
    Institute for Genome Research, University of Tokushima, Tokushima 770 8503, Japan
    Genes Dev 18:1655-66. 2004
    ..Our findings show that distinct Argonaute proteins act at different steps of the small RNA silencing mechanism and suggest that there are inherent differences between siRNA-initiated RISCs and miRNA-initiated RISCs in Drosophila...
  41. pmc Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura
    Benjamin P Berman
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Genome Biol 5:R61. 2004
    ..Nine of these clusters overlapped known enhancers. Here, we report the results of in vivo functional analysis of 27 remaining clusters...
  42. ncbi Concentration-dependent activities of the even-skipped protein in Drosophila embryos
    A S Manoukian
    Banting and Best Department of Medical Research, University of Toronto, C H Best Institute, Ontario, Canada
    Genes Dev 6:1740-51. 1992
    ..Two tiers of response times appeared to distinguish between genes that were direct [fushi tarazu (ftz), odd-skipped (odd), runt (run), paired, and wingless] and indirect [eve, hairy, and engrailed (en)] ..
  43. ncbi Synthetic oligonucleotides recreate Drosophila fushi tarazu zebra-stripe expression
    J Topol
    Division of Chemistry, California Institute of Technology, Pasadena 91125
    Genes Dev 5:855-67. 1991
    A complex array of activator and repressor elements located within 669 bp proximal to the fushi tarazu (ftz) transcriptional start site is sufficient to generate the "zebra-stripe" expression pattern characteristic of the ftz gene...
  44. ncbi Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated
    L Pick
    Department of Cell Biology, University of Basel, Switzerland
    Genes Dev 4:1224-39. 1990
    The Drosophila fushi tarazu (ftz) upstream element is an enhancer-like element that is required for the correct expression of ftz in developing embryos and that directs transcription from a minimal promoter in a ftz-like seven-striped ..
  45. ncbi Transcriptional regulation of the Drosophila segmentation gene fushi tarazu (ftz)
    C R Dearolf
    Division of Chemistry, California Institute of Technology, Pasadena 91125
    Bioessays 12:109-13. 1990
    b>ftz is one of the 'pair rule' segmentation genes of Drosophila melanogaster, and is an important component of the segmentation process in the fruit fly...
  46. ncbi The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system
    M A Kania
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Genes Dev 4:1701-13. 1990
    ..overlap of the runt protein pattern with the patterns of the pair-rule genes hairy (h), even-skipped (eve), and fushi tarazu (ftz). We found that the patterns of runt and hairy are complementary...
  47. ncbi A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback
    D Tautz
    Institut fur Genetik, Mikrobiologie der Universität München, Federal Republic of Germany
    Chromosoma 98:81-5. 1989
    ..The non-radioactive in situ hybridization method is as sensitive as conventional methods, but is faster and easier to perform. This may make it a useful tool for a variety of other systems...
  48. ncbi The caudal gene product is a direct activator of fushi tarazu transcription during Drosophila embryogenesis
    C R Dearolf
    Division of Chemistry, California Institute of Technology, Pasadena 91125
    Nature 341:340-3. 1989
    A drosophila pair-rule segmentation gene, fushi tarazu (ftz), encodes a protein which is expressed in a characteristic seven-stripe pattern...
  49. ncbi Regulation and function of the Drosophila segmentation gene fushi tarazu
    Y Hiromi
    Cell 50:963-74. 1987
    The Drosophila segmentation gene fushi tarazu (ftz) is expressed in a pattern of seven stripes at the blastoderm stage...
  50. ncbi Expression and function of the segmentation gene fushi tarazu during Drosophila neurogenesis
    C Q Doe
    Department of Biological Sciences, Stanford University, CA 94305
    Science 239:170-5. 1988
    Segmentation genes control cell identities during early pattern formation in Drosophila. One of these genes, fushi tarazu (ftz), is now shown also to control cell fate during neurogenesis...
  51. ncbi Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila
    M Frasch
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, New York 10027
    Genes Dev 1:981-95. 1987
    ..the position-dependent expression of two segmentation genes that contain a homeo box, even-skipped (eve) and fushi tarazu (ftz)...
  52. ncbi Expression, modification, and localization of the fushi tarazu protein in Drosophila embryos
    H M Krause
    Department of Cell Biology, University of Basel, Switzerland
    Genes Dev 2:1021-36. 1988
    The fushi tarazu (ftz) protein of Drosophila is required during embryogenesis for the process of body segmentation...
  53. ncbi Expression, function, and regulation of the hairy segmentation protein in the Drosophila embryo
    S B Carroll
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Genes Dev 2:883-90. 1988
    ..of alternate embryonic segment primordia and the normal spatial expression of another pair-rule gene, fushi tarazu (ftz)...
  54. ncbi Genes that control dorsoventral polarity affect gene expression along the anteroposterior axis of the Drosophila embryo
    S B Carroll
    Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder 80309 0347
    Development 99:327-32. 1987
    ..We have used the expression of the fushi tarazu (ftz) segmentation gene as a positional marker to investigate the relationship between the dorsoventral and ..
  55. ncbi A test for adaptive change in DNA sequences controlling transcription
    D L Jenkins
    Department of Genetics, University of Nottingham, Queens Medical Centre, U K
    Proc Biol Sci 261:203-7. 1995
    ..This is despite highly significant evidence that all parts of the sequence have been subject to strong selective constraint). The test can be applied generally to investigate adaptive evolution in the control of gene expression...
  56. ncbi Non-periodic cues generate seven ftz stripes in the Drosophila embryo
    Y Yu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mech Dev 50:163-75. 1995
    We have examined the expression pattern of the segmentation gene fushi tarazu (ftz) by in situ hybridization to whole mount embryos using digoxygenin labeled probes...
  57. ncbi Two homeo domain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos
    J Walter
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520
    Genes Dev 8:1678-92. 1994
    ..in vivo UV cross-linking to directly measure DNA binding by the homeo domain proteins even-skipped (eve) and fushi tarazu (ftz) in Drosophila embryos...
  58. ncbi Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
    Z Paroush
    Laboratory of Developmental Genetics, University of Oxford, England
    Cell 79:805-15. 1994
    ....
  59. ncbi Neurogenic expression of snail is controlled by separable CNS and PNS promoter elements
    Y T Ip
    Department of Biology, University of California, San Diego, La Jolla 92093 0322
    Development 120:199-207. 1994
    ..The separate control of CNS and PNS sna expression and independence of proneural gene regulation add to a growing body of evidence that current genetic models of neurogenesis are substantially incomplete...
  60. pmc Multiple proteins interact with the fushi tarazu proximal enhancer
    W Han
    Brookdale Center for Molecular Biology, Mt Sinai School of Medicine, New York, New York 10029
    Mol Cell Biol 13:5549-59. 1993
    The expression of the Drosophila segmentation gene fushi tarazu (ftz) is controlled at the level of transcription. The proximal enhancer, located approximately 3...
  61. ncbi Disperse versus compact elements for the regulation of runt stripes in Drosophila
    M Klingler
    Zoologisches Institut, Luisenstrasse 14, Munich, D 80333, Germany
    Dev Biol 177:73-84. 1996
    ..We did not find autoregulatory elements as described for even-skipped and fushi tarazu. The regulation of runt by other pair-rule genes is mediated by a large region, extending over 5 kb upstream ..
  62. ncbi The Dichaete gene of Drosophila melanogaster encodes a SOX-domain protein required for embryonic segmentation
    S R Russell
    Department of Genetics, University of Cambridge, UK
    Development 122:3669-76. 1996
    ....
  63. ncbi Concentration-dependent patterning by an ectopic expression domain of the Drosophila gap gene knirps
    D Kosman
    Department of Biology, New York University, NY 10003, USA
    Development 124:1343-54. 1997
    ..Evidence is presented that the level and timing of expression, as well as protein diffusion, are important for determining the specific responses of target genes...
  64. ncbi Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins
    D Kosman
    Brookdale Center for Molecular Biology, Box 1126, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Genes Evol 208:290-4. 1998
    ..Antigenicity of the purified recombinant proteins may be increased by precipitation in double-distilled water. The results of using the serums obtained for fluorescent staining of Drosophila embryos are shown...
  65. ncbi Segmentation: painting stripes from flies to vertebrates
    L Pick
    Brookdale Center for Developmental and Molecular Biology, Mt Sinai School of Medicine, New York, NY 10029, USA
    Dev Genet 23:1-10. 1998
  66. ncbi Dynamic changes in the functions of Odd-skipped during early Drosophila embryogenesis
    B Saulier-Le Drean
    Banting and Best Department of Medical Research, Charles H Best Institute, University of Toronto, Toronto, Ontario, Canada, M5G 1L6
    Development 125:4851-61. 1998
    ..Moreover, one target gene, fushi tarazu, is both repressed and activated by Odd, the outcome depending upon the stage of development...
  67. ncbi Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
    J R Kennerdell
    Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
    Cell 95:1017-26. 1998
    ..Our results demonstrate that dsRNA interference can be used to analyze many aspects of gene function...
  68. ncbi Differential interactions between Brother proteins and Runt domain proteins in the Drosophila embryo and eye
    L H Li
    Department of Biochemistry and Cell Biology and the Institute for Cell and Developmental Biology, SUNY at Stony Brook, Stony Brook, NY 11794 5215, USA
    Development 126:3313-22. 1999
    ..Our results firmly establish the importance of the Brother and Big brother proteins for the biological activities of Runt and Lozenge, and further suggest that Brother protein function is not restricted to enhancing DNA-binding...
  69. pmc Quantitative analysis of gene function in the Drosophila embryo
    W D Tracey
    Department of Biochemistry and Cell Biology and the Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    Genetics 154:273-84. 2000
    ..The maternal GAL4 system will have applications both for the measurement of gene activity in reverse genetic experiments as well as for the identification of genetic factors that have quantitative effects on gene function in vivo...
  70. ncbi Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both mad and groucho transcriptional repression
    T M Phippen
    Division of Basic Sciences and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 275:37628-37. 2000
    ..Hairy defines a new class of proteins that requires both CtBP and Groucho co-factors for proper function...
  71. ncbi Establishment and maintenance of parasegmental compartments
    S C Hughes
    Banting and Best Department of Medical Research, University of Toronto, Charles H Best Institute, Toronto, Ontario, M5G 1L6, Canada
    Development 128:1109-18. 2001
    ..The establishment and maintenance of vertebrate metameres may be governed by similar processes and properties...
  72. ncbi Conserved signals and machinery for RNA transport in Drosophila oogenesis and embryogenesis
    S L Bullock
    Developmental Genetics Laboratory, Imperial Cancer Research Fund, London, UK
    Nature 414:611-6. 2001
    ..We propose that Egl and BicD are core components of a selective dynein motor complex that drives transcript localization in a variety of tissues...
  73. pmc Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome
    Benjamin P Berman
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:757-62. 2002
    ..We tested one of the newly identified clusters, mapping upstream of the gap gene giant (gt), and show that it acts as an enhancer that recapitulates the posterior expression pattern of gt...
  74. pmc Extraction of functional binding sites from unique regulatory regions: the Drosophila early developmental enhancers
    Dmitri A Papatsenko
    Department of Biology, New York University, New York, NY 10003 6688, USA
    Genome Res 12:470-81. 2002
    ..We also discuss the definition of true binding sites and the possible biological principles that govern patterning of regulatory regions and the distribution of transcriptional signals...
  75. pmc Distance preferences in the arrangement of binding motifs and hierarchical levels in organization of transcription regulatory information
    Vsevolod J Makeev
    Scientific Center Genetika, Moscow 113545, Russia
    Nucleic Acids Res 31:6016-26. 2003
    ..We discuss the role of the hierarchy in understanding transcriptional regulation and in detection of transcription regulatory regions in genomes...
  76. ncbi Ftz modulates Runt-dependent activation and repression of segment-polarity gene transcription
    Deborah Swantek
    Department of Biochemistry and Cell Biology and the Center for Developmental Genetics, State University of New York at Stony Brook, Stony Brook, NY 11794 5140, USA
    Development 131:2281-90. 2004
    ..is both necessary and sufficient for slp1 activation in all somatic blastoderm nuclei that do not express the Fushi tarazu (Ftz) transcription factor...
  77. ncbi Multiplex detection of RNA expression in Drosophila embryos
    Dave Kosman
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Science 305:846. 2004
    ....
  78. ncbi Groucho-dependent repression by sloppy-paired 1 differentially positions anterior pair-rule stripes in the Drosophila embryo
    Luiz P Andrioli
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Dev Biol 276:541-51. 2004
    ..The Slp1 protein contains a protein motif (EH1) which mediates binding to the transcriptional corepressor Groucho (Gro). We show that this domain is required for Slp1-mediated repression in vivo...
  79. ncbi Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor
    Barbara H Jennings
    Developmental Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Mol Cell 22:645-55. 2006
    ..Our structural and functional analysis explains the rigid conservation of the WRPW motif, the sequence flexibility of eh1 motifs, and other aspects of repressor recognition by Gro in vivo...
  80. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution II: dynamics
    Soile V E Keränen
    Berkeley Drosophila Transcription Network Project, Genomics Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720, USA
    Genome Biol 7:R124. 2006
    ..To accurately describe gene expression and computationally model animal transcriptional networks, it is essential to determine the changing locations of cells in developing embryos...
  81. pmc Transcription elongation controls cell fate specification in the Drosophila embryo
    Xiaoling Wang
    Department of Biochemistry, Stony Brook University, Stony Brook, New York 11794, USA
    Genes Dev 21:1031-6. 2007
    ..We find that the initial repression of slp1 in response to Runt and Fushi-tarazu (Ftz) does not involve chromatin remodeling, or histone modification...
  82. pmc Dynactin suppresses the retrograde movement of apically localized mRNA in Drosophila blastoderm embryos
    Georgia Vendra
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK
    RNA 13:1860-7. 2007
    ....
  83. pmc Differential in vivo requirements for oligomerization during Groucho-mediated repression
    Barbara H Jennings
    Developmental Genetics Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, UK
    EMBO Rep 9:76-83. 2008
    ..Our results show that homo-oligomerization of Gro is not obligatory for its action in vivo, and that Gro represses transcription through more than one molecular mechanism...
  84. pmc Characterization of the Drosophila segment determination morphome
    Svetlana Surkova
    Department of Computational Biology, Center for Advanced Studies, St Petersburg State Polytechnical University, 29 Polytehnicheskaya Street, St Petersburg, 195251, Russia
    Dev Biol 313:844-62. 2008
    ..As the first quantitatively characterized morphogenetic field, this system and its behavior constitute an extraordinarily rich set of materials for the study of canalization and embryonic regulation at the molecular level...
  85. doi A quantitative spatiotemporal atlas of gene expression in the Drosophila blastoderm
    Charless C Fowlkes
    Berkeley Drosophila Transcription Network Project, University of California, Irvine, CA 92697, USA
    Cell 133:364-74. 2008
    ..We present a VirtualEmbryo containing data for 95 genes at six time cohorts. We show that known gene-regulatory interactions can be automatically recovered from this data set and predict hundreds of new interactions...
  86. pmc FlyEx, the quantitative atlas on segmentation gene expression at cellular resolution
    Andrei Pisarev
    Department of Computational Biology, St Petersburg State Polytechnical University, St Petersburg 195251, Russia
    Nucleic Acids Res 37:D560-6. 2009
    ..5 h of development. FlyEx supports the data downloads and construction of personal reference datasets, that makes it possible to more effectively use and analyze data...
  87. pmc Egalitarian is a selective RNA-binding protein linking mRNA localization signals to the dynein motor
    Martin Dienstbier
    Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Genes Dev 23:1546-58. 2009
    ....
  88. pmc Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
    Stewart MacArthur
    Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
    Genome Biol 10:R80. 2009
    ....
  89. pmc Non-additive interactions involving two distinct elements mediate sloppy-paired regulation by pair-rule transcription factors
    Lisa Prazak
    Department of Biochemistry and Cell Biology and the Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794 5215, USA
    Dev Biol 344:1048-59. 2010
    ..stripes and mediates repression by Even-skipped (Eve) as well as by the combination of Runt and Fushi-tarazu (Ftz)...
  90. pmc Distinct contributions of conserved modules to Runt transcription factor activity
    Pegine B Walrad
    Department of Biochemistry and Cell Biology and the Center for Developmental Genetics, Graduate Programs in Molecular and Cellular Biology and Biochemistry and Structural Biology, Stony Brook University, Stony Brook, NY 11794 5215, USA
    Mol Biol Cell 21:2315-26. 2010
    ..These results provide a foundation for further studies on the molecular interactions that contribute to the context-dependent properties of Runx proteins as developmental regulators...
  91. pmc The role of chromatin accessibility in directing the widespread, overlapping patterns of Drosophila transcription factor binding
    Xiao Yong Li
    Genomics Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road MS 84 171, Berkeley, CA 94720, USA
    Genome Biol 12:R34. 2011
    ..The primary biochemical mechanisms that drive these genome-wide occupancy patterns have yet to be established...
  92. pmc Dynamic reprogramming of chromatin accessibility during Drosophila embryo development
    Sean Thomas
    Department of Genome Sciences, University of Washington, Foege S310A, 1705 NE Pacific Street, Box 355065, Seattle, WA 98195, USA
    Genome Biol 12:R43. 2011
    ..Understanding the scope and features of chromatin dynamics during embryogenesis, and identifying regulatory elements important for directing developmental processes remain key goals of developmental biology...
  93. pmc How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation
    Mark D Schroeder
    Laboratory of Developmental Neurogenetics, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Development 138:3067-78. 2011
    ..We find that runt (run), fushi tarazu (ftz) and odd skipped (odd) establish most of their pattern through stripe-specific elements, arguing for a ..
  94. pmc A conserved developmental patterning network produces quantitatively different output in multiple species of Drosophila
    Charless C Fowlkes
    Department of Computer Science, University of California Irvine, Irvine, California, USA
    PLoS Genet 7:e1002346. 2011
    ..Our results emphasize that transcriptional networks can diverge over short evolutionary timescales and that even small changes can lead to distinct output in terms of the placement and number of equivalent cells...
  95. ncbi The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors
    U Grossniklaus
    Biozentrum, University of Basel, Switzerland
    Genes Dev 6:1030-51. 1992
    ..The two genes appear to share an enhancer element situated upstream of slp1 that acts on both the proximal slp1 promoter and the distal slp2 promoter...
  96. pmc Molecular analysis of odd-skipped, a zinc finger encoding segmentation gene with a novel pair-rule expression pattern
    D E Coulter
    Department of Biochemistry and Molecular Biology, St Louis University Medical School, MO 63104
    EMBO J 9:3795-804. 1990
    ..Similar double to single segment transitions have now been reported for four of the six pair-rule genes analyzed...
  97. pmc Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila
    M P Scott
    Proc Natl Acad Sci U S A 81:4115-9. 1984
    ..DNA from each of these 3' exons also hybridized weakly to DNA from the fushi tarazu locus of the ANT-C...
  98. ncbi Control of segmental asymmetry in Drosophila embryos
    A S Manoukian
    Banting and Best Department of Medical Research, C H Best Institute, University of Toronto, Ontario, Canada
    Development 118:785-96. 1993
    ..are first defined at the blastoderm stage by alternating stripes of transcripts encoded by the pair-rule genes fushi tarazu (ftz) and even-skipped (eve) and later by stripes encoded by the segment polarity genes engrailed (en) and ..
  99. ncbi The regulation of enhancer-promoter interactions in the Drosophila embryo
    J Zhou
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cold Spring Harb Symp Quant Biol 62:307-12. 1997
  100. ncbi Interaction of gap genes in the Drosophila head: tailless regulates expression of empty spiracles in early embryonic patterning and brain development
    B Hartmann
    Institute of Zoology, University of Basel, Rheinsprung 9, 4051, Basel, Switzerland
    Mech Dev 109:161-72. 2001
    ..These results are the first demonstration of direct transcriptional regulation between gap genes in the head...
  101. ncbi Pattern abnormalities induced by ectopic expression of the Drosophila gene hairy are associated with repression of ftz transcription
    D Ish-Horowicz
    Department of Zoology, University of Oxford, England
    Cell 51:405-15. 1987
    ..We show that h expression outside these domains, driven by an hsp70 promoter, suppresses the expression of fushi tarazu (ftz). The kinetics of action favor h acting directly as a transcriptional repressor...

Research Grants15

  1. Signaling Mechanisms of the Drosophila JAK/STAT Pathway
    Hong Luo; Fiscal Year: 2003
    ..abstract_text> ..
  2. Genetic Transfer in the Evolution of Infectious Disease
    Rob DeSalle; Fiscal Year: 2005
    ....
  3. Mechanism of Gene Silencing by DNA Methylation
    Yi Zhang; Fiscal Year: 2005
    ..The proposed studies will provide a thorough characterization of the MeCP1 complex. They will also reveal the potential targets and repression mechanism of the MeCP1 complex. ..
  4. Evolution of insect gastrulation
    Matthew Ronshaugen; Fiscal Year: 2006
    ..It is our hope that this will lead to a specific understanding of the evolution of transcriptional regulation and to events that underlie transition of cells toward a migratory state. ..
  5. Role of histone methyltransferases hDOTIL in leukemogenesis
    Yi Zhang; Fiscal Year: 2009
    ..We will map the nuclear localization signal of hDOTIL and the AF10 interaction domains. We will also study how mis-targeting of hDOTIL by CALM-AF10 results in Hox gene upregulation and leukemogenesis. ..
  6. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  7. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  8. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  9. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2007
    ..Our proposed studies will provide insights that should facilitate new therapies for treatment of motoneuron diseases and injury. ..
  10. Molecular and genetic analysis of sanpodo
    James B Skeath; Fiscal Year: 2010
    ..Such insight should help us understand the etiology of diseases in which this process is de-regulated and design new methods to treat these diseases. ..
  11. Mechanisms of Polycomb Silencing
    Yi Zhang; Fiscal Year: 2010
    ..5. .Determine the transcriptional effect and understand the mechanism of H3K27 methylation and H2A ubiquitylation using a reconstituted chromatin transcription system. More description in proposal. ..
  12. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  13. University of Oregon Animal Resource Improvements
    Judith Eisen; Fiscal Year: 2008
    ..This will significantly increase our ability to ensure the health of our many genetically-distinct, and therefore irreplaceable lines of stickleback. [unreadable] [unreadable] [unreadable]..
  14. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  15. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..